Digestive Diseases and Sciences

Long non-coding RNAs (lncRNAs) are transcripts longer than 200 nucleotides and play important roles in a variety of diseases. LncRNAs are involved in many biologic processes including cell differentiation, development, and apoptosis. The intestinal barrier is considered one of the most important protective barriers in humans. Severe damage or dysfunction of the intestinal barrier may be associated with the occurrence and development of many diseases, such as inflammatory bowel disease and ulcerative colitis. LncRNAs have been found to be associated with intestinal barrier function in some studies, which are at an early stage. In this review, we introduce the roles of LncRNAs in the intestinal barrier and investigate the possibility of lncRNAs as a research field in the intestinal barrier.

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Metformin, Microbiome and Protection Against Colorectal Cancer

Georgina R. Jones & Mark P. Molloy

doi : 10.1007/s10620-020-06390-4

Digestive Diseases and Sciences volume 66, pages1409–1414(2021)

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Various Modalities Accurate in Diagnosing a Disrupted or Disconnected Pancreatic Duct in Acute Pancreatitis: A Systematic Review

Hester C. Timmerhuis, Sven M. van Dijk, Robert C. Verdonk, Thomas L. Bollen, Marco J. Bruno, Paul Fockens, Jeanin E. van Hooft, Rogier P. Voermans, Marc G. Besselink & Hjalmar C. van Santvoort for the Dutch Pancreatitis Study Group

doi : 10.1007/s10620-020-06413-0

Digestive Diseases and Sciences volume 66, pages1415–1424(2021)

Severe pancreatitis may result in a disrupted pancreatic duct, which is associated with a complicated clinical course. Diagnosis of a disrupted pancreatic duct is not standardized in clinical practice or international guidelines. We performed a systematic review of the literature on imaging modalities for diagnosing a disrupted pancreatic duct in patients with acute pancreatitis.

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Endoscopic Transpapillary Gallbladder Drainage for Acute Cholecystitis

Zain A. Sobani, Christina Ling & Tarun Rustagi

doi : 10.1007/s10620-020-06422-z

Digestive Diseases and Sciences volume 66, pages1425–1435(2021)

The mainstay of management of acute cholecystitis has been surgical, with percutaneous gallbladder drainage in patients deemed high risk for surgical intervention. Endoscopic management of acute cholecytitis with transpapillary and transmural drainage of the gall bladder is emerging as a viable alternative in high-risk surgical patients. In this article, we discuss the background, current status, technical challenges and strategies to overcome them, adverse events, and outcomes of endoscopic transpapillary gallbladder drainage for management of acute cholecystitis.

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Bleeding Edge Therapy: Ileocolic Intussusception Due to Ileocecal Valve Adenocarcinoma and Its Management in an Adult Patient—Case Report and Literature Review

M. Zanni, S. Vaccari, A. Lauro, I. R. Marino, M. Cervellera, V. D’Andrea & V. Tonini

doi : 10.1007/s10620-021-06849-y

Digestive Diseases and Sciences volume 66, pages1436–1440(2021)

Adenocarcinoma as the primary cause of bowel intussusception is uncommon. We describe the case of a 86-year-old patient admitted for ileocecal intussusception due to the presence of adenocarcinoma, located in the ileocecal valve and right colon. The etiologies of intussusception, its diagnosis, and conservative or surgical treatments are discussed, with attention placed on the indications for reduction of the invagination prior to surgical resection.

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Author Spotlight: Manuel Zanni

Manuel Zanni

doi : 10.1007/s10620-021-06850-5

Digestive Diseases and Sciences volume 66, page1441(2021)

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Use of the Wireless Motility Capsule in the Diagnosis of Gastric Hypochlorhydria: pHinding Extra Value

George Triadafilopoulos & Charles Lombard

doi : 10.1007/s10620-020-06605-8

Digestive Diseases and Sciences volume 66, pages1442–1445(2021)

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Low Rates of Advance Care Planning (ACP) Discussions Despite Readiness to Engage in ACP Among Liver Transplant Candidates

Connie W. Wang, Adrienne Lebsack, Rebecca L. Sudore & Jennifer C. Lai

doi : 10.1007/s10620-020-06369-1

Digestive Diseases and Sciences volume 66, pages1446–1451(2021)

Patients with end-stage liver disease awaiting liver transplantation (LT) are seriously ill and experience fluctuating periods of clinical decompensation. Discussion of a patient’s advance care planning (ACP) wishes early in their dynamic disease course is critical to providing value-aligned care while awaiting LT. We aimed to evaluate current ACP documentation and assess readiness to engage in ACP in this population.

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Development of an Algorithm to Identify Cases of Nonalcoholic Steatohepatitis Cirrhosis in the Electronic Health Record

Christopher J. Danford, Jennifer Y. Lee, Ian A. Strohbehn, Kathleen E. Corey & Michelle Lai

doi : 10.1007/s10620-020-06388-y

Digestive Diseases and Sciences volume 66, pages1452–1460(2021)

Current genetic research of nonalcoholic steatohepatitis (NASH) cirrhosis is limited by our ability to accurately identify cases on a large scale. Our objective was to develop and validate an electronic health record (EHR) algorithm to accurately identify cases of NASH cirrhosis in the EHR.

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Gender and Racial Differences in Hospitalizations for Primary Biliary Cholangitis in the USA

Adeyinka Charles Adejumo, Daud H. Akhtar, Brittany B. Dennis, George Cholankeril, Quazim Alayo, Olumuyiwa A. Ogundipe, Donghee Kim & Aijaz Ahmed

doi : 10.1007/s10620-020-06402-3

Digestive Diseases and Sciences volume 66, pages1461–1476(2021)

The prevalence, characteristics, burden and trends of primary biliary cholangitis (PBC) hospitalizations in the USA remain unclear.

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Adherence to Adalimumab Was Not Improved by a Reminder-Based Intervention with an Electronic Needle Container

Johannes P. D. Schultheiss, Sandra Altena, Max R. Clevers, Dominique Baas, Bindia Jharap & Herma H. Fidder

doi : 10.1007/s10620-020-06395-z

Adherence to adalimumab in inflammatory bowel disease (IBD) patients is reported to be below par. Non-adherence may result in loss-of-response and increased hospitalization. We analyzed the effect of an electronic needle container (ENC) on adherence to adalimumab.

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Upregulation of Fecal Epithelial Heparanase mRNA Is Associated with Increased Ulcerative Colitis Activity and Cancerization Risk

Ying Cui, Jun Zhang, Yan Chen & Le-gao Chen

doi : 10.1007/s10620-020-06350-y

Digestive Diseases and Sciences volume 66, pages1488–1498(2021)

Heparanase (HPSE) is considered to play an important role in the occurrence, development and carcinogenesis of ulcerative colitis (UC). There are no reports about the detection of HPSE mRNA in feces to predict UC activity and cancerization risk.

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Circular RNA PTK2 Accelerates Cell Proliferation and Inhibits Cell Apoptosis in Gastric Carcinoma via miR-139-3p

Deliang Yu & Chi Zhang

doi : 10.1007/s10620-020-06358-4

Digestive Diseases and Sciences volume 66, pages1499–1509(2021)

Gastric carcinoma (GC) is one of the most common malignant tumors. Although increasing studies have indicated that circular RNAs function as ideal biomarkers for multiple cancers, only a few researches elucidated the correlation between circular RNA PTK2 (circPTK2) and human cancers.

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Integrin-Linked-Kinase Overexpression Is Implicated in Mechanisms of Genomic Instability in Human Colorectal Cancer

Panagiota Chadla, Marina Arbi, Sofia Nikou, Theodoros Kalliakoudas, Helen Papadaki, Stavros Taraviras, Zoi Lygerou & Vasiliki Bravou

doi : 10.1007/s10620-020-06364-6

Digestive Diseases and Sciences volume 66, pages1510–1523(2021)

Genomic instability is a hallmark of cancer cells contributing to tumor development and progression. Integrin-linked kinase (ILK) is a focal adhesion protein with well-established role in carcinogenesis. We have previously shown that ILK overexpression is critically implicated in human colorectal cancer (CRC) progression. In light of the recent findings that ILK regulates centrosomes and mitotic spindle formation, we aimed to determine its implication in mechanisms of genomic instability in human CRC.

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Hsa-circRNA-103809 Promotes Hepatocellular Carcinoma Development via MicroRNA-1270/PLAG1 Like Zinc Finger 2 Axis

Yajuan Cao, Qingsong Tao, Xiaoming Kao & Xinhua Zhu

doi : 10.1007/s10620-020-06416-x

Digestive Diseases and Sciences volume 66, pages1524–1532(2021)

Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related death in the worldwide. A great number of reports manifested that circular RNA hsa-circRNA-103809 (circRNA-103809) could work in several cancers.

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Using the Secretion Ratios of Insulin and C-peptide During the 2-h Oral Glucose Tolerance Test to Diagnose Insulinoma

Jing Liao, Fei Ding, Wei Luo, Xin Nie, Yong He & Guixing Li

doi : 10.1007/s10620-020-06379-z

Digestive Diseases and Sciences volume 66, pages1533–1539(2021)

Insulinoma, owing to the low incidence and small volume of the tumor, is often undiagnosed. The 72-h fast test is centered on diagnosing insulinoma; however, it cannot be performed on outpatients. Our aim was to evaluate the results of a 3-h oral glucose tolerance test (3-h OGTT) for insulinoma diagnosis.

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Double Guidewire Technique Using an Uneven Double Lumen Catheter for Endoscopic Ultrasound-Guided Interventions

Yousuke Nakai, Hiroki Oyama, Sachiko Kanai, Kensaku Noguchi, Tatsuya Sato, Ryunosuke Hakuta, Kazunaga Ishigaki, Kei Saito, Tomotaka Saito, Tsuyoshi Hamada, Naminatsu Takahara, Suguru Mizuno, Hirofumi Kogure, Hiroyuki Isayama & Kazuhiko Koike

doi : 10.1007/s10620-020-06345-9

Digestive Diseases and Sciences volume 66, pages1540–1547(2021)

Endoscopic ultrasonography (EUS)-guided interventions are often performed using a single guidewire (SGW), but there are a few reports on the use of double guidewire (DGW) technique to facilitate multiple drainage placement during EUS-guided drainage of pancreatic fluid collections. This DGW technique may have advantages other than multiple drainage placement during EUS-guided interventions such as scope stabilization, support for stone extraction and device insertion.

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Risk of Gastrointestinal Endoscopic Procedure-Related Bleeding in Patients With or Without Continued Antithrombotic Therapy

Kiyoaki Yabe, Akira Horiuchi, Takahiro Kudo, Ichitaro Horiuchi, Yasuyuki Ichise, Masashi Kajiyama & Naoki Tanaka

doi : 10.1007/s10620-020-06393-1

Digestive Diseases and Sciences volume 66, pages1548–1555(2021)

Prospective studies on bleeding risk during/after gastrointestinal endoscopic procedures are rare.

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Patient-Reported Outcomes and Blood-Based Parameters Identify Response to Treatment in Eosinophilic Esophagitis

Christine Lingblom, Sofie Albinsson, Leif Johansson, Helen Larsson & Christine Wenner?s

doi : 10.1007/s10620-020-06368-2

Digestive Diseases and Sciences volume 66, pages1556–1564(2021)

Noninvasive methods to assess treatment response in eosinophilic esophagitis are needed.

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Elimination of Dietary Triggers Is Successful in Treating Symptoms of Gastroesophageal Reflux Disease

Cesare Tosetti, Edoardo Savarino, Edoardo Benedetto, Rudi De Bastiani on behalf of the Study Group for the Evaluation of GERD Triggering Foods

doi : 10.1007/s10620-020-06414-z

Digestive Diseases and Sciences volume 66, pages1565–1571(2021)

The relationship between aliments and pathophysiological abnormalities leading to gastroesophageal reflux disease (GERD) symptoms elicitation is unclear. Nevertheless, patients often report symptoms after ingestion of specific foods.

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Wide Area Transepithelial Sampling with Computer-Assisted Analysis (WATS3D) Is Cost-Effective in Barrett’s Esophagus Screening

Mendel E. Singer & Michael S. Smith

doi : 10.1007/s10620-020-06412-1

Digestive Diseases and Sciences volume 66, pages1572–1579(2021)

Wide area transepithelial sampling with three-dimensional computer-assisted analysis (WATS3D) is an adjunct to the standard random 4-quadrant forceps biopsies (FB, “Seattle protocol”) that significantly increases the detection of Barrett’s esophagus (BE) and associated neoplasia in patients undergoing screening or surveillance.

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Long-Term Quality of Life Following Endoscopic Therapy Compared to Esophagectomy for Neoplastic Barrett’s Esophagus

Chanakyaram A. Reddy, Anna Tavakkoli, Vincent L. Chen, Sheryl Korsnes, Aarti Oza Bedi, Philip W. Carrott, Andrew C. Chang, Kiran H. Lagisetty, Richard S. Kwon, B. Joseph Elmunzer, Mark B. Orringer, Cyrus Piraka, Anoop Prabhu, Rishindra M. Reddy, Erik Wamsteker & Joel H. Rubenstein

doi : 10.1007/s10620-020-06377-1

Digestive Diseases and Sciences volume 66, pages1580–1587(2021)

Endoscopic therapy (ET) and esophagectomy result in similar survival for Barrett’s esophagus (BE) with high-grade dysplasia (HGD) or T1a esophageal adenocarcinoma (EAC), but the long-term quality of life (QOL) has not been compared.

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The Meaning of Incidental Goblet Cells at the Gastroesophageal Junction

Kevin O. Turner, Robert M. Genta & Amnon Sonnenberg

doi : 10.1007/s10620-020-06357-5

Digestive Diseases and Sciences volume 66, pages1588–1592(2021)

The causes for the occurrence of goblet cells at the gastroesophageal junction (GEJ-GC) are unknown. The aim of our study was to compare the concurrent histologic changes of the stomach in (1) patients with GEJ-GC, but without Barrett’s esophagus (BE) to those in (2) patients with BE and in (3) controls without GEJ-GC or BE.

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Improving All-Cause Inpatient Mortality After Percutaneous Endoscopic Gastrostomy

Daniel J. Stein, Matthew B. Moore, Gila Hoffman & Joseph D. Feuerstein

doi : 10.1007/s10620-020-06396-y

Digestive Diseases and Sciences volume 66, pages1593–1599(2021)

Percutaneous gastrostomy (PEG) is a common inpatient procedure. Prior data from National Inpatient Sample (NIS) in 2006 reported a mortality rate of 10.8% and recommended more careful selection of PEG candidates. This study assessed for improvement in the last 10 years in mortality rate and complications for hospitalized patients.

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Dietary Factors and Gastric Intestinal Metaplasia Risk Among US Veterans

Mimi C. Tan, Niharika Mallepally, Quynh Ho, Yan Liu, Hashem B. El-Serag & Aaron P. Thrift

doi : 10.1007/s10620-020-06399-9

Digestive Diseases and Sciences volume 66, pages1600–1610(2021)

Studies on diet and gastric intestinal metaplasia (GIM) risk are lacking in US populations.

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Oral IBGard™ Before Colonoscopy: A Single-Center Double-Blinded, Randomized, Placebo-Controlled Trial

James Y. Han, Zain Moosvi, Erica Duh, Sunhee Park, Gregory C. Albers, Jason B. Samarasena & William Karnes

doi : 10.1007/s10620-020-06383-3

Digestive Diseases and Sciences volume 66, pages1611–1619(2021)

Peppermint oil is well known to inhibit smooth muscle contractions, and its topical administration during colonoscopy is reported to reduce colonic spasms.

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FDG-PET–CT Enterography Helps Determine Clinical Significance of Suspected Ileocecal Thickening: A Prospective Study

Abhi K. Singh, Rajender Kumar, Pankaj Gupta, Praveen Kumar-M, Shubhra Mishra, Harshal S. Mandavdhare, Harjeet Singh, Kaushal K. Prasad, Usha Dutta & Vishal Sharma

doi : 10.1007/s10620-020-06361-9

Digestive Diseases and Sciences volume 66, pages1620–1630(2021)

Ileocecal thickening (ICT) on imaging could result from diverse etiologies but may also be clinically insignificant.

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Ustekinumab Does Not Increase Risk of Adverse Events: A Meta-Analysis of Randomized Controlled Trials

Vineet S. Rolston, Jessica Kimmel, Violeta Popov, Brian P. Bosworth, David Hudesman, Lisa B. Malter, Simon Hong & Shannon Chang

doi : 10.1007/s10620-020-06344-w

Digestive Diseases and Sciences volume 66, pages1631–1638(2021)

Ustekinumab (UST) is a monoclonal antibody inhibitor of IL-12/IL-23 approved for the treatment of Crohn’s disease (CD) and ulcerative colitis (UC). We conducted a meta-analysis to compare rates of adverse events (AEs) in randomized controlled trials (RCTs) of UST for all indications.

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Fecal Calprotectin May Predict Adverse Pregnancy-Related Outcomes in Patients with Inflammatory Bowel Disease

Parul Tandon, Eugenia Y. Lee, Cynthia Maxwell, Lara Hitz, Lindsy Ambrosio, Levinus Dieleman, Brendan Halloran, Karen Kroeker & Vivian M. Huang

doi : 10.1007/s10620-020-06381-5

Digestive Diseases and Sciences volume 66, pages1639–1649(2021)

The role of fecal calprotectin in predicting pregnancy-related outcomes in inflammatory bowel disease (IBD) remains unknown.

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Poor Drug Sustainability in Inflammatory Bowel Disease Patients in Clinical Remission on Thiopurine Monotherapy

Bhairavi Balram, Joshua Lubov, Yves Theoret, Waqqas Afif, Alain Bitton, Gary Wild, Peter L. Lakatos & Talat Bessissow

doi : 10.1007/s10620-020-06427-8

Digestive Diseases and Sciences volume 66, pages1650–1657(2021)

Immunomodulator monotherapy is an important component in the treatment of inflammatory bowel disease (IBD). However, there is conflicting literature about thiopurines maintaining long-term remission in patients with active IBD.

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Effectiveness of Infliximab on Deep Radiological Remission in Chinese Patients with Perianal Fistulizing Crohn’s Disease

Mingming Zhu, Xitao Xu, Qi Feng, Zhe Cui, Tianrong Wang, Yunqi Yan & Zhihua Ran

doi : 10.1007/s10620-020-06398-w

Digestive Diseases and Sciences volume 66, pages1658–1668(2021)

Information concerning deep radiological healing of perianal fistulas in Chinese patients with CD is limited. The present study aimed to establish the effectiveness of infliximab on CD-related perianal fistulas using magnetic resonance imaging (MRI) and identify predictors of deep radiological remission of fistulas.

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Increasing Incidence of Advanced Non-cardia Gastric Cancers Among Younger Hispanics in the USA

Zhensheng Wang, Hashem B. El-Serag & Aaron P. Thrift

doi : 10.1007/s10620-020-06397-x

Digestive Diseases and Sciences volume 66, pages1669–1672(2021)

Recent findings indicate a shift in the epidemiology of non-cardia gastric cancer in the USA. In particular, an uprising trend in incidence rates among non-Hispanic whites aged <?50 years.

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A Comparison of Tumor-Associated and Non-Tumor-Associated Gastric Microbiota in Gastric Cancer Patients

Zhen-Feng Wu, Kun Zou, Guan-Nan Wu, Zhao-Jia Jin, Chun-Jie Xiang, Shuo Xu, Yao-Hui Wang, Xiao-Yu Wu, Che Chen, Zhe Xu, Wei-Su Li, Xue-Quan Yao, Jun-Feng Zhang & Fu-Kun Liu

doi : 10.1007/s10620-020-06415-y

Digestive Diseases and Sciences volume 66, pages1673–1682(2021)

How gastric cancer (GC) incidence is associated with changes in the gastric microbiome has not been firmly established. The present study therefore aims to investigate the microbial communities present within the gastric mucosa of patients with superficial gastritis (SG) or GC.

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Temporary Trend, Characteristics and Clinical Outcomes of Acute Pancreatitis Patients Infected with Human Immunodeficiency Virus

Hedong Han, Wei Guo, Honglei Guo, Xin Wei, Xiaochun Xiao, Yiming Ruan, Cheng Wu, Yang Cao & Jia He

doi : 10.1007/s10620-020-06355-7

Digestive Diseases and Sciences volume 66, pages1683–1692(2021)

Compared to general population, human immunodeficiency virus (HIV) infection may increase frequency of acute pancreatitis (AP); however, evidence regarding effects of HIV infection on AP-related outcomes is limited and controversial.

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Use of Butorphanol as Treatment for Cholestatic Itch

Rachel Shireen Golpanian, Gil Yosipovitch & Cynthia Levy

doi : 10.1007/s10620-020-06392-2

Digestive Diseases and Sciences volume 66, pages1693–1699(2021)

Pruritus is a debilitating symptom of cholestatic diseases such as primary biliary cholangitis and primary sclerosing cholangitis and often results in major reduction in quality of life for afflicted patients. Classic treatment options for the treatment of cholestatic pruritus include antihistamines, bile acid resins, serotonin reuptake inhibitors, and mu-opioid antagonists. Unfortunately, these drugs are not always successful in treating pruritus of cholestasis and may be associated with adverse effects. Recent advances in our understanding of itch pathophysiology have led to the use of butorphanol, a kappa-opioid agonist and mu-opioid antagonist, for the treatment of various forms of pruritus. Reports of butorphanol to treat cholestatic itch specifically are rare.

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Comparison of Two Specialized Histology Needles for Endoscopic Ultrasound (EUS)-Guided Liver Biopsy: A Pilot Study

Rintaro Hashimoto, David P. Lee, Jason B. Samarasena, Vishal S. Chandan, Wenchang Guo, John G. Lee & Kenneth J. Chang

doi : 10.1007/s10620-020-06391-3

Digestive Diseases and Sciences volume 66, pages1700–1706(2021)

EUS-guided liver biopsy (EUS-LB) has been shown to be a safe and effective alternative to percutaneous liver biopsy. The optimal needle device and technique for EUS-LB is still evolving. The aim of this study was to compare the efficacy of two second-generation 19G fine-needle biopsy (FNB) (Franseen- and Fork-tip) devices for EUS-LB.

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The Changing Burden of Alcoholic Hepatitis: Rising Incidence and Associations with Age, Gender, Race, and Geography

Sahil D. Doshi, Matthew J. Stotts, Rebecca A. Hubbard & David S. Goldberg

doi : 10.1007/s10620-020-06346-8

Digestive Diseases and Sciences volume 66, pages1707–1714(2021)

Alcoholic hepatitis is a major cause of morbidity and mortality. However, there are limited population-based data on its incidence, demographics, and temporal trends. We performed a retrospective cohort study using the State Inpatient Databases from Florida, Massachusetts, New York, and Washington from 2010 to 2014. We included patients aged 20–79 years admitted with alcoholic hepatitis and calculated incidence using population denominators obtained from the Centers for Disease Control and Prevention WONDER database. We fit multivariable Poisson regression models to explore interactions between alcoholic hepatitis incidence rates and several predictors including state, calendar year, age, race/ethnicity, and gender. Among 56,973 unique individuals with alcoholic hepatitis, the majority were male (39,702; 69.7%) and white non-Hispanic (40,934; 72.0%). In multivariable Poisson models, there was a significant interaction between calendar year and age group (p?<?0.001), with the highest incidence rates in those ages 40–49 and 50–59 across all years. The absolute increase in incidence rate across calendar years was highest in the 20–29 and 30–39 age groups in every state. Female gender was associated with a lower rate (incidence rate ratio (IRR) 0.42, 95% confidence interval (CI) 0.41–0.42, p?<?0.001). Compared to white non-Hispanics, black non-Hispanics (IRR 0.79, CI 0.77–0.81, p?<?0.001) and Hispanics (0.66, CI 0.65–0.68, p?<?0.001) had lower incidence rates. The incidence of alcoholic hepatitis in the USA varies by age, gender, race/ethnicity, and state of residence. The group with the fastest rising incidence is those aged 20–39. More work is needed to evaluate the reasons for the temporal trends for admissions for alcoholic hepatitis.

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Azathioprine Monotherapy Is Equivalent to Dual Therapy in Maintaining Remission in Autoimmune Hepatitis

Bridgette B. McNally & Elizabeth J. Carey

doi : 10.1007/s10620-020-06347-7

Digestive Diseases and Sciences volume 66, pages1715–1719(2021)

Standard of care treatment for AIH includes prednisone monotherapy or dual therapy prednisone–azathioprine. However, many hepatologists alternatively use azathioprine monotherapy to avoid side effects of long-term corticosteroids.

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Lower Serum Sodium Levels Are Associated with the Therapeutic Effect of Sorafenib on Hepatocellular Carcinoma

Tadashi Kegasawa, Ryotaro Sakamori, Kazuki Maesaka, Ryoko Yamada, Yuki Tahata, Ayako Urabe, Takahiro Kodama, Hayato Hikita, Kazuho Imanaka, Kazuyoshi Ohkawa, Naoki Hiramatsu, Masahide Oshita, Yukinori Yamada, Masami Inada, Takayuki Yakushijin, Yasuharu Imai, Tomohide Tatsumi & Tetsuo Takehara

doi : 10.1007/s10620-020-06380-6

Digestive Diseases and Sciences volume 66, pages1720–1729(2021)

Although the serum sodium level has been reported to be a prognostic and predictive marker for the therapeutic effects of lung cancer and renal cell carcinoma treated with molecular targeted therapy, the serum sodium level has not been investigated in hepatocellular carcinoma (HCC) patients treated with sorafenib. The aim of our analysis was to assess the prognostic role of serum sodium levels in these patients.

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Albumin–Bilirubin (ALBI) Grade-Based Nomogram for Patients with Hepatocellular Carcinoma Undergoing Transarterial Chemoembolization

Shu-Yein Ho, Chia-Yang Hsu, Po-Hong Liu, Rheun-Chuan Lee, Chih-Chieh Ko, Yi-Hsiang Huang, Chien-Wei Su, Ming-Chih Hou & Teh-Ia Huo

doi : 10.1007/s10620-020-06384-2

Digestive Diseases and Sciences volume 66, pages1730–1738(2021)

The prognosis of patients with hepatocellular carcinoma (HCC) undergoing transarterial chemoembolization (TACE) is highly heterogeneous because of variable characteristics of tumor burden and liver dysfunction. We aimed to propose and validate an albumin–bilirubin (ALBI) grade-based prognostic nomogram for HCC patients undergoing TACE.

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Comparable Incidence of Hepatocellular Carcinoma in Chronic Hepatitis B Patients Treated with Entecavir or Tenofovir

Jung Woo Shin, Joonho Jeong, Seok Won Jung, Seung Bum Lee, Bo Ryung Park, Min-Ju Kim, Eun Ji Park & Neung Hwa Park

doi : 10.1007/s10620-020-06375-3

Digestive Diseases and Sciences volume 66, pages1739–1750(2021)

Adherence to medication and maintained virologic response (MVR) are related to the risk of adverse clinical outcomes. This study aimed to compare the efficacy of entecavir (ETV) and tenofovir disoproxil fumarate (TDF) in relation to the adverse clinical outcomes among chronic hepatitis B (CHB) patients stratified according to adherence to medication and MVR.

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IgG4-Related Disease with Ascites: Report of a Case Simulating Primary Peritoneal Papillary Serous Carcinoma

Lan-ping Zhu, Samiullah Khan, Yang-yang Hui, Bo Yang, Sai-yu Wang, Kai-di Sun, Zi-han Yu, Jing-wen Zhao, Bang-mao Wang & Xin Chen

doi : 10.1007/s10620-020-06376-2

Digestive Diseases and Sciences volume 66, pages1751–1756(2021)

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Letter to the Editor on “Early Rapid Fluid Therapy Is Associated with Increased Rate of Noninvasive Positive-Pressure Ventilation in Hemoconcentrated Patients with Severe Acute Pancreatitis”

Hilal Sipahioglu & Antonio M. Esquinas

doi : 10.1007/s10620-020-06736-y

Digestive Diseases and Sciences volume 66, pages1757–1758(2021)

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Comments on ‘Initial Computed Tomography Findings of Long and Distended Colon Are Risk Factors for the Recurrence of Sigmoid Volvulus’

Sabri Selcuk Atamanalp

doi : 10.1007/s10620-020-06580-0

Digestive Diseases and Sciences volume 66, pages1759–1760(2021)

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Hospitals and All Stakeholders, Including ERCP Personnel, Should Equitably Share Profits from Cost Savings from Decreased Hospital LOS by Performing Non-emergent ERCPs on Weekends

Mitchell S. Cappell

doi : 10.1007/s10620-020-06785-3

Digestive Diseases and Sciences volume 66, pages1761–1762(2021)

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Reply to “Hospitals and All Stakeholders, Including ERCP Personnel, Should Equitably Share Profits from Cost Savings from Decreased Hospital LOS by Performing Non-emergent ERCPs on Weekends”

John A. Martin

doi : 10.1007/s10620-021-06933-3

Digestive Diseases and Sciences volume 66, pages1763–1764(2021)

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Correction to: Pathophysiology of Gastroparesis Syndromes Includes Anatomic and Physiologic Abnormalities

Thomas L. Abell, Archana Kedar, Abigail Stocker, Karen Beatty, Lindsay McElmurray, Michael Hughes, Hani Rashed, William Kennedy, Gwen Wendelschafer-Crabb, Xiu Yang, Mostafa Fraig, Leila Gobejishvili, Endashaw Omer, Ed Miller, Michael Griswold & Christina Pinkston

doi : 10.1007/s10620-020-06374-4

Digestive Diseases and Sciences volume 66, page1765(2021)

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