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Comment on report of a large reduction in cortical GABA following ketone ingestion
Richard J. MaddockÂÂ
doi : 10.1038/s41386-022-01511-1
Volume 48 Issue 6, May 2023
Kappa opioid receptors as modulators of novelty processing
Kathryn Braden & Daniel C. CastroÂ
Controlled human drug administration studies are necessary to define the THC-sparing effects of CBD and other cannabis constituents
Elisa Pabon & Ziva D. CooperÂ
Perspective on equitable translational studies and clinical support for an unbiased inclusion of the LGBTQIA2S+community
Teddy G. Goetz, Krisha Aghi, Christoph Anacker, Diane Ehrensaft, Neir Eshel, Jordan Marrocco, Jared W. Young & Troy A. RoepkeÂ
doi : 10.1038/s41386-023-01558-8
Research regarding the mental health of the Lesbian, Gay, Bisexual, Transgender, Queer, Intersex, Asexual, 2 Spirit (LGBTQIA2S+) community has been historically biased by individual and structural homophobia, biphobia, and transphobia, resulting in research that does not represent the best quality science.
Systemic kappa opioid receptor antagonism accelerates reinforcement learning via augmentation of novelty processing in male mice
Zahra Z. Farahbakhsh, Keaton Song, Hannah E. Branthwaite, Kirsty R. Erickson, Snigdha Mukerjee, Suzanne O. Nolan & Cody A. SicilianoÂ
doi : 10.1038/s41386-023-01547-x
Selective inhibition of kappa opioid receptors (KORs) is highly anticipated as a pharmacotherapeutic intervention for substance use disorders and depression. The accepted explanation for KOR antagonist-induced amelioration of aberrant behaviors posits that KORs globally function as a negative valence system; antagonism thereby blunts the behavioral influence of negative internal states such as anhedonia and negative affect.
Does cannabidiol make cannabis safer? A randomised, double-blind, cross-over trial of cannabis with four different CBD:THC ratios
Amir Englund, Dominic Oliver, Edward Chesney, Lucy Chester, Jack Wilson, Simina Sovi, Andrea De Micheli, John Hodsoll, Paolo Fusar-Poli, John Strang, Robin M. Murray, Tom P. Freeman & Philip McGuireÂ
doi : 10.1038/s41386-022-01478-z
As countries adopt more permissive cannabis policies, it is increasingly important to identify strategies that can reduce the harmful effects of cannabis use. This study aimed to determine if increasing the CBD content of cannabis can reduce its harmful effects.
mGluR5 PAMs rescue cortical and behavioural defects in a mouse model of CDKL5 deficiency disorder
Antonia Gurgone, Riccardo Pizzo, Alessandra Raspanti, Giuseppe Chiantia, Sunaina Devi, Debora Comai, Noemi Morello, Federica Pilotto, Sara Gnavi, Leonardo Lupori, Raffaele Mazziotti, Giulia Sagona, Elena Putignano, Alessio Nocentini, Claudiu T. Supuran, Andrea Marcantoni, Tommaso Pizzorusso & Maurizio GiustettoÂ
doi : 10.1038/s41386-022-01412-3
Cyclin-dependent kinase-like 5 (CDKL5) deficiency disorder (CDD) is a devastating rare neurodevelopmental disease without a cure, caused by mutations of the serine/threonine kinase CDKL5 highly expressed in the forebrain.
Altered neuronal activity in the ventromedial prefrontal cortex drives nicotine intake escalation
Myriam Abarkan, Giulia R. Fois, Caroline Vouillac-Mendoza, Serge H. Ahmed & Karine GuillemÂ
doi : 10.1038/s41386-022-01428-9
Nicotine addiction develops after prolonged drug use and escalation of drug intake. However, because of difficulties in demonstrating escalation of nicotine use in rats, its underlying neuroadaptations still remain poorly understood.
Anandamide and 2-arachidonoylglycerol differentially modulate autistic-like traits in a genetic model of autism based on FMR1 deletion in rats
Sara Schiavi, Antonia Manduca, Emilia Carbone, Valeria Buzzelli, Alessandro Rava, Alessandro Feo, Fabrizio Ascone, Maria Morena, Patrizia Campolongo, Matthew N. Hill & Viviana TrezzaÂ
doi : 10.1038/s41386-022-01454-7
Autism spectrum disorder (ASD) has a multifactorial etiology. Major efforts are underway to understand the neurobiological bases of ASD and to develop efficacious treatment strategies. Recently, the use of cannabinoid compounds in children with neurodevelopmental disorders including ASD has received increasing attention.
Rostromedial tegmental nucleus nociceptin/orphanin FQ (N/OFQ) signaling regulates anxiety- and depression-like behaviors in alcohol withdrawn rats
Wenfu Li, Zhiheng Ren, Ying Tang, Yixin Fu, Shizhu Sun, Ruxuan Ding, Jiawei Hou, Yunlin Mai, Bo Zhan, Yingxin Zhu, Wanhong Zuo, Jiang-Hong Ye & Rao FuÂ
doi : 10.1038/s41386-022-01482-3
Recent studies indicate that stimulation of the rostromedial tegmental nucleus (RMTg) can drive a negative affective state and that nociceptin/orphanin FQ (N/OFQ) may play a role in affective disorders and drug addiction. The N/OFQ precursor prepronociceptin encoding genes Pnoc are situated in RMTg neurons.
Male-selective effects of oxytocin agonism on alcohol intake: behavioral assessment in socially housed prairie voles and involvement of RAGE
Sheena Potretzke, Yangmiao Zhang, Ju Li, Kristopher M. Fecteau, David W. Erikson, Marcel Hibert & Andrey E. RyabininÂ
doi : 10.1038/s41386-022-01490-3
Targeting the oxytocin (OXT) peptide system has emerged as a promising new approach for the treatment of alcohol use disorder (AUD). However, further advancements in this development depend on properly modeling various complex social aspects of AUD and its treatment.
Clinical response to EPA supplementation in patients with major depressive disorder is associated with higher plasma concentrations of pro-resolving lipid mediators
Stefania Lamon-Fava, Minying Liu, Boadie W. Dunlop, Becky Kinkead, Pamela J. Schettler, Jennifer C. Felger, Thomas R. Ziegler, Maurizio Fava, David Mischoulon & Mark Hyman RapaportÂ
doi : 10.1038/s41386-022-01527-7
Chronic inflammation has been implicated in the pathophysiology of major depressive disorder (MDD). Activating the resolution of inflammation through �‰-3 fatty acid supplementation may prove to be a successful therapeutic strategy for the treatment of MDD.
Nicotine dependence and insula subregions: functional connectivity and cue-induced activation
Dara G. Ghahremani, Jean-Baptiste F. Pochon, Maylen Perez Diaz, Rachel F. Tyndale, Andy C. Dean & Edythe D. LondonÂ
doi : 10.1038/s41386-023-01528-0
Nicotine dependence is a major predictor of relapse in people with Tobacco Use Disorder (TUD). Accordingly, therapies that reduce nicotine dependence may promote sustained abstinence from smoking. The insular cortex has been identified as a promising target in brain-based therapies for TUD, and has three major sub-regions (ventral anterior, dorsal anterior, and posterior) that serve distinct functional networks.
Oxytocin effects on amygdala reactivity to angry faces in males and females with antisocial personality disorder
Haang Jeung-Maarse, Mike M. Schmitgen, Ruth Schmitt, Katja Bertsch & Sabine C. HerpertzÂ
doi : 10.1038/s41386-023-01549-9
The amygdala is a key region in current neurocircuitry models of reactive aggression as it is crucially involved in detecting social threat and provocation. An increased amygdala reactivity to angry faces has been reported in aggression-prone individuals and the neuropeptide oxytocin (OT) could dampen anger-related amygdala reactivity in a number of mental disorders.
Association between the epigenetic lifespan predictor GrimAge and history of suicide attempt in bipolar disorder
Camila N. C. Lima, Emese H. C. Kovács, Salahudeen Mirza, Alexandra Del Favero-Campbell, Alexandre Paim Diaz, Joao Quevedo, Benney M. R. Argue, Jenny Gringer Richards, Aislinn Williams, John A. Wemmie, Vincent A. Magnotta, Jess G. Fiedorowicz, Jair C. Soares, Marie E. Gaine & Gabriel R. FriesÂ
doi : 10.1038/s41386-023-01557-9
Bipolar disorder (BD) has been previously associated with premature mortality and aging, including acceleration of epigenetic aging. Suicide attempts (SA) are greatly elevated in BD and are associated with decreased lifespan, biological aging, and poorer clinical outcomes.
Impact of the gut microbiome on nicotine’s motivational effects and glial cells in the ventral tegmental area in male mice
Alina Lakosa, Anaïs Rahimian, Flavio Tomasi, Fabio Marti, Lauren M. Reynolds, Léa Tochon, Vincent David, Anne Danckaert, Candice Canonne, Sylvana Tahraoui, Fabrice de Chaumont, Benoît Forget, Uwe Maskos & Morgane BessonÂ
doi : 10.1038/s41386-023-01563-x
A link between gut dysbiosis and the pathogenesis of brain disorders has been identified. A role for gut bacteria in drug reward and addiction has been suggested but very few studies have investigated their impact on brain and behavioral responses to addictive drugs so far.
In Memoriam�Robert M. A. Hirschfeld, MD, MSc
Martin B. KellerÂÂ
Retraction Note: Safety and efficacy of dapoxetine in the treatment of premature ejaculation: a double-blind, placebo-controlled, fixed-dose, randomized study
Mohammad R. SafarinejadÂ
