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Novel evidence for endocannabinoid-mediated enhancement of cocaine intake in response to stress
Mary M. TorregrossaÂÂ
doi : 10.1038/s41386-023-01602-7
Volume 48 Issue 8, July 2023
Role of mesolimbic cannabinoid receptor 1 in stress-driven increases in cocaine self-administration in male rats
Jayme R. McReynolds, Colten P. Wolf, Dylan M. Starck, Jacob C. Mathy, Rebecca Schaps, Leslie A. Krause, Cecilia J. Hillard & John R. MantschÂ
doi : 10.1038/s41386-023-01589-1
Stress is prevalent in the lives of those with substance use disorders (SUDs) and influences SUD outcomes. Understanding the neurobiological mechanisms through which stress promotes drug use is important for the development of effective SUD interventions.
An ensemble recruited by α2a-adrenergic receptors is engaged in a stressor-specific manner in mice
Jordan A. Brown, Nicholas Petersen, Samuel W. Centanni, Allie Y. Jin, Hye Jean Yoon, Stephanie A. Cajigas, Michelle N. Bedenbaugh, Joseph R. Luchsinger, Sachin Patel, Erin S. Calipari, Richard B. Simerly & Danny G. WinderÂ
doi : 10.1038/s41386-022-01442-x
α2a-adrenergic receptor (α2a-AR) agonists are candidate substance use disorder therapeutics due to their ability to recruit noradrenergic autoreceptors to dampen stress system engagement. However, we recently found that postsynaptic α2a-ARs are required for stress-induced reinstatement of cocaine-conditioned behavior.
FKBP5 inhibitors modulate alcohol drinking and trauma-related behaviors in a model of comorbid post-traumatic stress and alcohol use disorder
Bryan Cruz, Valentina Vozella, Benjamin A. Carper, Joy C. Xu, Dean Kirson, Shawn Hirsch, Tracy Nolen, Lauren Bradley, Katie Fain, Meg Crawford, Thomas R. Kosten, Eric P. Zorrilla & Marisa RobertoÂ
doi : 10.1038/s41386-022-01497-w
Post-traumatic stress disorder (PTSD) leads to enhanced alcohol drinking and development of alcohol use disorder (AUD). Identifying shared neural mechanisms might help discover new therapies for PTSD/AUD. Here, we employed a rat model of comorbid PTSD/AUD to evaluate compounds that inhibit FK506-binding protein 51 (FKBP5), a co-chaperone modulator of glucocorticoid receptors implicated in stress-related disorders.
Novel non-stimulants rescue hyperactive phenotype in an adgrl3.1 mutant zebrafish model of ADHD
Hildur Sóley Sveinsdóttir, Christian Christensen, Haraldur Þorsteinsson, Perrine Lavalou, Matthew O. Parker, Alena Shkumatava, William H. J. Norton, Emile Andriambeloson, Stéphanie Wagner & Karl Ægir KarlssonÂ
doi : 10.1038/s41386-022-01505-z
ADHD is a highly prevalent neurodevelopmental disorder. The first-line therapeutic for ADHD, methylphenidate, can cause serious side effects including weight loss, insomnia, and hypertension. Therefore, the development of non-stimulant-based therapeutics has been prioritized.
mGluR5 in hippocampal CA1 pyramidal neurons mediates stress-induced anxiety-like behavior
Xin Li, Zhuo-Jun Du, Jun-Nan Xu, Zhi-Man Liang, Song Lin, Hao Chen, Shu-Ji Li, Xiao-Wen Li, Jian-Ming Yang & Tian-Ming GaoÂ
doi : 10.1038/s41386-023-01548-w
Pharmacological manipulation of mGluR5 has showed that mGluR5 is implicated in the pathophysiology of anxiety and mGluR5 has been proposed as a potential drug target for anxiety disorders.
The effect of lysergic acid diethylamide (LSD) on whole-brain functional and effective connectivity
Peter Bedford, Daniel J. Hauke, Zheng Wang, Volker Roth, Monika Nagy-Huber, Friederike Holze, Laura Ley, Patrick Vizeli, Matthias E. Liechti, Stefan Borgwardt, Felix Müller & Andreea O. DiaconescuÂ
doi : 10.1038/s41386-023-01574-8
Psychedelics have emerged as promising candidate treatments for various psychiatric conditions, and given their clinical potential, there is a need to identify biomarkers that underlie their effects.
N-acetylcysteine does not alter neurometabolite levels in non-treatment seeking adolescents who use alcohol heavily: A preliminary randomized clinical trial
Anna E. Kirkland, Brittney D. Browning, ReJoyce Green, Helen Liu, Anna M. Maralit, Pamela L. Ferguson, Dieter J. Meyerhoff, James J. Prisciandaro, Robert Miranda Jr., Kathleen T. Brady, Rachel L. Tomko, Kevin M. Gray & Lindsay M. SquegliaÂ
doi : 10.1038/s41386-023-01553-z
Current treatments for adolescent alcohol use disorder (AUD) are mainly psychosocial and limited in their efficacy. As such, pharmacotherapies are being investigated as potential adjunctive treatments to bolster treatment outcomes.
Behavioral and brain reactivity to uncertain stress prospectively predicts binge drinking in youth
Stephanie M. Gorka, Milena Radoman, Jagan Jimmy, Kayla A. Kreutzer, Charles Manzler & Stacey CulpÂ
doi : 10.1038/s41386-023-01571-x
Prior studies show that individuals with alcohol use disorder exhibit exaggerated behavioral and brain reactivity to uncertain threats (U-threat). It is posited this brain-based factor emerges early in life and contributes to the onset and escalation of alcohol problems.
Predictors of placebo response in three large clinical trials of the V1a receptor antagonist balovaptan in autism spectrum disorder
Russell Tobe, Yajing Zhu, Teresa Gleissl, Simona Rossomanno, Jeremy Veenstra-VanderWeele, Janice Smith & Eric HollanderÂ
doi : 10.1038/s41386-023-01573-9
High rates of placebo response are increasingly implicated in failed autism spectrum disorder (ASD) clinical trials. Despite this, there are limited investigations of placebo response in ASD. We sought to identify baseline predictors of placebo response and quantify their influence on clinical scales of interest for three harmonized randomized clinical trials of balovaptan, a V1a receptor antagonist.
The effects of D-Cycloserine on corticospinal excitability after repeated spaced intermittent theta-burst transcranial magnetic stimulation: A randomized controlled trial in healthy individuals
James G. Wrightson, Jaeden Cole, Maya N. Sohn & Alexander McGirrÂ
doi : 10.1038/s41386-023-01575-7
Repeated spaced TMS protocols, also termed accelerated TMS protocols, are of increasing therapeutic interest. The long-term potentiation (LTP)-like effects of repeated spaced intermittent theta-burst transcranial magnetic stimulation (iTBS) are presumed to be N-Methyl-D-Aspartate receptor (NMDA-R) dependent; however, this has not been tested.
Long-term safety and maintenance of response with esketamine nasal spray in participants with treatment-resistant depression: interim results of the SUSTAIN-3 study
Naim Zaki, Li (Nancy) Chen, Rosanne Lane, Teodora Doherty, Wayne C. Drevets, Randall L. Morrison, Gerard Sanacora, Samuel T. Wilkinson, Vanina Popova & Dong-Jing FuÂ
doi : 10.1038/s41386-023-01577-5
Patients with treatment-resistant depression (TRD) have higher rates of relapse and pronounced decreases in daily functioning and health-related quality of life compared to patients with major depressive disorder who are not treatment-resistant, underscoring the need for treatment choices with sustained efficacy and long-term tolerability.
A sex-specific role for the bed nucleus of the stria terminalis in proactive defensive behavior
Diana P. Guerra, Wei Wang, Karienn A. Souza & Justin M. MoscarelloÂ
doi : 10.1038/s41386-023-01581-9
The bed nucleus of the stria terminalis (BNST) is a forebrain region implicated in aversive responses to uncertain threat. Much of the work on the role of BNST in defensive behavior has used Pavlovian paradigms in which the subject reacts to aversive stimuli delivered in a pattern determined entirely by the experimenter.
Circulating PACAP levels are associated with increased amygdala-default mode network resting-state connectivity in posttraumatic stress disorder
Kevin J. Clancy, Quentin Devignes, Poornima Kumar, Victor May, Sayamwong E. Hammack, Eylül Akman, Emily J. Casteen, Cameron D. Pernia, Sydney A. Jobson, Michael W. Lewis, Nikolaos P. Daskalakis, William A. Carlezon Jr., Kerry J. Ressler, Scott L. Rauch & Isabelle M. RossoÂ
doi : 10.1038/s41386-023-01593-5
The pituitary adenylate cyclase-activating polypeptide (PACAP) system is implicated in posttraumatic stress disorder (PTSD) and related amygdala-mediated arousal and threat reactivity.
Correction: Kappa opioid receptors as modulators of novelty processing
Kathryn Braden & Daniel C. CastroÂ
