New England Journal of Medicine




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سفارش

Addressing Serious Illness Care in Medicare Advantage

Claire K. Ankuda, M.D., M.P.H., Melissa D. Aldridge, Ph.D., M.B.A., R. Tyler Braun, Ph.D., Norma B. Coe, Ph.D., David C. Grabowski, Ph.D., David J. Meyers, Ph.D., M.P.H., Andrew Ryan, Ph.D., David Stevenson, Ph.D., and Joan M. Teno, M.D.

doi : 10.1056/NEJMp2302252

Vol. 388 No. 19

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Corporate Citizenship and Institutional Responses Post-Dobbs — Critical Lessons from Two Restrictive States

Justin R. Lappen, M.D., Leilah Zahedi-Spung, M.D., and Ashley R. Brant, D.O., M.P.H.

doi : 10.1056/NEJMp2302101

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Ethical Conflicts for Clinicians under Tennessee Abortion Law

Allison M. McCarthy, Ph.D., Elise W. Boos, M.D., Uchenna E. Anani, M.D., and Ellen W. Clayton, M.D., J.D.

doi : 10.1056/NEJMp2303213

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First-Line Venetoclax Combinations in Chronic Lymphocytic Leukemia

Barbara Eichhorst, M.D., Carsten U. Niemann, M.D., Arnon P. Kater, M.D., Moritz Fürstenau, M.D., Julia von Tresckow, M.D., Can Zhang, Ph.D., Sandra Robrecht, Ph.D., Michael Gregor, M.D., Gunnar Juliusson, M.D., Patrick Thornton, M.D., Philipp B. Staber, M.D., Tamar Tadmor, M.D.,

doi : 10.1056/NEJMoa2213093

Randomized trials of venetoclax plus anti-CD20 antibodies as first-line treatment in fit patients (i.e., those with a low burden of coexisting conditions) with advanced chronic lymphocytic leukemia (CLL) have been lacking.

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Phase 3 Trial of Epicutaneous Immunotherapy in Toddlers with Peanut Allergy

Matthew Greenhawt, M.D., Sayantani B. Sindher, M.D., Julie Wang, M.D., Michael O’Sullivan, M.D., George du Toit, M.D., Edwin H. Kim, M.D., Deborah Albright, M.D., Sara Anvari, M.D., Nicolette Arends, M.D., Peter D. Arkwright, Ph.D., Philippe Bégin, M.D., Ph.D., Katharina Blumchen, M.D., Thierry Bourrier, M.D., Terri Brown-Whitehorn, M.D., Heather Cassell, M.D., Edmond S. Chan, M.D., Christina E. Ciaccio, M.D., Antoine Deschildre, M.D., Amandine Divaret-Chauveau, M.D., Stacy L. Dorris, M.D., Morna J. Dorsey, M.D., Thomas Eiwegger, M.D., Michel Erlewyn-Lajeunesse, D.M., David M. Fleischer, M.D., Lara S. Ford, M.B., B.S., M.P.H., Maria Garcia-Lloret, M.D., Lisa Giovannini-Chami, M.D., Ph.D., Jonathan O. Hourihane, D.M., Nicola Jay, M.B., B.S., Stacie M. Jones, M.D., Leigh Ann Kerns, M.D., Kirsten M. Kloepfer, M.D., Stephanie Leonard, M.D., Guillaume Lezmi, M.D., Ph.D., Jay A. Lieberman, M.D., Jeanne Lomas, D.O., Melanie Makhija, M.D., Christopher Parrish, M.D., Jane Peake, M.B., B.S., Kirsten P. Perrett, M.B., B.S., Ph.D., Daniel Petroni, M.D., Ph.D., Wolfgang Pfützner, M.D., Jacqueline A. Pongracic, M.D., Patrick Quinn, M.B., B.S., Rachel G. Robison, M.D., Georgiana Sanders, M.D., Lynda Schneider, M.D., Hemant P. Sharma, M.D., M.H.S., Juan Trujillo, M.D., Paul J. Turner, M.D., Ph.D., Katherine Tuttle, M.D., Julia E. Upton, M.D., Pooja Varshney, M.D., Brian P. Vickery, M.D., Christian Vogelberg, M.D., Brynn Wainstein, M.B., Ch.B., Ph.D., Robert A. Wood, M.D., Katharine J. Bee, Ph.D., Dianne E. Campbell, M.D., Ph.D., Todd D. Green, M.D., Rihab Rouissi, M.D., Aurélie Peillon, M.S., Henry T. Bahnson, M.P.H., Timothée Bois, M.Sc., Hugh A. Sampson, M.D., and A. Wesley Burks, M.D.

doi : 10.1056/NEJMoa2212895

No approved treatment for peanut allergy exists for children younger than 4 years of age, and the efficacy and safety of epicutaneous immunotherapy with a peanut patch in toddlers with peanut allergy are unknown.

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Cabozantinib plus Nivolumab and Ipilimumab in Renal-Cell Carcinoma

Toni K. Choueiri, M.D., Thomas Powles, M.D., Laurence Albiges, M.D., Ph.D., Mauricio Burotto, M.D., Cezary Szczylik, M.D., Ph.D., Bogdan Zurawski, M.D., Ph.D., Eduardo Yanez Ruiz, M.D., Marco Maruzzo, M.D., Ph.D., Alberto Suarez Zaizar, M.D., Luis E. Fein, M.D., Fabio A. Schutz, M.D., Daniel Y.C. Heng, M.D., Fong Wang, M.D., Ph.D., Fabio Mataveli, M.D., Ph.D., Yu-Lin Chang, M.S., Maximiliano van Kooten Losio, M.D., Ph.D., Cristina Suarez, M.D., Ph.D., and Robert J. Motzer, M.D. for the COSMIC-313 Investigators*

doi : 10.1056/NEJMoa2212851

The efficacy and safety of treatment with cabozantinib in combination with nivolumab and ipilimumab in patients with previously untreated advanced renal-cell carcinoma are unknown.

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Racial Inequality in Receipt of Medications for Opioid Use Disorder

Michael L. Barnett, M.D., Ellen Meara, Ph.D., Terri Lewinson, Ph.D., M.S.W., Brianna Hardy, B.S., Deanna Chyn, M.P.H., Moraa Onsando, M.D., M.P.H., Haiden A. Huskamp, Ph.D., Ateev Mehrotra, M.D., M.P.H., and Nancy E. Morden, M.D., M.P.H.

doi : 10.1056/NEJMsa2212412

Since 2010, Black persons in the United States have had a greater increase in opioid overdose–related mortality than other groups, but national-level evidence characterizing racial and ethnic disparities in the use of medications for opioid use disorder (OUD) is limited.

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Human Papillomavirus Vaccination

Lauri E. Markowitz, M.D., and Elizabeth R. Unger, M.D., Ph.D.

doi : 10.1056/NEJMcp2108502

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Dietary Zinc Deficiency–Associated Dermatitis in a Child

Rohit Kothari, M.D., and Sanjay Khare, M.D.

doi : 10.1056/NEJMicm2213071

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Eosinophilic Fasciitis

Katharina S. Shaw, M.D., and Ruth Ann Vleugels, M.D., M.P.H.

doi : 10.1056/NEJMicm2212023

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Case 14-2023: A 31-Year-Old Man with Redness of the Right Eye

Miriam B. Barshak, M.D., Caitlin M. Dugdale, M.D., and Roberto Pineda, M.D.

doi : 10.1056/NEJMcpc2211511

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Time-Limited Initial Therapy for Young, Fit Patients with CLL

Jennifer A. Woyach, M.D., and John C. Byrd, M.D.

doi : 10.1056/NEJMe2302557

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Good News for Toddlers with Peanut Allergy

Alkis Togias, M.D.

doi : 10.1056/NEJMe2301157

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Audio Interview: Ending the Covid-19 Emergency

Eric J. Rubin, M.D., Ph.D., Lindsey R. Baden, M.D., and Stephen Morrissey, Ph.D.

doi : 10.1056/NEJMe2305545

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Detection of Prion Protein Seeding Activity in Tear Fluids

doi : 10.1056/NEJMc2214647

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Durability of Bivalent Boosters against Omicron Subvariants

doi : 10.1056/NEJMc2302462

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Baxdrostat for Treatment-Resistant Hypertension

doi : 10.1056/NEJMc2302673

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Focused Ultrasound Ablation in Parkinson’s Disease

doi : 10.1056/NEJMc2303750

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Choosing the Right Path toward Polio Eradication

doi : 10.1056/NEJMc2303169

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