New England Journal of Medicine




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سفارش

U.S. Law and Discrimination in Health Care

Kimani Paul-Emile, J.D., Ph.D.

doi : 10.1056/NEJMp2202164

Vol. 388 No. 21

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Enhancing Regulations to Reduce Exposure to PFAS — Federal Action on “Forever Chemicals�

Joseph M. Braun, Ph.D., R.N., M.S.P.H.

doi : 10.1056/NEJMp2303333

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Public Health’s Role in a Post-Dobbs World — The New York City Abortion Access Hub

Tara B. Stein, M.D., M.P.H., and Ashwin Vasan, M.D., Ph.D.

doi : 10.1056/NEJMp2301278

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Hydrocortisone in Severe Community-Acquired Pneumonia

Pierre-François Dequin, M.D., Ph.D., Ferhat Meziani, M.D., Ph.D., Jean-Pierre Quenot, M.D., Ph.D., Toufik Kamel, M.D., Jean-Damien Ricard, M.D., Ph.D., Julio Badie, M.D., Jean Reignier, M.D., Ph.D., Nicholas Heming, M.D., Ph.D., Gaëtan Plantefève, M.D., Bertrand Souweine, M.D., Ph.D., Guillaume Voiriot, M.D., Ph.D., Gwenhaël Colin, M.D., Jean-Pierre Frat, M.D., Ph.D., Jean-Paul Mira, M.D., Ph.D., Nicolas Barbarot, M.D., Bruno François, M.D., Guillaume Louis, M.D., Sébastien Gibot, M.D., Ph.D., Christophe Guitton, M.D., Ph.D., Christophe Giacardi, M.D., Sami Hraiech, M.D., Ph.D., Sylvie Vimeux, M.D., Erwan L’Her, M.D., Ph.D., Henri Faure, M.D., Jean-Etienne Herbrecht, M.D., Camille Bouisse, M.D., Aurélie Joret, M.D., Nicolas Terzi, M.D., Ph.D., Arnaud Gacouin, M.D., Charlotte Quentin, M.D., Mercé Jourdain, M.D., Ph.D., Marie Leclerc, M.Sc., Carine Coffre, M.Sc., Hélène Bourgoin, Pharm.D., Céline Lengellé, Pharm.D., Caroline Caille-Fénérol, M.Sc., Bruno Giraudeau, Ph.D., and Amélie Le Gouge, M.Sc. for the CRICS-TriGGERSep Network*

doi : 10.1056/NEJMoa2215145

Whether the antiinflammatory and immunomodulatory effects of glucocorticoids may decrease mortality among patients with severe community-acquired pneumonia is unclear.

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Meningococcal ACWYX Conjugate Vaccine in 2-to-29-Year-Olds in Mali and Gambia

Fadima C. Haidara, M.D., Ama Umesi, M.B., B.S., Samba O. Sow, M.D., Magnus Ochoge, M.B., B.Ch., Fatoumata Diallo, M.D., Abdulazeez Imam, M.B., B.S., Youssouf Traore, M.D., Lucy Affleck, M.B., Ch.B., Moussa F. Doumbia, M.D., Bubacarr Daffeh, M.B., Ch.B., Mamoudou Kodio, Pharm.D., Oghenebrume Wariri, M.B., B.S., Awa Traoré, Pharm.D., Edrissa Jallow, B.Sc., Beate Kampmann, Ph.D., Dhananjay Kapse, M.D., Prasad S. Kulkarni, M.D., Asha Mallya, Ph.D., Sunil Goel, Ph.D., Pankaj Sharma, M.Sc., Annamraju D. Sarma, Ph.D., Nikhil Avalaskar, M.Pharm., F. Marc LaForce, M.D., Mark R. Alderson, Ph.D., Abdi Naficy, M.D., Steve Lamola, M.D., Yuxiao Tang, Ph.D., Lionel Martellet, M.A., Nancy Hosken, Ph.D., Evangelos Simeonidis, Ph.D., Jo Anne Welsch, Ph.D., Milagritos D. Tapia, M.D., and Ed Clarke, M.B., Ch.B.

doi : 10.1056/NEJMoa2214924

An effective, affordable, multivalent meningococcal conjugate vaccine is needed to prevent epidemic meningitis in the African meningitis belt. Data on the safety and immunogenicity of NmCV-5, a pentavalent vaccine targeting the A, C, W, Y, and X serogroups, have been limited.

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Platelet Transfusion before CVC Placement in Patients with Thrombocytopenia

Floor L.F. van Baarle, M.D., Emma K. van de Weerdt, M.D., Ph.D., Walter J.F.M. van der Velden, M.D., Ph.D., Roelof A. Ruiterkamp, M.Sc., Pieter R. Tuinman, M.D., Ph.D., Paula F. Ypma, M.D., Ph.D., Walter M. van den Bergh, M.D., Ph.D., Astrid M.P. Demandt, M.D., Emile D. Kerver, M.D., A.J. Gerard Jansen, M.D., Ph.D., Peter E. Westerweel, M.D., Ph.D., Sesmu M. Arbous, M.D., Ph.D., Rogier M. Determann, M.D., Ph.D., Walther N.K.A. van Mook, M.D., Ph.D., Mirelle Koeman, M.D., Ph.D., Anja B.U. Mäkelburg, M.D., Ph.D., Krijn P. van Lienden, M.D., Ph.D., Jan M. Binnekade, Ph.D., Bart J. Biemond, M.D., Ph.D., and Alexander P.J. Vlaar, M.D., Ph.D.

doi : 10.1056/NEJMoa2214322

Transfusion guidelines regarding platelet-count thresholds before the placement of a central venous catheter (CVC) offer conflicting recommendations because of a lack of good-quality evidence. The routine use of ultrasound guidance has decreased CVC-related bleeding complications.

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Upadacitinib Induction and Maintenance Therapy for Crohn’s Disease

Edward V. Loftus, Jr., M.D., Julian Panés, M.D., Ana P. Lacerda, M.D., Laurent Peyrin-Biroulet, M.D., Ph.D., Geert D’Haens, M.D., Remo Panaccione, M.D., Walter Reinisch, M.D., Edouard Louis, M.D., Ph.D., Minhu Chen, M.D., Hiroshi Nakase, M.D., Jakob Begun, M.D., Brigid S. Boland, M.D., Charles Phillips, M.D., Mohamed-Eslam F. Mohamed, Ph.D., Jianzhong Liu, M.D., Ziqian Geng, Ph.D., Tian Feng, Ph.D., Elena Dubcenco, M.D., and Jean-Frederic Colombel, M.D.

doi : 10.1056/NEJMoa2212728

Upadacitinib, an oral selective Janus kinase (JAK) inhibitor, is under investigation for the treatment of Crohn’s disease.

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The Current and Future State of AI Interpretation of Medical Images

Pranav Rajpurkar, Ph.D., and Matthew P. Lungren, M.D., M.P.H.

doi : 10.1056/NEJMra2301725

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Malignant Syphilis

Ming J. Liu, M.D., and Wei Lv, M.D.

doi : 10.1056/NEJMicm2213894

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Medication-Related Osteonecrosis of the Jaw

Yu-Feng Chen, D.D.S., M.D.S., and Hong-Po Chang, D.M.D., Ph.D.

doi : 10.1056/NEJMicm2209172

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Case 16-2023: A 13-Year-Old Boy with Depression and Hypotension

Kevin R. Schwartz, M.D., Abigail L. Donovan, M.D., Bryan D. Hayes, Pharm.D., Mai Uchida, M.D., and Joy B. Rosen, M.S.

doi : 10.1056/NEJMcpc2201237

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Time to Treat Severe Community-Acquired Pneumonia with Steroids?

Joshua P. Metlay, M.D., Ph.D., and Grant W. Waterer, M.B., B.S., Ph.D.

doi : 10.1056/NEJMe2302544

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Global Control of Meningococcal Disease

David S. Stephens, M.D.

doi : 10.1056/NEJMe2301698

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JAK1 Inhibition to Treat Crohn’s Disease

Maria T. Abreu, M.D.

doi : 10.1056/NEJMe2301147

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Audio Interview: The Lasting Effects of Covid-19

Eric J. Rubin, M.D., Ph.D., Lindsey R. Baden, M.D., and Stephen Morrissey, Ph.D.

doi : 10.1056/NEJMe2306166

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BCL2 Inhibition in Refractory Hairy-Cell Leukemia

doi : 10.1056/NEJMc2215613

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Antidepressant Augmentation versus Switch in Treatment-Resistant Geriatric Depression

doi : 10.1056/NEJMc2304804

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Hydrochlorothiazide and Prevention of Kidney-Stone Recurrence

doi : 10.1056/NEJMc2304100

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Deep Intronic FGF14 GAA Repeat Expansion in Late-Onset Cerebellar Ataxia

doi : 10.1056/NEJMc2301605

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