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Bridging the gap of referral to nephrology care
Nestor Oliva-Damaso, Navdeep Tangri, Pierre Delanaye & Richard J. GlassockÂ
doi : 10.1038/s41581-023-00693-1
Volume 19 Issue 5, May 2023
The cilia mechanosensation debate gets (bio)physical
Dagmar Wachten & Pleasantine MillÂ
Regulated cell death pathways in kidney disease
Ana B. Sanz, Maria Dolores Sanchez-Niño, Adrian M. Ramos & Alberto OrtizÂ
doi : 10.1038/s41581-023-00694-0
Disorders of cell number that result from an imbalance between the death of parenchymal cells and the proliferation or recruitment of maladaptive cells contributes to the pathogenesis of kidney disease. Acute kidney injury can result from an acute loss of kidney epithelial cells. In chronic kidney disease, loss of kidney epithelial cells leads to glomerulosclerosis and tubular atrophy, whereas interstitial inflammation and fibrosis result from an excess of leukocytes and myofibroblasts.
Role of necroptosis in kidney health and disease
Benedikt Kolbrink, Friedrich A. von Samson-Himmelstjerna, James M. Murphy & Stefan KrautwaldÂ
doi : 10.1038/s41581-022-00658-w
Cell death, particularly that of tubule epithelial cells, contributes critically to the pathophysiology of kidney disease. A body of evidence accumulated over the past 15 years has ascribed a central pathophysiological role to a particular form of regulated necrosis, termed necroptosis, to acute tubular necrosis, nephron loss and maladaptive renal fibrogenesis.
Ferroptotic mechanisms and therapeutic targeting of iron metabolism and lipid peroxidation in the kidney
Hülya Bayır, Scott J. Dixon, Yulia Y. Tyurina, John A. Kellum & Valerian E. KaganÂ
doi : 10.1038/s41581-023-00689-x
Ferroptosis is a mechanism of regulated necrotic cell death characterized by iron-dependent, lipid peroxidation-driven membrane destruction that can be inhibited by glutathione peroxidase 4. Morphologically, it is characterized by cellular, organelle and cytoplasmic swelling and the loss of plasma membrane integrity, with the release of intracellular components.
Gasdermins and pyroptosis in the kidney
Esteban E. Elias, Brayden Lyons & Daniel A. MuruveÂ
doi : 10.1038/s41581-022-00662-0
Pyroptosis is a form of regulated cell death that is mediated by the membrane-targeting, pore-forming gasdermin family of proteins. Pyroptosis was initially described as a caspase 1- and inflammasome-dependent cell death pathway typified by the loss of membrane integrity and the secretion of cytokines such as IL-1β.
