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Lower Esophageal Sphincter and Pylorus Distensibility Before and After Endoscopic Sleeve Gastroplasty
Firas Bahdi, Sagar Shah, Philip Kozan & Danny Issa
doi : 10.1007/s10620-023-07932-2
Volume 68, issue 7, July 2023
Isolated Esophageal Lichen Planus Causing Pseudoachalasia
Jane Lim & Ali Rezaie
Biologics Imperative: Drug Positioning After First-Line Treatment with Anti-TNFs
Tommaso Innocenti
Taking a JAB at How Gastroenterologists Can Increase Vaccination Rates in Patients with Inflammatory Bowel Disease
Mazen Almasry & Freddy Caldera
Does Gluten Avoidance in Patients with Celiac Disease Increase the Risk of Developing Eating Disorders?
Sophie R. Abber & Helen Burton Murray
NEN Gain or NEN Loss: Endoscopic Resection for Rectal Neuroendocrine Neoplasms < 15 mm
Roberta Elisa Rossi & Sara Massironi
How a GI Fellow Found a Following: Harnessing the Power of Social Media for Education and Fun
Benjamin Schmidt
doi : 10.1007/s10620-023-07850-3
Over the past fifteen years, social media has become a central part of nearly all aspects of society, including the broad field of healthcare. Over the past two years, I (the author) have created a social media platform on which I have produced video content that educates and entertains about numerous issues in healthcare and medicine.
Genotype–Phenotype Correlations in Autosomal Dominant and Recessive APC Mutation-Negative Colorectal Adenomatous Polyposis
Li-Hua Zhu, Jian Dong, Wen-Liang Li, Zhi-Yong Kou & Jun Yang
doi : 10.1007/s10620-023-07890-9
The most prevalent type of intestinal polyposis, colorectal adenomatous polyposis (CAP), is regarded as a precancerous lesion of colorectal cancer with obvious genetic characteristics. Early screening and intervention can significantly improve patients’ survival and prognosis. The adenomatous polyposis coli (APC) mutation is believed to be the primary cause of CAP.
Pancreatic Cancer Biomarkers: Oncogenic Mutations, Tissue and Liquid Biopsies, and Radiomics—A Review
Maria João Amaral, Rui Caetano Oliveira, Paulo Donato & José Guilherme Tralhão
doi : 10.1007/s10620-023-07904-6
Pancreatic cancer is one of the most fatal malignancies, as approximately 80% of patients are at advanced stages by the time of diagnosis. The main reason for the poor overall survival is late diagnosis that is partially due to the lack of tools for early-stage detection.
Incorporating the Molecular Mimicry of Environmental Antigens into the Causality of Autoimmune Hepatitis
Albert J. CzajaÂ
doi : 10.1007/s10620-023-07967-5
Molecular mimicry between foreign and self-antigens has been implicated as a cause of autoimmune hepatitis in experimental models and cross-reacting antibodies in patients. This review describes the experimental and clinical evidence for molecular mimicry as a cause of autoimmune hepatitis, indicates the limitations and uncertainties of this premise, and encourages investigations that assess diverse environmental antigens as sources of disease-relevant molecular mimics.
Etiologies and Outcomes of Transaminase Elevation > 1000 IU/L: A Systematic Review and Meta-Analysis
Mouhand F. Mohamed, Neha Wadhavkar, Yousef Elfanagely, Daniel Marino, Azizullah Beran, Mohamed Abdallah & Kittichai Promrat
doi : 10.1007/s10620-023-07962-w
Among liver injury causes, few result in marked elevation of liver enzymes to a level > 1,000 international units per liter (IU/L). This review summarizes common etiologies of marked transaminase elevation and associated prognostic factors.
Nightshade Vegetables: A Dietary Trigger for Worsening Inflammatory Bowel Disease and Irritable Bowel Syndrome?
Rebecca Kuang, David J. Levinthal, Amir A. Ghaffari, Claudia Ramos del Aguila de Rivers, Aylin Tansel & David G. Binion
doi : 10.1007/s10620-023-07955-9
The Solanaceae family of plants, commonly known as Nightshade vegetables or Nightshades, contains a diverse range of crops of over 2000 members with significant culinary, economic, and cultural importance.
Lower Extremity Palpable Purpura in a Patient with Quiescent Inflammatory Bowel Disease
Kimberly Darlington, Paul Googe, Priyanka Vedak, Animesh Jain, Millie D. Long, Edward L. Barnes & Hans H. Herfarth
Predicting the Recurrence of Common Bile Duct Stones After ERCP Treatment with Automated Machine Learning Algorithms
Yuqi Shi, Jiaxi Lin, Jinzhou Zhu, Jingwen Gao, Lu Liu, Minyue Yin, Chenyan Yu, Xiaolin Liu, Yu Wang & Chunfang Xu
doi : 10.1007/s10620-023-07949-7
Recurrence of common bile duct stones (CBDs) commonly happens after endoscopic retrograde cholangiopancreatography (ERCP). The clinical prediction models for the recurrence of CBDs after ERCP are lacking.
Predicting Persistent Acute Respiratory Failure in Acute Pancreatitis: The Accuracy of Two Lung Injury Indices
Lan Li, Shiyu Liu, Xiaoying Zhang, Wenhua He, Ping Zhu, Jiahua Shi, Wen Wang, Xing Sun, Na Shi, Liang Xia, Nonghua Lu, Anthony R. Philips, Vikesh K. Singh, Robert Sutton, Yin Zhu, Wei Huang, John A. Windsor, Lihui Deng, Tao Jin & Qing Xia
doi : 10.1007/s10620-023-07855-y
Early and accurate identification of patients with acute pancreatitis (AP) at high risk of persistent acute respiratory failure (PARF) is crucial. We sought to determine the accuracy of simplified Lung Injury Prediction Score (sLIPS) and simplified Early Acute Lung Injury (sEALI) for predicting PARF in ward AP patients.
Hospital Frailty Risk Score (HFRS) Predicts Adverse Outcomes Among Hospitalized Patients with Chronic Pancreatitis
Vivek Kumar, Ebrahim Barkoudah, David X. Jin, Peter Banks & Julia McNabb-Baltar
doi : 10.1007/s10620-023-07946-w
The prevalence of frailty among patients with chronic pancreatitis (CP) and its impact on clinical outcomes is unclear. We report the impact of frailty on mortality, readmission rates, and healthcare utilization among patients with chronic pancreatitis in the United States.
Maladaptive Food Attitudes and Behaviors in Individuals with Celiac Disease and Their Association with Quality of Life
Yara Gholmie, Anne R. Lee, Rose-Marie Satherley, Janet Schebendach, Patricia Zybert, Peter H. R. Green, Benjamin Lebwohl & Randi Wolf
doi : 10.1007/s10620-023-07912-6
The only treatment for celiac disease (CeD) is strict lifelong adherence to a gluten-free diet (GFD). In some individuals the demands of a GFD may contribute to maladaptive eating attitudes and behaviors that impair quality of life (QOL). The Celiac Disease Food Attitudes and Behaviors (CD-FAB) is an easily administered and scored 11-item tool querying potentially maladaptive food attitudes and behaviors resulting from beliefs around gluten exposures and food safety.
Use of Behavior Change Techniques and Quality of Commercially Available Inflammatory Bowel Disease Apps
Amy E. Noser, Brittany D. Lancaster, Kevin A. Hommel, Caroline M. Roberts, Jessica A. King, Elizabeth Alt, Emily M. Fredericks & Rachelle R. Ramsey
doi : 10.1007/s10620-023-07884-7
Inclusion of evidence-based behavior change techniques (e.g., self-monitoring) in mobile health apps has the potential to promote adherence to inflammatory bowel disease treatment. While inflammatory bowel disease management apps exist, the extent to which they incorporate behavior change techniques remains unknown.
Interventions Increase Vaccination Rates in Inflammatory Bowel Disease and Rheumatoid Arthritis: A Systematic Review and Meta-Analysis
Jalpa Patel, Mohamed Noureldin, Dina Fakhouri, Francis A. Farraye, Iris Kovar-Gough, Bradley Warren, Akbar K. Waljee & Marc S. Piper
doi : 10.1007/s10620-023-07903-7
Patients with immune-mediated conditions such as IBD and RA are at risk for vaccine-preventable infections. Despite guideline recommendations, prior studies have shown suboptimal vaccination rates.
Feasibility of Reduced Clinical Monitoring in Patients with Inflammatory Bowel Disease Treated with Thiopurine Therapy
Fenna M. Jansen, Lisa J. T. Smits, Pepijn W. A. Thomas, Dirk J. de Jong, Joany E. Kreijne, Willemijn A. van Dop, Nathan den Broeder & Frank Hoentjen
doi : 10.1007/s10620-023-07950-0
Outpatient visits and laboratory assessments are routinely scheduled every 3 to 4Â months in thiopurine-treated patients with inflammatory bowel disease (IBD) to timely detect thiopurine-related adverse events (AEs). AEs that require therapy adjustment beyond 12Â months of treatment are rare.
Gaps in Confirmatory Fibrosis Risk Assessment in Primary Care Patients with Nonalcoholic Fatty Liver Disease
Joseph A. Moore, William H. Wheless, Jingwen Zhang, Justin Marsden, Patrick D. Mauldin, William P. Moran & Andrew D. Schreiner
doi : 10.1007/s10620-023-07959-5
As recommendations for non-invasive fibrosis risk assessment in nonalcoholic fatty liver disease (NAFLD) emerge, it is not known how often they are performed in primary care.
Delayed Diagnostic Paracentesis Is Associated with Increased Preventable Healthcare Utilization in Disadvantaged Patient Populations with Advanced Liver Disease and Elevated INR
Cristal Brown, Nazan Aksan, Patrick Chang, Priyanka Jagannathan, Maria Goretti Ochi, Michael Pignone & Linda Feagins
doi : 10.1007/s10620-023-07937-x
Patients hospitalized with cirrhosis, ascites, and elevated INR often experience delays in timely diagnostic paracentesis.
Nicotinamide Riboside Improves Enteric Neuropathy in Streptozocin-Induced Diabetic Rats Through Myenteric Plexus Neuroprotection
Christopher J. Costa, Melanie W. Cohen, David C. Goldberg, Wilfredo Mellado & Dianna E. Willis
doi : 10.1007/s10620-023-07913-5
Diabetes Mellitus causes a systemic oxidative stress due in part to the hyperglycemia and the reactive oxygen species generated. Up to 75% of diabetic patients present with an autonomic neuropathy affecting the Enteric Nervous System. Deficits in the human population are chronic dysmotilities with either increased (i.e., constipation) or decreased (i.e., diarrhea) total gastrointestinal transit times. These are recapitulated in the streptozocin-induced diabetic rat, which is a model of Type I Diabetes Mellitus.
Local Pentraxin-2 Deficit Is a Feature of Intestinal Fibrosis in Crohn’s Disease
Steven Levitte, Franklin V. Peale, Iny Jhun, Jacqueline McBride & Margaret Neighbors
doi : 10.1007/s10620-023-07909-1
Pentraxin-2 (PTX-2) is a homo-pentameric plasma protein showing evidence of antifibrotic activity in Phase 2 clinical trials in idiopathic pulmonary fibrosis (IPF). Whether PTX-2 plays a role in other fibrotic diseases, including intestinal fibrosis which commonly occurs in inflammatory bowel disease (IBD), remains unknown.
Sodium Butyrate Inhibits Oxidative Stress and NF-κB/NLRP3 Activation in Dextran Sulfate Sodium Salt-Induced Colitis in Mice with Involvement of the Nrf2 Signaling Pathway and Mitophagy
Zhongbo Bian, Qiuyu Zhang, Yong Qin, Xiaodie Sun, Lulin Liu, Huahuan Liu, Lianzhi Mao, Yiran Yan, Wenzhen Liao, Longying Zha & Suxia Sun
doi : 10.1007/s10620-023-07845-0
Sodium butyrate (NaB) is a short-chain fatty acid produced by intestinal microbial fermentation of dietary fiber, and has been shown to be effective in inhibiting ulcerative colitis (UC). However, how NaB regulates inflammation and oxidative stress in the pathogenesis of UC is not clear.
High Expression Level of BRD4 Is Associated with a Poor Prognosis and Immune Infiltration in Esophageal Squamous Cell Carcinoma
Li Li, Lin Gao, Hong Zhou, Chao Shi, Xiaojuan Zhang, Dongmei Zhang & Hongbin Liu
doi : 10.1007/s10620-023-07907-3
Bromodomain-containing protein 4 (BRD4) is a reader of histone acetylation and is associated with a variety of diseases.
Joint Effects Between CDKN2B/P15 Methylation and Environmental Factors on the Susceptibility to Gastric Cancer
Haibo Zhou, Chuang Nie, Wenjing Tian, Xu Han, Jing Wang, Xinyu Du, Qi Wang, Xiaojie Zhu, Guanghui Xiang & Yashuang Zhao
doi : 10.1007/s10620-023-07917-1
The incidence of gastric cancer has long been at a high level in China, seriously affecting the health of Chinese people.
Karyopherin Subunit Alpha 1 Enhances the Malignant Behaviors of Colon Cancer Cells via Promoting Nuclear Factor-κB p65 Nuclear Translocation
Lianrong Zhao, Di Wu, Qiao Qu, Zhilong Li & Hongzhuan Yin
doi : 10.1007/s10620-023-07936-y
Aberrant nuclear factor-κB p65 (NF-κB p65) nuclear import commonly occurs in multiple cancers, including colon cancer. According to BioGRID, we noted that Karyopherin subunit alpha 1 (KPNA1), an important molecular transporter between the nucleus and the cytoplasm, may interact with NF-κB p65.
Tcf21 Alleviates Pancreatic Fibrosis by Regulating the Epithelial-Mesenchymal Transformation of Pancreatic Stellate Cells
Yan-Hong Ni, Rong Wang, Wen Wang, Da-Zhou Li, Gang Liu, Chuan-Shen Jiang, Yi Wang, Xia Lin & Xiang-Peng Zeng
doi : 10.1007/s10620-023-07849-w
The activation of pancreatic stellate cells (PSCs) plays a key role in the occurrence and development of chronic pancreatitis (CP) and pancreatic fibrosis, which is related to the process of epithelial-mesenchymal transition (EMT). This study was designed to investigate the effect and mechanism of Tcf21 (one of tumor suppressor genes) on pancreatic inflammation and fibrosis in vivo and in vitro.
Activation of Vitamin D/VDR Signaling Reverses Gemcitabine Resistance of Pancreatic Cancer Cells Through Inhibition of MUC1 Expression
Daoyan Wei, Liang Wang, Yi Liu, Margarete A. Hafley, Lin Tan, Philip L. Lorenzi, Peiying Yang, Xiangsheng Zuo & Robert S. Bresalier
doi : 10.1007/s10620-023-07931-3
Pancreatic ductal adenocarcinoma (PDA) has a poor prognosis due to its therapeutic resistance. Inactivation of vitamin D/vitamin D receptor (VDR) signaling may contribute to the malignant phenotype of PDA and altered expression of oncoprotein mucin 1 (MUC1) may be involved in drug resistance of cancer cells.
Differences in Bacterial Translocation and Liver Injury in Ethanol Versus Diet-Induced Liver Disease
Cynthia L. Hsu, Yanhan Wang, Yi Duan, Huikuan Chu, Phillipp Hartmann, Cristina Llorente, Rongrong Zhou & Bernd Schnabl
doi : 10.1007/s10620-023-07860-1
Alcohol-associated liver disease (ALD) and non-alcoholic fatty liver disease (NAFLD)/non-alcoholic steatohepatitis (NASH) are two of the most common etiologies of chronic liver disease worldwide.
TEA Domain Transcription Factor 1 Inhibits Ferroptosis and Sorafenib Sensitivity of Hepatocellular Carcinoma Cells
Hongmin Li, Haitao Lan, Ming Zhang, Fen Zhao, Ning An & Cheng Yi
doi : 10.1007/s10620-023-07824-5
Ferroptosis, as a unique form of cell death, plays crucial negative roles in tumorigenesis and progression. This study aimed to investigate the role and molecular mechanism of TEA domain transcription factor 1 (TEAD1) in HCC and its effect on sorafenib-induced ferroptosis.
Predictive Model for Positive Video Capsule Endoscopy in Iron Deficiency Anemia
Shadi Hamdeh, Jihan Fathallah, Hui Zhang, Amber Charoen, Barakat Aburajab Altamimi, Florence-Damilola Odufalu, Devashree Dave, Amer El Sayed, Laura R. Glick, Scott Grisolano, Christine Hachem, Muhammad Bader Hammami, Khaldoun Haj Mahmoud, Alexander N. Levy, Vijaya L. Rao, Hong Gi Shim, Carol Semrad, Mojtaba Olyaee & Dejan Micic
doi : 10.1007/s10620-023-07918-0
Bleeding from the gastrointestinal tract can contribute to the development of iron deficiency anemia (IDA) among individuals without another obvious source of bleeding. In order to identify patients most likely to benefit from examination of the small bowel, our aim was to create a risk score for positive video capsule endoscopy (VCE) in IDA utilizing a multicenter collection of studies.
Bladder Pain Sensitivity Is a Potential Risk Factor for Irritable Bowel Syndrome
Arielle E. Shlobin, Frank F. Tu, Cody R. Sain, Matthew J. Kmiecik, Diana Kantarovich, Lavisha Singh, Chi E. Wang & Kevin M. Hellman
doi : 10.1007/s10620-023-07868-7
Although dysmenorrhea is a highly prevalent risk factor for irritable bowel syndrome (IBS), the factors underlying this risk are not fully understood. Prior studies support a hypothesis that repeated distressing menstrual pain promotes cross-organ pelvic sensitization with heightened visceral sensitivity.
Collagenous Gastritis Is an Underdiagnosed Cause of Anemia and Abdominal Pain: Systematic Scoping Review
Landon Kozai, Arvin Tan, Kevin E. Nebrejas, Chase Warashina & Yoshito Nishimura
doi : 10.1007/s10620-023-07938-w
Collagenous gastritis (CG) is a rare disease characterized by infiltration of the lamina propria with mononuclear cells and subepithelial deposition of collagen. Due to its nonspecific presentation, it is often misdiagnosed. The clinical characteristics, endoscopic, and histopathologic features, and treatment outcomes of CG have not been well defined.
Celiac Disease on the Rise in the US Military Population: A 22 Year Retrospective Epidemiologic Study
Rachel U. Lee, Shauna L. Stahlman & Jared S. Magee
doi : 10.1007/s10620-023-07964-8
We describe celiac disease epidemiology in the US military population.
Ustekinumab Versus Anti-tumour Necrosis Factor Alpha Agents as Second-Line Biologics in Crohn's Disease
Carl Eriksson, Jonas Söderling, Sara Karlqvist, Gabriella Bröms, Åsa H. Everhov, Daniel Bergemalm, Jonas F. Ludvigsson, The SWIBREG study group, Ola Olén & Jonas Halfvarson
doi : 10.1007/s10620-023-07897-2
We aimed to assess the comparative effectiveness and safety of ustekinumab vs tumour necrosis factor-alpha (anti-TNF) agents after first-line treatment with anti-TNF in CD.
Frequent Occurrence of Perianal Disease and Granuloma Formation in Patients with Crohn’s Disease and Coexistent Orofacial Granulomatosis
Marianne Malmquist, Hardis Rabe, Petter Malmborg, Gita Gale, Maja Ideström, Gudmundur Vignir Sigurdsson, Bengt Hasséus, Agnes E. Wold & Robert Saalman
doi : 10.1007/s10620-023-07821-8
Orofacial granulomatosis (OFG) is an inflammatory disorder of the perioral region and oral cavity. Crohn’s disease (CD) in conjunction with OFG (CD-OFG), has been suggested to constitute a phenotype of CD with distinct features at diagnosis.
Very Early Pouchitis Is Associated with an Increased Likelihood of Chronic Inflammatory Conditions of the Pouch
Scott Esckilsen, Bharati Kochar, Kimberly N. Weaver, Hans H. Herfarth & Edward L. Barnes
doi : 10.1007/s10620-023-07947-9
Chronic inflammatory conditions of the pouch are common after ileal pouch-anal anastomosis (IPAA) for ulcerative colitis (UC).
Efficacy of Endoscopic Resection for Rectal Neuroendocrine Tumors Smaller than 15Â mm
Yasuhiko Hamada, Kyosuke Tanaka, Katsumi Mukai, Youichirou Baba, Makoto Kobayashi, Shintaro Tominaga, Hiroyuki Kawabata, Shoma Sawai, Masabumi Kaneko, Shinya Sugimoto, Hidekazu Inoue, Maya Mimuro, Satoshi Tamaru & Hayato Nakagawa
doi : 10.1007/s10620-023-07914-4
Local resection, including endoscopic resection, is recommended for rectal neuroendocrine tumors (NETs) < 15 mm in patients without risk factors for metastasis, though the short- and long-term outcomes are unclear.
Risk Factors for Cholangitis After Pancreatoduodenectomy: A Systematic Review
Youcef Salaheddine, Anne Claire Henry, Lois A. Daamen, Wouter J. M. Derksen, Krijn P. van Lienden, I. Quintus Molenaar, Hjalmar C. van Santvoort, Frank P. Vleggaar & Robert C. Verdonk
doi : 10.1007/s10620-023-07929-x
Cholangitis is a late complication after pancreatoduodenectomy with considerable clinical impact and is difficult to treat. The aim of this systematic review was to provide an overview of the literature identifying risk factors for postoperative cholangitis.
Pancreatic Dysfunction and Reduction in Quality of Life Is Common After Pancreaticoduodenectomy
Shradha Kanwat, Harjeet Singh, Arun Kumar Sharma, Vishal Sharma, Pankaj Gupta, Vikas Gupta, Thakur Deen Yadav & Rajesh Gupta
doi : 10.1007/s10620-023-07966-6
Improvements in survival after pancreaticoduodenectomy has increased the number of patients potentially at risk of pancreatic insufficiency.
Safety and Efficacy of Transjugular Intrahepatic Portosystemic Shunt for Non-tumoral Cirrhotic Portal Vein Thrombosis Not Responding to Anticoagulation Therapy
Amar Mukund, Uday Kumar Marri, Ankur Jindal, Ashok Choudhury, Yashwant Patidar & Shiv Kumar Sarin
doi : 10.1007/s10620-023-07930-4
To evaluate the feasibility, safety, and efficacy of add-on transjugular–intrahepatic–portosystemic shunt (TIPS) for portal vein recanalization (PVR) in cirrhotic patients with non-tumoral chronic portal vein thrombosis (PVT) after 6 months of monitored anticoagulation therapy (ACT).
MELD 3.0 Score for Predicting Survival in Patients with Cirrhosis After Transjugular Intrahepatic Portosystemic Shunt Creation
Jinlei Song, Xiaoze Wang, Yuling Yan, Tong Xiang & Xuefeng Luo
doi : 10.1007/s10620-023-07834-3
The selection of appropriate candidates for transjugular intrahepatic portosystemic shunt (TIPS) is important and challenging. To validate the Model for End-Stage Liver Disease (MELD) 3.0 in predicting mortality in patients with cirrhosis after TIPS creation.
Low Rate of Hepatitis B Reactivation Among Patients with Chronic Hepatitis C During Direct Acting Antiviral Therapy
Nehna Abdul Majeed, Ahmad Samer Alawad, Kin Seng Liem, Varun Takyar, Harvey Alter, Jordan J. Feld, Harry L. A. Janssen & Marc G. Ghany
doi : 10.1007/s10620-023-07916-2
Hepatitis B virus (HBV) reactivation has been reported in patients co-infected with hepatitis C virus (HCV) during direct acting antiviral (DAA) therapy, leading the United States Food and Drug Administration (U.S. FDA) to issue a black box warning on all DAA drug labels recommending monitoring for HBV reactivation. We conducted a comprehensive evaluation to assess the rate of HBV reactivation among patients with chronic hepatitis C (CHC) during DAA therapy.
