Arthritis Care and Research




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سفارش

Immediate Open Access: The Good, the Bad, and the Impact on Academic Society Publishing

Amr H. Sawalha, Daniel H. Solomon, Kelli D. Allen, Patricia Katz, Ed Yelin

doi : 10.1002/acr.25131

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Unfolding a Case of Budd-Chiari Syndrome and Recurrent Aseptic Meningitis

Yashswee KC, Abhishek Nandan, Sarah Ford, Nishant Desai

doi : 10.1002/acr.25082

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Update on the Efficacy and Safety Profile of Voclosporin: An Integrated Analysis of Clinical Trials in Lupus Nephritis

Cristina Arriens, Y. K. Onno Teng, Ellen M. Ginzler, Samir V. Parikh, Anca D. Askanase, Amit Saxena, Keisha Gibson, Dawn J. Caster, Tatsuya Atsumi, Laura Lisk, Simrat Randhawa, Rashieda Gluck, Neil Solomons, Robert B. Huizinga

doi : 10.1002/acr.25007

This integrated analysis evaluates the efficacy and safety of voclosporin, a novel calcineurin inhibitor, at 23.7 mg twice daily in combination with mycophenolate mofetil (MMF) and oral glucocorticoids in lupus nephritis (LN) using pooled data from two large phase II and phase III clinical trials. The purpose was to expand the pool of patients for safety analyses and to increase power for efficacy analyses in patient subpopulations.

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Association of Ultraviolet B Radiation and Risk of Systemic Lupus Erythematosus Among Women in the Nurses’ Health Studies

Medha Barbhaiya, Jaime E. Hart, Susan Malspeis, Sara K. Tedeschi, Trang VoPham, Jeffrey A. Sparks, Elizabeth W. Karlson, Francine Laden, Karen H. Costenbader

doi : 10.1002/acr.24974

Ultraviolet (UV) radiation exposure is associated with photosensitivity, rashes, and flares in systemic lupus erythematosus (SLE). However, it is not known whether UV exposure increases risk of developing SLE. We examined UV exposure and SLE risk in a large prospective cohort.

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Health-Related Quality of Life in Adults With Adolescent- and Adult-Onset Systemic Lupus Erythematosus: A Longitudinal Study of a Multiethnic US Cohort

R. Ezequiel Borgia, Manuel F. Ugarte-Gil, Luis M. Vilá, John D. Reveille, Gerald McGwin Jr., Graciela S. Alarcón

doi : 10.1002/acr.25006

The long-term impact of childhood-onset systemic lupus erythematosus (SLE) on health-related quality of life (HRQoL) in adult SLE patients in comparison to those with adult-onset SLE is unknown. We aim to examine and compare HRQoL trajectories in adults with adolescent- and adult-onset SLE.

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Performance of Modified ALMS and BLISS Criteria with Standard of Care Treatment in Two US Health Care Systems

Arezou Khosroshahi, David Tong, Gaobin Bao, Jinan Al-Naqeeb, Pranab Ghosh, Elena Peeva, Kirk A. Easley, Roberta Weiss, S. Sam Lim

doi : 10.1002/acr.25025

A retrospective cohort study was undertaken in a predominantly Black population undergoing standard treatment for lupus nephritis (LN) to estimate the incidence of, and risk factors for, complete response (CR) according to modified Aspreva Lupus Management Study (mALMS) and modified Belimumab International Study in Lupus Nephritis (mBLISS) criteria by 12 months.

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A Provider-Based Approach to Address Racial Disparities in Lupus Clinical Trial Participation

Nicole I. Wanty, Dexter L. Cooper, Andrew Simkus, Eric C. Twombly, Sheryl McCalla, S. Kristen D. Holtz, Aisha T. Langford, Thometta Cozart, Barry Gorlitsky, Catherine Moore, Donna Culton, Christopher T. Richardson, Richard M. Wardrop, Jeff Newcomb, Cynthia Aranow, Sam Lim, Allen Anandarajah, Saira Z. Sheikh

doi : 10.1002/acr.25054

Substantial disparities exist in clinical trial participation, which is problematic in diseases such as lupus that disproportionately affect racial/ethnic minority populations. Our objective was to examine the effectiveness of an online educational course aiming to train medical providers to refer Black and Latino patients to lupus clinical trials (LCTs).

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Patient and Physician Global Assessments of Disease Status in Systemic Sclerosis

Laura Ross, Mandana Nikpour, Julie D'Aoust, Dinesh Khanna, Peter A. Merkel, John D. Pauling, Murray Baron

doi : 10.1002/acr.25056

Global assessments of disease by both patients and physicians are widely used in clinical studies of systemic sclerosis (SSc). They are commonly secondary end points in randomized controlled trials (RCTs) and are considered important items in composite measures of treatment response.

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Association of Systemic Sclerosis With Incident Clinically Evident Heart Failure

Chun-Yu Lin, Hung-An Chen, Tsang-Wei Chang, Tsai-Ching Hsu, Yu-Jih Su

doi : 10.1002/acr.25016

Primary myocardial involvement is an important cause of death in systemic sclerosis (SSc). Subclinical diastolic/systolic heart dysfunction is recognized; however, whether this indicates a subsequent increased risk of clinically overt heart failure (HF) remains largely unknown. We aimed to investigate the risk of clinically overt HF in a large, unselected SSc cohort.

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A Multimodal Prediction Model for Diagnosing Pulmonary Hypertension in Systemic Sclerosis

Justin K. Lui, Kari R. Gillmeyer, Ruchika A. Sangani, Robert J. Smyth, Deepa M. Gopal, Marcin A. Trojanowski, Andreea M. Bujor, Renda Soylemez Wiener, Michael P. LaValley, Elizabeth S. Klings

doi : 10.1002/acr.24969

Diagnosis of pulmonary hypertension (PH) in systemic sclerosis (SSc) requires an invasive right heart catheterization (RHC), often based on an elevated estimated pulmonary artery systolic pressure on screening echocardiography.

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Clinical Phenotypes of Patients With Systemic Sclerosis With Distinct Molecular Signatures in Skin

Monica Yang, Vivien Goh, Jungwha Lee, Monica Espinoza, Yiwei Yuan, Mary Carns, Kathleen Aren, Lorinda Chung, Dinesh Khanna, Zsuzsanna H. McMahan, Rishi Agrawal, Lauren Beussink Nelson, Sanjiv J. Shah, Michael L. Whitfield, Monique Hinchcliff

doi : 10.1002/acr.24998

Systemic sclerosis (SSc) patients are classified according to degree of skin fibrosis (limited and diffuse cutaneous [lc and dc]) and serum autoantibodies. We undertook the present multicenter study to determine whether intrinsic subset (IS) classification based upon skin gene expression yields additional valuable clinical information.

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Prediction Models to Estimate the Future Risk of Osteoarthritis in the General Population: A Systematic Review

Tom Appleyard, Martin J. Thomas, Deborah Antcliff, George Peat

doi : 10.1002/acr.25035

To evaluate the performance and applicability of multivariable prediction models for osteoarthritis (OA).

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Identification of Symptom Phenotypes of Hand Osteoarthritis Using Hierarchical Clustering: Results From the DIGICOD Cohort

Marie Binvignat, Gabriel Pires, Nicolas Tchitchek, Félicie Costantino, Alice Courties, David Klatzmann, Atul J. Butte, Bernard Combe, Maxime Dougados, Pascal Richette, Encarnita Mariotti-Ferrandiz, Francis Berenbaum, Jérémie Sellam

doi : 10.1002/acr.25047

We aimed to delineate phenotypes in hand osteoarthritis (HOA) based on cardinal symptoms (pain, functional limitation, stiffness, and aesthetic discomfort).

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Associations Between Dietary Intake of Vitamin K and Changes in Symptomatic and Structural Changes in Patients With Knee Osteoarthritis

Zetao Liao, Jun Chang, Zhaohua Zhu, Weiyu Han, Tao Meng, Shuang Zheng, Liudan Tu, Benny Antony, Tania Winzenberg, Anita E. Wluka, Flavia Cicuttini, Changhai Ding

doi : 10.1002/acr.24964

To investigate associations of dietary vitamin K intake with changes in knee symptoms and structures in patients with knee osteoarthritis (OA).

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Predicting Chronic Opioid Use Among Patients With Osteoarthritis Using Electronic Health Record Data

Jeff T. Mohl, Nikita Stempniewicz, John K. Cuddeback, David M. Kent, Elizabeth A. MacLean, Lance Nicholls, Christopher Kerrigan, Elizabeth L. Ciemins

doi : 10.1002/acr.25013

To estimate the risk of a patient with osteoarthritis (OA) developing chronic opioid use (COU) within 1 year of a new opioid prescription by using electronic health record (EHR) data and predictive models.

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Patient Acceptable Symptom State Versus Latent Class Analysis Outcome Classification: A Comparative Longitudinal Study of Knee Arthroplasty

Daniel L. Riddle, Levent Dumenci

doi : 10.1002/acr.24962

To determine whether Patient Acceptable Symptom State (PASS), a single-item deterministic binary measure of pain and function outcome satisfaction, leads to better differentiation of outcome classification versus latent class analysis probability-based outcome subgroups 1 year after knee arthroplasty (KA).

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Association of Change in Body Mass Index With Incidence and Progression of the Structural Defects of Hip Osteoarthritis: Data From the Osteoarthritis Initiative and the Cohort Hip and Cohort Knee study

Zubeyir Salis, Amanda Sainsbury

doi : 10.1002/acr.25057

To define the association between change in body mass index (BMI) and the incidence and progression of structural defects of hip osteoarthritis as assessed by radiography.

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Influence of Self-Reported Knee Instability on Outcomes Following Education and Exercise: A Cohort Study of 2,466 Patients With Knee Osteoarthritis

Halit Selçuk, Ewa M. Roos, Dorte T. Grønne, Jonas B. Thorlund, Zübeyir Sarı, Søren T. Skou

doi : 10.1002/acr.25060

To study the influence of self-reported knee instability on changes in knee pain and gait speed following patient education and supervised exercise therapy in patients with knee osteoarthritis (OA).

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Monitoring and Achievement of Target Serum Urate Among Gout Patients Receiving Long-Term Urate-Lowering Therapy in the American College of Rheumatology RISE Registry

Nevin Hammam, Jing Li, Julia Kay, Zara Izadi, Jinoos Yazdany, Gabriela Schmajuk

doi : 10.1002/acr.25009

The American College of Rheumatology's (ACR) 2020 guidelines for the management of gout recommend using a treat-to-target approach to lower serum urate (SU). Using the ACR's Rheumatology Informatics System for Effectiveness registry, we examined the use of a treat-to-target approach among gout patients receiving long-term urate-lowering therapy (ULT) and followed longitudinally by rheumatologists.

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Childhood-Onset Lupus Nephritis in the Childhood Arthritis and Rheumatology Research Alliance Registry: Short-Term Kidney Status and Variation in Care

Emily A. Smitherman, Rouba A. Chahine, Timothy Beukelman, Laura B. Lewandowski, A. K. M. Fazlur Rahman, Scott E. Wenderfer, Jeffrey R. Curtis, Aimee O. Hersh, for the CARRA Registry Investigators

doi : 10.1002/acr.25002

The goal was to characterize short-term kidney status and describe variation in early care utilization in a multicenter cohort of patients with childhood-onset systemic lupus erythematosus (cSLE) and nephritis.

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Virtually Speaking: The Impact of a Nationwide Synchronous and Asynchronous Learning Forum

Anisha B. Dua, Marcy B. Bolster, Lianne S. Gensler, Jason Kolfenbach, Mary H. Mamut, Philip Seo, Beth L. Jonas

doi : 10.1002/acr.24972

To address significant disruptions in didactic education precipitated by the COVID-19 pandemic, a group of rheumatology program directors collaborated with the American College of Rheumatology to create a virtual fellows-in-training (V-FIT) program.

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Hydroxychloroquine and Risk of Long QT Syndrome in Rheumatoid Arthritis: A Veterans Cohort Study With Nineteen-Year Follow-up

Mercedes E. Quiñones, Joyce K. Joseph, Sharon Dowell, Hans J. Moore, Pamela E. Karasik, Gregg C. Fonarow, Ross D. Fletcher, Yan Cheng, Qing Zeng-Treitler, Cherinne Arundel, Angelike P. Liappis, Helen M. Sheriff, Sijian Zhang, Daniel D. Taub, Michael S. Heimall, Charles Faselis, Gail S. Kerr, Ali Ahmed

doi : 10.1002/acr.25005

Recent evidence suggests that hydroxychloroquine use is not associated with higher 1-year risk of long QT syndrome (LQTS) in patients with rheumatoid arthritis (RA). Less is known about its long-term risk, the examination of which was the objective of this study.

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Phases and Natural History of Sjögren's Disease: A New Model for an Old Disease?

Adrian Y. S. Lee, Jing Jing Wang, Tom P. Gordon, Joanne H. Reed

doi : 10.1002/acr.25011

Sjögren's disease (SjD) is an archetypal and heterogenous autoimmune disorder that is characterized by exocrine glandular dysfunction. A proportion of patients develop severe extraglandular manifestations, such as cryoglobulinemia, and have an increased risk of lymphoma, both of which can adversely affect quality of life and occasionally mortality.

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Predictors of Pain Reduction Among Fibromyalgia Patients Using Medical Cannabis: A Long-Term Prospective Cohort Study

Romina Sotoodeh, Lilach Eyal Waldman, Antonio Vigano, Yola Moride, Michelle Canac-Marquis, Tristan Spilak, Rihab Gamaoun, Maja Kalaba, Yasmina Hachem, Pierre Beaulieu, Julie Desroches, Mark A. Ware, Jordi Perez, Yoram Shir, Mary-Ann Fitzcharles, Marc O. Martel

doi : 10.1002/acr.24985

Many patients with fibromyalgia (FM) report using cannabis as a strategy to improve pain. Given that pain often co-occurs with symptoms of anxiety and depression (i.e., negative affect) and sleep problems among patients with FM, improvements in these symptoms might indirectly contribute to reductions in pain intensity following cannabis use.

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Frequency and Clinical Utility of Antibodies to Extractable Nuclear Antigen in the Setting of a Negative Antinuclear Antibody Test

Ai Li Yeo, Samar Ojaimi, Suong Le, Michelle Leech, Eric Morand

doi : 10.1002/acr.24990

Simultaneous antibody testing during screening for autoimmune conditions is discouraged. The incidence of positive extractable nuclear antigen (ENA) in the setting of a negative antinuclear antibody (ANA) has been reported as low. Our objective was to characterize the frequency of diagnosis of new ANA-associated rheumatic disease (AARD) in the setting of a negative ANA with a positive ENA.

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