دسترسی یکساله به بیش از ۵۰۰ ژورنال روز جهان موجود در سامانه
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http://medilib.ir
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Immediate Open Access: The Good, the Bad, and the Impact on Academic Society Publishing
Amr H. Sawalha, Daniel H. Solomon, Kelli D. Allen, Patricia Katz, Ed Yelin
doi : 10.1002/art.42522
A Combination of Autoantibodies Predicts the Fate of Cancer-Associated Dermatomyositis
Manabu Fujimoto
doi : 10.1002/art.42472
Identification of Cell-Specific Differential DNA Methylation Associated With Methotrexate Treatment Response in Rheumatoid Arthritis
Cameron Adams, Nisha Nair, Darren Plant, Suzanne M. M. Verstappen, Hong L. Quach, Diana L. Quach, Alex Carvidi, Joanne Nititham, Mary Nakamura, Jonathan Graf, Anne Barton, Lindsey A. Criswell, Lisa F. Barcellos
doi : 10.1002/art.42464
We undertook this study to estimate changes in cell-specific DNA methylation (DNAm) associated with methotrexate (MTX) response using whole blood samples collected from rheumatoid arthritis (RA) patients before and after initiation of MTX treatment.
Reduction of Proinflammatory Effector Functions Through Remodeling of Fatty Acid Metabolism in CD8+ T Cells From Rheumatoid Arthritis Patients
Franziska V. Kraus, Simon Keck, Karel D. Klika, Jürgen Graf, Rui A. Carvalho, Hanns-Martin Lorenz, M. Margarida Souto-Carneiro
doi : 10.1002/art.42456
Rheumatoid arthritis (RA) CD8+ T cells maintain their effector proinflammatory phenotype by changing their metabolism toward aerobic glycolysis.
Autoantibodies to Disease-Related Proteins in Joints as Novel Biomarkers for the Diagnosis of Rheumatoid Arthritis
Erik Lönnblom, Monica Leu Agelii, Outi Sareila, Lei Cheng, Bingze Xu, Johan Viljanen, Ingiäld Hafström, Maria L. E. Andersson, Göran Bergström, Anna-Karin HultgÃ¥rd Ekwall, Anna Rudin, Alf Kastbom, Christopher Sjöwall, Lennart T. H. Jacobsson, Jan Kihlberg, Inger Gjertsson, Rikard Holmdahl
doi : 10.1002/art.42463
This study was undertaken to develop and characterize a multiplex immunoassay for detection of autoantibodies against peptides derived from proteins known to play a role in development of arthritis and that are also expressed in joints.
Association of Dipeptidylpeptidase 4 (CD26) With Chondrocyte Senescence and Radiographic Progression in Knee Osteoarthritis
Yu-Hsiu Chen, Xin Zhang, Ching-Heng Chou, Ming-Feng Hsueh, David Attarian, Yi-Ju Li, Virginia Byers Kraus
doi : 10.1002/art.42455
To evaluate the association of dipeptidylpeptidase 4 (DPP-4; also known as CD26) with cellular senescence of human cartilage and progression of knee osteoarthritis (OA).
Development of a Magnetic Resonance Imaging–Based Definition of Knee Osteoarthritis: Data From the Multicenter Osteoarthritis Study
Jean W. Liew, Gabriela Rabasa, Michael LaValley, Jamie Collins, Joshua Stefanik, Frank W. Roemer, Ali Guermazi, Cora E. Lewis, Michael Nevitt, James Torner, David Felson
doi : 10.1002/art.42454
Although magnetic resonance imaging (MRI) is the imaging modality of choice for research, there is no widely accepted MRI definition of knee osteoarthritis (OA). We undertook this study to test the performance of different MRI definitions of OA.
Promotion of Joint Degeneration and Chondrocyte Metabolic Dysfunction by Excessive Growth Hormone in Mice
Shouan Zhu, Huanhuan Liu, Trent Davis, Craig R. G. Willis, Reetobrata Basu, Luke Witzigreuter, Stephen Bell, Nathaniel Szewczyk, Martin K. Lotz, Marcheta Hill, Roberto J. Fajardo, Patrick M. O'Connor, Darlene E. Berryman, John J. Kopchick
doi : 10.1002/art.42470
Many patients with acromegaly, a hormonal disorder with excessive growth hormone (GH) production, report pain in joints. We undertook this study to characterize the joint pathology of mice with overexpression of bovine GH (bGH) or a GH receptor antagonist (GHa) and to investigate the effect of GH on regulation of chondrocyte cellular metabolism.
Contribution of Type H Blood Vessels to Pathologic Osteogenesis and Inflammation in an Experimental Spondyloarthritis Model
Merlijn H. Kaaij, Jan Piet van Hamburg, Charlotte C. N. van Rooijen, Anika Grüneboom, Yik Y. Kan, Desiree Pots, Georg Schett, Leo J. van Ruijven, Leonie M. van Duivenvoorde, Leonie F. A. Huitema, Dominique L. P. Baeten, Sander W. Tas
doi : 10.1002/art.42449
Spondyloarthritis (SpA) is characterized by pathologic osteogenesis, inflammation, and extensive angiogenesis in axial and peripheral tissues. Current therapies effectively target inflammation, but these therapies lack efficacy in preventing pathologic osteogenesis.
Evolution of Magnetic Resonance Imaging Lesions at the Sacroiliac Joints During and After Pregnancy by Serial Magnetic Resonance Imaging From Gestational Week Twenty to Twelve Months Postpartum
Rosa Marie Kiil, Ulrich Weber, Anne Gitte Loft, Rikke Damkjær Maimburg, Anne Grethe Jurik
doi : 10.1002/art.42457
Sacroiliac (SI) joint magnetic resonance imaging (MRI) findings simulating sacroiliitis related to axial spondyloarthritis (SpA) may occur in women before and after birth. This study was undertaken to explore the prevalence, evolution, and topography of SI joint MRI lesions in pregnant and postpartum women.
Analysis of Single-Cell Transcriptome and Surface Protein Expression in Ankylosing Spondylitis Identifies OX40-Positive and Glucocorticoid-Induced Tumor Necrosis Factor Receptor–Positive Pathogenic Th17 Cells
Kijong Yi, Sungsin Jo, Woogil Song, Hae-In Lee, Hui-Ju Kim, Ji-Hyoun Kang, Seon Uk Kim, Seung Hoon Lee, Jinsung Park, Tae-Hwan Kim, Jeong Seok Lee, Eun Young Lee, Tae-Jong Kim
doi : 10.1002/art.42476
To demonstrate the immune landscape of blood and synovial cells in the setting of ankylosing spondylitis (AS) through the analysis of both single-cell transcriptome and surface protein expression, and to unveil the molecular characteristics of pathogenic Th17 cells.
Povetacicept, an Enhanced Dual APRIL/BAFF Antagonist That Modulates B Lymphocytes and Pathogenic Autoantibodies for the Treatment of Lupus and Other B Cell–Related Autoimmune Diseases
Lawrence S. Evans, Katherine E. Lewis, Daniel DeMonte, Janhavi G. Bhandari, Logan B. Garrett, Joseph L. Kuijper, Daniel Ardourel, Martin F. Wolfson, Susan Debrot, Sherri Mudri, Kayla Kleist, Luana L. Griffin, LuAnne Hebb, Russell J. Sanderson, NingXin Wang, Michelle Seaberg, Allison G. Chunyk, Jing Yang, Youji Hong, Zahra Maria, David J. Messenheimer, Pamela M. Holland, Stanford L. Peng, Mark W. Rixon, Stacey R. Dillon
doi : 10.1002/art.42462
Dysregulated APRIL/BAFF signaling is implicated in the pathogenesis of multiple autoimmune diseases, including systemic lupus erythematosus and lupus nephritis. We undertook this study to develop and evaluate a high-affinity APRIL/BAFF antagonist to overcome the clinical limitations of existing B cell inhibitors.
Amelioration of Autoimmunity in a Lupus Mouse Model by Modulation of T-Bet–Promoted Energy Metabolism in Pathogenic Age/Autoimmune-Associated B Cells
Xiaxia Han, Shuangshuang Gu, Soon-Min Hong, Yang Jiang, Jinsong Zhang, Chao Yao, Zhihua Yin, Zhizhong Ye, Huihua Ding, Sheng Chen, Dai Dai, Nan Shen
doi : 10.1002/art.42433
Emerging evidence indicates that a distinct CD11c+T-bet+ B cell subset, termed age/autoimmune-associated B cells (ABCs), is the major pathogenic autoantibody producer in lupus. Human lupus is associated with significant metabolic alterations, but how ABCs orchestrate their typical transcription factors and metabolic programs to meet specific functional requirements is unclear.
Regulation of Photosensitivity by the Hippo Pathway in Lupus Skin
Grace A. Hile, Patrick Coit, Bin Xu, Amanda M. Victory, Mehrnaz Gharaee-Kermani, Shannon N. Estadt, Mitra P. Maz, Jacob W. S. Martens, Rachael Wasikowski, Craig Dobry, Lam C. Tsoi, Ramiro Iglesias-Bartolome, Celine C. Berthier, Allison C. Billi, Johann E. Gudjonsson, Amr H. Sawalha, J. Michelle Kahlenberg
doi : 10.1002/art.42460
Photosensitivity is one of the most common manifestations of systemic lupus erythematosus (SLE), yet its pathogenesis is not well understood. The normal-appearing epidermis of patients with SLE exhibits increased ultraviolet B (UVB)–driven cell death that persists in cell culture. Here, we investigated the role of epigenetic modification and Hippo signaling in enhanced UVB-induced apoptosis seen in SLE keratinocytes.
Improvement in Disease Activity in Refractory Juvenile Dermatomyositis Following Abatacept Therapy
Rodolfo V. Curiel, William Nguyen, Gulnara Mamyrova, Derek Jones, Alison Ehrlich, Kathleen A. Brindle, Shahriar Haji-Momenian, Robert Sheets, Hanna Kim, Olcay Y. Jones, Lisa G. Rider, on behalf of the Abatacept in Dermatomyositis (AID) Trial Investigators
doi : 10.1002/art.42450
This open-label, 24-week study was conducted to evaluate the safety and efficacy of abatacept in patients with refractory juvenile dermatomyositis (DM).
Association of Anti-CCAR1 Autoantibodies With Decreased Cancer Risk Relative to the General Population in Patients With Anti–Transcriptional Intermediary Factor 1γ–Positive Dermatomyositis
David Fiorentino, Christopher A. Mecoli, Tak Igusa, Jemima Albayda, Julie J. Paik, Eleni Tiniakou, Brittany Adler, Andrew L. Mammen, Ami A. Shah, Antony Rosen, Lisa Christopher-Stine, Livia Casciola-Rosen
doi : 10.1002/art.42474
To describe the disease specificity, clinical phenotype, and risk of cancer in dermatomyositis (DM) patients with autoantibodies against cell division cycle and apoptosis regulator protein 1 (anti-CCAR1).
Association of Juvenile Dermatomyositis Disease Activity With the Expansion of Blood Memory B and T Cell Subsets Lacking Follicular Markers
Jacqueline S. Gofshteyn, Leanne Mansfield, Jacob Spitznagle, Preetha Balasubramanian, Jacob Cardenas, Thomas Miller, Jinghua Gu, Xuan Wang, Marilynn Punaro, Julie Fuller, Lorien Nassi, Katie Stewart, Marina Ohouo, Cristy Stagnar, Jeanine Baisch, Lynnette Walters, Yuanyuan Wang, Helena Yan, Darawan Rinchai, Damien Chaussabel, Simone Caielli, Seunghee Hong, Karen Onel, Tracey Wright, Virginia Pascual
doi : 10.1002/art.42446
This study was undertaken to identify blood markers of juvenile dermatomyositis (DM) disease activity (DA), which are needed to improve disease management.
Clinical Images: IgG4-related disease: a giant cell arteritis mimic
Mahmut Kaymakci, Mohanad Elfishawi, Matthew J. Koster, Philip D. Hurst, Kenneth J. Warrington
doi : 10.1002/art.42469
Heightened Proinflammatory Glycosylation of Borrelia burgdorferi IgG Antibodies in Synovial Fluid in Patients With Antibiotic-Refractory Lyme Arthritis
Jurgen T. Sanes, Catherine E. Costello, Allen C. Steere
doi : 10.1002/art.42465
Terminal glycans on the Fc portion of IgG antibodies are critical for antibody-triggered, proinflammatory or antiinflammatory responses. We undertook this study to compare glycan profiles of total IgG1 and Borrelia burgdorferi (Bb)–specific IgG1 antibodies in patients with oral antibiotic–responsive or antibiotic-refractory Lyme arthritis (LA).
Serum Urate–Lowering Efficacy and Safety of Tigulixostat in Gout Patients With Hyperuricemia: A Randomized, Double-Blind, Placebo-Controlled, Dose-Finding Trial
Robert Terkeltaub, Jisoo Lee, Jiyoung Min, Seonghye Shin, Kenneth G. Saag
doi : 10.1002/art.42447
To evaluate the safety and efficacy of the nonpurine xanthine oxidase inhibitor tigulixostat for lowering serum urate level in gout patients with hyperuricemia.
Novel Somatic UBA1 Variant in a Patient With VEXAS Syndrome
Blanka Stiburkova, Katerina Pavelcova, Monika Belickova, Samuel J. Magaziner, Jason C. Collins, Achim Werner, David B. Beck, Veronika Balajkova, Cyril Salek, Martin Vostry, Herman Mann, Jiri Vencovsky
doi : 10.1002/art.42471
Somatic mutations in UBA1 have recently been causally linked to a severe adult-onset inflammatory condition referred to as VEXAS (vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic) syndrome. Ubiquitin-activating enzyme E1 (UBA-1) is of fundamental importance to the modulation of ubiquitin homeostasis and to the majority of downstream ubiquitylation-dependent cellular processes.
Common dysbiosis features between patients of different social environments in Takayasu arteritis: comment on the article by Fan et al
Tsuyoshi Shirai, Satoshi Watanabe, Natsuko O. Shinozaki, Kairi Baba, Hiroyuki Yamasaki, Tomonori Ishii, Hiroshi Fujii
doi : 10.1002/art.42438
NF-κB kinase subunit ɛ in neuropsychiatric systemic lupus erythematosus: comment on the article by Karino et al
An-Fang Huang, Wang-Dong Xu
doi : 10.1002/art.42445
Should lipoprotein(a) be routinely measured after COVID-19? Comment on the article by Stahl et al
Dimitrios Patoulias, Athina Dimosiari, Theodoros Michailidis
doi : 10.1002/art.42453
