Elena Nikiphorou, Annelies Boonen
doi : 10.1093/rheumatology/kead011
Rheumatology, Volume 62, Issue 7, July 2023, Pages 2333–2334
Maurizio Cutolo, Emanuele Gotelli, Vanessa Smith
doi : 10.1093/rheumatology/keac630
Rheumatology, Volume 62, Issue 7, July 2023, Pages 2335–2337
Ning Li
doi : 10.1093/rheumatology/kead029
Rheumatology, Volume 62, Issue 7, July 2023, Pages 2338–2340
Fabiola Atzeni, Alessandra Alciati
doi : 10.1093/rheumatology/kead045
Rheumatology, Volume 62, Issue 7, July 2023, Pages 2341–2342
VinÃcius Viana Abreu Montanaro, Julián SolÃs-GarcÃa del Pozo, Thiago Falcão Hora, Beatriz H León, Carlos de Cabo, Javier Solera
doi : 10.1093/rheumatology/kead067
Rheumatology, Volume 62, Issue 7, July 2023, Pages 2343–2351
Satoyoshi syndrome is a rare multisystem disease of presumed autoimmune aetiology. We carried out a systematic review to evaluate the available evidence to support that autoimmune hypothesis.
Jean-Guillaume Letarouilly, Patrick Vermersch, René-Marc Flipo
doi : 10.1093/rheumatology/keac665
Rheumatology, Volume 62, Issue 7, July 2023, Pages 2352–2359
Dealing with patients with both multiple sclerosis (MS) and inflammatory rheumatic disorders (IRDs) is not uncommon for a rheumatologist, as there is a statistical association between SpA and MS.
Dhivya Das, Ernest Choy
doi : 10.1093/rheumatology/keac671
Rheumatology, Volume 62, Issue 7, July 2023, Pages 2360–2365
Non-inflammatory’ pain, pain that is not associated with measures of inflammation, is common in patients with inflammatory arthritis including RA. One important cause of non-inflammatory pain is concomitant fibromyalgia.
R Naveen, Ioannis Parodis, Mrudula Joshi, Parikshit Sen, Julius Lindblom, Vishwesh Agarwal, James B Lilleker, Ai Lyn Tan, Arvind Nune, Samuel Katsuyuki Shinjo, Babur Salim, Nelly Ziade, Tsvetelina Velikova, Abraham Edgar Gracia-Ramos, Miguel A Saavedra, Jessica Day, Ashima Makol, Oliver Distler, Hector Chinoy, Vikas Agarwal, Rohit Aggarwal, Latika Gupta, Elena Nikiphorou, COVAD Study Group
doi : 10.1093/rheumatology/keac624
Rheumatology, Volume 62, Issue 7, July 2023, Pages 2366–2376
The COVID-19 vaccination in autoimmune diseases (COVAD) study aimed to assess short-term COVID-19 vaccination-related adverse events (AEs) in RA patients.
Ji-Won Kim, Sang Wan Chung, Jung Yoon Pyo, Sung Hae Chang, Min Uk Kim, Chan Ho Park, Ji Sung Lee, Jeong Seok Lee, You-Jung Ha, Eun Ha Kang, Yeon-Ah Lee, Yong-Beom Park, Eun Young Lee, Jung-Yoon Choe
doi : 10.1093/rheumatology/keac651
Rheumatology, Volume 62, Issue 7, July 2023, Pages 2377–2385
To examine the association between MTX, LEF and tacrolimus use and the progression of RA-associated interstitial lung disease (ILD).
Ernest Choy, Vivian Bykerk, Yvonne C Lee, Hubert van Hoogstraten, Kerri Ford, Amy Praestgaard, Serge Perrot, Janet Pope, Anthony Sebba
doi : 10.1093/rheumatology/keac659
Rheumatology, Volume 62, Issue 7, July 2023, Pages 2386–2393
In some patients with RA, joint pain is more severe than expected based on the amount of joint swelling [referred to as disproportionate articular pain (DP)]. We assessed DP prevalence and the effects of sarilumab, an IL-6 inhibitor, on DP.
Rozemarijn Witkam, James M Gwinnutt, Jennifer Humphreys, Suzanne M M Verstappen, RAMS Co-Investigators
doi : 10.1093/rheumatology/keac662
Rheumatology, Volume 62, Issue 7, July 2023, Pages 2394–2401
To understand the relationships between deprivation and obesity with self-reported disability and disease activity in people with RA, and to determine whether BMI mediates the relationship between area-level deprivation and these outcomes.
Julien Duquesne, Vincent Bouget, Paul Henry Cournède, Bruno Fautrel, Francis Guillemin, Pascal H P de Jong, Judith W Heutz, Marloes Verstappen, Annette H M van der Helm-van Mil, Xavier Mariette, Samuel Bitoun
doi : 10.1093/rheumatology/keac645
Rheumatology, Volume 62, Issue 7, July 2023, Pages 2402–2409
Around 30% of patients with RA have an inadequate response to MTX. We aimed to use routine clinical and biological data to build machine learning models predicting EULAR inadequate response to MTX and to identify simple predictive biomarkers.
Boaz Palterer, Gianfranco Vitiello, Marco Del Carria, Bernardo D’Onofrio, Laura Martinez-Prat, Michael Mahler, Daniele Cammelli, Paola Parronchi
doi : 10.1093/rheumatology/keac667
Rheumatology, Volume 62, Issue 7, July 2023, Pages 2410–2417
RA is a chronic inflammatory disease in which possible interstitial lung disease (ILD) is an extra-articular manifestation that carries significant morbidity and mortality.
Takemichi Fukasawa, Satoshi Toyama, Atsushi Enomoto, Asako Yoshizaki-Ogawa, Yuta Norimatsu, Shoko Tateishi, Hiroko Kanda, Kiyoshi Miyagawa, Shinichi Sato, Ayumi Yoshizaki
doi : 10.1093/rheumatology/keac664
Rheumatology, Volume 62, Issue 7, July 2023, Pages 2418–2425
PsA is one of the most serious comorbidities associated with psoriasis. While the early intervention in PsA is demanded, risk factors of PsA development are not well-known. This is the first prospective study to evaluate the clinical significance of nailfold capillary (NFC) changes in patients with psoriasis.
Mark D Russell, Edward Roddy, Andrew I Rutherford, Benjamin Ellis, Sam Norton, Abdel Douiri, Martin C Gulliford, Andrew P Cope, James B Galloway
doi : 10.1093/rheumatology/keac638
Rheumatology, Volume 62, Issue 7, July 2023, Pages 2426–2434
To investigate associations between treat-to-target urate-lowering therapy (ULT) and hospitalizations for gout.
Shuhui Hu, Mingshu Sun, Maichao Li, Xiaomei Xue, Robert Terkeltaub, Can Wang, Ming Wang, Jie Lu, Zijing Ran, Hailong Li, Aichang Ji, Wenyan Sun, Xinde Li, Yuwei He, Zhen Liu, Hui Zhang, Xuefeng Wang, Xiaopeng Ji, Nicola Dalbeth, Changgui Li
doi : 10.1093/rheumatology/keac656
Rheumatology, Volume 62, Issue 7, July 2023, Pages 2435–2443
Gout flares during urate-lowering therapy (ULT) initiation are common, but predictors of these flares are poorly understood. The aim of this study was to determine whether serum CA72-4 is an independent predictor for gout flares during ULT initiation.
Anushka Soni, Revathi Nishtala, Stanley Ng, Rosemarie Barnett, Te-yuan Chyou, Charlotte Cavill, Raj Sengupta
doi : 10.1093/rheumatology/keac679
Rheumatology, Volume 62, Issue 7, July 2023, Pages 2444–2452
This study investigates longitudinal patterns, predictors and long-term impact of pain in axial spondyloarthritis (axSpA), using clinical and self-tracking data.
R Naveen, Elena Nikiphorou, Mrudula Joshi, Parikshit Sen, Julius Lindblom, Vishwesh Agarwal, James B Lilleker, Ai Lyn Tan, Babur Salim, Nelly Ziade, Tsvetelina Velikova, Abraham Edgar Gracia-Ramos, Masataka Kuwana, Jessica Day, Ashima Makol, Oliver Distler, Hector Chinoy, Lisa S Traboco, Suryo Anggoro Kusumo Wibowo, Erick Adrian Zamora Tehozol, Jorge Rojas Serrano, Ignacio GarcÃa-De La Torre, COVAD Study Group , Rohit Aggarwal, Latika Gupta, Vikas Agarwal, Ioannis Parodis
doi : 10.1093/rheumatology/keac661
Rheumatology, Volume 62, Issue 7, July 2023, Pages 2453–2463
To determine COVID-19 vaccine-related adverse events (AEs) in the seven-day post-vaccination period in patients with SLE vs autoimmune rheumatic diseases (AIRDs), non-rheumatic autoimmune diseases (nrAIDs), and healthy controls (HC).
Yu Shan, Shingo Nakayamada, Aya Nawata, Kaoru Yamagata, Koshiro Sonomoto, Hiroaki Tanaka, Yurie Satoh-Kanda, Mai-Phuong Nguyen, Yasuyuki Todoroki, Atsushi Nagayasu, Masanobu Ueno, Ryuichiro Kanda, Yuya Fujita, Tong Zhang, He Hao, Jieqing Zhou, Xiaoxue Ma, Junpei Anan, Anh Phuong Nguyen, Yoshiya Tanaka
doi : 10.1093/rheumatology/keac646
Rheumatology, Volume 62, Issue 7, July 2023, Pages 2464–2474
T peripheral helper (Tph) cells have major roles in pathological processes in SLE. We sought to clarify the mechanisms of Tph cell differentiation and their relevance to clinical features in patients with SLE.
Laura PelegrÃn, Montse Morató, Olga Araújo, Marc Figueras-Roca, Javier Zarranz-Ventura, Alfredo Adán, Ricard Cervera, Ricardo P Casaroli-Marano, Vanesa Budi, LucÃa Barrera-López, José RÃos, José Hernández-RodrÃguez, Gerard Espinosa
doi : 10.1093/rheumatology/keac626
Rheumatology, Volume 62, Issue 7, July 2023, Pages 2475–2482
The aim of the present study was to detect preclinical changes in SLE patients in retinal microvascularization or retinal and optical nerve structure by optical coherence tomography.
Corrado Campochiaro, Anna-Maria Hoffmann-Vold, Jerome Avouac, Jörg Henes, Jeska de Vries-Bouwstra, Vanessa Smith, Elise Siegert, Paolo Airò, Fahrettin Oksel, Raffaele Pellerito, Marie Vanthuyne, Maria Rosa Pozzi, Murat Inanc, Jean Sibilia, Armando Gabrielli, Oliver Distler, Yannick Allanore, EUSTAR Collaborators
doi : 10.1093/rheumatology/keac660
Rheumatology, Volume 62, Issue 7, July 2023, Pages 2483–2491
Interstitial lung disease (ILD) is the leading cause of morbidity and mortality in systemic sclerosis (SSc) patients. We aimed to investigate the impact of sex on SSc-ILD.
Alexandru Garaiman, Farhad Nooralahzadeh, Carina Mihai, Nicolas Perez Gonzalez, Nikitas Gkikopoulos, Mike Oliver Becker, Oliver Distler, Michael Krauthammer, Britta Maurer
doi : 10.1093/rheumatology/keac541
Rheumatology, Volume 62, Issue 7, July 2023, Pages 2492–2500
The first objective of this study was to implement and assess the performance and reliability of a vision transformer (ViT)-based deep-learning model, an ‘off-the-shelf’ artificial intelligence solution, for identifying distinct signs of microangiopathy in nailfold capilloroscopy (NFC) images of patients with SSc. The second objective was to compare the ViT’s analysis performance with that of practising rheumatologists.
Ahmad Ramahi, Alain Lescoat, David Roofeh, Vivek Nagaraja, Rajaie Namas, Suiyuan Huang, John Varga, David O’Dwyer, Bonnie Wang, Kevin Flaherty, Ella Kazerooni, Dinesh Khanna
doi : 10.1093/rheumatology/keac639
Rheumatology, Volume 62, Issue 7, July 2023, Pages 2501–2509
The aim of this study was to identify risk factors of percent predicted forced vital capacity (ppFVC) decline in patients with SSc-associated interstitial lung disease (SSc-ILD).
Panagiotis Dolgyras, Antonios Lazaridis, Panagiota Anyfanti, Eleni Gavriilaki, Nikolaos Koletsos, Areti Triantafyllou, Barbara Nikolaidou, Vasiliki Galanapoulou, Stella Douma, Eugenia Gkaliagkousi
doi : 10.1093/rheumatology/keac652
Rheumatology, Volume 62, Issue 7, July 2023, Pages 2510–2516
Systemic vasculitides (SVs) are a highly inflammatory group of diseases characterized by significant cardiovascular (CV) mortality. Microvascular damage closely linked with accelerated atherosclerosis and thrombosis represents a core pathophysiological mechanism contributing to the excess CV risk of patients with SVs.
Mats L Junek, Lily Zhao, Stephanie Garner, David Cuthbertson, Christian Pagnoux, Curry L Koening, Carol A Langford, Carol A McAlear, Paul A Monach, Larry W Moreland, Rennie L Rhee, Philip Seo, Ulrich Specks, Antoine G Sreih, Kenneth Warrington, Michael E Wechsler, Peter A Merkel, Nader A Khalidi
doi : 10.1093/rheumatology/keac663
Rheumatology, Volume 62, Issue 7, July 2023, Pages 2517–2524
ANCA-associated vasculitis (AAV) is a group of multisystem diseases that can have several ocular manifestations. There are published data on ocular manifestations of granulomatosis with polyangiitis (GPA), but few for eosinophilic granulomatosis with polyangiitis (EGPA) or microscopic polyangiitis (MPA).
Masahiro Kogami, Yoshiyuki Abe, Taiki Ando, Ayako Makiyama, Ken Yamaji, Naoto Tamura
doi : 10.1093/rheumatology/keac627
Rheumatology, Volume 62, Issue 7, July 2023, Pages 2525–2533,
Anti-melanoma differentiation-associated gene 5 (MDA5) antibody-positive DM is characterized by rapidly progressive interstitial lung disease and has a poor prognosis. We aimed to investigate whether anti-MDA5 antibody titres and cytokine levels predict clinical course, and evaluate changes in both parameters before and after diagnosis.
Clio P Mavragani, Kyriakos A Kirou, Surya V Seshan, Mary K Crow
doi : 10.1093/rheumatology/keac641
Rheumatology, Volume 62, Issue 7, July 2023, Pages 2534–2538
To investigate the expression of type I IFN (IFN-I) and neutrophil transcripts in kidney tissue from patients with different classes of LN and their association with distinct clinical and histopathological features.
Rachel S Wallwork, Ami A Shah, Livia Casciola-Rosen
doi : 10.1093/rheumatology/keac614
Rheumatology, Volume 62, Issue 7, July 2023, Pages 2539–2543,
To define the clinical phenotype of SSc patients with antibodies against Sjogren’s syndrome (SS)/scleroderma autoantigen 1 (SSSCA1), and to examine the association between these antibodies and cancer in SSc patients.
Christian Ammitzbøll, Marianne Kragh Thomsen, Jakob Bøgh Andersen, Jens Magnus Berth Jensen, Marie-Louise From Hermansen, Anders Dahl Johannsen, Mads Lamm Larsen, Clara Elbæk Mistegaard, Susan Mikkelsen, Fruzsina Szabados, Signe Risbøl Vils, Christian Erikstrup, Ellen-Margrethe Hauge, Anne Troldborg
doi : 10.1093/rheumatology/keac666
Rheumatology, Volume 62, Issue 7, July 2023, Pages 2544–2549
To investigate the effect of either a booster vaccine (one dose) or revaccination (two doses 3 weeks apart) on the antibody response to the COVID-19 mRNA vaccines in patients with rheumatic disease (RD) treated with rituximab (RTX) who had not produced vaccine-reactive antibodies after the initial two vaccine doses. Further, to examine if B cell levels in peripheral blood predicted seroconversion.
Keita Ninagawa, Masaru Kato, Satonori Tsuneta, Suguru Ishizaka, Hideyuki Ujiie, Ryo Hisada, Michihito Kono, Yuichiro Fujieda, Yoichi M Ito, Tatsuya Atsumi Author Notes
doi : 10.1093/rheumatology/keac674
Rheumatology, Volume 62, Issue 7, July 2023, Pages 2550–2555
Nintedanib is an inhibitor of tyrosine kinases that has been shown to slow the progression of interstitial lung disease (ILD), including ILD associated with SSc. The aim of this study was to explore the effect of nintedanib on cardiomyopathy associated with systemic sclerosis (SSc).
Pitcha Chompoopong, Michael P Skolka, Floranne C Ernste, Margherita Milone, Teerin Liewluck
doi : 10.1093/rheumatology/keac668
Rheumatology, Volume 62, Issue 7, July 2023, Pages 2556–2562
Symptomatic myopathy in sarcoidosis patients is not always due to sarcoid myopathy (ScM). We investigated the clinical and pathological spectrum including myxovirus resistance protein A (MxA) expression among sarcoidosis patients.
Luo-Yi Wang, Rui-Xue Wang, Chen Wang, Su-Fang Chen, Xiao-Jing Sun, Zhi-Ying Li, Min Chen, Mark A Little, Ming-Hui Zhao
doi : 10.1093/rheumatology/keac621
Rheumatology, Volume 62, Issue 7, July 2023, Pages 2563–2573
Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a group of life-threatening autoimmune diseases. Inhibitors of apoptosis proteins (IAPs) are a class of molecules engaged in cell death and inflammation, interventions of which are proven effective in a number of inflammatory diseases.
Jun Qiao, Sheng-Xiao Zhang, Min-Jing Chang, Rong Zhao, Shan Song, Jia-Wei Hao, Can Wang, Jing-Xi Hu, Chong Gao, Cai-Hong Wang, Xiao-Feng Li
doi : 10.1093/rheumatology/keac625
Rheumatology, Volume 62, Issue 7, July 2023, Pages 2574–2584
To leverage the high clinical heterogeneity of systemic lupus erythematosus (SLE), we developed and validated a new stratification scheme by integrating genome-scale transcriptomic profiles to identify patient subtypes sharing similar transcriptomic markers and drug targets.
Dornatien C Anang, Hannah A W Walter, Johan Lim, Ilse Niewold, Linda van der Weele, Eleonora Aronica, Filip Eftimov, Joost Raaphorst, Barbera D C van Schaik, Antoine H C van Kampen, Anneke J van der Kooi, Niek de Vries
doi : 10.1093/rheumatology/keac602
Rheumatology, Volume 62, Issue 7, July 2023, Pages 2585–2593
To unravel B-cell receptor (BcR) characteristics in muscle tissues and peripheral blood and gain more insight into BcR repertoire changes in peripheral blood in idiopathic inflammatory myopathies (IIMs), and study how this correlates to the clinical response to IVIG.
Lina Al-Jaberi, Megan M Simonds, Anne Marie C Brescia
doi : 10.1093/rheumatology/keac617
Rheumatology, Volume 62, Issue 7, July 2023, Pages 2594–2600
Oligoarticular JIA disease progression and outcomes are variable. Our objective is to detect protein markers that would allow for earlier intervention to potentially halt disease progression. In this retrospective study of serial SF samples, elevated expression of CCL24, CXCL9 and CXCL10 was linked to the eventual need for advanced medications.
Chris Wincup, Nicky Dunn, Caroline Ruetsch-Chelli, Ali Manouchehrinia, Nastya Kharlamova, Meena Naja, Barbara Seitz-Polski, David A Isenberg, Anna Fogdell-Hahn, Coziana Ciurtin, Elizabeth C Jury
doi : 10.1093/rheumatology/keac608
Rheumatology, Volume 62, Issue 7, July 2023, Pages 2601–2610
High rates of anti-drug antibodies (ADA) to rituximab have been demonstrated in patients undergoing treatment for SLE. However, little is known with regard to their long-term dynamics, impact on drug kinetics and subsequent implications for treatment response. In this study, we aimed to evaluate ADA persistence over time, impact on circulating drug levels, assess clinical outcomes and whether they are capable of neutralizing rituximab.
Megan M Hanlon, Trudy McGarry, Viviana Marzaioli, Success Amaechi, Qingxuan Song, Sunil Nagpal, Douglas J Veale, Ursula Fearon
doi : 10.1093/rheumatology/keac640
Rheumatology, Volume 62, Issue 7, July 2023, Pages 2611–2620
Myeloid cells with a monocyte/macrophage phenotype are present in large numbers in the RA joint, significantly contributing to disease; however, distinct macrophage functions have yet to be elucidated. This study investigates the metabolic activity of infiltrating polarized macrophages and their impact on pro-inflammatory responses in RA.
Sara MartÃnez-Ramos, Carlos Rafael-Vidal, Beatriz Malvar-Fernández, Angela Rodriguez-Trillo, Douglas Veale, Ursula Fearon, Carmen Conde, Javier Conde-Aranda, Timothy R D J Radstake, Jose MarÃa Pego-Reigosa, Kris A Reedquist, Samuel GarcÃa
doi : 10.1093/rheumatology/keac654
Rheumatology, Volume 62, Issue 7, July 2023, Pages 2621–2630
Class 3 semaphorins are reduced in the synovial tissue of RA patients and these proteins are involved in the pathogenesis of the disease. The aim of this study was to identify the transcription factors involved in the expression of class 3 semaphorins in the synovium of RA patients.
doi : 10.1093/rheumatology/kead113
Rheumatology, Volume 62, Issue 7, July 2023, Page 2631
doi : 10.1093/rheumatology/keac536
Rheumatology, Volume 62, Issue 7, July 2023, Page 2632
Tatiana Oliveira, Reşit Yıldırım, Claire Deakin, David Isenberg
doi : 10.1093/rheumatology/kead010
Rheumatology, Volume 62, Issue 7, July 2023, Pages e211–e212
Marlene Sousa, PatrÃcia Martins, Bernardo Santos, Emanuel Costa, Filipe Cunha Santos, Raquel Freitas, Margarida Faria, Frederico Martins, Teresa Rodrigues, Tânia Santiago, José A P Silva, LuÃs S Inês
doi : 10.1093/rheumatology/kead049
Rheumatology, Volume 62, Issue 7, July 2023, Pages e213–e215
Jean-Baptiste Vulsteke, Frédéric Coutant, David Goncalves, Benoit Nespola, Petra De Haes, Wim A Wuyts, Daniel Blockmans, Ellen De Langhe, Nicole Fabien, Xavier Bossuyt
doi : 10.1093/rheumatology/kead060
Rheumatology, Volume 62, Issue 7, July 2023, Pages e216–e218
Claire Lloyd-Davies, Nicholas Shenker
doi : 10.1093/rheumatology/keac684
Rheumatology, Volume 62, Issue 7, July 2023, Pages e219–e220
Deepak Nagra, Mark D Russell, Edward Alveyn, Surinder S Birring, David Elias, Sathiyaa Balachandran, James B Galloway
doi : 10.1093/rheumatology/keac670
Rheumatology, Volume 62, Issue 7, July 2023, Pages e221–e222
Yakai Fu, Jia Li, Antao Xu, Jie Chen, Xiaodong Wang, Shuang Ye
doi : 10.1093/rheumatology/keac694
Rheumatology, Volume 62, Issue 7, July 2023, Pages e223–e225
Tracy M Frech, Colin Maguire, Aaron C Petrey, Gregory J Stoddard, Anthony J Donato
doi : 10.1093/rheumatology/keac719
Rheumatology, Volume 62, Issue 7, July 2023, Pages e226–e228
Roshni Lachmipersad, Leon de Prez, Anne Kamps, Jos Runhaar
doi : 10.1093/rheumatology/kead040
Rheumatology, Volume 62, Issue 7, July 2023, Pages e229–e230
Ihsane Hmamouchi, Adewale Adebajo
doi : 10.1093/rheumatology/kead146
Rheumatology, Volume 62, Issue 7, July 2023, Page e231
Alla Ishchenko
doi : 10.1093/rheumatology/kead145
Rheumatology, Volume 62, Issue 7, July 2023, Page e232
Fei Sun, Jian Zhu
doi : 10.1093/rheumatology/keac701
Rheumatology, Volume 62, Issue 7, July 2023, Pages e233–e234
Katsuhide Kusaka, Shingo Nakayamada, Shigeru Iwata, Yoshiya Tanaka
doi : 10.1093/rheumatology/keac720
Rheumatology, Volume 62, Issue 7, July 2023, Pages e235–e236
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