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Welcome editorial by the new NDT Editor-in-Chief
Hans-Joachim Anders
doi : 10.1093/ndt/gfad055
Nephrology Dialysis Transplantation, Volume 38, Issue 7, July 2023, Pages 1575–1576
Cold haemodialysis: the instrumental power of large cohorts
Christian Combe, Sébastien Rubin
doi : 10.1093/ndt/gfad054
Nephrology Dialysis Transplantation, Volume 38, Issue 7, July 2023, Pages 1577–1579
Health-related quality of life in kidney transplant recipients: can we do better?
Hannah Beckwith, Edwina A Brown
doi : 10.1093/ndt/gfad060
Nephrology Dialysis Transplantation, Volume 38, Issue 7, July 2023, Pages 1580–1582
Urinary extracellular vesicles and tubular transport
Crissy F Rudolphi, Charles J Blijdorp, Hester van Willigenburg, Mahdi Salih, Ewout J Hoorn
doi : 10.1093/ndt/gfac235
Nephrology Dialysis Transplantation, Volume 38, Issue 7, July 2023, Pages 1583–1590
Tubular transport is a key function of the kidney to maintain electrolyte and acid-base homeostasis. Urinary extracellular vesicles (uEVs) harbor water, electrolyte, and acid-base transporters expressed at the apical plasma membrane of tubular epithelial cells.
Malignancies in adult kidney transplant candidates and recipients: current status
Krystyna Serkies, Alicja Dębska-Ślizień, Anna Kowalczyk, Sławomir Lizakowski, Jolanta Małyszko
doi : 10.1093/ndt/gfac239
Nephrology Dialysis Transplantation, Volume 38, Issue 7, July 2023, Pages 1591–1602
Posttransplant malignancies, particularly recurrent and de novo, in solid organs including kidney transplant recipients (KTRs) are a significant complication associated with substantial mortality, largely attributed to the long-term immunosuppression necessary to maintain allograft tolerance.
Fluids in the ICU: which is the right one?
Timo Mayerhöfer, Andrew D Shaw, Christian J Wiedermann, Michael Joannidis
doi : 10.1093/ndt/gfac279
Nephrology Dialysis Transplantation, Volume 38, Issue 7, July 2023, Pages 1603–1612
The administration of fluids is one of the most common interventions in the intensive care unit. The effects and side effects of intravenous fluids depend on the amount administered and their specific composition.
The 3-Step Model of informed consent for living kidney donation: a proposal on behalf of the DESCaRTES Working Group of the European Renal Association
Alessandra Agnese Grossi, Mehmet Sukru Sever, Rachel Hellemans, Christophe Mariat, Marta Crespo, Bruno Watschinger, Licia Peruzzi, Erol Demir, Arzu Velioglu, Ilaria Gandolfini, Gabriel C Oniscu, Luuk Hilbrands, Geir Mjoen
doi : 10.1093/ndt/gfad022
Nephrology Dialysis Transplantation, Volume 38, Issue 7, July 2023, Pages 1613–1622
Living donation challenges the ethical principle of non-maleficence in that it exposes healthy persons to risks for the benefit of someone else. This makes safety, informed consent (IC) and education a priority.
RESET-PKD: a pilot trial on short-term ketogenic interventions in autosomal dominant polycystic kidney disease
Simon Oehm, Konstantin Steinke, Johannes Schmidt, Sita Arjune, Polina Todorova, Christoph Heinrich Lindemann, Fabian Wöstmann, Franziska Meyer, Florian Siedek, Thomas Weimbs, Roman-Ulrich Müller, Franziska Grundmann
doi : 10.1093/ndt/gfac311
Nephrology Dialysis Transplantation, Volume 38, Issue 7, July 2023, Pages 1623–1635
Ketogenic dietary interventions (KDI) have been shown to be effective in animal models of polycystic kidney disease (PKD), but data from clinical trials are lacking.
Sleep duration and cognitive function among older adults with chronic kidney disease: results from the National Health and Nutrition Examination Survey (2011–2014)
Fatima Warsame, Nadia M Chu, Jingyao Hong, Aarti Mathur, Deidra C Crews, George Bayliss, Dorry L Segev, Mara A McAdams-DeMarco
doi : 10.1093/ndt/gfac325
Nephrology Dialysis Transplantation, Volume 38, Issue 7, July 2023, Pages 1636–1644
Short and long sleep durations are associated with cognitive dysfunction. Given the increased prevalence of sleep abnormalities in the chronic kidney disease (CKD) population, we tested whether the association between sleep duration and cognitive function differed between older adults with and without CKD.
Tolvaptan treatment is associated with altered mineral metabolism parameters and increased bone mineral density in ADPKD patients
Matteo Bargagli, Andri Vetsch, Manuel A Anderegg, Nasser A Dhayat, Uyen Huynh-Do, Nicolas Faller, Bruno Vogt, Pietro Manuel Ferraro, Daniel G Fuster
doi : 10.1093/ndt/gfac298
Nephrology Dialysis Transplantation, Volume 38, Issue 7, July 2023, Pages 1645–1654
Autosomal dominant polycystic kidney disease (ADPKD) is characterized by a unique bone and mineral phenotype. The impact of tolvaptan treatment on mineral metabolism and bone mineral density (BMD) is unknown.
Long-term outcomes and prognostic factors for survival of patients with ANCA-associated vasculitis
Beatriz Sánchez �lamo, Laura Moi, Ingeborg Bajema, Mikkel Faurschou, Oliver Flossmann, Thomas Hauser, Zdenka Hruskova, David Jayne, Raashid Luqmani, Alfred Mahr, Anna Åkesson, Kerstin Westman, the EUVAS
doi : 10.1093/ndt/gfac320
Nephrology Dialysis Transplantation, Volume 38, Issue 7, July 2023, Pages 1655–1665
Despite newer treatments with immunosuppressive agents, there still exists a considerable morbidity and mortality risk among patients with anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV).
A systematic review and meta-analysis of the effect of intravitreal VEGF inhibitors on cardiorenal outcomes
Jennifer S Lees, Stephen J H Dobbin, Benjamin M P Elyan, David F Gilmour, Laurie P Tomlinson, Ninian N Lang, Patrick B Mark
doi : 10.1093/ndt/gfac305
Nephrology Dialysis Transplantation, Volume 38, Issue 7, July 2023, Pages 1666–1681
Vascular endothelial growth factor inhibitors (VEGFis) have transformed the treatment of many retinal diseases, including diabetic maculopathy. Increasing evidence supports systemic absorption of intravitreal VEGFi and development of significant cardiorenal side effects.
Social determinants of health and the transition from advanced chronic kidney disease to kidney failure
Gregory L Hundemer, Pietro Ravani, Manish M Sood, Deborah Zimmerman, Amber O Molnar, Danielle Moorman, Matthew J Oliver, Christine White, Swapnil Hiremath, Ayub Akbari
doi : 10.1093/ndt/gfac302
Nephrology Dialysis Transplantation, Volume 38, Issue 7, July 2023, Pages 1682–1690
The transition from chronic kidney disease (CKD) to kidney failure is a vulnerable time for patients, with suboptimal transitions associated with increased morbidity and mortality. Whether social determinants of health are associated with suboptimal transitions is not well understood.
Prediction of all-cause mortality for chronic kidney disease patients using four models of machine learning
Nu Thuy Dung Tran, Margaux Balezeaux, Maelys Granal, Denis Fouque, Michel Ducher, Jean-Pierre Fauvel
doi : 10.1093/ndt/gfac316
Nephrology Dialysis Transplantation, Volume 38, Issue 7, July 2023, Pages 1691–1699
The prediction tools developed from general population data to predict all-cause mortality are not adapted to chronic kidney disease (CKD) patients, because this population displays a higher mortality risk. This study aimed to create a clinical prediction tool with good predictive performance to predict the 2-year all-cause mortality of stage 4 or stage 5 CKD patients.
Effectiveness of cold HD for the prevention of HD hypotension and mortality in the general HD population
Carmine Zoccali, Giovanni Tripepi, Luca Neri, Matteo Savoia, Maria Eva Baró Salvador, Pedro Ponce, Jeffrey Hymes, Frank Maddux, Francesca Mallamaci, Stefano Stuard
doi : 10.1093/ndt/gfad003
Nephrology Dialysis Transplantation, Volume 38, Issue 7, July 2023, Pages 1700–1706
Cold hemodialysis (HD) prevented intradialysis hypotension (IDH) in small, short-term, randomized trials in selected patients with IDH. Whether this treatments prevents IDH and mortality in the HD population at large is unknown.
Age and gender differences in symptom experience and health-related quality of life in kidney transplant recipients: a cross-sectional study
Denise M J Veltkamp, Yiman Wang, Yvette Meuleman, Friedo W Dekker, Wieneke M Michels, Paul J M van der Boog, Aiko P J de Vries
doi : 10.1093/ndt/gfad023
Nephrology Dialysis Transplantation, Volume 38, Issue 7, July 2023, Pages 1707–1718
Health-related quality of life (HRQOL) is an increasingly important patient-reported outcome in kidney transplant recipients (KTRs). This study explored relationships between symptom prevalence and burden with HRQOL, and age and gender differences in symptom experience.
Iron deficiency and cognitive functioning in kidney transplant recipients: findings of the TransplantLines biobank and cohort study
Joanna Sophia J Vinke, Aaltje L Ziengs, Anne M Buunk, Lisanne van Sonderen, Antonio W Gomes-Neto, TransplantLines Investigators, Stefan P Berger, Stephan J L Bakker, Michele F Eisenga, Jacoba M Spikman, Martin H De Borst
doi : 10.1093/ndt/gfad013
Nephrology Dialysis Transplantation, Volume 38, Issue 7, July 2023, Pages 1719–1728
Neurocognitive impairment is common in kidney transplant recipients (KTRs). Adequate brain functioning requires energy and neurotransmitter activity, for which iron is essential. We aimed to investigate iron deficiency (ID) as a potentially modifiable risk factor for cognitive impairment in KTRs.
MicroRNA-145 and microRNA-486 are potential serum biomarkers for vascular calcification
Sara Fernández-Villabrille, Beatriz MartÃn-Carro, Julia MartÃn-VÃrgala, Cristina Alonso-Montes, Carmen Palomo-Antequera, Raúl GarcÃa-Castro, Susana López-Ongil, Adriana S Dusso, José Luis Fernández-MartÃn, Manuel Naves-DÃaz, Jorge B Cannata-AndÃa, Natalia Carrillo-López, Sara Panizo
doi : 10.1093/ndt/gfad027
Nephrology Dialysis Transplantation, Volume 38, Issue 7, July 2023, Pages 1729–1740
MicroRNAs (miRs) regulate vascular calcification (VC), and their quantification may contribute to suspicion of the presence of VC.
Deep learning automation of MEST-C classification in IgA nephropathy
Adrien Jaugey, Elise Maréchal, Georges Tarris, Michel Paindavoine, Laurent Martin, Melchior Chabannes, Mathilde Funes de la Vega, Mélanie Chaintreuil, Coline Robier, Didier Ducloux, Thomas Crépin, Sophie Felix, Amélie Jacq, Doris Calmo, Claire Tinel, Gilbert Zanetta, Jean-Michel Rebibou, Mathieu Legendre
doi : 10.1093/ndt/gfad039
Nephrology Dialysis Transplantation, Volume 38, Issue 7, July 2023, Pages 1741–1751
Although the MEST-C classification is among the best prognostic tools in immunoglobulin A nephropathy (IgAN), it has a wide interobserver variability between specialized pathologists and others. Therefore we trained and evaluated a tool using a neural network to automate the MEST-C grading.
Far infrared treatment on the arteriovenous fistula induces changes in sVCAM and sICAM in patients on hemodialysis
Kristine Lindhard, Boyle L Jensen, Brian L Pedersen, Christine Meyer-Olesen, Marianne Rix, Henrik P Hansen, Casper Schalkwijk, Marjo Waarenburg, James Heaf, Ditte Hansen
doi : 10.1093/ndt/gfad032
Nephrology Dialysis Transplantation, Volume 38, Issue 7, July 2023, Pages 1752–1760
There is a substantial risk of developing stenosis and dysfunction in the arteriovenous fistula (AVF) in patients on hemodialysis (HD). Far infrared radiation (FIR) is a non-invasive local intervention with a potentially beneficial effect on AVF patency. The underlying mechanism is not clear. It was hypothesized that a single FIR treatment reduces factors of inflammation and promotes endothelial vasodilators in the AVF.
Real-time prediction of intradialytic hypotension using machine learning and cloud computing infrastructure
Hanjie Zhang, Lin-Chun Wang, Sheetal Chaudhuri, Aaron Pickering, Len Usvyat, John Larkin, Pete Waguespack, Zuwen Kuang, Jeroen P Kooman, Franklin W Maddux, Peter Kotanko
doi : 10.1093/ndt/gfad070
Nephrology Dialysis Transplantation, Volume 38, Issue 7, July 2023, Pages 1761–1769
In maintenance hemodialysis patients, intradialytic hypotension (IDH) is a frequent complication that has been associated with poor clinical outcomes. Prediction of IDH may facilitate timely interventions and eventually reduce IDH rates.
Effect of intravitreal anti-vascular endothelial growth factor treatment for neovascular age-related macular degeneration on renal function
James E Neffendorf, Tracey Mare, Andrew R H Simpson, Cristina Soare, Varo Kirthi, Claire C Sharpe, Timothy L Jackson
doi : 10.1093/ndt/gfad035
Nephrology Dialysis Transplantation, Volume 38, Issue 7, July 2023, Pages 1770–1772
Plasma oxalate and glycolate concentrations in dialysis patients with and without primary hyperoxaluria type 1
Elisabeth L Metry, Sander F Garrelfs, Hessel Peters-Sengers, Frederic M Vaz, Joost A Bijlsma, Aegida Neradova, Michiel J S Oosterveld, Jaap W Groothoff
doi : 10.1093/ndt/gfad049
Nephrology Dialysis Transplantation, Volume 38, Issue 7, July 2023, Pages 1773–1775
