John P. A. Ioannidis, MD, DSc1,2,3; Francesco Zonta, PhD4; Michael Levitt, PhD5
doi : 10.1001/jamainternmed.2023.1547
July 2023, Vol 183, No. 7, Pages 632-748
Autumn D. Zuckerman, PharmD1; Megan P. Schneider, PharmD1; Stacie B. Dusetzina, PhD2
Agne Ulyte, MD, PhD1; R. J. Waken, PhD2; Arnold M. Epstein, MD, MA3,4; E. John Orav, PhD4; Michael L. Barnett, MD, MS3,4; Karen E. Joynt Maddox, MD, MPH2,5; David C. Grabowski, PhD1
doi : 10.1001/jamainternmed.2023.0770
Importance In response to the COVID-19 pandemic, Medicare introduced a public health emergency (PHE) waiver in March 2020, removing a 3-day hospitalization requirement before fee-for-service beneficiaries could receive skilled nursing facility (SNF) care benefits.
Songqiao Liu, MD, PhD1; Chen Yao, PhD2; Jianfeng Xie, MD, PhD1; Hong Liu, MD, PhD3; Hongliang Wang, MD, PhD4; Zhaofen Lin, MD5; Bingyu Qin, MD6; Difen Wang, MD7; Weihua Lu, MD8; Xiaochun Ma, MD, PhD9; Yan Liu, MD10; Ling Liu, MD,, PhD1; Chi Zhang, MD, PhD11; Lei Xu, MD, PhD12; Ruiqiang Zheng, MD13; Feihu Zhou, MD, PhD14; Zhongmin Liu, MD15; Guoqiang Zhang, MD, PhD16; Lixin Zhou, MD, PhD17; Jian Liu, MD, PhD18; Aihua Fei, MD19; Guoxiu Zhang, MD20; Yimin Zhu, MD, PhD21; Kejian Qian, MD, PhD22; Ruilan Wang, MD, PhD23; Yafeng Liang, MD24; Meili Duan, MD, PhD25; Dawei Wu, MD26; Rongqing Sun, MD27; Ying Wang, MD, PhD28; Xijing Zhang, MD, PhD29; Quan Cao, MD, PhD30; Mingshi Yang, MD, PhD31; Minggen Jin, MD, PhD32; Yan Song, MD, PhD33; Ling Huang, MD, PhD34; Fachun Zhou, MD35; Dechang Chen, MD, PhD36; Qun Liang, MD, PhD37; Chuanyun Qian, MD, PhD38; Zhongzhi Tang, MD39; Zhong Zhang, MD, PhD40; Qiming Feng, MD, PhD41; Zhiyong Peng, MD, PhD42; Renhua Sun, MD43; Zhenju Song, MD, PhD44; Yunbo Sun, MD45; Yanfen Chai, MD46; Lihua Zhou, MD, PhD47; Chen Cheng, MD, PhD48; Li Li, MD, PhD49; Xiaoyan Yan, MD, PhD2; Junhua Zhang, MD, PhD50; Yingzi Huang, MD, PhD1; Fengmei Guo, MD, PhD1; Chuan Li, MD, PhD48; Yi Yang, MD, PhD1; Hongcai Shang, MD, PhD10; Haibo Qiu, MD, PhD1; for the EXIT-SEP Investigators
doi : 10.1001/jamainternmed.2023.0780
Importance Previous research has suggested that Xuebijing injection (XBJ), an herbal-based intravenous preparation, may reduce mortality among patients with sepsis.
Jacques Donzé, MD, MSc1,2,3,4; Gregor John, MD1,5,6; Daniel Genné, MD7; Marco Mancinetti, MD, MME8,9; Alexandre Gouveia, MD10; Marie Méan, MD11; Lukas Bütikofer, PhD12; Drahomir Aujesky, MD, MSc13; Jeffrey Schnipper, MD, MSc4
doi : 10.1001/jamainternmed.2023.0791
Importance Hospital readmissions are frequent, costly, and sometimes preventable. Although these issues have been well publicized and incentives to reduce them introduced, the best interventions for reducing readmissions remain unclear.
Dan P. Ly, MD, PhD, MPP1,2; Mia A. Giuriato, BBA, MA3; Zirui Song, MD, PhD3,4,5
doi : 10.1001/jamainternmed.2023.0898
Importance Prescription drug prices are a leading concern among patients and policy makers. There have been large and sharp price increases for some drugs, but the long-term implications of large drug price increases remain poorly understood.
Ilana F. Gareen, PhD1,2; Roee Gutman, PhD2,3; JoRean Sicks, MS2; Tina D. Tailor, MD4; Richard M. Hoffman, MD, MPH5; Amal N. Trivedi, MD, MPH6,7; Efren Flores, MD8; Ellen Underwood, MS2; Jerson Cochancela, MS3; Caroline Chiles, MD9
doi : 10.1001/jamainternmed.2023.1116
Importance Low-dose computed tomography (LDCT) lung screening has been shown to reduce lung cancer mortality. Significant incidental findings (SIFs) have been widely reported in patients undergoing LDCT lung screening. However, the exact nature of these SIF findings has not been described.
William B. Feldman, MD, DPhil, MPH1,2,3; Jerry Avorn, MD1,3; Aaron S. Kesselheim, MD, JD, MPH1,3; Joshua J. Gagne, PharmD, ScD1,3,4
doi : 10.1001/jamainternmed.2023.1245
Importance Clinical guidelines on chronic obstructive pulmonary disease (COPD) recommend inhalers containing long-acting muscarinic antagonists (LAMAs) and long-acting β-agonists (LABAs) over inhalers containing inhaled corticosteroids (ICSs) and LABAs. However, data from randomized clinical trials comparing these combination inhalers (LAMA-LABAs vs ICS-LABAs) have been conflicting and raised concerns of generalizability.
Carolyn J. Crandall, MD, MS, MACP1; Joseph C. Larson, MS2; John T. Schousboe, MD, PhD3; JoAnn E. Manson, MD, DrPH4; Nelson B. Watts, MD5; John A. Robbins, MD6; Peter Schnatz, DO7,8; Rami Nassir, PhD9; Aladdin H. Shadyab, PhD10; Karen C. Johnson, MD, MPH11; Jane A. Cauley, DrPH12; Kristine E. Ensrud, MD, MPH13
doi : 10.1001/jamainternmed.2023.1253
Importance The best approach to identify younger postmenopausal women for osteoporosis screening is uncertain. The Fracture Risk Assessment Tool (FRAX), which includes self-identified racial and ethnic information, and the Osteoporosis Self-assessment Tool (OST), which does not, are risk assessment tools recommended by US Preventive Services Task Force guidelines to identify candidates for bone mineral density (BMD) testing in this age group.
Deborah J. Wexler, MD, MSc1; Ian H. de Boer, MD2; Alokananda Ghosh, MD, PhD3; Naji Younes, PhD3; Ionut Bebu, PhD3; Silvio E. Inzucchi, MD4; Janet B. McGill, MD5; Sunder Mudaliar, MD6; David Schade, MD7; Michael W. Steffes, MD, PhD8; William V. Tamborlane, MD9; Meng H. Tan, MD10; Faramarz Ismail-Beigi, MD, PhD11; for the GRADE Research Group
doi : 10.1001/jamainternmed.2023.1487
Importance Type 2 diabetes (T2D) is the leading cause of kidney disease in the US. It is not known whether glucose-lowering medications differentially affect kidney function.
Timothy S. Anderson, MD, MAS1,2,3; Shoshana J. Herzig, MD, MPH1,2; Bocheng Jing, MS3,4; W. John Boscardin, PhD3,4,5; Kathy Fung, MS3,4; Edward R. Marcantonio, MD, SM1,2; Michael A. Steinman, MD3,4
doi : 10.1001/jamainternmed.2023.1667
Importance Asymptomatic blood pressure (BP) elevations are common in hospitalized older adults, and widespread heterogeneity in the clinical management of elevated inpatient BPs exists.
Vincent Mor, PhD1
Ellis F. Unger, MD1; David B. Clissold, JD1
Robert M. Wachter, MD1
Kelly E. Anderson, PhD, MPP1; Andrew Xuan, MPH2; Gerard F. Anderson, PhD2; Mariana P. Socal, MD, PhD, MPP2
Maryam Mooghali, MD, MSc1,2; Joseph S. Ross, MD, MHS1,2,3; Kushal T. Kadakia, MSc4; Sanket S. Dhruva, MD, MHS5,6
Shelley A. Jazowski, PhD, MPH1; Avi U. Vaidya, MPH1; Julie M. Donohue, PhD2; Stacie B. Dusetzina, PhD1,3; Rachel E. Sachs, JD, MPH4
Catherine L. Auriemma, MD, MS1,2,3; Maayra I.  Butt, MS1; Jasmine A. Silvestri, MPH1; Scott D. Halpern, MD, PhD1,2,3; Katherine R. Courtright, MD, MS1,2,3
Nan Zhang, BS1; Siyao Cheng, MS2; Xuhong Geng, MD2
Vincenzo Russo, MD, PhD1; Antonia Ascrizzi, MD1; Alfredo Mauriello, MD1
Michael P. Lavelle, MD1; John P. Morrow, MD1; James A. Reiffel, MD1
Kapil Rajendran, MD, DM1; Vinayakumar Desabandhu, MD, DM1; Pranay Ghanshyam Jambhulkar, MD, DM1
Zhao-Wei Yin, MD1; Pan Li, MD1; WenBiao Chen, PhD2
Amy Joy Houtrow, MD, PhD, MPH1
Elizabeth M. Viglianti, MD, MPH, MSc1; Lisa M. Meeks, PhD2; Andrea L. Oliverio, MD, MSc3
Yi-Jui Chiu, MD1; Kuan-Yu Chiang, MD1; Nin-Chieh Hsu, MD, PhD2
Anna L. Goldman, MD, MPA, MPH1; Michael L. Barnett, MD, MS2,3
Steven A. Wisel, MD1; Justin A. Steggerda, MD1; Irene K. Kim, MD1
Larry A. Weinrauch, MD1; John A. D’Elia, MD1
Xingxing S. Cheng, MD, MS1
Mazen M. Kawji, MD1,2
Ding Peng, MD1; Xiulian Li, MD1; Guojun Zhao, PhD1
Li Wang, MD1; Caiyun Duan, BS1; Lan Ma, MD, MS1
Frederick Green, MBBS1; Zeynep Ersoy Guller, MD1; Suhail Aslam, BMBCh2
John P. A. Ioannidis, MD, DSc1,2,3; Francesco Zonta, PhD4; Michael Levitt, PhD5
doi : 10.1001/jamainternmed.2023.1547
July 2023, Vol 183, No. 7, Pages 632-748
Autumn D. Zuckerman, PharmD1; Megan P. Schneider, PharmD1; Stacie B. Dusetzina, PhD2
Agne Ulyte, MD, PhD1; R. J. Waken, PhD2; Arnold M. Epstein, MD, MA3,4; E. John Orav, PhD4; Michael L. Barnett, MD, MS3,4; Karen E. Joynt Maddox, MD, MPH2,5; David C. Grabowski, PhD1
doi : 10.1001/jamainternmed.2023.0770
Importance In response to the COVID-19 pandemic, Medicare introduced a public health emergency (PHE) waiver in March 2020, removing a 3-day hospitalization requirement before fee-for-service beneficiaries could receive skilled nursing facility (SNF) care benefits.
Songqiao Liu, MD, PhD1; Chen Yao, PhD2; Jianfeng Xie, MD, PhD1; Hong Liu, MD, PhD3; Hongliang Wang, MD, PhD4; Zhaofen Lin, MD5; Bingyu Qin, MD6; Difen Wang, MD7; Weihua Lu, MD8; Xiaochun Ma, MD, PhD9; Yan Liu, MD10; Ling Liu, MD,, PhD1; Chi Zhang, MD, PhD11; Lei Xu, MD, PhD12; Ruiqiang Zheng, MD13; Feihu Zhou, MD, PhD14; Zhongmin Liu, MD15; Guoqiang Zhang, MD, PhD16; Lixin Zhou, MD, PhD17; Jian Liu, MD, PhD18; Aihua Fei, MD19; Guoxiu Zhang, MD20; Yimin Zhu, MD, PhD21; Kejian Qian, MD, PhD22; Ruilan Wang, MD, PhD23; Yafeng Liang, MD24; Meili Duan, MD, PhD25; Dawei Wu, MD26; Rongqing Sun, MD27; Ying Wang, MD, PhD28; Xijing Zhang, MD, PhD29; Quan Cao, MD, PhD30; Mingshi Yang, MD, PhD31; Minggen Jin, MD, PhD32; Yan Song, MD, PhD33; Ling Huang, MD, PhD34; Fachun Zhou, MD35; Dechang Chen, MD, PhD36; Qun Liang, MD, PhD37; Chuanyun Qian, MD, PhD38; Zhongzhi Tang, MD39; Zhong Zhang, MD, PhD40; Qiming Feng, MD, PhD41; Zhiyong Peng, MD, PhD42; Renhua Sun, MD43; Zhenju Song, MD, PhD44; Yunbo Sun, MD45; Yanfen Chai, MD46; Lihua Zhou, MD, PhD47; Chen Cheng, MD, PhD48; Li Li, MD, PhD49; Xiaoyan Yan, MD, PhD2; Junhua Zhang, MD, PhD50; Yingzi Huang, MD, PhD1; Fengmei Guo, MD, PhD1; Chuan Li, MD, PhD48; Yi Yang, MD, PhD1; Hongcai Shang, MD, PhD10; Haibo Qiu, MD, PhD1; for the EXIT-SEP Investigators
doi : 10.1001/jamainternmed.2023.0780
Importance Previous research has suggested that Xuebijing injection (XBJ), an herbal-based intravenous preparation, may reduce mortality among patients with sepsis.
Jacques Donzé, MD, MSc1,2,3,4; Gregor John, MD1,5,6; Daniel Genné, MD7; Marco Mancinetti, MD, MME8,9; Alexandre Gouveia, MD10; Marie Méan, MD11; Lukas Bütikofer, PhD12; Drahomir Aujesky, MD, MSc13; Jeffrey Schnipper, MD, MSc4
doi : 10.1001/jamainternmed.2023.0791
Importance Hospital readmissions are frequent, costly, and sometimes preventable. Although these issues have been well publicized and incentives to reduce them introduced, the best interventions for reducing readmissions remain unclear.
Dan P. Ly, MD, PhD, MPP1,2; Mia A. Giuriato, BBA, MA3; Zirui Song, MD, PhD3,4,5
doi : 10.1001/jamainternmed.2023.0898
Importance Prescription drug prices are a leading concern among patients and policy makers. There have been large and sharp price increases for some drugs, but the long-term implications of large drug price increases remain poorly understood.
Ilana F. Gareen, PhD1,2; Roee Gutman, PhD2,3; JoRean Sicks, MS2; Tina D. Tailor, MD4; Richard M. Hoffman, MD, MPH5; Amal N. Trivedi, MD, MPH6,7; Efren Flores, MD8; Ellen Underwood, MS2; Jerson Cochancela, MS3; Caroline Chiles, MD9
doi : 10.1001/jamainternmed.2023.1116
Importance Low-dose computed tomography (LDCT) lung screening has been shown to reduce lung cancer mortality. Significant incidental findings (SIFs) have been widely reported in patients undergoing LDCT lung screening. However, the exact nature of these SIF findings has not been described.
William B. Feldman, MD, DPhil, MPH1,2,3; Jerry Avorn, MD1,3; Aaron S. Kesselheim, MD, JD, MPH1,3; Joshua J. Gagne, PharmD, ScD1,3,4
doi : 10.1001/jamainternmed.2023.1245
Importance Clinical guidelines on chronic obstructive pulmonary disease (COPD) recommend inhalers containing long-acting muscarinic antagonists (LAMAs) and long-acting β-agonists (LABAs) over inhalers containing inhaled corticosteroids (ICSs) and LABAs. However, data from randomized clinical trials comparing these combination inhalers (LAMA-LABAs vs ICS-LABAs) have been conflicting and raised concerns of generalizability.
Carolyn J. Crandall, MD, MS, MACP1; Joseph C. Larson, MS2; John T. Schousboe, MD, PhD3; JoAnn E. Manson, MD, DrPH4; Nelson B. Watts, MD5; John A. Robbins, MD6; Peter Schnatz, DO7,8; Rami Nassir, PhD9; Aladdin H. Shadyab, PhD10; Karen C. Johnson, MD, MPH11; Jane A. Cauley, DrPH12; Kristine E. Ensrud, MD, MPH13
doi : 10.1001/jamainternmed.2023.1253
Importance The best approach to identify younger postmenopausal women for osteoporosis screening is uncertain. The Fracture Risk Assessment Tool (FRAX), which includes self-identified racial and ethnic information, and the Osteoporosis Self-assessment Tool (OST), which does not, are risk assessment tools recommended by US Preventive Services Task Force guidelines to identify candidates for bone mineral density (BMD) testing in this age group.
Deborah J. Wexler, MD, MSc1; Ian H. de Boer, MD2; Alokananda Ghosh, MD, PhD3; Naji Younes, PhD3; Ionut Bebu, PhD3; Silvio E. Inzucchi, MD4; Janet B. McGill, MD5; Sunder Mudaliar, MD6; David Schade, MD7; Michael W. Steffes, MD, PhD8; William V. Tamborlane, MD9; Meng H. Tan, MD10; Faramarz Ismail-Beigi, MD, PhD11; for the GRADE Research Group
doi : 10.1001/jamainternmed.2023.1487
Importance Type 2 diabetes (T2D) is the leading cause of kidney disease in the US. It is not known whether glucose-lowering medications differentially affect kidney function.
Timothy S. Anderson, MD, MAS1,2,3; Shoshana J. Herzig, MD, MPH1,2; Bocheng Jing, MS3,4; W. John Boscardin, PhD3,4,5; Kathy Fung, MS3,4; Edward R. Marcantonio, MD, SM1,2; Michael A. Steinman, MD3,4
doi : 10.1001/jamainternmed.2023.1667
Importance Asymptomatic blood pressure (BP) elevations are common in hospitalized older adults, and widespread heterogeneity in the clinical management of elevated inpatient BPs exists.
Vincent Mor, PhD1
Ellis F. Unger, MD1; David B. Clissold, JD1
Robert M. Wachter, MD1
Kelly E. Anderson, PhD, MPP1; Andrew Xuan, MPH2; Gerard F. Anderson, PhD2; Mariana P. Socal, MD, PhD, MPP2
Maryam Mooghali, MD, MSc1,2; Joseph S. Ross, MD, MHS1,2,3; Kushal T. Kadakia, MSc4; Sanket S. Dhruva, MD, MHS5,6
Shelley A. Jazowski, PhD, MPH1; Avi U. Vaidya, MPH1; Julie M. Donohue, PhD2; Stacie B. Dusetzina, PhD1,3; Rachel E. Sachs, JD, MPH4
Catherine L. Auriemma, MD, MS1,2,3; Maayra I.  Butt, MS1; Jasmine A. Silvestri, MPH1; Scott D. Halpern, MD, PhD1,2,3; Katherine R. Courtright, MD, MS1,2,3
Nan Zhang, BS1; Siyao Cheng, MS2; Xuhong Geng, MD2
Vincenzo Russo, MD, PhD1; Antonia Ascrizzi, MD1; Alfredo Mauriello, MD1
Michael P. Lavelle, MD1; John P. Morrow, MD1; James A. Reiffel, MD1
Kapil Rajendran, MD, DM1; Vinayakumar Desabandhu, MD, DM1; Pranay Ghanshyam Jambhulkar, MD, DM1
Zhao-Wei Yin, MD1; Pan Li, MD1; WenBiao Chen, PhD2
Amy Joy Houtrow, MD, PhD, MPH1
Elizabeth M. Viglianti, MD, MPH, MSc1; Lisa M. Meeks, PhD2; Andrea L. Oliverio, MD, MSc3
Yi-Jui Chiu, MD1; Kuan-Yu Chiang, MD1; Nin-Chieh Hsu, MD, PhD2
Anna L. Goldman, MD, MPA, MPH1; Michael L. Barnett, MD, MS2,3
Steven A. Wisel, MD1; Justin A. Steggerda, MD1; Irene K. Kim, MD1
Larry A. Weinrauch, MD1; John A. D’Elia, MD1
Xingxing S. Cheng, MD, MS1
Mazen M. Kawji, MD1,2
Ding Peng, MD1; Xiulian Li, MD1; Guojun Zhao, PhD1
Li Wang, MD1; Caiyun Duan, BS1; Lan Ma, MD, MS1
Frederick Green, MBBS1; Zeynep Ersoy Guller, MD1; Suhail Aslam, BMBCh2
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