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Advancing Global Respiratory Health, Sleep, and Critical Care: Editorial from the New American Journal of Respiratory and Critical Care Medicine Team
Fernando J. Martinez 1, Laurent Brochard 2,5, Andrew Bush 3, Gavin Donaldson 6, and MeiLan K. Han 4
doi : 10.1164/rccm.202111-2650ED
Volume 205, Issue 1 | January 1 2022
Gaining Insights into Asthma-related COVID-19 Risk
Tara F. Carr and Monica Kraft
From Mass to Flow: Emerging Sepsis Diagnostics Based on Flow Cytometry Analysis of Neutrophils
Franck Verdonk 1,2, Joe L. Hsu 3, and Brice Gaudilliere 4
Cut from the Same Cloth: Similarities between Hypersensitivity Pneumonitis and Idiopathic Pulmonary Fibrosis
Monica M. Yang and Paul J. Wolters
The Future of Outcome Prediction for Preterm Infants in the Neonatal ICU
Colm P. Travers , Waldemar A. Carlo , and Namasivayam Ambalavanan
Reduced Aerobic Exercise Capacity in Adults Born at Very Low Birth Weight: No Small Matter!
Andrew T. Lovering 1 and Joseph W. Duke 2
Preterm Birth Enhances Ambient Pollution Toxicity: Oxidative Stress and Placental Function
Rosalind J. Wright 1,2
Sleep Apnea–Specific Hypoxic Burden and Not the Sleepy Phenotype as a Novel Measure of Cardiovascular and Mortality Risk in a Clinical Cohort
Reena Mehra 1,2,3,4* and Ali Azarbarzin 5
2021 American Thoracic Society BEAR Cage Winning Proposal: Microbiome Transplant in Pulmonary Arterial Hypertension
Daphne M. Moutsoglou
Global Initiative for Asthma Strategy 2021: Executive Summary and Rationale for Key Changes
Helen K. Reddel 1, Leonard B. Bacharier 2, Eric D. Bateman 3, Christopher E. Brightling 4, Guy G. Brusselle 5,6, Roland Buhl 7, Alvaro A. Cruz 8, Liesbeth Duijts 9, Jeffrey M. Drazen 10,11, J. Mark FitzGerald 12, Louise J. Fleming 13, Hiromasa Inoue 14, Fanny W. Ko 15, Jerry A. Krishnan 16, Mark L. Levy 17, Jiangtao Lin 18, Kevin Mortimer 19,20, Paulo M. Pitrez 21, Aziz Sheikh 22, Arzu A. Yorgancioglu 23, and Louis-Philippe Boulet 24,25 ... Show less
doi : 10.1164/rccm.202109-2205PP
The Global Initiative for Asthma (GINA) Strategy Report provides clinicians with an annually updated evidence-based strategy for asthma management and prevention, which can be adapted for local circumstances (e.g., medication availability). This article summarizes key recommendations from GINA 2021, and the evidence underpinning recent changes.
Asthma Phenotypes and COVID-19 Risk: A Population-based Observational Study
Chloe I. Bloom 1, Paul Cullinan 2, and Jadwiga A. Wedzicha 1
doi : 10.1164/rccm.202107-1704OC Â
Rationale: Studies have suggested some patients with asthma are at risk of severe coronavirus disease (COVID-19), but they have had limited data on asthma phenotype and have not considered if risks are specific to COVID-19.
Two New Neutrophil Subsets Define a Discriminating Sepsis Signature
Aïda Meghraoui-Kheddar 1, Benjamin G. Chousterman 2,3, Noëlline Guillou 1, Sierra M. Barone 4, Samuel Granjeaud 5, Helene Vallet 1,6, Aurélien Corneau 7, Karim Guessous 2, Charles de Roquetaillade 2,3, Alexandre Boissonnas 1, Jonathan M. Irish 4,8, and Christophe Combadière 1 ... Show less
doi : 10.1164/rccm.202104-1027OC
Rationale: Sepsis is the leading cause of death in adult ICUs. At present, sepsis diagnosis relies on nonspecific clinical features. It could transform clinical care to have immune-cell biomarkers that could predict sepsis diagnosis and guide treatment. For decades, neutrophil phenotypes have been studied in sepsis, but a diagnostic cell subset has yet to be identified.
Lung Microenvironments and Disease Progression in Fibrotic Hypersensitivity Pneumonitis
Laurens J. De Sadeleer 1,2, John E. McDonough 1,3, Jonas C. Schupp 3,4, Xiting Yan 3, Arno Vanstapel 1,5, Anke Van Herck 1, Stephanie Everaerts 1,2, Vincent Geudens 1, Annelore Sacreas 1, Tinne Goos 1,2, Celine Aelbrecht 1, Tim S. Nawrot 6,7, Dries S. Martens 6, Dominique Schols 8, Sandra Claes 8, Johny A. Verschakelen 9, Eric K. Verbeken 5, Maximilian Ackermann 10,11, Anabelle Decottignies 12, Manon Mahieu 12, Tillie-Louise Hackett 13, James C. Hogg 13, Bart M. Vanaudenaerde 1, Stijn E. Verleden 1,14, Naftali Kaminski 3, and Wim A. Wuyts 1,2 ... Show less
doi : 10.1164/rccm.202103-0569OC Â
Rationale: Fibrotic hypersensitivity pneumonitis (fHP) is an interstitial lung disease caused by sensitization to an inhaled allergen.
Hourly Kinetics of Critical Organ Dysfunction in Extremely Preterm Infants
Orlyn C. Lavilla 1*, Khyzer B. Aziz 2*, Allison C. Lure 1, Daniel Gipson 1, Diomel de la Cruz 1, and James L. Wynn 1,3
doi : 10.1164/rccm.202106-1359OC Â Â
Rationale: Use of severity of illness scores to classify patients for clinical care and research is common outside of the neonatal ICU. Extremely premature (<29 weeks’ gestation) infants with extremely low birth weight (<1,000 g) experience significant mortality and develop severe pathology during the protracted birth hospitalization.
Reduced Exercise Capacity in Adults Born at Very Low Birth Weight: A Population-based Cohort Study
Jun Yang 1, Michael J. Epton 2, Sarah L. Harris 3, John Horwood 4, Rachel A. Kingsford 1, Richard Troughton 5,6, Charlotte Greer 5, and Brian A. Darlow 3
doi : 10.1164/rccm.202103-0755OC Â
Rationale: Population-based data regarding the consequences of very low birth weight (VLBW) and bronchopulmonary dysplasia (BPD) on adult exercise capacity are limited.
Increased Impact of Air Pollution on Lung Function in Preterm versus Term Infants: The BILD Study
Fabienne Decrue 1,2, Olga Gorlanova 1,2, Yasmin Salem 1,2, Danielle Vienneau 3,4, Kees de Hoogh 3,4, Amanda Gisler 1, Jakob Usemann 1,2,5, Insa Korten 1,2, Uri Nahum 1,2, Pablo Sinues 1,6, Sven Schulzke 1, Oliver Fuchs 1,2, Philipp Latzin 1,2, Martin Röösli 3,4, and Urs Frey 1,2;
doi : 10.1164/rccm.202102-0272OC Â Â
Rationale: Infants born prematurely have impaired capacity to deal with oxidative stress shortly after birth.
Sleep Apnea–Specific Hypoxic Burden, Symptom Subtypes, and Risk of Cardiovascular Events and All-Cause Mortality
Wojciech Trzepizur 1,2, Margaux Blanchard 3,4, Timothée Ganem 1, Frédéric Balusson 5, Mathieu Feuilloy 3,4, Jean-Marc Girault 3,4, Nicole Meslier 1,2, Emmanuel Oger 5, Audrey Paris 6, Thierry Pigeanne 7, Jean-Louis Racineux 8, AbdelKebir Sabil 9, Chloé Gervès-Pinquié 8, and Frédéric Gagnadoux 1,2;
doi : 10.1164/rccm.202105-1274OC
Rationale: Data from population-based cohorts suggest that symptom subtypes and obstructive sleep apnea (OSA)–specific hypoxic burden (HB) could help to better identify patients with OSA at high cardiovascular (CV) risk.
Phenotypic Heterogeneity in Chronic Obstructive Pulmonary Disease
Malvika Kaul , Solomon Krow , Ai-Yui M. Tan , and Sunit Singla
The Bronchial Circulation in COVID-19 Pneumonia
Maximilian Ackermann 1,2, Paul Tafforeau 3, Willi L. Wagner 4, Claire L. Walsh 5, Christopher Werlein 6,7, Mark P. Kühnel 6,7, Florian P. Länger 6,7, Catherine Disney 8, Andrew J. Bodey 9, Alexandre Bellier 10, Stijn E. Verleden 11, Peter D. Lee 8, Steven J. Mentzer 12, and Danny D. Jonigk 6,7
Amyloid Nodules Masquerading as Multifocal Lung Cancer
Silva Kristo 1, Tianle Zou 2, Elizabeth U. Dexter 3, and Saraswati Pokharel 4
Decreased Fatty Acid Oxidation and Altered Lactate Production during Exercise in Patients with Post-acute COVID-19 Syndrome
Esther de Boer 1,2, Irina Petrache 1,2*, Nir M. Goldstein 1, J. Tod Olin 1, Rebecca C. Keith 1,2, Brian Modena 1, Michael P. Mohning 1,2, Zulma X. Yunt 1,2, Inigo San-Millán 2,3‡, and Jeffrey J. Swigris 1,2‡
Combustible and Electronic Cigarette Exposures Increase ACE2 Activity and SARS-CoV-2 Spike Binding
Arunava Ghosh 1*, Vishruth Girish 2*, Monet Lou Yuan 2,3, Raymond D. Coakley 1, Joe A. Wrennall 1, Neil E. Alexis 1, Erin L. Sausville 2, Anand Vasudevan 2, Alexander R. Chait 2,4, Jason M. Sheltzer 2, and Robert Tarran 1‡
Contrast-enhanced Magnetic Resonance Imaging Does Not Detect a Progression in Lung Morphological Score in Preschool Children with Cystic Fibrosis
Gaël Dournes 1,2*, Ilyes Benlala 1,2, and François Laurent 1,2
Reply to Dournes et al.: Contrast-enhanced Magnetic Resonance Imaging Does Not Detect a Progression in Lung Morphological Score in Preschool Children with Cystic Fibrosis
Mirjam Stahl 1,2,3*, Eva Steinke 1,2, Mark O. Wielpütz 4,5, and Marcus A. Mall 1,2,3; on behalf of all the authors
Climate Change Health Effects and What You Can Do
Sharon Chinthrajah , Erika Garcia , Zainab Hasan , Angela Hy , and Lauren Wong
doi : 10.1164/rccm.2051P1 Â
