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Transcriptome-based Signatures: The Future Biomarkers in Obstructive Pulmonary Diseases Such as Asthma and Chronic Obstructive Pulmonary Disease?
Maarten van den Berge 1 and Alen Faiz 2
doi : 10.1164/rccm.202110-2353ED
Volume 205, Issue 2 | January 15 2022
Repurposing Propofol as a Prognostic Probe for Return of Consciousness
Michael S. Avidan 1 and George A. Mashour 2
Pediatric Pneumonia: Another Problem Plagued by Inequity in Health Care
Engi F. Attia 1, Joel D. Kaufman 2,3, and Elizabeth Maleche-Obimbo 4
Inhaled Treprostinil in Pulmonary Hypertension in the Context of Interstitial Lung Disease: A Success, Finally
Jürgen Behr
Dynamism of the Human Lung Proteome during Alveolarization: Moving beyond the Transcriptome
Cristina M. Alvira
Dreaming of New Obstructive Sleep Apnea Treatments
Amy S. Jordan 1,2 and Kristina Kairaitis 3,4,5
Expanding the Tuberculosis Cascade of Care to Treat Undiagnosed and Subclinical Tuberculosis in High-Burden Settings
Max O’Donnell 1,2 and Barun Mathema 3
Constant Vt Ventilation and Surfactant Dysfunction: An Overlooked Cause of Ventilator-induced Lung Injury
Richard K. Albert
doi : 10.1164/rccm.202107-1690CP
Ventilator-induced lung injury (VILI) is currently ascribed to volutrauma and/or atelectrauma, but the effect of constant Vt ventilation (CVtV) has received little attention. This Perspective summarizes the literature documenting that CVtV causes VILI and reviews the mechanisms by which it occurs.
Development of a Blood-based Transcriptional Risk Score for Chronic Obstructive Pulmonary Disease
Matthew Moll 1,2, Adel Boueiz 1,2, Auyon J. Ghosh 1,2, Aabida Saferali 1, Sool Lee 1,3, Zhonghui Xu 1, Jeong H. Yun 1,2, Brian D. Hobbs 1,2, Craig P. Hersh 1,2, Don D. Sin 4,5, Ruth Tal-Singer 6, Edwin K. Silverman 1,2, Michael H. Cho 1,2*, and Peter J. Castaldi 1,7*;
doi : 10.1164/rccm.202107-1584OC Â
Rationale: The ability of peripheral blood biomarkers to assess chronic obstructive pulmonary disease (COPD) risk and progression is unknown. Genetics and gene expression may capture important aspects of COPD-related biology that predict disease activity.
Brain Responses to Propofol in Advance of Recovery from Coma and Disorders of Consciousness: A Preliminary Study
Catherine Duclos 1,2, Charlotte Maschke 2,3, Yacine Mahdid 2,3, Danielle Nadin 2,3, Alexander Rokos 2,3, Caroline Arbour 4,5, Mohamed Badawy 6,7,8, Justin Létourneau 6,7,8, Adrian M. Owen 9,10,11, Gilles Plourde 6,7,8, and Stefanie Blain-Moraes 1,2
doi : 10.1164/rccm.202105-1223OC Â
Rationale: Predicting recovery of consciousness in unresponsive, brain-injured individuals has crucial implications for clinical decision-making. Propofol induces distinctive brain network reconfiguration in the healthy brain as it loses consciousness. In patients with disorders of consciousness, the brain network’s reconfiguration to propofol may reveal the patient’s underlying capacity for consciousness.
Resources and Geographic Access to Care for Severe Pediatric Pneumonia in Four Resource-limited Settings
Suzanne M. Simkovich 1,2,3*, Lindsay J. Underhill 1,2*, Miles A. Kirby 4, Mary E. Crocker 5, Dina Goodman 1,2, John P. McCracken 6, Lisa M. Thompson 7, Anaité Diaz-Artiga 8, Adly Castañaza-Gonzalez 8, Sarada S. Garg 9, Kalpana Balakrishnan 9, Gurusamy Thangavel 9, Ghislaine Rosa 10, Jennifer L. Peel 11, Thomas F. Clasen 12, Eric D. McCollum 13,14, William Checkley 1,2, and the HAPIN Investigators
doi : 10.1164/rccm.202104-1013OC
Rationale: Pneumonia is the leading cause of death in children worldwide. Identifying and appropriately managing severe pneumonia in a timely manner improves outcomes. Little is known about the readiness of healthcare facilities to manage severe pediatric pneumonia in low-resource settings.
Efficacy of Inhaled Treprostinil on Multiple Disease Progression Events in Patients with Pulmonary Hypertension due to Parenchymal Lung Disease in the INCREASE Trial
Steven D. Nathan 1, Victor F. Tapson 2, Jean Elwing 3, Franz Rischard 4, Jinesh Mehta 5, Shelley Shapiro 6,7, Eric Shen 8, Chunqin Deng 8, Peter Smith 8, and Aaron Waxman 9
doi : 10.1164/rccm.202107-1766OC
Rationale: The INCREASE study of inhaled treprostinil met its primary endpoint of change in 6-minute-walk distance at Week 16. In addition, there were significantly fewer clinical worsening events in patients receiving inhaled treprostinil. However, the incidence of multiple events in the same patient is unknown.
Proteomic Analysis of Human Lung Development
Geremy Clair 1, Lisa M. Bramer 1, Ravi Misra 2, Matthew D. McGraw 2, Soumyaroop Bhattacharya 2, Joseph A. Kitzmiller 3, Song Feng 1, Vincent G. Danna 1, Gautam Bandyopadhyay 2, Harsh Bhotika 4, Heidie L. Huyck 2, Gail H. Deutsch 5, Thomas J. Mariani 2, James P. Carson 6, Jeffrey A. Whitsett 3, Gloria S. Pryhuber 2, Joshua N. Adkins 1, and Charles Ansong 1
doi : 10.1164/rccm.202008-3303OC Â
Rationale: The current understanding of human lung development derives mostly from animal studies. Although transcript-level studies have analyzed human donor tissue to identify genes expressed during normal human lung development, protein-level analysis that would enable the generation of new hypotheses on the processes involved in pulmonary development are lacking.
Ventilatory Drive Withdrawal Rather Than Reduced Genioglossus Compensation as a Mechanism of Obstructive Sleep Apnea in REM Sleep
Ludovico Messineo 1,2, Danny J. Eckert 1, Luigi Taranto-Montemurro 2, Daniel Vena 2, Ali Azarbarzin 2, Lauren B. Hess 2, Nicole Calianese 2, David P. White 2, Andrew Wellman 2, Laura Gell 2, and Scott A. Sands 2,3
doi : 10.1164/rccm.202101-0237OC
Rationale: REM sleep is associated with reduced ventilation and greater obstructive sleep apnea (OSA) severity than non-REM (nREM) sleep for reasons that have not been fully elucidated.
Tuberculosis Pathways to Care and Transmission of Multidrug Resistance in India
Sachin R. Atre 1, Jayshri D. Jagtap 1, Mujtaba I. Faqih 1, Yogita K. Dumbare 1, Trupti U. Sawant 1, Sunil L. Ambike 1, Jitendra S. Bhawalkar 1, Sandeep K. Bharaswadkar 2, Padmaja K. Jogewar 3, Ramji S. Adkekar 3, Balasaheb P. Hodgar 4, Vaishali Jadhav 5, Nitin D. Mokashi 6, Jonathan E. Golub 7, Avika Dixit 8,9, and Maha R. Farhat 8,10
doi : 10.1164/rccm.202012-4333OC
Rationale: India is experiencing a regional increase in cases of multidrug-resistant tuberculosis (MDR-TB).
Use of Wearables and Implantable Devices to Monitor Pulmonary Health in the Outpatient Setting
Vladimir Glinskii 1, Raquel Lyn 1, Christopher Thomas 1, and Vinicio A. de Jesus Perez 1,2
The Pressure Paradox: Abdominal Compression to Detect Lung Hyperinflation in COVID-19 Acute Respiratory Distress Syndrome
Dekel Stavi 1,2,3,4*, Alberto Goffi 1,3,5,6*‡, Mufid Al Shalabi 3,7, Thomas Piraino 1,3,8, Lu Chen 1,5, Robert Jackson 6, and Laurent Brochard 1,3,5,6‡
False-Positive Cuff Leak Test due to Glossoptosis
Shunsaku Goto 1,2, Jun-ya Ishikawa 2, Masafumi Idei 2, and Takeshi Nomura 2
Pregnant and Peripartum Women with COVID-19 Have High Survival with Extracorporeal Membrane Oxygenation: An Extracorporeal Life Support Organization Registry Analysis
Erika R. O’Neil 1,2*, Huiming Lin 3, Amir A. Shamshirsaz 1,2, Emily E. Naoum 4, Peter R. Rycus 5, Peta M. A. Alexander 6,7, Jamel P. Ortoleva 8, Meng Li 3‡, and Marc M. Anders 1,2‡
Patients with Obstructive Sleep Apnea on Oronasal Continuous Positive Airway Pressure Breathe Predominantly through the Nose during Natural Sleep
Jeane Lima de Andrade Xavier , Fernanda Madeiro Leite Viana Weaver , George Lago Pinheiro , Paulo Henrique Sousa Fernandes , Pedro R. Genta , and Geraldo Lorenzi-Filho *
circGSAP: A New Clinical Biomarker for Idiopathic Pulmonary Hypertension?
Xishi Sun 1,2*, Riken Chen 3*, Xiaoyun Yao 4*, Zhenzhen Zheng 2*, Chaoyu Wang 5*, Jiahui Chen 4*, and Junfen Cheng 2‡
Reply to Sun et al.: circGASP: A New Clinical Biomarker for Idiopathic Pulmonary Hypertension?
Yuan-Yuan Sun , Lan Wang , Jin-Ming Liu , and Ping Yuan *
High Circulating Plasma Soluble Receptor for Advanced Glycation End-Products in Early COVID-19–associated Acute Respiratory Distress Syndrome: Pathophysiological Significance?
Amit Jain *
Reply to Jain: High Circulating Plasma Soluble Receptor for Advanced Glycation End-Products in Early COVID-19–associated Acute Respiratory Distress Syndrome: Pathophysiological Significance?
Guillaume Dumas 1*, Natacha Kapandji 1, Elie Azoulay 1, and Jean-Michel Constantin 2,3;
