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Endotyping Asthma: Profiling the Metabolic Dimension?
Michael J. Wilde 1 and Salman Siddiqui 2
doi : 10.1164/rccm.202111-2605ED
Volume 205, Issue 3 | February 1 2022
An Alarmin Role for P2Y13 Receptor during Viral-driven Asthma Exacerbations
Adam J. Byrne , Sejal Saglani , and Robert J. Snelgrove *
If All That You Have Is a Hammer…: Can We Phenotype Our Patients with Chronic Obstructive Pulmonary Disease?
Kenneth R. Chapman 1,2
Making Sense of Phase II Trials for Investigational Agents in COVID-19: The Case of Ilomedin in Mechanically Ventilated Patients
Fernando G. Zampieri 1 and Adit Ginde 2
Disconcerting and Counterintuitive Findings from a Trial of Exercise in Cystic Fibrosis: Can Exercise Make Our Patients Worse?
Melanie Chin and Shawn D. Aaron
Beyond the Retrotrapezoid Nucleus in Congenital Central Hypoventilation Syndrome
Raouf Amin
Tuberculosis: First in Flight
Kevin P. Fennelly 1, Leonardo Martinez 2, and Anna Maria Mandalakas 3
Treatment Trials in Young Patients with Chronic Obstructive Pulmonary Disease and Pre–Chronic Obstructive Pulmonary Disease Patients: Time to Move Forward
Fernando J. Martinez 1*‡, Alvar Agusti 2,3,4,5*, Bartolome R. Celli 6*, MeiLan K. Han 7‡, James P. Allinson 8‡, Surya P. Bhatt 9, Peter Calverley 10‡, Sanjay H. Chotirmall 11‡, Badrul Chowdhury 12, Patrick Darken 13, Carla A. Da Silva 14, Gavin Donaldson 8‡, Paul Dorinsky 13, Mark Dransfield 9, Rosa Faner 15, David M. Halpin 16, Paul Jones 17, Jerry A. Krishnan 18‡, Nicholas Locantore 19, Fernando D. Martinez 20‡, Hana Mullerova 21, David Price 22,23, Klaus F. Rabe 24,25‡, Colin Reisner 26, Dave Singh 27, Jørgen Vestbo 28, Claus F. Vogelmeier 29, Robert A. Wise 30, Ruth Tal-Singer 31‖, and Jadwiga A. Wedzicha 8‖‡
doi : 10.1164/rccm.202107-1663SO
Chronic obstructive pulmonary disease (COPD) is the end result of a series of dynamic and cumulative gene–environment interactions over a lifetime. The evolving understanding of COPD biology provides novel opportunities for prevention, early diagnosis, and intervention.
Metabo-Endotypes of Asthma Reveal Differences in Lung Function: Discovery and Validation in Two TOPMed Cohorts
Rachel S. Kelly 1*, Kevin M. Mendez 1*, Mengna Huang 1, Brian D. Hobbs 1,2, Clary B. Clish 3, Robert Gerszten 4, Michael H. Cho 1,2, Craig E. Wheelock 5,6,7, Michael J. McGeachie 1, Su H. Chu 1, Juan C. Celedón 8, Scott T. Weiss 1, and Jessica Lasky-Su 1;
doi : 10.1164/rccm.202105-1268OC
Rationale: Current guidelines do not sufficiently capture the heterogeneous nature of asthma; a more detailed molecular classification is needed. Metabolomics represents a novel and compelling approach to derive asthma endotypes (i.e., subtypes defined by functional and/or pathobiological mechanisms).
Targeting the P2Y13 Receptor Suppresses IL-33 and HMGB1 Release and Ameliorates Experimental Asthma
Rhiannon B. Werder 1,2,3,4*, Md Ashik Ullah 1*, Muhammed Mahfuzur Rahman 1,2, Jennifer Simpson 1,2,5, Jason P. Lynch 1,6,7, Natasha Collinson 1, Sonja Rittchen 1,8, Ridwan B. Rashid 1,2, Md Al Amin Sikder 1,2, Herlina Y. Handoko 1, Bodie F. Curren 1,2, Ismail Sebina 1, Gunter Hartel 1, Alec Bissell 1, Sylvia Ngo 1, Tejasri Yarlagadda 9, Sumaira Z. Hasnain 10,11, Wenying Lu 12, Sukhwinder S. Sohal 12, Megan Martin 13, Simon Bowler 10,13, Lucy D. Burr 10,13, Laurent O. Martinez 14, Bernard Robaye 15, Kirsten Spann 9, Manuel A. R. Ferreira 1, and Simon Phipps 1,2,11
doi : 10.1164/rccm.202009-3686OC Â
Rationale: The alarmins IL-33 and HMGB1 (high mobility group box 1) contribute to type 2 inflammation and asthma pathogenesis.
Alpha-1 Antitrypsin MZ Heterozygosity Is an Endotype of Chronic Obstructive Pulmonary Disease
Auyon J. Ghosh 1,2, Brian D. Hobbs 1,2,3, Matthew Moll 1,2, Aabida Saferali 1, Adel Boueiz 1,2,3, Jeong H. Yun 1,2,3, Frank Sciurba 4, Lucas Barwick 5, Andrew H. Limper 6, Kevin Flaherty 7, Gerard Criner 8*, Kevin K. Brown 9, Robert Wise 10, Fernando J. Martinez 11*, David Lomas 12, Peter J. Castaldi 1,3, Vincent J. Carey 1,3, Dawn L. DeMeo 1,2,3*, Michael H. Cho 1,2,3, Edwin K. Silverman 1,2,3, and Craig P. Hersh 1,2,3
doi : 10.1164/rccm.202106-1404OC Â
Rationale: Multiple studies have demonstrated an increased risk of chronic obstructive pulmonary disease (COPD) in heterozygous carriers of the AAT (alpha-1 antitrypsin) Z allele. However, it is not known if MZ subjects with COPD are phenotypically different from noncarriers (MM genotype) with COPD.
Prostacyclin in Intubated Patients with COVID-19 and Severe Endotheliopathy: A Multicenter, Randomized Clinical Trial
Pär I. Johansson 1,2, Peter Søe-Jensen 3, Morten H. Bestle 2,4, Niels E. Clausen 5, Klaus T. Kristiansen 6, Theis Lange 7, Jakob Stensballe 1,8, and Anders Perner 2,9
doi : 10.1164/rccm.202108-1855OC Â
Rationale: The mortality in patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) who require mechanical ventilation remains high, and endotheliopathy has been implicated.
Effects of a Partially Supervised Conditioning Program in Cystic Fibrosis: An International Multicenter, Randomized Controlled Trial (ACTIVATE-CF)
Helge Hebestreit 1, Susi Kriemler 2, Christian Schindler 3, Lothar Stein 4, Chantal Karila 5, Don S. Urquhart 6, David M. Orenstein 7, Larry C. Lands 8, Jonathan Schaeff 1, Ernst Eber 9, and Thomas Radtke 2;
doi : 10.1164/rccm.202106-1419OC Â
Rationale: The long-term effects of vigorous physical activity (PA) on lung function in cystic fibrosis are unclear.
Cerebral Autoregulation during Orthostatic Challenge in Congenital Central Hypoventilation Syndrome
Eric L. Vu 1,2,3*, Emma C. Dunne 4*, Allison Bradley 4, Amy Zhou 4, Michael S. Carroll 4, Casey M. Rand 3,4, Kenneth M. Brady 1,2,3,5, Tracey M. Stewart 4, and Debra E. Weese-Mayer 3,4,5
doi : 10.1164/rccm.202103-0732OC
Rationale: Congenital central hypoventilation syndrome (CCHS) is a rare autonomic disorder with altered regulation of breathing, heart rate (HR), and blood pressure (BP). Aberrant cerebral oxygenation in response to hypercapnia/hypoxia in CCHS raises the concern that altered cerebral autoregulation may contribute to CCHS-related, variably impaired neurodevelopment.
Molecular Detection of Airborne Mycobacterium tuberculosis in South African High Schools
Erick W. Bunyasi 1,2, Keren Middelkoop 3, Anastasia Koch 4, Zeenat Hoosen 3, Humphrey Mulenga 1,2, Angelique K. K. Luabeya 1,2, Justin Shenje 1,2, Simon C. Mendelsohn 1,2, Michele Tameris 1,2, Thomas J. Scriba 1,2, Digby F. Warner 4,5, Robin Wood 3, Jason R. Andrews 6, and Mark Hatherill 1,2 ... Show less Erick W. Bunyasi 1,2, Keren Middelkoop 3, Anastasia Koch 4, Zeenat Hoosen 3, Humphrey Mulenga 1,2, Angelique K. K. Luabeya 1,2, Justin Shenje 1,2, Simon C. Mendelsohn 1,2, Michele Tameris 1,2, Thomas J. Scriba 1,2, Digby F. Warner 4,5, Robin Wood 3, Jason R. Andrews 6, and Mark Hatherill 1,2
doi : 10.1164/rccm.202102-0405OC Â
Rationale: South African adolescents carry a high tuberculosis disease burden. It is not known if schools are high-risk settings for Mycobacterium tuberculosis (MTB) transmission.
A Severe COVID-19 Pneumonia Revealing a Lepidic Adenocarcinoma: A Diagnostic Challenge during the Pandemic Period
Alexandre Elabbadi 1, Anne Fajac 2, Martine Antoine 2, Jacques Cadranel 3, Guillaume Voiriot 1, Muriel Fartoukh 1, and Aude Gibelin 1
Pseudomembranous Invasive Tracheobronchial Aspergillosis
Shinshu Katayama1 , Ken Tonai 1 , Daisuke Minakata2 , and Shin Nunomiya 1
Phenotypes of Patients with COVID-19 Who Have a Positive Clinical Response to Helmet Noninvasive Ventilation
Domenico Luca Grieco 1,2*, Luca S. Menga 1,2, Melania Cesarano 1,2, Savino Spadaro 3, Maria Maddalena Bitondo 4, Cecilia Berardi 1,2, Tommaso Rosà 1,2, Filippo Bongiovanni 1,2, Salvatore Maurizio Maggiore 5,6, Massimo Antonelli 1,2, and the COVID-ICU Gemelli Study Group
Construct Validity of PaO2/FiO2 Ratios in Defining Acute Respiratory Distress Syndrome
Sheng-Yuan Ruan 1*, Chun-Ta Huang 1, Hou-Tai Chang 2, Wei-Lun Liu 3, Wei-Jhen Wang 4, Yun-Ting Tseng 4, Han-Ching Yang 5, Lu-Cheng Kuo 1, Jung-Yien Chien 1, and Huey-Dong Wu 1
Air Pollution as a Risk Factor for Lung Cancer: Potential Mechanisms
Chris Ward 1, Shakti D. Shukla 2, and E. Haydn Walters 3*
Reply to Ward et al.: Air Pollution as a Risk Factor for Lung Cancer: Potential Mechanisms
Meng Zhu *, Yanqian Huang *, Hongxia Ma ‡, and Hongbing Shen
Pleuroparenchymal Fibroelastosis Induced by Liver Transplantation?
Satoshi Watanabe *, Kazuhiko Iwasaki , and Kazuo Kasahara
Reply to Watanabe et al.: Pleuroparenchymal Fibroelastosis Induced by Liver Transplantation?
Damanjit Goondi , Angela Franko , and Kerri A. Johannson *
Erratum: Synergistic Association of House Endotoxin Exposure and Ambient Air Pollution with Asthma Outcomes
Long COVID Patient Fact Sheet
Stacey J. Butler , Lekshmi Santhosh , Samir Gupta , Ann M. Parker , and Andrea S. Gershon
doi : 10.1164/rccm.2053P5
