James E. Gern 1,2
doi : 10.1164/rccm.202201-0023ED
Volume 205, Issue 6 | March 15 2022
David M. Stieb 1,2
Catherine S. Sassoon 1 and Jordi Mancebo 2
Scott M. Matson 1, Melissa Griffith 2, and Joyce S. Lee 2
Shyamala Dakshinamurti 1,2
Neil W. Schluger
Craig L. Phillips 1,2, Elizabeth A. Cayanan 1, and Brendon J. Yee 1,3
Nirav R. Bhakta 1, and John R. Balmes 1,2
Renda Soylemez Wiener , Anna M. Barker , Lisa Carter-Harris , Tanner J. Caverly , David A. Crocker , Angela Denietolis , Charlotte Doherty , Angela Fagerlin , Mary Gallagher-Seaman , Michael K. Gould , Paul K. J. Han , Abigail N. Herbst , Mayuko Ito Fukunaga , Megan B. McCullough , Danielle A. Miano , Samantha L. Quaife , Christopher G. Slatore , and Gemmae M. Fix ;
Mark Dransfield 1, Steven Rowe 2, Claus F. Vogelmeier 3, Jadwiga Wedzicha 4, Gerard J. Criner 5, MeiLan K. Han 6, Fernando J. Martinez 7, and Peter Calverley 8
doi : 10.1164/rccm.202109-2064TR
Chronic obstructive pulmonary disease (COPD) manifests with a variety of clinical presentations, reflecting its complex pathology. Currently, care focuses on symptom amelioration and prevention of complications and thus is generally tailored to disease severity rather than targeting specific pathophysiologic mechanisms.
Sabina Illi 1,2, Martin Depner 1, Petra Ina Pfefferle 2,3, Harald Renz 2,4,5, Caroline Roduit 6,7,8, Diana Hazard Taft 9, Karen M. Kalanetra 9, David A. Mills 9, Freda M. Farquharson 10, Petra Louis 10, Elisabeth Schmausser-Hechfellner 1, Amandine Divaret-Chauveau 11,12,13, Roger Lauener 6,8, Anne M. Karvonen 14, Juha Pekkanen 14,15, Pirkka V. Kirjavainen 14,16, Marjut Roponen 17, Josef Riedler 18, Michael Kabesch 19, Bianca Schaub 2,20, Erika von Mutius 1,2,20, and the PASTURE Study Group
doi : 10.1164/rccm.202106-1458OC
Rationale: In murine models, microbial exposures induce protection from experimental allergic asthma through innate immunity.
Anne Bozack 1,2,3, Stanley Pierre 4, Nicholas DeFelice 2, Elena Colicino 2, Darby Jack 5, Steven N. Chillrud 6, Andrew Rundle 7, Alfred Astua 8, James W. Quinn 7, Laura McGuinn 2, Qiang Yang 6, Keely Johnson 9, Joseph Masci 10, Laureen Lukban 11, Duncan Maru 11,12, and Alison G. Lee 1
doi : 10.1164/rccm.202104-0845OC Â
Rationale: Risk factors for coronavirus disease (COVID-19) mortality may include environmental exposures such as air pollution.
L. Felipe Damiani 1,2,3, Doreen Engelberts 1, Luca Bastia 1,4, Kohei Osada 1, Bhushan H. Katira 1,5, Gail Otulakowski 1, Ewan C. Goligher 6,7,8, W. Darlene Reid 6,9, Sebastián Dubo 10, Alejandro Bruhn 3, Martin Post 1,11, Brian P. Kavanagh 1,6,11†, and Laurent J. Brochard 6,12 ... Show less
doi : 10.1164/rccm.202105-1089OC
Rationale: Reverse triggering dyssynchrony (RT) is a patient–ventilator interaction where a respiratory muscle contraction is triggered by a passive mechanical insufflation. Its impact on diaphragm structure and function is unknown.
Dinesh Khanna 1, Celia J. F. Lin 2*, Daniel E. Furst 3,4, Bridget Wagner 2, Mauro Zucchetto 5, Ganesh Raghu 6, Fernando J. Martinez 7, Jonathan Goldin 8, Jeffrey Siegel 2‡, and Christopher P. Denton 9; for the focuSSced Investigators
doi : 10.1164/rccm.202103-0714OC
Rationale: Tocilizumab, an anti–IL-6 receptor antibody, had no statistically significant effect on skin sclerosis but preserved lung function over 48 weeks in patients with early systemic sclerosis (SSc)-associated interstitial lung disease (ILD) in a phase 3 randomized controlled trial.
Brittany Ann Ruschkowski 1, Yousef Esmaeil 2, Kate Daniel 1, Chantal Gaudet 1, Behzad Yeganeh 1, David Grynspan 2, and Robert P. Jankov 1,2,3
doi : 10.1164/rccm.202104-1021OC
Rationale: Extremely preterm infants develop bronchopulmonary dysplasia (BPD), a chronic lung injury that lacks effective treatment. TSP-1 (thrombospondin-1) is an antiangiogenic protein that activates TGF-β1 (transforming growth factor-β1), a cytokine strongly linked to both experimental and human BPD.
Arielle Elmaleh-Sachs 1, Pallavi Balte 1, Elizabeth C. Oelsner 1, Norrina B. Allen 2, Aaron Baugh 3, Alain G. Bertoni 4, John L. Hankinson 5, Jim Pankow 6, Wendy S. Post 7, Joseph E. Schwartz 8, Benjamin M. Smith 1, Karol Watson 9, and R. Graham Barr 1,10
doi : 10.1164/rccm.202107-1612OC
Rationale: Normal values for FEV1 and FVC are currently calculated using cross-sectional reference equations that include terms for race/ethnicity, an approach that may reinforce disparities and is of unclear clinical benefit.
Susanna S. S. Ng 1, Wilson W. S. Tam 2, Richard W. W. Lee 3, Tat-On Chan 1, Karen Yiu 1, Brian T. Y. Yuen 4, Ka-Tak Wong 4, Jean Woo 1, Ronald C. W. Ma 1,5, Ken K. P. Chan 4, Fanny W. S. Ko 4, Peter A. Cistulli 6,7, and David S. Hui 1
doi : 10.1164/rccm.202106-1401OC
Rationale: Craniofacial structure is believed to modulate the effect of weight loss on obstructive sleep apnea (OSA), but whether this affects metabolic profile after weight loss compared with continuous positive airway pressure (CPAP) is unknown among obese Chinese patients with OSA.
Michael Gilmartin , Ahmad Basirat , Conor Barry , Hassan Rahman , Aoife Doolan , Darragh Halpenny , Brendan Hogan , Minesh Kooblall , and Stephen J. Lane *
Haruki Kobayashi
Meredith C. McCormack 1*, Aparna Balasubramanian 1, Elizabeth C. Matsui 2, Roger D. Peng 3, Robert A. Wise 1, and Corinne A. Keet 1
Jonathan Witonsky 1*, Jennifer R. Elhawary 1, Celeste Eng 1, José R. RodrÃÂguez-Santana 2, Luisa N. Borrell 3‡, and Esteban G. Burchard 1‡
Inès Van Rossem *, Shane Hanon , Sylvia Verbanck , and Eef Vanderhelst
Brendan T. Keenan 1, Ulysses J. Magalang 2, Diego R. Mazzotti 3, Nigel McArdle 4,5,6, Thorarinn Gislason 7,8, Bhajan Singh 4,5,6, Greg Maislin 1, and Allan I. Pack 1*
Wojciech Trzepizur 1,2*, Margaux Blanchard 3,4, AbdelKebir Sabil 5, Chloé Gervès-Pinquié 6, and Frédéric Gagnadoux 1,2;
Nehan Sher , Naomi Habib , Shiri Etzioni , and Marilyn Glassberg
doi : 10.1164/rccm.2056P11
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