Rosalie A. Scholtes Michaël J. B. van Baar Megan D. Kok Petter Bjornstad David Z. I. Cherney Jaap A. Joles Daniël H. van Raalte
doi : 10.1111/nep.13839
Volume 26, Issue 5, May 2021, Pages: 377-390
This invited review describes the renal haemodynamic and protective effects of commonly prescribed drugs in people with type 2 diabetes and their interaction with SGLT2 inhibitors.
Esmee M. van der Willik Caroline B. Terwee Willem Jan W. Bos Marc H. Hemmelder Kitty J. Jager Carmine Zoccali Friedo W. Dekker Yvette Meuleman
doi : 10.1111/nep.13843
Volume 26, Issue 5, May 2021, Pages: 391-399
The review provides insight into the interpretation of PROM scores by introducing the different types and characteristics of PROMs, and the most relevant concepts for the interpretation of PROM scores, ie minimal detectable change, minimal important change and response shift.
Guangming Chen Xiaoyun Shan Huabin Wang
doi : 10.1111/nep.13851
Volume 26, Issue 5, May 2021, Pages: 400-407
Among 513 type 2 diabetics with impaired kidney function, the correlation of urinary albumin?to?creatinine ratio and estimated glomerular filtration rate decline with urinary alpha?1?microglobulin?to?creatinine ratio is stronger than with urinary neutrophil gelatinase?associated lipocalin?to?creatinine ratio. Urinary alpha?1?microglobulin may therefore have a higher diagnostic utility than urinary neutrophil gelatinase?associated lipocalin for kidney dysfunction among diabetic subjects.
Jorge I. Fonseca?Correa Carlos Nava?Santana Luis Tamez?Pedroza Armando Paz?Cortes Airy Santillan?Ceron Luis J. Rojas?Concha Juan Pablo Pantoja?Mill?n Mauricio Sierra?Salazar David Velazquez?Fern?ndez Miguel F. Herrera Ricardo Correa?Rotter Juan C. Ramirez?Sandoval
doi : 10.1111/nep.13854
Volume 26, Issue 5, May 2021, Pages: 408-419
The authors present an analysis of biochemical findings related to hyperparathyroidism (HPT) comparing primary HPT with secondary/tertiary HPT. Early and persistent hypocalcaemia after parathyroidectomy in severe HPT were a common event associated directly to preoperative ALP levels. Subjects with persistently low postoperative iPTH tend to attain normal serum calcium levels more frequently after 1 year.
Thomas Phillips Matthew Stammers Gary Leggatt Becky Bonfield Simon Fraser Kirsten Armstrong Kristin Veighey
doi : 10.1111/nep.13847
Volume 26, Issue 5, May 2021, Pages: 420-431
This study reviewed biomarkers and comorbidities linked to AKI associated with COVID?19 infections in 632 patients. 34.2% developed AKI with a 50% increased mortality. Severity of AKI was linked to both comorbidities and biomarkers.
Rumei Luan Geng Tian Xin Ci Qian Zheng Linlin Wu Xuehong Lu
doi : 10.1111/nep.13855
Volume 26, Issue 5, May 2021, Pages: 432-441
An RNA?sequence analysis of RNAs in urinary exosomes identified a number of differentially expressed circular RNAs in immunoglobulin A nephropathy (IgAN) patients as compared to healthy controls. These circRNAs are associated with the regulation of pathways relevant to IgAN and may provide useful non?invasive biomarkers for this condition.
Zoe M. Jenkins Eric J. Tan Emmet O'Flaherty Simon Knowles David R. Thompson Chantal F. Ski Susan L. Rossell Carolee Coco Francesco L. Ierino Hilton Gock David J. Castle
doi : 10.1111/nep.13850
Volume 26, Issue 5, May 2021, Pages: 442-453
This study demonstrated that a psychosocial intervention programme, the Kidney Optimal Health Program, is feasible and efficacious in reducing symptoms of depression and anxiety in individuals with advanced chronic kidney disease.
Chanchana Boonyakrai Talerngsak Kanjanabuch Pongpratch Puapatanakul Guttiga Halue David W. Johnson Pichet Lorvinitnun Kittisak Tangjittrong Piyawan Kittiskulnam Krit Pongpirul Brian Bieber Kriang Tungsanga Thailand PDOPPS Steering Committee
doi : 10.1111/nep.13859
Volume 26, Issue 5, May 2021, Pages: 454-462
This study shows an association between self?reported appetite loss and clinical outcomes in patients undergoing peritoneal dialysis. Patient?reported poor appetite was independently associated with higher risks of peritonitis, HD transfer, and all?cause mortality.
Xue Z. Wong Azzeri Amirah Chye C. Gan Shabaruddin Fatiha Dahlui Maznah Rosnawati Yahya Shubash Ganapathy Soek S. Tan Rosmawati Mohamed Soo K. Lim
doi : 10.1111/nep.13862
Volume 26, Issue 5, May 2021, Pages: 463-470
HCV core antigen (HCV Ag) correlated well with HCV RNA among 227 haemodialysis patients, and can be a cost saving strategy over HCV RNA testing to confirm active HCV infection among HD patients.
Samuel Chan Mark Morrison Carmel M. Hawley Scott B. Campbell Ross S. Francis Nicole M. Isbel Elaine M. Pascoe David W. Johnson
doi : 10.1111/nep.13853
Volume 26, Issue 5, May 2021, Pages: 471-478
This small study looks at gastrointestinal microbiota pre? and post?living donor kidney transplantation in both the recipients and their donors. Faecal samples were analysed before, and 4–8?weeks following surgery. Kidney transplantation resulted in significant alterations in gut microbiota richness, diversity, composition and functional parameters in the recipients but not the kidney donors.
Sayaka Nagata Akihiro Fukuda Masao Kikuchi Yuji Sato Masanao Nagatomo Junko Aburaya Shouichi Fujimoto Kazuo Kitamura
doi : 10.1111/nep.13845
Volume 26, Issue 5, May 2021, Pages: 479-484
Nagata and colleagues measure the concentration of Big angiotensin?25 (Bang?25) in urine by a novel Amplified Luminescent Proximity Homogeneous Assay?based ELISA method, which uses antibodies specific to the N?terminus of Ang II and the C?terminus of Bang?25. In a validation cohort, urinary Bang?25 levels inversely correlated with kidney function and directly with urinary albumin excretion.
Leping Shao Weina Jiang Wenfeng Wang Yan Cai Yan Sun Ruixiao Zhang Luyan Bian Haixia Fu Shujian Zhang Cuiping Mou Huasheng Du Qingqing You Jian Hua Xinping Fan Yan Gao Wencong Guo
doi : 10.1111/nep.13811
Volume 26, Issue 5, May 2021, Pages: 485-486
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