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Update on diagnosis, pathophysiology, and management of diabetic kidney disease
Mai Sugahara Wai Lun Will Pak Tetsuhiro Tanaka Sydney C. W. Tang Masaomi Nangaku
doi : 10.1111/nep.13860
Volume 26, Issue 6, June 2021, Pages: 491-500
This article reviewed recent advances in the pathogenesis and treatment of diabetic kidney disease (DKD). Special focus is put on the phenotypic heterogeneity of DKD, and the recent studies that showed the therapeutic benefits of SGLT2 inhibitors and GLP?1 receptor agonists. Potential future therapeutic strategies are also explored.
Be careful with ecological associations
Stefanos Roumeliotis Samar Abd ElHafeez Kitty J. Jager Friedo W. Dekker Vianda S. Stel Annalisa Pitino Carmine Zoccali Giovanni Tripepi
doi : 10.1111/nep.13861
Volume 26, Issue 6, June 2021, Pages: 501-505
This article describes the application of ecological studies to provide an answer to specific epidemiological questions. This paper focuses on the problem of ecological fallacy, a bias which occurs when conclusions about a given relationship in individuals are deduced from inferences about the group to which those individuals belong.
Impact of worsening renal function on peak oxygen uptake in patients with acute myocardial infarction
Asami Ogura Kazuhiro P. Izawa Hideto Tawa Fumie Kureha Masaaki Wada Masashi Kanai Ikko Kubo Ryohei Yoshikawa Yuichi Matsuda
doi : 10.1111/nep.13864
Volume 26, Issue 6, June 2021, Pages: 506-512
This is a retrospective cohort study on 94 patients followed for up to 6 months in Japan showing that worsening of kidney function after acute myocardial infarction (MI) is associated with peak oxygen uptake on exercise test, and this association is independent of baseline kidney function. Thus a decline is kidney function post MI may have implications for worse outcomes than the absolute level of kidney function.
Early predictors of acute kidney injury in COVID?19 patients
Cigdem Yildirim Hasan Selcuk Ozger Emre Yasar Nazrin Tombul Ozlem Gulbahar Mehmet Yildiz Gulendam Bozdayi Ulver Derici Murat Dizbay
doi : 10.1111/nep.13856
Volume 26, Issue 6, June 2021, Pages: 513-521
This observational single?center study assessed the frequency and predictors of acute kidney injury in 348 hospitalized patients with COVID?19. In this cohort, AKI was diagnosed in 4.9% of patients and proteinuria (spot urine analysis) in 20%. Albuminuria/creatinine ratio, cystatin C? and D?dimer were identified as potential predictors of AKI on admission.
Renal supportive care programs: An observational study assessing impact on hospitalization and survival outcomes
Xiu Xian Chia Rebecca Johnston Rajesh Aggarwal Thang Huynh Stephanie Notaras Dragana Zekanovic Katrina Gordon Victoria Sasongko Angela Makris
doi : 10.1111/nep.13869
Volume 26, Issue 6, June 2021, Pages: 522-529
The study analysed the impact of renal supportive care (RSC) on hospitalization and survival outcomes of non?dialysis ESKD patients. RSC can significantly decrease the number and length of hospitalisations in conservatively managed ESKD patients.
Predictors of technique failure and mortality on peritoneal dialysis: An analysis of New Zealand peritoneal dialysis registry data
Ashik Hayat Walaa Saweirs
doi : 10.1111/nep.13837
Volume 26, Issue 6, June 2021, Pages: 530-540
Among over 6,000 PD patients from the New Zealand Peritoneal Dialysis Registry, multiple factors are associated with the risk of technique failure, and the authors call for the construction of a mathematical model for early prediction so that a planned transition to HD can be initiated in a timely manner.
Changes in renal function and predictors affecting renal outcome of living kidney donors: a nationwide prospective cohort study
Yunmi Kim Min Ji Kim Yu Ho Lee Jung Pyo Lee Jeong?Hoon Lee Jaeseok Yang Myoung Soo Kim Taehee Kim Sun Woo Kang Yeong Hoon Kim KOTRY study group
doi : 10.1111/nep.13880
Volume 26, Issue 6, June 2021, Pages: 541-548
A population cohort study of live donors registered in the Korean Organ Transplant Registry showing that over 1 in 5 live?donors developed chronic kidney disease at 2?years post?donation, and had exhibited decline in eGFR over time. The authors also showed that higher systolic blood pressure was associated with the development of chronic kidney disease suggesting that close long?term follow?up of these donors are required.
Wnt/??catenin signalling mediates cardiac hypertrophy in type 4 cardiorenal syndrome
Yue Zhao Yanping Lei Yueyan Li Jingjing Zhang Huifang Tang
doi : 10.1111/nep.13848
Volume 26, Issue 6, June 2021, Pages: 549-560
This study has explored the mechanism underlying cardiorenal syndrome type 4 by studying a rat model of 5/6 subtotal nephrectomy. In this model, the Wnt/??catenin pathway was found to induce cardiac hypertrophy and blockade of this pathway led to renoprotection and reversal of cardiac injury.
Administration route governs the complication: A case report of anaphylaxis due to intravenous erythropoiesis?stimulating agent
Yukari Mae Ayami Ida Tomoaki Takata Hajime Isomoto
doi : 10.1111/nep.13846
Volume 26, Issue 6, June 2021, Pages: 561
Long?term therapeutic effects of multi?target therapy in a patient with membranous lupus nephritis: An interesting repeat kidney biopsy case
Kazunori Karasawa Tomo Nakakita Yoei Miyabe Kenichi Akiyama Takahito Moriyama Keiko Uchida Kosaku Nitta
doi : 10.1111/nep.13852
Volume 26, Issue 6, June 2021, Pages: 562-563
