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Going deeper: molecular inflammatory scores in IBD
James C Lee 1,2
doi : 10.1136/gutjnl-2022-328539
July 2023 - Volume 72 - 7
Disentangling tryptophan metabolism in inflammatory bowel diseases
ChristophتBecker,تTimon ErikتAdolph
Proton pump inhibitors and the risk of inflammatory bowel disease: cause, protopathic bias or others?
Byong DukتYe
Time to consider a holistic approach to the treatment of non-alcoholic fatty liver disease in obese young people?
Christopher DتByrne,تGiovanniتTargher
Joint Asian Pacific Association of Gastroenterology (APAGE)Ø°Asian Pacific Society of Digestive Endoscopy (APSDE) clinical practice guidelines on the use of non-invasive biomarkers for diagnosis of colorectal neoplasia
Francis K LتChan,تMartin C SتWong,تAndrew TتChan,تJames EتEast,تHan-MoتChiu,تGovind KتMakharia,تDavidتWeller,تChoon JinتOoi,تJulajakتLimsrivilai,تYutakaتSaito,تDao VتHang,تJon DتEmery,تDadangتMakmun,تKaichunتWu,تRaja Affendi RajaتAli,تSiew CتNg
doi : 10.1136/gutjnl-2023-329429
Screening for colorectal cancer (CRC) is effective in reducing CRC related mortality. Current screening methods include endoscopy based and biomarker based approaches. This guideline is a joint official statement of the Asian Pacific Association of Gastroenterology (APAGE) and the Asian Pacific Society of Digestive Endoscopy (APSDE), developed in response to the increasing use of, and accumulating supportive evidence for the role of, non-invasive biomarkers for the diagnosis of CRC and its precursor lesions.
Standardisation of EUS-guided FNB technique for molecular profiling in pancreatic cancer: results of a randomised trial
Ji YoungتBang,تNiragتJhala,تAnjaliتSeth,تKonradتKrall,تUdayakumarتNavaneethan,تRobertتHawes,تCharles MelbernتWilcox,تShyamتVaradarajulu
Helicobacter pyloriتpromotes colorectal carcinogenesis by deregulating intestinal immunity and inducing a mucus-degrading microbiota signature
AnnaتRalser,تAlisaتDietl,تSebastianتJarosch,تVeronikaتEngelsberger,تAndreasتWanisch,تKlaus PeterتJanssen,تMoritzتMiddelhoff,تMichaelتVieth,تMichaelتQuante,تDirkتHaller,تDirk HتBusch,تLiتDeng,تRaquelتMej’as-Luque,تMarkusتGerhard
doi : 10.1136/gutjnl-2022-328075
ObjectiveتHelicobacter pyloriتinfection is the most prevalent bacterial infection worldwide. Besides being the most important risk factor for gastric cancer development, epidemiological data show that infected individuals harbour a nearly twofold increased risk to develop colorectal cancer (CRC). However, a direct causal and functional connection betweenتH. pyloriتinfection and colon cancer is lacking.
Biopsy and blood-based molecular biomarker of inflammation in IBD
CarmenتArgmann,تRuixueتHou,تRyan CتUngaro,تHaritzتIrizar,تZainabتAl-Taie,تRuiqiتHuang,تRomanتKosoy,تSwatiتVenkat,تWon-MinتSong,تAntonio FتDi'Narzo,تBojanتLosic,تKeتHao,تLaurenتPeters,تPhillip HتComella,تGabrielleتWei,تAshishتAtreja,تMilindتMahajan,تAlinaتIuga,تPrerak TتDesai,تPatrickتBranigan,تAleksandarتStojmirovic,تJacquelineتPerrigoue,تCarrieتBrodmerkel,تMarkتCurran,تJoshua RتFriedman,تAmyتHart,تEsiتLamousژ-Smith,تJanتWehkamp,تSaurabhتMehandru,تEric EتSchadt,تBruce EتSands,تMarla CتDubinsky,تJean-FredericتColombel,تAndrewتKasarskis,تMayteتSu‡rez-Fari–as
doi : 10.1136/gutjnl-2021-326451
ObjectiveتIBD therapies and treatments are evolving to deeper levels of remission. Molecular measures of disease may augment current endpoints including the potential for less invasive assessments.
Proton pump inhibitors and the risk of inflammatory bowel disease: population-based cohort study
DevinتAbrahami,تRicheekتPradhan,تHuiتYin,تRussellتYanofsky,تEmily GibsonتMcDonald,تAlainتBitton,تLaurentتAzoulay
doi : 10.1136/gutjnl-2022-328866
ObjectiveتTo determine whether the use of proton pump inhibitors (PPIs) compared with the use of histamine-2 receptor antagonists (H2RAs) is associated with an increased risk of inflammatory bowel disease (IBD).
Rewiring the altered tryptophan metabolism as a novel therapeutic strategy in inflammatory bowel diseases
ChloژتMichaudel,تCamilleتDanne,تAllisonتAgus,تAurژlieتMagniez,تAnneتAucouturier,تMadeleineتSpatz,تAntoineتLefevre,تJulienتKirchgesner,تNathalieتRolhion,تYazhouتWang,تAonghusتLavelle,تChloژتGalbert,تGregoryتDa Costa,تMaximeتPoirier,تAlexiaتLapiڈre,تJulienتPlanchais,تPetrتN‡dvorn’k,تPeterتIlles,تCyrianeتOeuvray,تLauraتCreusot,تMarie-LaureتMichel,تNicolasتBenech,تAnneتBourrier,تIsabelleتNion-Larmurier,تCeciliaتLandman,تMathias LتRichard,تPatrickتEmond,تPhilippeتSeksik,تLaurentتBeaugerie,تRafael RoseتArguello,تDavidتMoulin,تSridharتMani,تZdenekتDvor‡k,تLuis GتBermœdez-Humar‡n,تPhilippeتLangella,تHarryتSokol
doi : 10.1136/gutjnl-2022-327337
ObjectiveتThe extent to which tryptophan (Trp) metabolism alterations explain or influence the outcome of inflammatory bowel diseases (IBDs) is still unclear. However, several Trp metabolism end-products are essential to intestinal homeostasis. Here, we investigated the role of metabolites from the kynurenine pathway.
Acetyltransferase fromتAkkermansia muciniphilaتblunts colorectal tumourigenesis by reprogramming tumour microenvironment
YiتJiang,تYuejieتXu,تChangتZheng,تLeiتYe,تPingتJiang,تSaraتMalik,تGuifangتXu,تQianتZhou,تMingmingتZhang
doi : 10.1136/gutjnl-2022-327853
ObjectiveتThe protein post-translational modification (PTM) in host cells can be rewritten by bacterial enzymes and represents an unprecedented mechanism in the communication between intestinal flora and the host. AlthoughتAkkermansia muciniphilaتhas been widely investigated as a probiotic and blunts colitis-associated tumourigenesis in mice, there is little understanding regarding whetherتA. muciniphilaتis involved in the PTM of colorectal cancer (CRC). This study investigates whether and howتA. muciniphilaتengages in the PTM of host CRC.
Impact of delayed screening invitations on screen-detected and interval cancers in the Dutch colorectal cancer screening programme: individual-level data analysis
EstherتToes-Zoutendijk,تLucieتde Jonge,تCarola Adrianaتvan Iersel,تManon C WتSpaander,تAnneke Jتvan Vuuren,تFolkertتvan Kemenade,تChristian RتRamakers,تEvelienتDekker,تIris DتNagetaal,تMonique Eتvan Leerdam,تIrisتLansdorp-Vogelaar
doi : 10.1136/gutjnl-2022-328559
ObjectiveتTo assess the impact of delayed invitation on screen-detected and interval colorectal cancers (CRC) within a faecal immunochemical testing (FIT)-based CRC screening programme.
Transcriptomic and immunophenotypic profiling reveals molecular and immunological hallmarks of colorectal cancer tumourigenesis
JessicaتRoelands,تManonتvan der Ploeg,تMarieke EتIjsselsteijn,تHaoتDang,تJurjen JتBoonstra,تJames C HتHardwick,تLukas J A CتHawinkels,تHansتMorreau,تNoel F C Cتde Miranda
doi : 10.1136/gutjnl-2022-327608
ObjectiveتBiological insights into the stepwise development and progression of colorectal cancer (CRC) are imperative to develop tailored approaches for early detection and optimal clinical management of this disease. Here, we aimed to dissect the transcriptional and immunologic alterations that accompany malignant transformation in CRC and to identify clinically relevant biomarkers through spatial profiling of pT1 CRC samples.
Preclinical mouse model of a misfolded PNLIP variant develops chronic pancreatitis
GuoyingتZhu,تSteven JتWilhelm,تLeah GتGeorge,تBrett MتCassidy,تSammyتZino,تCliff JتLuke,تMinaتHanna,تStephenتStone,تNhungتPhan,تNeelتMatiwala,تSamuel JتBallentine,تMark EتLowe,تXunjunتXiao
doi : 10.1136/gutjnl-2022-327960
ObjectiveتIncreasing evidence implicates mutation-induced protein misfolding and endoplasm reticulum (ER) stress in the pathophysiology of chronic pancreatitis (CP). The paucity of animal models harbouring genetic risk variants has hampered our understanding of how misfolded proteins trigger CP.
Activated regulatory T-cells promote duodenal bacterial translocation into necrotic areas in severe acute pancreatitis
Juliane Glaubitz, Anika Wilden, Fabian Frost, Sabine Ameling, Georg Homuth, Hala Mazloum, Malte Christoph RÚºhlemann, Corinna Bang, Ali A Aghdassi, Christoph Budde, Tilmann Pickartz, Andre Franke, Barbara M BrÚ‘ker, Uwe Voelker, Julia Mayerle, Markus M Lerch, Frank-Ulrich Weiss, Matthias Sendler
doi : 10.1136/gutjnl-2022-327448
ObjectiveتIn acute pancreatitis (AP), bacterial translocation and subsequent infection of pancreatic necrosis are the main risk factors for severe disease and late death. Understanding how immunological host defence mechanisms fail to protect the intestinal barrier is of great importance in reducing the mortality risk of the disease.ت
S100A10 promotes HCC development and progression via transfer in extracellular vesicles and regulating their protein cargos
XiaتWang,تHongyangتHuang,تKaren Man-FongتSze,تJinتWang,تLuتTian,تJingyiتLu,تYu-ManتTsui,تHoi TangتMa,تEvaتLee,تAoتChen,تJoyceتLee,تYingتWang,تJudy Wai PingتYam,تTan-ToتCheung,تXinyuanتGuan,تIrene Oi-LinتNg
doi : 10.1136/gutjnl-2022-327998
ObjectiveتGrowing evidence indicates that tumour cells exhibit characteristics similar to their lineage progenitor cells. We found that S100 calcium binding protein A10 (S100A10) exhibited an expression pattern similar to that of liver progenitor genes. However, the role of S100A10 in hepatocellular carcinoma (HCC) progression is unclear. Furthermore, extracellular vesicles (EVs) are critical mediators of tumourigenesis and metastasis, but the extracellular functions of S100A10, particularly those related to EVs (EV-S100A10), are unknown.
Randomised phase 2 study (JADE) of the HBV capsid assembly modulator JNJ-56136379 with or without a nucleos(t)ide analogue in patients with chronic hepatitis B infection
Harry L AتJanssen,تJinlinتHou,تTarikتAsselah,تHenry L YتChan,تFabienتZoulim,تYasuhitoتTanaka,تEwaتJanczewska,تRonald GتNahass,تStefanتBourgeois,تMariaتButi,تPietroتLampertico,تOliverتLenz,تThierryتVerbinnen,تJorisتVandenbossche,تWillemتTalloen,تRonaldتKalmeijer,تMariaتBeumont,تMichaelتBiermer,تUmeshتShukla
doi : 10.1136/gutjnl-2022-328041
ObjectiveتWe present the final analysis results of the phase 2 JADE study (ClinicalTrials.gov Identifier:تNCT03361956).
Diagnostic accuracy of FibroScan-AST (FAST) score for the non-invasive identification of patients with fibrotic non-alcoholic steatohepatitis: a systematic review and meta-analysis
FedericoتRavaioli,تEltonتDajti,تAlessandroتMantovani,تPhilip NoelتNewsome,تGiovanniتTargher,تAntonioتColecchia
doi : 10.1136/gutjnl-2022-328689
ObjectiveتA simple combined score with liver stiffness, controlled attenuation parameter and serum aspartate aminotransferase (AST), the FibroScan-AST (FAST) score, has been proposed to non-invasively identify patients with fibrotic non-alcoholic steatohepatitis (NASH). We performed a systematic review and meta-analysis of published studies to evaluate the overall diagnostic accuracy of the FAST score in identifying patients with fibrotic NASH.
LAMS versus plastic stents for infected pancreatic walled off necrosis (WON): has the addition of the TENSION trial to the AXIOMA study eased the tension?
AvinashتTiwari,تAltafتShah,تJaswinderتSingh
Unravelling the risk of developing gastric cancer in autoimmune gastritis
Unravelling the risk of developing gastric cancer in autoimmune gastritis
Single-cell gene expression links SARS-CoV-2 infection and gut serotonin
Alyce MتMartin,تMichaelتRoach,تLauren AتJones,تDanielتThorpe,تRosemary AتColeman,تCaitlinتAllman,تRobertتEdwards,تDamien JتKeating
Ageing trajectory of the gut microbiota is associated with metabolic diseases in a chronological age-dependent manner
JingXiangتFu,تWenتQiu,تHuiminتZheng,تCancanتQi,تShixianتHu,تWeiتWu,تHuidiتWang,تGuangyanتWu,تPeihuaتCao,تZhenchaoتMa,تChaoتZheng,تWen-JunتMa,تHong-WeiتZhou,تYanتHe
Comparative effects of non-alcoholic fatty liver disease and metabolic dysfunction-associated fatty liver disease on risk of incident cardiovascular events: a meta-analysis of about 13 million individuals
AlessandroتMantovani,تAlessandroتCsermely,تHerbertتTilg,تChristopher DتByrne,تGiovanniتTargher
Sudden onset of multiple seborrhoeic keratoses in a patient with well-differentiated neuroendocrine tumours of the gut
VeronikaتSchmidt,تRolandتBlum,تMatthiasتMڑhrenschlager
