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Engineered IFN-α and anti-PDL1 containing compounds to target the liver and restore antiviral protection for HBV cure
Paola Fisicaro
doi : 10.1136/gutjnl-2022-328902
August 2023 - Volume 72 - 8
Meltdown of the cold tumour microenvironment: a new ‘translational’ approach to augment immunotherapy efficacy
Alfred Sze-Lok Cheng
‘Invisible’ immune checkpoint molecule causing resistance to anti-PD1 therapy in HCC
Tim FÂ Greten
Long versus short peroral endoscopic myotomy for the treatment of achalasia: results of a non-inferiority randomised controlled trial
Pietro Familiari, Federica Borrelli de Andreis, Rosario Landi, Francesca Mangiola, Ivo Boskoski, Andrea Tringali, Vincenzo Perri, Guido Costamagna
Dose escalation randomised study of efmarodocokin alfa in healthy volunteers and patients with ulcerative colitis
Frank Wagner, John C Mansfield, Annemarie N Lekkerkerker, Yehong Wang, Mary Keir, Ajit Dash, Brandon Butcher, Brandon Harder, Luz D Orozco, Jordan S Mar, Hao Chen, Michael E Rothenberg
Haim Leibovitzh, Sun-Ho Lee, Juan Antonio Raygoza Garay, Osvaldo Espin-Garcia, Mingyue Xue, Anna Neustaeter, Ashleigh Goethel, Hien Q Huynh, Anne M Griffiths, Dan Turner, Karen L Madsen, Paul Moayyedi, A Hillary Steinhart, Mark S Silverberg, Colette Deslandres, Alain Bitton, David R Mack, Kevan Jacobson, Maria Cino, Guy Aumais, Charles N Bernstein, Remo Panaccione, Batia Weiss, Jonas Halfvarson, Wei Xu, Williams Turpin, Kenneth Croitoru
Immune response and barrier dysfunction-related proteomic signatures in preclinical phase of Crohn’s disease highlight earliest events of pathogenesis
Faecal metabolome and its determinants in inflammatory bowel disease
Arnau Vich Vila, Shixian Hu, Sergio Andreu-Sánchez, Valerie Collij, Bernadien H Jansen, Hannah E Augustijn, Laura A Bolte, Renate A A A Ruigrok, Galeb Abu-Ali, Cosmas Giallourakis, Jessica Schneider, John Parkinson, Amal Al-Garawi, Alexandra Zhernakova, Ranko Gacesa, Jingyuan Fu, Rinse K Weersma
Gut microbiome modulates the effects of a personalised postprandial-targeting (PPT) diet on cardiometabolic markers: a diet intervention in pre-diabetes
Orly Ben-Yacov, Anastasia Godneva, Michal Rein, Smadar Shilo, Maya Lotan-Pompan, Adina Weinberger, Eran Segal
Targeting m6A reader YTHDF1 augments antitumour immunity and boosts anti-PD-1 efficacy in colorectal cancer
Yi Bao, Jianning Zhai, Huarong Chen, Chi Chun Wong, Cong Liang, Yanqiang Ding, Dan Huang, Hongyan Gou, Danyu Chen, Yasi Pan, Wei Kang, Ka Fai To, Jun Yu
IL-17A-producing CD8+Â T cells promote PDAC via induction of inflammatory cancer-associated fibroblasts
Felix Simon Ruben Picard, Veronika Lutz, Anna Brichkina, Felix Neuhaus, Teresa Ruckenbrod, Anna Hupfer, Hartmann Raifer, Matthias Klein, Tobias Bopp, Petra Ina Pfefferle, Rajkumar Savai, Immo Prinz, Ari Waisman, Sonja Moos, Hyun-Dong Chang, Stefan Heinrich, Detlef K Bartsch, Malte Buchholz, Shiv Singh, Mengyu Tu, Lukas Klein, Christian Bauer, Robert Liefke, Andreas Burchert, Ho-Ryun Chung, Philipp Mayer, Thomas M Gress, Matthias Lauth, Matthias Gaida, Magdalena Huber
Spatially restricted tumour-associated and host-associated immune drivers correlate with the recurrence sites of pancreatic cancer
Eva Karamitopoulou, Anna Silvia Wenning, Animesh Acharjee, Inti Zlobec, Pauline Aeschbacher, Aurel Perren, Beat Gloor
Patient selection for urgent endoscopic retrograde cholangio-pancreatography by endoscopic ultrasound in predicted severe acute biliary pancreatitis (APEC-2): a multicentre prospective study
Nora D Hallensleben, Pauline M C Stassen, Nicolien J Schepers, Marc G Besselink, Marie-Paule G F Anten, Olaf J Bakker, Thomas L Bollen, David W da Costa, Sven M van Dijk, Hendrik M van Dullemen, Marcel G W Dijkgraaf, Brechje van Eijck, Casper H J van Eijck, Willemien Erkelens, Nicole S Erler, Paul Fockens, Erwin-Jan M van Geenen, Janneke van Grinsven, Wouter L Hazen, Robbert A Hollemans, Jeanin E van Hooft, Jeroen M Jansen, Frank J G M Kubben, Sjoerd D Kuiken, Alexander C Poen, Rutger Quispel, Rogier J de Ridder, Tessa E H Römkens, Erik J Schoon, Matthijs P Schwartz, Tom C J Seerden, Xavier J N M Smeets, B W Marcel Spanier, Adriaan C I T L Tan, Willem J Thijs, Robin Timmer, Devica S Umans, Niels G Venneman, Robert C Verdonk, Frank P Vleggaar, Wim van de Vrie, Roy L J van Wanrooij, Ben J Witteman, Hjalmar C van Santvoort, Stefan A W Bouwense, Marco J Bruno
Engineered anti-PDL1 with IFNα targets both immunoinhibitory and activating signals in the liver to break HBV immune tolerance
Chao-Yang Meng, Shiyu Sun, Yong Liang, Hairong Xu, Chao Zhang, Min Zhang, Fu-Sheng Wang, Yang-Xin Fu, Hua Peng
Targeting tumour-intrinsic N7-methylguanosine tRNA modification inhibits MDSC recruitment and improves anti-PD-1 efficacy
Haining Liu, Xuezhen Zeng, Xuxin Ren, Yifan Zhang, Manling Huang, Li Tan, Zihao Dai, Jiaming Lai, Wenxuan Xie, Zebin Chen, Sui Peng, Lixia Xu, Shuling Chen, Shunli Shen, Ming Kuang, Shuibin Lin
doi : 10.1136/gutjnl-2022-327230
Objective Intrahepatic cholangiocarcinoma (ICC) exhibits very low response rate to immune checkpoint inhibitors (ICIs) and the underlying mechanism is largely unknown. We investigate the tumour immune microenvironment (TIME) of ICCs and the underlying regulatory mechanisms with the aim of developing new target to inhibit tumour growth and improve anti-programmed cell death protein-1 (PD-1) efficacy.
Isoformic PD-1-mediated immunosuppression underlies resistance to PD-1 blockade in hepatocellular carcinoma patients
Zhiwu Tan, Mei Sum Chiu, Xinxiang Yang, Ming Yue, Tan To Cheung, Dongyan Zhou, Yuewen Wang, Anthony Wing-Hung Chan, Chi Wing Yan, Ka Yi Kwan, Yik Chun Wong, Xin Li, Jingying Zhou, Ka Fai To, Jiye Zhu, Chung Mau Lo, Alfred Sze-Lok Cheng, Stephen Lam Chan, Li Liu, You-Qiang Song, Kwan Man, Zhiwei Chen
doi : 10.1136/gutjnl-2022-327133
Objective Immune checkpoint blockade (ICB) has improved cancer treatment, yet why most hepatocellular carcinoma (HCC) patients are resistant to PD-1 ICB remains elusive. Here, we elucidated the role of a programmed cell death protein 1 (PD-1) isoform, Δ42PD-1, in HCC progression and resistance to nivolumab ICB.
Sympathetic nervous activation, mitochondrial dysfunction and outcome in acutely decompensated cirrhosis: the metabolomic prognostic models (CLIF-C MET)
Emmanuel Weiss, Carlos de la Peña-Ramirez, Ferran Aguilar, Juan-Jose Lozano, Cristina Sánchez-Garrido, Patricia Sierra, Pedro Izquierdo-Bueno Martin, Juan Manuel Diaz, François Fenaille, Florence A Castelli, Thierry Gustot, Wim Laleman, AgustÃn Albillos, Carlo Alessandria, Marco Domenicali, Paolo Caraceni, Salvatore Piano, Faouzi Saliba, Stefan Zeuzem, Alexander L Gerbes, Julia A Wendon, Christian Jansen, Wenyi Gu, Maria Papp, Raj Mookerjee, Carmine Gabriele Gambino, Cesar Jiménez, Ilaria Giovo, Giacomo Zaccherini, Manuela Merli, Antonella Putignano, Frank Erhard Uschner, Thomas Berg, Tony Bruns, Christian Trautwein, Alexander Zipprich, Rafael Bañares, José Presa, Joan Genesca, Victor Vargas, Javier Fernández, Mauro Bernardi, Paolo Angeli, Rajiv Jalan, Joan Claria, Christophe Junot, Richard Moreau, Jonel Trebicka, Vicente Arroyo
doi : 10.1136/gutjnl-2022-328708
Background and aims Current prognostic scores of patients with acutely decompensated cirrhosis (AD), particularly those with acute-on-chronic liver failure (ACLF), underestimate the risk of mortality. This is probably because systemic inflammation (SI), the major driver of AD/ACLF, is not reflected in the scores. SI induces metabolic changes, which impair delivery of the necessary energy for the immune reaction. This investigation aimed to identify metabolites associated with short-term (28-day) death and to design metabolomic prognostic models.
Emerging interleukin targets in the tumour microenvironment: implications for the treatment of gastrointestinal tumours
Lindsay Kathleen Dickerson, Jason A Carter, Karan Kohli, Venu G Pillarisetty
Timing of energy intake and the therapeutic potential of intermittent fasting and time-restricted eating in NAFLD
Thomas Marjot, Jeremy W Tomlinson, Leanne Hodson, David W Ray
Epidemiology of inflammatory bowel disease in men with high-risk homosexual activity
Emad Mansoor, Scott A Martin, Abe Perez, Vu Quang Nguyen, Jeffry A Katz, Shubham Gupta, Fabio Cominelli
Role of the DOMINO diet application for managing IBS in primary care and beyond
Jan Tack, Karen Van den Houte, Florencia Carbone
Microbiome variance of the small bowel in Crohn’s disease
Lucas Wauters, Raul Y Tito, Matthias Ceulemans, An Outtier, Leen Rymenans, Chloë Verspecht, João Sabino, Marc Ferrante, Séverine Vermeire, Tim Vanuytsel, Jeroen Raes
Most excess years of potential life loss among individuals with cirrhosis during the pandemic were not related to COVID-19
Yunyu Zhao, Yee Hui Yeo, Jamil Samaan, Fan Lv, Xinyuan He, Ning Gao, Justin Park, Ju Dong Yang, Walid Ayoub, Michelle C Odden, Fanpu Ji, Mindie H Nguyen
Blood and guts
Robin John Dart, Mallika Sekhar, Katie Planche, Martyn Caplin, Charles Murray
