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Notch signalling mediates OA pain in mice
Jessica McHughÂÂ
doi : 10.1038/s41584-023-00989-3
Volume 19 Issue 7, July 2023
Bone-forming properties of an ascorbic acid derivative
Robert PhillipsÂÂ
Cognitive functional therapy improves low back pain
Jessica McHughÂ
High risk of autoimmune diseases after COVID-19
Chetan Sharma & Jagadeesh BayryÂ
Down syndrome: insights into autoimmune mechanisms
Bernard Khor & Jane H. BucknerÂ
Failure of cartilage regeneration: emerging hypotheses and related therapeutic strategies
Sathish Muthu, Jasmijn V. Korpershoek, Emanuel J. Novais, Gwenllian F. Tawy, Anthony P. Hollander & Ivan MartinÂ
doi : 10.1038/s41584-023-00979-5
Osteoarthritis (OA) is a disabling condition that affects billions of people worldwide and places a considerable burden on patients and on society owing to its prevalence and economic cost. As cartilage injuries are generally associated with the progressive onset of OA, robustly effective approaches for cartilage regeneration are necessary.
Shared inflammatory pathways of rheumatoid arthritis and atherosclerotic cardiovascular disease
Brittany N. Weber, Jon T. Giles & Katherine P. LiaoÂ
doi : 10.1038/s41584-023-00969-7
The association between chronic inflammation and increased risk of cardiovascular disease in rheumatoid arthritis (RA) is well established. In the general population, inflammation is an established independent risk factor for cardiovascular disease, and much interest is placed on controlling inflammation to reduce cardiovascular events.
Bone marrow lesions: plugging the holes in our knowledge using animal models
Rebecca T. Hansen, Chantal Chenu, Nidhi Sofat & Andrew A. PitsillidesÂ
doi : 10.1038/s41584-023-00971-z
Bone marrow lesions (BMLs), which are early signs of osteoarthritis (OA) that are associated with the presence, onset and severity of pain, represent an emerging imaging biomarker and clinical target. Little is known, however, regarding their early spatial and temporal development, structural relationships or aetiopathogenesis, because of the sparsity of human early OA imaging and paucity of relevant tissue samples.
Disease stratification in GCA and PMR: state of the art and future perspectives
Alessandro Tomelleri, Kornelis S. M. van der Geest, Muhammad Asim Khurshid, Alwin Sebastian, Fiona Coath, Daniel Robbins, Barbara Pierscionek, Christian Dejaco, Eric Matteson, Yannick van Sleen & Bhaskar DasguptaÂ
doi : 10.1038/s41584-023-00976-8
Giant cell arteritis (GCA) and polymyalgia rheumatica (PMR) are closely related conditions characterized by systemic inflammation, a predominant IL-6 signature, an excellent response to glucocorticoids, a tendency to a chronic and relapsing course, and older age of the affected population.
