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Cover Image
Andreas Nikolis,Kaitlyn M. Enright,?ke ?hrlund,Per Winl?f,Sebastian Cotofana
doi : 10.1111/jocd.14144
Volume 20, Issue 5 p. i-i
The cover image is based on the Original Article A randomized, split-face, double-blind, comparative study of the safety and efficacy of small- and large-particle hyaluronic acid fi llers for the treatment of nasolabial folds by Andreas Nikolis et al
JCD — Editorial Commentary, May, 2021
Debraj Shome MD, FRCS, FACS, FAACS, MBA Michael H. Gold MD
doi : 10.1111/jocd.14123
Volume 20, Issue 5 p. 1359-1360
Microbotox for the treatment of wide facial pores: A promising therapeutic approach
Yasmina Ahmed El Attar MD Ahmad Nofal MD
doi : 10.1111/jocd.13675
Volume 20, Issue 5 p. 1361-1366
Microbotox is the injection of multiple microdroplets of diluted onabotulinum toxin A into the upper dermis. It has been previously used in one study only to decrease pore size and to improve skin texture.
Bioactivity of abobotulinum toxin is preserved till 2 weeks upon storage at room temperature: Half body comparative study on rabbit model
Pelin Esme MD Aysenur Botsali MD Hakan Erbil MD Okan Ali Aksoy Ercan Caliskan MD
doi : 10.1111/jocd.13836
Volume 20, Issue 5 p. 1367-1373
Breakages of the cold chain of botulinum neurotoxin A (BONT?A) preparations is not a rare event and occurs due to several unexpected and unintentional reasons during daily practice and intervention schedules could not be proposed due to the lack of data.
Botulinum toxin type A attenuates hypertrophic scar formation via the inhibition of TGF??1/Smad and ERK pathways
Yue?Hua Li MD Jiaomei Yang PhD Zhao Zheng MD Da?Hai Hu PhD Zhi?Dong Wang MD
doi : 10.1111/jocd.13842
Volume 20, Issue 5 p. 1374-1380
Hypertrophic scar is a common complication in would healing process, and how to effectively prevent and treat it has been a hot and difficult research issue. Previous studies have showed that botulinum toxin type A (BTA) has effects on the prevention and treatment of hypertrophic scar, but little is known about the specific mechanisms.
An unusual adverse event of botulinum toxin injection in the lower face
Mariam Patr?cia Auada Souto MD, PhD Lu?s Ricardo Martinh?o Souto MD, PhD
doi : 10.1111/jocd.13869
Volume 20, Issue 5 p. 1381-1384
In the lower third of the face, botulinum toxin A is used to obtain a more harmonious contour. The anatomical complexity of the face requires a more precise application of botulinum toxin.
To click or not to click – The importance of understanding the layers of the forehead when injecting neuromodulators – A clinical, prospective, interventional, split?face study
Kristina Davidovic MD Dmitry V. Melnikov MD, PhD Konstantin Frank MD Diana Gavril MD Jeremy B. Green MD David L. Freytag Stephan Heisinger MD Tatjana Pavicic MD Michael H. Gold MD Sebastian Cotofana MD, PhD
doi : 10.1111/jocd.13875
Volume 20, Issue 5 p. 1385-1392
Differences in the effectiveness of neuromodulator treatments for horizontal forehead lines dependent on depth of product administration have been described. However, knowledge in respect to the fascial anatomy of the forehead still remains elusive.
Botulinum toxin A as monotherapy for syringoma
José Luis Zaldivar?Fujigaki MSc Lucia Achell Nava MD
doi : 10.1111/jocd.13919
Volume 20, Issue 5 p. 1393-1395
Syringoma is a benign adnexal tumor of the skin originating from the eccrine sweat duct.
Botulinum toxin in treating Hailey?Hailey disease: A systematic review
Hanlin Zhang B.S. Keyun Tang B.S. Yuchen Wang B.S. Rouyu Fang M.D. Qiuning Sun M.D.
doi : 10.1111/jocd.13963
Volume 20, Issue 5 p. 1396-1402
Hailey?Hailey disease is a rare disorder characterized by recurrent painful blistering, erosions, maceration in the intertriginous regions. Botulinum toxin has been used in the treatment of Hailey?Hailey disease.
Improvement of en coup de sabre after botulinum toxin injection
Aslan Yürekli MD
doi : 10.1111/jocd.13974
Volume 20, Issue 5 p. 1403-1404
Influence of botulinum toxin type A esthetic injections on facial expressions
Rémi Foissac MD Marc J. Benatar MD
doi : 10.1111/jocd.13980
Volume 20, Issue 5 p. 1405-1410
Botulinum toxin type A (BoNT?A) injection remains the leading medical cosmetic procedure worldwide, with a high rate of patient satisfaction.
The healing effects of facial BOTOX injection on symptoms of depression alongside its effects on beauty preservation
Mohammad Khademi MD Masoumeh Roohaninasab MD Azadeh Goodarzi MD Farnoosh Seirafianpour MD Milad Dodangeh MD Arash Khademi MD
doi : 10.1111/jocd.13990
Volume 20, Issue 5 p. 1411-1415
Beauty is closely associated with a sense of calm, confidence, and hope for a better life.
Non?tuberculous mycobacterial infection post botulinum toxin injection
Rajat Kandhari MD
doi : 10.1111/jocd.14018
Volume 20, Issue 5 p. 1416-1417
Management of nail psoriasis with a single injection of abobotulinum toxin
Ay?enur Botsali MD .Hakan Erbil MD
doi : 10.1111/jocd.13633
Volume 20, Issue 5 p. 1418-1420
Nail psoriasis is challenging; as topical agents generally fail and systemic therapies are doubted especially when the involvement of the skin is rather localized.
Injectable Platelet?Rich Fibrin (PRF): The newest biomaterial and its use in various dermatological conditions in our practice: A case series
Bansod Shashank .Madke Bhushan
doi : 10.1111/jocd.13742
Volume 20, Issue 5 p. 1421-1426
Injectable platelet?rich fibrin (I?PRF) is a second generation, fully autologous, blood?derived biomaterial having three?dimensional fibrin meshwork, like that of a PRF clot, while retaining the fluid nature, just like platelet?rich plasma (PRP).
Evaluation of adding platelet?rich plasma to combined medical therapy in androgenetic alopecia
Wafaa Mohammad Ramadan Arwa Mohammad Hassan Mayada A. Ismail Yasmina Ahmed El Attar
doi : 10.1111/jocd.13935
Volume 20, Issue 5 p. 1427-1434
Androgenetic alopecia (AGA) is a common hair loss disorder.
Safety in immediate reconstitution of poly?l?lactic acid for facial biostimulation treatment
Bruna Souza Felix Bravo MD Raquel de Melo Carvalho MD
doi : 10.1111/jocd.13597
Volume 20, Issue 5 p. 1435-1438
Poly?L?lactic acid is presented as freeze?dried preparation of 150 mg per vial and, according to consensus, the recommendation on your preparation is hydrate in sterile water for injection (SWFI) or bacteriostatic water at room temperature for ?24 hours.
Ultrasound assessment of tissue integration of the crosslinked hyaluronic acid filler VYC?25L in facial lower?third aesthetic treatment: A prospective multicenter study
Fernando Urdiales?G?lvez MD Jord?n Barres?Caballer MD Sara Carrasco?S?nchez MD
doi : 10.1111/jocd.13632
Volume 20, Issue 5 p. 1439-1449
Dermal fillers have become an integral part of any aesthetic physician's intervention.
A randomized, split?face, double?blind, comparative study of the safety and efficacy of small? and large?particle hyaluronic acid fillers for the treatment of nasolabial folds
Andreas Nikolis Kaitlyn M. Enright ?ke ?hrlund Per Winl?f Sebastian Cotofana
doi : 10.1111/jocd.13668
Volume 20, Issue 5 p. 1450-1458
Injections of hyaluronic acid (HA) for tissue augmentation are one of the most common aesthetic treatments performed worldwide. However, few studies have compared the safety and efficacy of small? and large?particle HA (SP?HA; LP?HA).
Evaluating an incobotulinumtoxinA and Cohesive Polydensified Matrix® hyaluronic acid filler combination to treat moderate?to?severe periorbital and perioral rhytids
Sheila C. Barbarino MD, FACS Julie A. Woodward MD Jennifer Levine MD, PLLC John Fezza MD
doi : 10.1111/jocd.13745
Volume 20, Issue 5 p. 1459-1466
To evaluate the effectiveness of treating mimetic facial lines with an incobotulinumtoxinA (INCO) and Cohesive Polydensified Matrix® hyaluronic acid (CPM?HA) combination.
Efficacy and safety of a new hyaluronic acid filler for nasolabial folds: A 52?week, multicenter, randomized, evaluator/subject?blind, split?face study
Hye In Cheon MD, PhD Jin Hee Kim MD Beom Joon Kim MD, PhD Yang Won Lee MD, PhD
doi : 10.1111/jocd.13773
Volume 20, Issue 5 p. 1467-1473
Hyaluronic acid fillers are known to be effective for correction of nasolabial folds. Recently, a novel biphasic hyaluronic acid filler incorporating lidocaine, DIVAVIVA medium has been introduced.
A hyaluronic acid?based filler reduces lipolysis in human mature adipocytes and maintains adherence and lipid accumulation of long?term differentiated human preadipocytes
Karim Nadra PhD Mathilde André BSc Emmanuelle Marchaud MSc Philippe Kestemont MD Frédéric Braccini MD Hugues Cartier MD Mayoura Kéophiphath PhD Ferial Fanian MD
doi : 10.1111/jocd.13794
Volume 20, Issue 5 p. 1474-1482
The beneficial role of subcutaneous adipose tissue in skin rejuvenation derived from its capacity to fill the under?layer volumes but also from its ability to regulate the extracellular matrix production by dermis fibroblasts. Hyaluronic acid (HA), a major component of the extracellular matrix, is a commonly used injectable dermal filler showing excellent efficiencies to maintain tissue augmentation even after its biodegradation
Late onset hypersensitivity reaction to hyaluronic acid dermal fillers manifesting as cutaneous and visceral angioedema
Amal Z. Alawami MD Zeina Tannous MD
doi : 10.1111/jocd.13894
Volume 20, Issue 5 p. 1483-1485
Hyaluronic acid fillers are gaining popularity all across the globe. Although this aesthetic treatment is considered relatively safe, or that most unwanted effects are related to technical faults of the injections or infections, hypersensitivity reactions are being reported in acute or delayed forms. We herein describe an unusual case of hypersensitivity reaction to hyaluronic acid dermal fillers of 12?month latency, manifesting as cutaneous and visceral angioedema, and refractory to steroids, antihistamines and omalizumab.
Physicians' and patients' self?perceptions of hyaluronic acid–based facial volumization: Are they compatible?
Rodrigo Amaral Lima MD, MSc Isabel Cristina Gomes Moura STAT, PhD Jo?o Bayama Galv?o Pitoni MD Marcia Ramos?e?Silva MD, PhD Adilson da Costa MD, MSc, PhD
doi : 10.1111/jocd.13928
Volume 20, Issue 5 p. 1486-1494
Facial filling based on hyaluronic acid (HA) is an esthetic procedure that is widely performed worldwide.
Enhanced patient retention after combination vs single modality treatment using hyaluronic acid filler and neuromodulator: A multicenter, retrospective review by The Flame Group
Shannon Humphrey MD, FRCPC Ada Trindade de Almeida MD Marva Safa MD Izolda Heydenrych MD Stefania Roberts MD Jonquille Chantrey MD Patricia Ogilvie MD
doi : 10.1111/jocd.13856
Volume 20, Issue 5 p. 1495-1498
It is believed that combination treatment with both neuromodulators (NM) and hyaluronic acid soft?tissue fillers (HA) results in superior aesthetic results and increased patient satisfaction compared to either treatment alone.
Subject and partner satisfaction with lip and perioral enhancement using flexible hyaluronic acid fillers
Vince Bertucci MD, FRCPC Andreas Nikolis MD Nowell Solish MD Vanessa Lane PhD Jessica Hicks PhD
doi : 10.1111/jocd.13956
Volume 20, Issue 5 p. 1499-1504
The injection of hyaluronic acid (HA) dermal fillers is a popular minimally invasive approach to improve lip volume and contour, and with improved techniques has gained popularity because full lips are often associated with beauty and youth. Patient satisfaction is a key driver for successful aesthetic procedures, influencing individual treatment plans and future recommendations.
Acute isolated trigeminal neuropathy following calcium hydroxylapatite?based soft tissue filler injection: A case report
Leniza Mingazova MD Elena Karpova MD, PhD Stanislav Murakov MD, PhD Olga Orlova MD, PhD Valery Golubev MD PhD Sebastian Cotofana MD, PhD
doi : 10.1111/jocd.13959
Volume 20, Issue 5 p. 1505-1511
Soft tissue filler injections are frequently performed with a relatively low number of severe adverse events reported. While venous complications have been described, the majority of adverse events are generally associated with the arterial vascular system
Comparison of 2.5% agarose gel vs hyaluronic acid filler, for the correction of moderate to severe nasolabial folds
Nicol? Scuderi MD Benedetta Fanelli MD Pasquale Fino MD Brian M. Kinney MD, MSME, FACS
doi : 10.1111/jocd.13962
Volume 20, Issue 5 p. 1512-1519
Agarose gel filler is a natural hydrocolloid with a three?dimensional structure similar to the extracellular matrix, with gel formed by hydrogen bonds and electrostatic interactions rather than through chemical cross?linking or polymerization.
Quantifiable clinical efficacy of injectable porcine collagen for the treatment of structural dark circles
Rui Zhao MD He Qiu MD Shuo Liu MD Lideng Cao MD Donglei Yu MD Hang Wang MD, PhD
doi : 10.1111/jocd.13982
Volume 20, Issue 5 p. 1520-1528
Dark circles are one of the most perplexing cosmetic problems for modern people. Nowadays, a new porcine collagen filler has been popular in China and many countries and has high safety.
Filler?induced granuloma from polycaprolactone?based collagen stimulator injection in the tear trough area: A case report
Chi?Hsuan Chiang MD Jui?Hui Peng MD Hsien?Li Peter Peng MD
doi : 10.1111/jocd.14010
Volume 20, Issue 5 p. 1529-1531
The clinical spectrum of periorbital vascular complications after facial injection
Ko?Eun Lee MD Gye?Jung Kim MD Ho?Seok Sa MD, PhD
doi : 10.1111/jocd.14019
Volume 20, Issue 5 p. 1532-1540
Serious complications due to periorbital vascular occlusion can occur after facial injections, including skin necrosis, ophthalmoplegia, blepharoptosis, and visual loss. Visual loss after facial filler injection is particularly rare, but it is known to have a poor prognosis despite treatment.
Ultrasound patterns of different dermal filler materials used in aesthetics
Fernando Urdiales?G?lvez MD Francisco M. De cabo?Francés MD Isabel Bové MD
doi : 10.1111/jocd.14032
Volume 20, Issue 5 p. 1541-1548
Hyaluronic acid (HA) injection procedures has experienced an unprecedented increase.
Delayed hypersensitivity reaction to hyaluronic acid dermal filler post?COVID?19 viral infection
Debraj Shome MD, FRCS, FACS, FAACS, MBA Komal Doshi MDS Sapna Vadera MDS Rinky Kapoor MD
doi : 10.1111/jocd.14046
Volume 20, Issue 5 p. 1549-1550
Comparison of hyaluronic acid filler ejection pressure with injection force for safe filler injection
Yongkoo Lee PhD Seung Min Oh MD, MMBA Won Lee MD, PhD Eun?Jung Yang MD, PhD
doi : 10.1111/jocd.14064
Volume 20, Issue 5 p. 1551-1556
Owing to the increase in the number of medical procedures performed every year, the frequency of filler injection?related complications has also increased.
Hypersensitivity reaction to Hyaluronic Acid Dermal filler following novel Coronavirus infection – a case report
MJ Rowland?Warmann BDS, MSc Aes Med, MClinDent Orthod, MJDF
doi : 10.1111/jocd.14074
Volume 20, Issue 5 p. 1557-1562
The incidence of hypersensitivity reactions to hyaluronic acid dermal fillers is between 0.3 and 4.25%, mediated by T?lymphocytes. Flu?like illness can trigger immunogenic reactions at the site of filler placement.
