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Comments on nitric oxide in children with asthma, low-dose oral immunotherapy for cow's milk allergy, and SARS-Cov-2 testing in school children
Philippe Eigenmann
doi : 10.1111/pai.13499
Volume 32, Issue 4 p. 631-634
PAI regularly publishes reviews to update you on major topics. This issue features a first review article on pediatric rhinitis by Papadopoulos and colleagues, followed by an update on food allergy written by current and past associate editors.
New concepts in pediatric rhinitis
Nikolaos G. Papadopoulos, Xenophon Aggelides, Sofia Stamataki, Emmanuel Prokopakis, Michael Katotomichelakis, Paraskevi Xepapadaki
doi : 10.1111/pai.13454
Volume 32, Issue 4 p. 635-646
Rhinitis—and especially allergic rhinitis (AR)—remains the most frequent hypersensitivity condition, affecting up to a quarter of the population and impacting the quality of life of individual patients and the health economy.
Update on food allergy
Rachel L. Peters, Marta Krawiec, Jennifer J. Koplin, Alexandra F. Santos
doi : 10.1111/pai.13443
Volume 32, Issue 4 p. 647-657
Food allergy is a major public health issue with growing prevalence in the urbanized world and significant impact on the lives of allergic patients and their families.
Addressing risk management difficulties in children with food allergies
Philippe A. Eigenmann, Motohiro Ebisawa, Matthew Greenhawt, Jonathan O’B Hourihane, Tamara T. Perry, Benjamin C. Remington, Robert A. Wood
doi : 10.1111/pai.13455
Volume 32, Issue 4 p. 658-666
Risk is a concept inherent in every medical procedure. It can be defined as the probability of an adverse event in a defined population over a specified period of time.
Hydrolysed formula and allergy prevention
Jon Genuneit, Robert J. Boyle
doi : 10.1111/pai.13470
Volume 32, Issue 4 p. 667-669
no Abstract
Effect of extensively hydrolyzed casein vs. conventional formula on the risk of asthma and allergies: The TRIGR randomized clinical trial
Suvi M. Virtanen, David Cuthbertson, Marisa Couluris, Erkki Savilahti, Mikael Knip, Jeffrey P. Krischer, the TRIGR Investigators
doi : 10.1111/pai.13452
Volume 32, Issue 4 p. 670-678
The role of hydrolyzed infant formulas in the prevention of asthma and allergies remains inconsistent. We tested whether extensively hydrolyzed casein formula compared to conventional cow's milk–based formula prevented asthma, allergic rhinitis, or atopic eczema.
High-dose vitamin D during pregnancy and pathway gene polymorphisms in prevention of offspring persistent wheeze
Nicklas Brustad, Jens H. Greve, Hooman Mirzakhani, Casper-Emil T. Pedersen, Anders U. Eliasen, Jakob Stokholm, Jessica Lasky-Su, Klaus B?nnelykke, Augusto A. Litonjua, Scott T. Weiss, Hans Bisgaard, Bo L. Chawes
doi : 10.1111/pai.13453
Volume 32, Issue 4 p. 679-689
Randomized controlled trials (RCTs) suggest a protective effect of high-dose vitamin D supplementation in pregnancy on offspring risk of persistent wheeze, but only in some individuals, which might be explained by variations in vitamin D pathway genes. This study aimed to investigate the effect of vitamin D supplementation by maternal and offspring vitamin D receptor (VDR) genotype and GC genotype, encoding vitamin D binding protein (VDBP), in two RCTs.
Neonatal jaundice, phototherapy and childhood allergic diseases: An updated systematic review and meta-analysis
Yasutaka Kuniyoshi, Yasushi Tsujimoto, Masahiro Banno, Shunsuke Taito, Takashi Ariie
doi : 10.1111/pai.13456
Volume 32, Issue 4 p. 690-701
Neonatal jaundice and phototherapy have been associated with the development of allergic diseases. It has been suggested, however, that effect estimates of the associations might be smaller than expected. We sought to update the evidence of their associations including recently published large longitudinal studies.
Emergence of pollen food allergy syndrome in asthmatic children in Paris
Christine Loraud, Charlotte Thibaut de Ménonville, Mélisande Bourgoin-Heck, Nathalie Cottel, Stéphanie Wanin, Jocelyne Just
doi : 10.1111/pai.13435
Volume 32, Issue 4 p. 702-708
Over the last few decades, the level of pollen from birch and homologous trees has increased in parts of Europe. Sensitization to birch pollen allergens (principally Bet v 1) has been associated with food cross-reactivity called pollen food allergy syndrome (PFAS).
Genetic effects of allergen-specific IgE levels on exhaled nitric oxide in schoolchildren with asthma: The STOPPA twin study
Anna M. Hedman, Ralf Kuja-Halkola, Anne K. ?rtqvist, Marianne van Hage, Catarina Almqvist, Bj?rn Nordlund
doi : 10.1111/pai.13438
Volume 32, Issue 4 p. 709-719
Exhaled nitric oxide and blood eosinophils are clinical asthma T-helper type 2 markers in use. Immunoglobulin E (IgE) is often involved in the inflammation associated with atopic asthma. The effect of both blood eosinophils and allergen-specific IgE on exhaled nitric oxide levels is not completely understood.
Safety and effectiveness of omalizumab for the treatment of chronic urticaria in pediatric patients
Coco Dekkers, Mehran Alizadeh Aghdam, Marlies de Graaf, André C. Knulst, Yolanda Meijer, Juul M. P.A. van den Reek, Marike B. Stadermann, Heike R?ckmann
doi : 10.1111/pai.13426
Volume 32, Issue 4 p. 720-726
Evidence on safety and effectiveness of omalizumab for treatment of chronic urticaria in pediatric patients is scarce and limited to case reports. In particular, drug survival of omalizumab has not yet been investigated, which is a key element in the evaluation of its clinical performance. The aim of this study was to investigate safety, effectiveness, and drug survival rates of omalizumab in a daily practice cohort of pediatric patients with chronic urticaria (CU).
The natural course of cow’s milk allergy and the development of atopic diseases into adulthood
Michaela M. Hansen, Susanne P. Nissen, Susanne Halken, Arne H?st
doi : 10.1111/pai.13440
Volume 32, Issue 4 p. 727-733
Previous studies have investigated the natural course of cow's milk allergy (CMA) and development of atopic diseases into adolescence. Studies with long-term follow-up into adulthood are lacking. The aim of this study was to investigate (a) the natural course of CMA in a 1-year birth cohort of Danish children from birth until 15 and 26 years of age and (b) the development of atopic diseases in a group of children with CMA (group A) compared to a random sample of 276 children from the same birth cohort (group B).
Long-term follow-up of fixed low-dose oral immunotherapy for children with severe cow’s milk allergy
Yoko Miura, Ken-ichi Nagakura, Makoto Nishino, Mari Takei, Kyohei Takahashi, Tomoyuki Asaumi, Kiyotake Ogura, Sakura Sato, Motohiro Ebisawa, Noriyuki Yanagida
doi : 10.1111/pai.13442
Volume 32, Issue 4 p. 734-741
The efficacy and safety of cow's milk (CM) low-dose oral immunotherapy (LOIT) at one-year follow-up have been previously reported. We investigated the outcome of fixed long-term LOIT in children with severe CM allergy.
An exploration of factors associated with food protein-induced enterocolitis syndrome: Birth, infant feeding and food triggers
Eric Lee, Elizabeth H. Barnes, Sam Mehr, Dianne E. Campbell
doi : 10.1111/pai.13448
Volume 32, Issue 4 p. 742-749
Food protein-induced enterocolitis syndrome (FPIES) is a non–IgE-mediated food allergic disorder with a well-characterized phenotype, but limited understanding of factors associated with food cross-reactivity, severity and tolerance.
Use of premedication with intravenous immune globulin in Kawasaki disease: A retrospective review
Elaine Liu, Jimmy Gonzalez, Anita Siu
doi : 10.1111/pai.13432
Volume 32, Issue 4 p. 750-755
Kawasaki disease (KD) is a significant febrile illness in children and is the leading cause of acquired pediatric heart disease in developed countries. Its recommended treatment is high-dose intravenous immune globulin (IVIG) plus aspirin.
Association between human leukocyte antigens (HLAs) and human neutrophil antigens (HNAs) and autoimmune neutropenia of infancy in Danish patients
Kaspar René Nielsen, Signe Rolskov Bojsen, Tania Nicole Masmas, Anne-Louise Fjordside, John Baech, Thure Mors Haunstrup, Rudi Steffensen
doi : 10.1111/pai.13450
Volume 32, Issue 4 p. 756-761
Autoimmune neutropenia of infancy (AIN) is a frequent cause of neutropenia in children. The disease is caused by antibodies against epitopes on the immunoglobulin G (IgG) Fc receptor type 3b (Fc?IIIb). We investigated the possible association of human neutrophil antigens (HNA), human leukocyte antigen (HLA)-DR, and HLA-DQ alleles with AIN and the association of these genotypes with the presence of autoantibodies.
Lessons from low seroprevalence of SARS-CoV-2 antibodies in schoolchildren: A cross-sectional study
Zsolt Szépfalusi, Klara Schmidthaler, Justyna Sieber, Sonja Kopanja, Florian G?tzinger, Anja Schoof, Jakub Hoz, Birgit Willinger, Athanasios Makristathis, Lukas Weseslindtner, Karin Stiasny, Barbara Bohle, Pavla Krotka, Alexandra Graf, Thomas Frischer
doi : 10.1111/pai.13459
Volume 32, Issue 4 p. 762-770
Children are discussed as hidden SARS-CoV-2 virus reservoir because of predominantly mild or even asymptomatic course of disease. The objective of this cross-sectional study in May-July 2020 was to assess the prevalence of SARS-CoV-2 antibodies and virus RNA in schoolchildren, consistent with previous infection by contact tracing.
Vitamin D insufficiency is associated with reduced regulatory T cell frequency in food-allergic infants
Melanie R. Neeland, Amanda R. Tursi, Kirsten P. Perrett, Richard Saffery, Jennifer J. Koplin, Kari C. Nadeau, Sandra Andorf
doi : 10.1111/pai.13439
Volume 32, Issue 4 p. 771-775
Machine learning approach and oral food challenge with heated egg
Yasutaka Kuniyoshi, Haruka Tokutake, Natsuki Takahashi, Azusa Kamura, Sumie Yasuda, Makoto Tashiro
doi : 10.1111/pai.13433
Volume 32, Issue 4 p. 776-778
Recurrent food anaphylaxis and risk factors in children
Guillaume Pouessel, Marie Balerdi, Stéphanie Lejeune, Valérie Deken, François Dubos, Matthieu Antoine, Antoine Deschildre, on behalf of the Pediatric Emergency Medicine Group
doi : 10.1111/pai.13429
Volume 32, Issue 4 p. 779-782
Impact of age on adherence and efficacy of peanut oral-immunotherapy using a standardized protocol
Rongbo Zhu, Kara Robertson, Jennifer L.P. Protudjer, Andrea Macikunas, Rebecca Kim, Samira Jeimy, Harold Kim
doi : 10.1111/pai.13447
Volume 32, Issue 4 p. 783-786
Maternal psychological distress during gestation is associated with infant food allergy
Minna Lukkarinen, Emma Puosi, Eeva-Leena Kataja, Laura S. Korhonen, Heikki Lukkarinen, Linnea Karlsson, Hasse Karlsson
doi : 10.1111/pai.13449
Volume 32, Issue 4 p. 787-792
More severe than CVID: Combined immunodeficiency due to a novel NFKB2 mutation
Marc Bienias, Anastasia Gabrielyan, Linda Geberzahn, Angela R?sen-Wolff, Angela Huebner, Eva-Maria Jacobsen, Nicole Toepfner, Mingyan Fang, Min Ae Lee-Kirsch, Joachim Roesler, Catharina Schuetz
doi : 10.1111/pai.13441
Volume 32, Issue 4 p. 793-797
STAT 1 mutation associated with chronic mucocutaneous candidiasis and pancytopenia
Aashima Dabas, Prerna Arora, Somesh Kumar, Seema Kapoor, Sangeeta Yadav
doi : 10.1111/pai.13451
Volume 32, Issue 4 p. 798-800
Peculiar immunophenotypic signature in MIS-C-affected children
Francesco Licciardi, Letizia Baldini, Marco Denina, Emanuela Ricotti, Carlotta Covizzi, Marta Dellepiane, Federica Mignone, Marisa Zoppo, Enrico Felici, Davide Montin
doi : 10.1111/pai.13434
Volume 32, Issue 4 p. 801-804
