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Comments on pollen season changes, vegetable consumption and asthma, and exercise-induced reactions after oral immunotherapy to foods
Philippe Eigenmann
doi : 10.1111/pai.13538
Volume 32, Issue 5 p. 809-812
Eosinophilic gastrointestinal disorders and allergen immunotherapy: Lights and shadows
Martina Votto, Maria De Filippo, Lucia Caminiti, Francesco Carella, Giovanna de Castro, Massimo Landi, Roberta Olcese, Mario Vernich, Gian Luigi Marseglia, Giorgio Ciprandi, Salvatore Barberi
doi : 10.1111/pai.13458
Volume 32, Issue 5 p. 814-823
Allergic diseases, such as IgE-mediated food allergy, asthma, and allergic rhinitis, are relevant health problems worldwide and show an increasing prevalence. Therapies for food allergies are food avoidance and the prompt administration of intramuscular epinephrine in anaphylaxis occurring after accidental exposure. However, allergen immunotherapy (AIT) is being investigated as a new potential tool for treating severe food allergies. Effective oral immunotherapy (OIT) and epicutaneous immunotherapy (EPIT) induce desensitization and restore immune tolerance to the causal allergen. While immediate side effects are well known, the long-term effects of food AIT are still underestimated. In this regard, eosinophilic gastrointestinal disorders (EGIDs), mainly eosinophilic esophagitis, have been reported as putative complications of OIT for food allergy and sublingual immunotherapy (SLIT) for allergic asthma and rhinitis. Fortunately, these complications are usually reversible and the patient recovers after AIT discontinuation. This review summarizes current knowledge on the possible causative link between eosinophilic gastrointestinal disorders and AIT, highlighting recent evidence and controversies.
Skin eruptions in children: Drug hypersensitivity vs viral exanthema
Sophia Tsabouri, Marina Atanaskovic-Markovic
doi : 10.1111/pai.13485
Volume 32, Issue 5 p. 824-834
Childhood rashes or exanthemas are common and are usually relatively benign. There are many causes of rash in children, including mainly viruses, and less often bacterial toxins, drugs, allergens and other diseases. Viral exanthema often appears while children are taking a medication in the course of a viral infection; it can mimic drug exanthema and is perceived as a drug allergy in 10% of cases. In the vast majority of cases, the distinction between virus-induced and drug-induced skin eruption during the acute phase is not possible. The drugs most commonly implicated are beta-lactams (BL) and non-steroidal anti-inflammatory drugs (NSAIDs). Viruses, commonly Epstein-Barr virus (EBV), human herpesvirus 6 (HHV6) and cytomegalovirus (CMV), and the bacterium, Mycoplasma pneumoniae, may cause exanthema either from the infection itself (active or latent) or because of interaction with drugs that are taken simultaneously. Determination of the exact diagnosis requires a careful clinical history and thorough physical examination. Haematological and biochemical investigations and histology are not always helpful in differentiating between the two types of exanthema. Serological and polymerase chain reaction (PCR) assays can be helpful, although a concomitant acute infection does not exclude drug hypersensitivity. A drug provocation test (DPT) is although considered the gold standard for the diagnosis and is not preferred by the patients. Skin tests are not well tolerated, and in vitro tests, such as the basophil activation test and lymphocyte transformation, are of low sensitivity and specificity and their relevance is debatable. Based on current evidence, we propose a systematic clinical approach for timely differential diagnosis and management of rashes in children who present a cutaneous eruption while receiving a drug.
Revisiting Koch's postulate to determine the plausibility of viral transmission by human milk
Philippe Van de Perre, Jean-Pierre Molès, Nicolas Nagot, Edouard Tuaillon, Pierre-Emmanuel Ceccaldi, Ameena Goga, Andrew J. Prendergast, Nigel Rollins
doi : 10.1111/pai.13473
Volume 32, Issue 5 p. 835-842
As breastfeeding is of utmost importance for child development and survival, identifying whether breast milk is a route of transmission for human viruses is critical.
EAACI guideline: Preventing the development of food allergy in infants and young children (2020 update)
Susanne Halken, Antonella Muraro, Debra de Silva, Ekaterina Khaleva, Elizabeth Angier, Stefania Arasi, Hasan Arshad, Henry T. Bahnson, Kirsten Beyer, Robert Boyle, George du Toit, Motohiro Ebisawa, Philippe Eigenmann, Kate Grimshaw, Arne Hoest, Carla Jones, Gideon Lack, Kari Nadeau, Liam O’Mahony, Hania Szajewska, Carina Venter, Valérie Verhasselt, Gary W. K. Wong, Graham Roberts, on behalf of European Academy of Allergy and Clinical Immunology Food Allergy and Anaphylaxis Guidelines Group
doi : 10.1111/pai.13496
Volume 32, Issue 5 p. 843-858
This guideline from the European Academy of Allergy and Clinical Immunology (EAACI) recommends approaches to prevent the development of immediate-onset / IgE-mediated food allergy in infants and young children. It is an update of a 2014 EAACI guideline.
Atopic diseases of the parents predict the offspring's atopic sensitization and food allergy
Kaisa Pyrh?nen, Petri Kulmala
doi : 10.1111/pai.13462
Volume 32, Issue 5 p. 859-871
In genetic studies and selected study populations, parental atopy has been associated with atopic diseases in offspring. Our aim was to identify the association between parental atopic diseases and the offspring's atopic sensitization and food allergies, and their effect modifications due to the offspring's sex.
Increased sensitization rates to tree pollens in allergic children and adolescents and a change in the pollen season in the metropolitan area of Seoul, Korea
Kyung Suk Lee, Kyunghoon Kim, Young-Jin Choi, Seung Yang, Chang-Ryul Kim, Jin-Hwa Moon, Kyu Rang Kim, Yung-Seop Lee, Jae-Won Oh
doi : 10.1111/pai.13472
Volume 32, Issue 5 p. 872-879
Children with allergies are at greater risk of becoming sensitized to allergenic pollens in response to environmental changes. This study investigated the relationship between changes in pollination associated with meteorologic changes and the sensitization rates of children to tree pollen allergens in the metropolitan area of Seoul, Korea.
Association between maternal diabetes mellitus and allergic diseases in children — A systematic review and meta-analysis
Zhi Li, Mei Yu, Pin Wang, Hong Qian, Yun Fan, Xiuzhu Li, Qiaoqiao Xu, Xinru Wang, Xu Wang, Chuncheng Lu
doi : 10.1111/pai.13498
Volume 32, Issue 5 p. 880-891
Existing knowledge suggests that gestational diabetes mellitus was inconsistently associated with offspring allergic diseases. The aim of this study was to identify the association between maternal diabetes mellitus and the risk of offspring allergic diseases by systematic review.
Prepregnancy BMI, gestational weight gain and risk of childhood atopic dermatitis: A systematic review and meta-analysis
Wenshu Chen, Lei Wang, Hao Yao, Huan Dai, Rongying Zheng, Weixi Zhang
doi : 10.1111/pai.13488
Volume 32, Issue 5 p. 892-904
Maternal weight before and during pregnancy influences the health of offspring. Several observational studies have investigated a link between the risk of childhood atopic dermatitis (AD) and prepregnancy maternal body mass index (BMI) and gestational weight gain (GWG), but the conclusions of these studies were inconsistent. The aim of this review was to evaluate the association between the risk of childhood AD and prepregnancy maternal BMI and GWG.
Integrated associations of nasopharyngeal and serum metabolome with bronchiolitis severity and asthma: A multicenter prospective cohort study
Michimasa Fujiogi, Carlos A. Camargo Jr., Yoshihiko Raita, Zhaozhong Zhu, Juan C. Celed?n, Jonathan M. Mansbach, Jonathan M. Spergel, Kohei Hasegawa
doi : 10.1111/pai.13466
Volume 32, Issue 5 p. 905-916
While infant bronchiolitis contributes to substantial acute (eg, severity) and chronic (eg, asthma development) morbidities, its pathobiology remains uncertain. We examined the integrated relationships of local (nasopharyngeal) and systemic (serum) responses with bronchiolitis morbidities.
Parental questionnaires provided reliable data on childhood asthma compared with national registers
Frida Str?mberg Celind, Styliana Vasileiadou, Emma Goks?r
doi : 10.1111/pai.13423
Volume 32, Issue 5 p. 917-924
Much of our knowledge of childhood asthma comes from questionnaire-based studies. Our main aim was to assess the agreement between parental-reported data at 12 years of age and data from two national Swedish registers.
Higher diversity of vegetable consumption is associated with less airway inflammation and prevalence of asthma in school-aged children
Francisca de Castro Mendes, Inês Paciência, Jo?o Cavaleiro Rufo, Mariana Farraia, Diana Silva, Patr?cia Padr?o, Lu?s Delgado, Vanessa Garcia-Larsen, André Moreira, Pedro Moreira
doi : 10.1111/pai.13446
Volume 32, Issue 5 p. 925-936
A diet rich in fruits and vegetables has been suggested to counteract the oxidative stress and inflammation that characterize asthma. We aimed to assess the association between vegetable and fruit diversity consumption and asthma and its related outcomes in school-aged children.
Association of serum periostin levels with clinical features in children with asthma
Süleyman Tolga Yavuz, Soyhan Bagci, Ahmet Bolat, Onur Akin, Rainer Ganschow
doi : 10.1111/pai.13444
Volume 32, Issue 5 p. 937-944
The aim of this study was to investigate the association of serum periostin levels with clinical features in children with asthma.
Cardio-metabolic risk factors during childhood in relation to lung function and asthma
Sara M. Mensink-Bout, Susana Santos, Johan C. de Jongste, Vincent W. V. Jaddoe, Liesbeth Duijts
doi : 10.1111/pai.13509
Volume 32, Issue 5 p. 945-952
Cardio-metabolic risk factors might have an adverse effect on respiratory outcomes, but associations in children are unknown. We aimed to study the longitudinal associations of cardio-metabolic risk factors with lung function and asthma at school age. We also examined whether any association was explained by child's body mass index (BMI).
Systematic evaluation of allergic phenotypes of rhinitis in children and adolescents
Ana Prieto, Carmen Rond?n, Ibon Eguiluz-Gracia, Candelaria Mu?oz, Almudena Testera-Montes, Gador Bogas, Esmeralda Nu?ez Cuadros, Paloma Campo, Maria J. Torres
doi : 10.1111/pai.13474
Volume 32, Issue 5 p. 953-962
Three allergic phenotypes of rhinitis have been described in adults: allergic rhinitis (AR), local allergic rhinitis (LAR), and dual allergic rhinitis (DAR, coexistence of AR and LAR). Nevertheless, most centers follow a diagnostic approach only based on skin prick test and serum allergen–specific IgE (collectively called atopy tests, AT). This approach prevents the recognition of LAR and DAR, the diagnosis of which requires a nasal allergen challenge (NAC). Here, we investigate the existence of LAR and DAR phenotypes in children and adolescents, and the misdiagnosis rate associated with a work-up exclusively based on AT.
‘Stay at home’: Is it good or not for house dust mite sensitized children with respiratory allergies?
Esra Yucel, Ayse Suleyman, Zeynep Hizli Demirkale, Nermin Guler, Zeynep Ulker Tamay, Cevdet Ozdemir
doi : 10.1111/pai.13477
Volume 32, Issue 5 p.963-970
Lockdown was imposed for children for 75 days in Turkey to limit the spread of COVID-19. During this period, children have to stay indoors, which might probably increase their exposures to indoor allergens and pollutants. Besides, reduced exposures to respiratory tract infections and outdoor pollutants might be favorable outcomes of this lockdown period. We evaluated the effects of the lockdown on house dust mite (HDM)–sensitized children with respiratory allergies.
Development of nasal allergen challenge with cockroach in children with asthma
Amanda K. Rudman Spergel, Michelle L. Sever, Jacqueline Johnson, Michelle A. Gill, Veronique Schulten, April Frazier, Carolyn M. Kercsmar, Stephanie Lovinsky-Desir, Dan A. Searing, Alessandro Sette, Baomei Shao, Stephen J. Teach, James E. Gern, William W. Busse, Alkis Togias, Robert A. Wood, Andrew H. Liu, On behalf of the National Institute of Allergy and Infectious Diseases Inner City Asthma Consortium
doi : 10.1111/pai.13480
Volume 32, Issue 5 p. 971-979
Nasal allergen challenge (NAC) could be a means to assess indication and/or an outcome of allergen-specific therapies, particularly for perennial allergens. NACs are not commonly conducted in children with asthma, and cockroach NACs are not well established. This study's objective was to identify a range of German cockroach extract doses that induce nasal symptoms and to assess the safety of cockroach NAC in children with asthma.
Omalizumab outcomes for up to 6 years in pediatric patients with severe persistent allergic asthma
Antonio Nieto Garc?a, Teresa Garriga-Baraut, Ana Mar?a Plaza Mart?n, Mar?a Nieto Cid, Javier Torres Borrego, Mar?a del Mar Folqué Giménez, Jaime Lozano Blasco, Montserrat Bosque Garc?a, Laura Moreno-Galarraga, Miguel Tortajada-Girbés, Cristina Rivas Juesas, Mar?a Pen?n Ant?n, Mar?a Araceli Caballero-Rabasco, Mirella Gaboli, Alejandro L?pez Neyra, Juan Navarro Mor?n, Andrea Freixa Benavente, Laura Valdesoiro Navarrete, Esther Ballester Asensio, Ver?nica Sanz Santiago, Raquel Romero Garc?a, ?lvaro Gimeno D?az de Atauri, Alfredo Valenzuela Soria, Mercedes S?nchez Mateos, José Batlles Garrido, Anselmo Andrés Mart?n, Elena Campos Alonso, Carmen Arag?n Fern?ndez, Elena V?zquez Rodr?guez, Luz Mart?nez Pardo, Genoveva del-R?o Camacho, ?ngel Maz?n Ramos
doi : 10.1111/pai.13484
Volume 32, Issue 5 p. 980-991
Various studies have assessed omalizumab outcomes in the clinical practice setting but follow-up and/or number of patients included were limited. We aim to describe the long-term outcomes of pediatric patients with severe persistent allergic asthma receiving omalizumab in the largest real-life cohort reported to date.
Overweight and exercise-induced bronchoconstriction – Is there a link?
Maiju Malmberg, L. Pekka Malmberg, Anna S. Pelkonen, Mika J. M?kel?, Anne Kotaniemi-Syrj?nen
doi : 10.1111/pai.13492
Volume 32, Issue 5 p. 992-998
The objective of this study was to evaluate the role of body mass index with regard to exercise performance, exercise-induced bronchoconstriction (EIB), and respiratory symptoms in 7- to 16-year-old children.
Chronic urticaria in children – New insights from a large cohort
Idit Lachover-Roth, Ahmad Rabie, Anat Cohen-Engler, Yossi Rosman, Keren Meir-Shafrir, Ronit Confino-Cohen
doi : 10.1111/pai.13457
Volume 32, Issue 5 p. 999-1005
Chronic spontaneous urticaria is well-described in adults, but less so in children. The aim of this study is to describe the demographics, clinical characteristics, comorbidities, and outcomes of children with chronic, spontaneous urticaria.
House dust microbiota and atopic dermatitis; effect of urbanization
Mahboobeh Mahdavinia, Leah R. Greenfield, Donyea Moore, Maresa Botha, Phillip Engen, Claudia Gray, Nonhlanhla Lunjani, Carol Hlela, Wisdom Basera, Lelani Hobane, Alexandra Watkins, Avumile Mankahla, Ben Gaunt, Heidi Facey-Thomas, Alan Landay, Ali Keshavarzian, Michael E. Levin
doi : 10.1111/pai.13471
Volume 32, Issue 5 p. 1006-1012
Previous studies have shown that a child's risk of developing atopic disease is impacted by both genetic and environmental factors. Because small children spend the majority of their time in their homes, exposure to microbial factors in their home environment may be protective or risk factors for development of atopic diseases, such as atopic dermatitis.
Associations between Environmental dust composition and Atopic Dermatitis in urban and rural settings
Thulja Trikamjee, Wisdom Basera, Maresa Botha, Heidi E. Facey-Thomas, Ben Gaunt, Jon Genuneit, Claudia L. Gray, Sabelo Hadebe, Carol Hlela, Frank Kirstein, Nonhlanhla Lunjani, Avumile Mankahla, Jordache Ramjith, Michael Levin
doi : 10.1111/pai.13476
Volume 32, Issue 5 p. 1013-1021
Environmental exposures are involved in the pathogenesis of the allergic phenotype and in determining which individual triggers a person becomes sensitized to. Atopic dermatitis (AD) may modulate these effects through increased penetration through the skin modifying the immune system and AD may be triggered or intensified by environmental exposures. These exposures and immune-modulating factors may differ in urban and rural environments.
Evaluation of baked egg oral immunotherapy in French children with hen's egg allergy
Vianney Gruzelle, Agnès Juchet, Audrey Martin-Blondel, Marine Michelet, Anne Chabbert-Broue, Alain Didier
doi : 10.1111/pai.13437
Volume 32, Issue 5 p. 1022-1028
Introduction and gradual incremental escalation of a low dose of baked egg may accelerate the resolution of severe hen's egg (HE) allergy for some children. The purpose of our study was to evaluate the efficacy and safety of baked egg oral immunotherapy (OIT) in children with HE allergy after a low-dose baked egg oral food challenge (OFC).
Medical clown support is associated with better quality of life of children with food allergy starting oral immunotherapy
Naama Epstein Rigbi, Naama Schwartz, Michael R. Goldberg, Michael B. Levy, Liat Nachshon, Arnon Elizur
doi : 10.1111/pai.13445
Volume 32, Issue 5 p. 1029-1037
The start of oral immunotherapy (OIT) for food allergy is a critical period in the treatment process, with a potential to influence patient quality of life (QOL) and subsequently treatment outcome. The association of medical clowning with QOL at OIT initiation was examined.
Food allergy treatment value: Child caregiver and patient perspectives
Moaz Abdelwadoud, Sanaz Eftekhari, Hannah Jaffee, Melanie Carver, T. Joseph Mattingly II
doi : 10.1111/pai.13464
Volume 32, Issue 5 p. 1038-1047
Food allergy is a major health problem that significantly impacts quality of life (QoL). There is growing focus to evaluate food allergy-related QoL and treatment options’ value beyond the clinical effectiveness perspective by engaging patients and caregivers. We aimed to identify and prioritize outcomes important to food allergy parents of children and patients allergic to milk, egg, and/or peanut, to guide comparative effectiveness research (CER) that focuses on evaluating food allergy treatment decisions.
Exercise-induced allergic reactions after achievement of desensitization to cow's milk and wheat
Shohei Kubota, Katsumasa Kitamura, Teruaki Matsui, Yoshihiro Takasato, Shiro Sugiura, Komei Ito
doi : 10.1111/pai.13479
Volume 32, Issue 5 p. 1048-1055
We have previously reported that more than half of the patients who achieved desensitization after wheat rush oral immunotherapy (OIT) developed exercise-induced allergic reaction on desensitization (EIARD). However, data on EIARDs after slow OIT are lacking. Therefore, this study aimed to investigate the results of exercise provocation tests (EPTs) in patients after slow OIT for cow's milk and wheat allergies.
Single-dose oral challenges to validate eliciting doses in children with cow’s milk allergy
Paul J. Turner, Yvonne M. d'Art, Bettina Duca, Sophia A. Chastell, Guadalupe Marco-Martin, Rosialzira N. Vera-Berrios, Olaya Alvarez, Raphaëlle Bazire, Pablo Rodr?guez del R?o, Marta Vazquez-Ortiz, Joseph L. Baumert, Ronald van Ree, Clare E. N. Mills, Montserrat Fernandez-Rivas, Jonathan O'B. Hourihane
doi : 10.1111/pai.13482
Volume 32, Issue 5 p. 1056-1065
There is increasing interest in the use of eliciting doses (EDs) to inform allergen risk management. The ED can be estimated from the distribution of threshold doses for allergic subjects undergoing food challenges within a specified population. Estimated ED05 values for cow's milk (the dose expected to cause objective allergic symptoms in 5% of the milk-allergic population) range from 0.5 mg to 13.9 mg cow's milk protein. We undertook a single-dose challenge study to validate a predicted ED05 for cow's milk of 0.5 mg protein.
Retrospective analysis of 222 oral food challenges with a single dose in acute food protein-induced enterocolitis syndrome
Stefano Miceli Sopo, Dario Sinatti, Mariannita Gelsomino
doi : 10.1111/pai.13489
Volume 32, Issue 5 p. 1066-1072
The method of performing oral food challenge (OFC) in acute food protein–induced enterocolitis syndrome (FPIES) has not been systematically studied. Therefore, there is a certain variability in the choice of the various centers.
Time trends of childhood food allergy in China: Three cross-sectional surveys in 1999, 2009, and 2019
Zhuoying Ma, Lin Chen, Ruoling Xian, Heping Fang, Juan Wang, Yan Hu
doi : 10.1111/pai.13490
Volume 32, Issue 5 p. 1073-1079
Many countries have recorded the trends of food allergy (FA) prevalence. Little is known about epidemiologic trends of childhood FA in China.
Prenatal exposure to acetaminophen increases the risk of atopic dermatitis in children: A nationwide nested case-control study in Taiwan
Cheng-Yuan Li, Ying-Xiu Dai, Yun-Ting Chang, Ya-Mei Bai, Shih-Jen Tsai, Tzeng-Ji Chen, Mu-Hong Chen
doi : 10.1111/pai.13465
Volume 32, Issue 5 p. 1080-1088
Acetaminophen (APAP) has been associated with the development of atopic diseases. However, little is known about the relationship between prenatal APAP exposure and atopic dermatitis (AD) in offspring.
Early-life environmental exposures associate with individual and cumulative allergic morbidity
Stanislaw J. Gabryszewski, Jesse Dudley, Robert W. Grundmeier, David A. Hill
doi : 10.1111/pai.13486
Volume 32, Issue 5 p. 1089-1093
Vernal allergic march
Daniele G. Ghiglioni, Gaia Bruschi, Gregorio P. Milani, Paola G. Marchisio
doi : 10.1111/pai.13483
Volume 32, Issue 5 p. 1093-1095
House dust mite sensitization, eczema, and wheeze increase risk of shellfish sensitization
Evelyn Xiu Ling Loo, Hui Xing Lau, Noor Hidayatul Aini Suaini, Lydia Su Yin Wong, Anne Eng Neo Goh, Oon Hoe Teoh, Hugo PS Van Bever, Lynette Pei-chi Shek, Bee Wah Lee, Kok Hian Tan, Keith M. Godfrey, Johan Gunnar Eriksson, Yap Seng Chong, Elizabeth Huiwen Tham
doi : 10.1111/pai.13493
Volume 32, Issue 5 p. 1096-1099
Soluble receptor for advanced glycation end products (sRAGE) and asthma: Mendelian randomisation study
Yoshihiko Raita, Zhaozhong Zhu, Robert J. Freishtat, Michimasa Fujiogi, Liming Liang, Jason T. Patregnani, Carlos A. Camargo, Kohei Hasegawa
doi : 10.1111/pai.13478
Volume 32, Issue 5 p. 1100-1103
Is the low pH of infant and toddler foods a concern?
Tayla Knight, Peter K. Smith, Velencia Soutter, Emma Oswald, Carina Venter
doi : 10.1111/pai.13414
Volume 32, Issue 5 p. 1103-1106
Management of food allergens: Time to prevent food allergic reactions at school
Juan Carlos Ortiz-Menéndez, Martha Cabrera, Belén Garz?n Garc?a
doi : 10.1111/pai.13424
Volume 32, Issue 5 p. 1106-1108
IL-10 receptor expression on lymphocytes and monocytes in children with food allergy
Natalia Nedelkopoulou, Anna Taparkou, Charalampos Agakidis, Antigoni Mavroudi, Ioannis Xinias, Evangelia Farmaki
doi : 10.1111/pai.13475
Volume 32, Issue 5 p. 1108-1111
Macadamia nut allergy in children: Clinical features and cross-reactivity with walnut and hazelnut
Koichi Yoshida, Shoichiro Shirane, Kazue Kinoshita, Emi Morikawa, Shoko Matsushita, Masako Toda, Haruyo Nakajima-Adachi, Akira Akasawa, Masami Narita
doi : 10.1111/pai.13469
Volume 32, Issue 5 p. 1111-1114
IgE-mediated fish allergy in pediatric age: Does canned tuna have a chance for tolerance?
Luca Pecoraro, Sonsoles Infante, Victoria Fuentes-Aparicio, Paula Cabrera-Freitag, Nadia Antonucci, Alberto Alvarez-Perea
doi : 10.1111/pai.13481
Volume 32, Issue 5 p. 1114-1117
Inflammatory manifestations in children with chronic granulomatous disease
Myris Satiko Shinzato Tatebe, Mayra de Barros Dorna, Ana Paula Beltran Moschione Castro, Antonio Carlos Pastorino
doi : 10.1111/pai.13487
Volume 32, Issue 5 p. 1117-1120
Evaluation of cutaneous symptoms in children infected with COVID-19
Azize P?nar Metbulut, Asl?nur ?zkaya Parlakay, Gülsüm ?clal Bayhan, Saliha Kan?k Yüksek, Belgin Gülhan, Zeynep ?engül Emeksiz, Emrah ?enel, Emine Dibek M?s?rl?o?lu
doi : 10.1111/pai.13467
Volume 32, Issue 5 p. 1120-1125
SARS-CoV-2-specific IgG1/IgG3 but not IgM in children with Pediatric Inflammatory Multi-System Syndrome
Marisol Perez-Toledo, Sian E. Faustini, Sian E. Jossi, Adrian M. Shields, Edith Marcial-Juarez, Hari Krishnan Kanthimathinathan, Joel D. Allen, Yasunori Watanabe, Margaret Goodall, Benjamin E. Willcox, Carrie R. Willcox, Mahboob Salim, David C. Wraith, Tonny V. Veenith, Eleni Syrimi, Mark T. Drayson, Deepthi Jyothish, Eslam Al-Abadi, Ashish Chikermane, Steven B. Welch, Kavitha Masilamani, Scott Hackett, Max Crispin, Barnaby R. Scholefield, Adam F. Cunningham, Alex G. Richter
doi : 10.1111/pai.13504
Volume 32, Issue 5 p. 1125-1129
Comments on Leung
Serdar Beken, Bengisu Guner, Ayse Korkmaz
doi : 10.1111/pai.13460
Volume 32, Issue 5 p. 1130-1131
