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Comments on vitamin D and sensitization, asthma treatment, and lung function development
Philippe Eigenmann
doi : 10.1111/pai.13575
Volume 32, Issue 6 p. 1137-1140
Respiratory syncytial virus and airway microbiota – A complex interplay and its reflection on morbidity
Giovanni A. Rossi,Stefania Ballarini,Michela Silvestri,Oliviero Sacco,Andrew A. Colin
doi : 10.1111/pai.13524
Volume 32, Issue 6 p. 1141-1151
The immunopathology of respiratory syncytial virus (RSV) infection varies considerably, severe disease occurring only in a minority of the affected children. The variability of the clinical presentation is in part explained by viral and environmental factors but, in infants and young children, disease severity is certainly linked to the physiologic immaturity of the innate and adaptive immune system. There is evidence that the maturation of the host immune response is positively influenced by the composition of the nasopharyngeal microbiome that, promoting an efficient reaction, can counteract the predisposition to develop viral respiratory infections and lower the risk of disease severity. However, interaction between the nasopharyngeal microbiota and respiratory viruses can be bidirectional since microbial dysbiosis may also represent a reflection of the disease-induced alterations of the local milieu. Moreover, viruses like RSV can also increase the virulence of potential pathogens in nasopharynx, a main reservoir of bacteria, and therefore promote their spread to the lower airways causing superinfection. Moreover, if negative changes in microbial community composition in early life may constitute a heightened risk toward severe RSV respiratory infection, on the contrary specific groups of microorganisms seem to be associated with protection. A better understanding into the potential negative and positive role of the different nasopharyngeal bacterial species on RSV infection may improve primary prevention and possibly care of this highly contagious disorder.
The role of the environment in shaping the trends of childhood asthma – An Asian perspective
Agnes S. Y. Leung,Elizabeth Huiwen Tham,Jing Li,Punchama Pacharn,Takumi Takizawa,Eun Lee,Yuhan Xing,Ting-Fan Leung,Soo-Jong Hong,Gary W. K. Wong
doi : 10.1111/pai.13508
Volume 32, Issue 6 p. 1152-1164
Asthma has now become one of the most common atopic disorders not only in developed countries but also in many developing countries. The etiology is likely due to a complex interaction between genetic and environmental factors. In many Asian countries, the prevalence of asthma has also been documented by validated instruments to be increasing rapidly over the past two decades. However, studies in rural areas in Asia with a traditional farming environment revealed markedly lower asthma prevalence when compared with residents in nearby cities despite having similar genetic background. Among the environmental factors implicated in the pathogenesis of asthma, air pollution, dietary patterns, viral infections, and early microbial exposure have been studied extensively around the world. Asia provides many opportunities to study these potential factors as there are many ethnic groups living in distinctly different environments. The understanding of the roles of these factors in affecting the early immune system and subsequent development of asthma will enable us to develop potential primary preventive strategies against a disease which affects millions worldwide.
Drug-induced enterocolitis syndrome: Similarities and differences compared with food protein-induced enterocolitis syndrome
Francesca Mori,Giulia Liccioli,Oliver Fuchs,Simona Barni,Mattia Giovannini,Lucrezia Sarti,Elio Novembre,Jean-Christoph Caubet
doi : 10.1111/pai.13491
Volume 32, Issue 6 p. 1165-1172
In 2014, drug-induced enterocolitis syndrome (DIES) was described for the first time. It is still a poorly known disease with symptoms that typically resemble those of food protein–induced enterocolitis syndrome (FPIES). To date, six more cases of DIES have been described and new clinical diagnostic criteria have been proposed based on those in the international guidelines for FPIES. In this paper, the authors describe three more cases of DIES. In addition, similarities and differences with FPIES have been deeply analyzed. To date, several unanswered questions need to be addressed, but clinicians must be instructed how to identify DIES, in order to make an allergy workup and give definite therapeutic indications to patients, especially in children where DIES seems to be more frequent.
Sex-specific associations of human milk long-chain polyunsaturated fatty acids and infant allergic conditions
Kozeta Miliku,Jacqueline Richelle,Allan B. Becker,Elinor Simons,Theo J. Moraes,Turvey E. Stuart,Piush J. Mandhane,Malcolm R. Sears,Padmaja Subbarao,Catherine J. Field,Meghan B. Azad
doi : 10.1111/pai.13500
Volume 32, Issue 6 p. 1173-1182
Polyunsaturated fatty acids (PUFAs) may influence immune development. We examined the association of PUFAs in human milk with food sensitization and atopic dermatitis among breastfed infants.
Association between vitamin D status and allergen sensitization in pediatric subjects in the Balearic Islands
Raquel Segovia-Ort?,Antonia Barcel? Bennasar,Diego De Sotto-Esteban,Pilar Sanch?s Cortés,Jaime Pons
doi : 10.1111/pai.13513
Volume 32, Issue 6 p. 1183-1189
Vitamin D has known effects on the immune system, and its deficiency has been associated with allergen sensitization.
Gestational diabetes and childhood asthma in a racially diverse US pregnancy cohort
Margaret A. Adgent,Tebeb Gebretsadik,Jada Reedus,Cornelia Graves,Etoi Garrison,Nicole Bush,Robert Davis,Kaja Z. LeWinn,Frances Tylavsky,Kecia N. Carroll
doi : 10.1111/pai.13523
Volume 32, Issue 6 p. 1190-1196
Childhood asthma is a common chronic disease that likely has prenatal origins. Gestational diabetes alters maternal physiology and may influence fetal risk for childhood-onset disease. However, the association between gestational diabetes and child asthma is not well characterized.
Genome-wide association studies of exacerbations in children using long-acting beta2-agonists
Elise M. A. Slob,Levi B. Richards,Susanne J. H. Vijverberg,Cristina Longo,Gerard H. Koppelman,Mari?«lle W. H. Pijnenburg,Elisabeth H. D. Bel,Anne H. Neerincx,Esther Herrera Luis,Javier Perez-Garcia,Fook Tim Chew,Yang Yie Sio,Anand K. Andiappan,Steve W. Turner,Somnath Mukhopadhyay,Colin N. A. Palmer,Daniel Hawcutt,Andrea L. Jorgensen,Esteban G. Burchard,Natalia Hernandez-Pacheco,Maria Pino-Yanes,Anke H. Maitland-van der Zee
doi : 10.1111/pai.13494
Volume 32, Issue 6 p. 1197-1207
Some children with asthma experience exacerbations despite long-acting beta2-agonist (LABA) treatment. While this variability is partly caused by genetic variation, no genome-wide study until now has investigated which genetic factors associated with risk of exacerbations despite LABA use in children with asthma. We aimed to assess whether genetic variation was associated with exacerbations in children treated with LABA from a global consortium.
Does lung function change in the months after an asthma exacerbation in children?
Joanne Martin,Marielle W. Pijnenburg,Graham Roberts,Katherine C. Pike,Helen Petsky,Anne B. Chang,Stanley J. Szefler,Peter Gergen,Francoise Vermeulen,Robin Vael,Steve Turner
doi : 10.1111/pai.13503
Volume 32, Issue 6 p. 1208-1216
There are limited data describing lung function changes in children after an asthma exacerbation. Our hypothesis was that lung function does not fully recover in children in the months following an asthma exacerbation.
Determinants of blood eosinophilia in moderate and severe asthmatic patients during childhood: Evidence from the severe asthma molecular phenotype (SAMP) cohort
Jocelyne Just,Sarah Saf,Tamazoust Guiddir,Nathalie Cottel,Flore Amat,Nathalie Lambert,Philippe Saint-Pierre,Mélisande Bourgoin-Heck
doi : 10.1111/pai.13507
Volume 32, Issue 6 p. 1217-1225
Asthma is a heterogeneous disease in which the interaction between genetic and environmental factors plays a major role. The significance of blood eosinophil is unclear. The aim of the study was to determine the significance of blood eosinophil count in moderate-to-severe asthmatic children of preschool age and school age.
Early age exposure to moisture and mould is related to FeNO at the age of 6 years
Christina Tischer,Anne M. Karvonen,Pirkka V. Kirjavainen,Claudia Flexeder,Marjut Roponen,Anne Hyv?¤rinen,Harald Renz,Urs Peter Frey,Oliver Fuchs,Juha Pekkanen
doi : 10.1111/pai.13526
Volume 32, Issue 6 p. 1226-1237
Exposure to indoor moisture damage and visible mold has been found to be associated with asthma and respiratory symptoms in several questionnaire-based studies by self-report. We aimed to define the prospective association between the early life exposure to residential moisture damage or mold and fractional exhaled nitric oxide (FeNO) and lung function parameters as objective markers for airway inflammation and asthma in 6-year-old children.
Asthma, bronchial hyperresponsiveness, allergy and lung function development until early adulthood: A systematic literature review
Hans Jacob L. Koefoed,Annelies M. Zwitserloot,Judith M. Vonk,Gerard H. Koppelman
doi : 10.1111/pai.13516
Volume 32, Issue 6 p. 1238-1254
It is unclear in which periods of life lung function deficits develop, and whether these are affected by risk factors such as asthma, bronchial hyper-responsiveness (BHR) and allergic comorbidity. The goal of this systematic review was to identify temporal associations of asthma, BHR and allergic comorbidity with large and small lung function development from birth until peak function in early adulthood.
Comparative effectiveness of probiotic strains on the prevention of pediatric atopic dermatitis: A systematic review and network meta-analysis
Carol Stephanie C. Tan-Lim,Natasha Ann R. Esteban-Ipac,Marysia Stella T. Recto,Mary Anne R. Castor,Roxanne J. Casis-Hao,Aimee Lou M. Nano
doi : 10.1111/pai.13514
Volume 32, Issue 6 p. 1255-1270
Atopic dermatitis is the most common chronic skin disease affecting the pediatric population. Probiotics have been proposed to be effective in preventing the development of pediatric atopic dermatitis. Although studies show promise for the use of probiotics, the evidence is still inconclusive due to significant heterogeneity and imprecision.
Health-related quality of life in children at the diagnosis of Vernal Keratoconjunctivitis
Maria Cristina Artesani,Mariacristina Esposito,Marta Sacchetti,Andrea Sansone,Antonino Romanzo,Luca Buzzonetti,Alessandro Giovanni Fiocchi,Maurizio Mennini
doi : 10.1111/pai.13520
Volume 32, Issue 6 p. 1271-1277
Vernal keratoconjunctivitis (VKC) is a bilateral, chronic, allergic condition mostly affecting children. Clinical evaluations may not necessarily reflect the impact of the disease on the patients’ health-related quality of life (HRQoL). We aimed to evaluate HRQoL in children at VKC diagnosis and to analyze correlations between HRQoL and clinical and laboratory variables.
Anaphylaxis in children and adolescents: The Portuguese Anaphylaxis Registry
?ngela Gaspar,Natacha Santos,Em?lia Faria,Ana Margarida Pereira,Eva Gomes,Rita Câmara,Rodrigo Rodrigues-Alves,Lu?s-Miguel Borrego,Isabel Carrapatoso,Leonor Carneiro-Le?o,M?rio Morais-Almeida,Lu?s Delgado,Elisa Pedro,Manuel Branco-Ferreira,Portuguese Society of Allergology and Clinical Immunology (SPAIC) Anaphylaxis Interest Group
doi : 10.1111/pai.13511
Volume 32, Issue 6 p. 1278-1286
Anaphylaxis is increasing at pediatric age; however, its characterization is hampered by underdiagnosis and underreporting. The aim of this study was to identify the causes of anaphylaxis in children and adolescents in Portugal, thus contributing to a better knowledge of its etiology, clinical manifestations, and management.
Oral immunotherapy in severe cow’s milk allergic patients treated with omalizumab: Real life survey from a Spanish registry
Mar?a Dolores Ib???±ez-Sand?n,Carmelo Escudero,Roc?o Cand?³n Morillo,Eva M. Lasa,Eva March??n-Mart?n,Silvia S??nchez-Garc?a,Soledad Terrados,Carlos Gonz??lez D?az,Sonsoles Juste,Antonio Martorell,Vanessa G??zquez Garc?a,Antonio Ram?rez Jim?©nez,?�ngel Abell??n,Mar?a D. Martos Calahorro,Ana I. Tabar,Joan Bartra,Rosa Garc?a Rodr?guez,Catalina G?³mez Gal??n,Mar?a Flora Mart?n-Mu?±oz,Jos?© Meseguer Arce,Juan C. Miralles,Ana M. Montoro de Francisco,Paloma Poza Guedes,Pablo Rodr?guez del R?o,The OmaBASE task force (Pediatric Allergy Committee, Spanish Society of Allergy and Clinical Immunology)
doi : 10.1111/pai.13517
Volume 32, Issue 6 p. 1287-1295
Oral immunotherapy is a frequent treatment for the management of food allergies, but adverse events (AE) are common. This study assessed the outcome of cow's milk oral immunotherapy (MOIT) in severe cow`s milk–allergic patients treated with omalizumab in a real-life setting.
Increased miR-21-3p and miR-487b-3p serum levels during anaphylactic reaction in food allergic children
Emilio Nu?±ez-Borque,Sergio Fernandez-Bravo,Pablo Rodriguez Del Rio,Ebrahim Mohammed Alwashali,David Lopez-Dominguez,Maria Dolores Gutierrez-Blazquez,Jose Julio Laguna,Jaime Tome-Amat,Julio Gallego-Delgado,Alicia Gomez-Lopez,Diana Betancor,Javier Cuesta-Herranz,Maria Dolores Iba?±ez-Sandin,Alberto Benito-Martin,Vanesa Esteban
doi : 10.1111/pai.13518
Volume 32, Issue 6 p. 1296-1306
Anaphylaxis is the most severe manifestation of allergic disorders. The poor knowledge of its molecular mechanisms often leads to under-diagnosis. MicroRNAs (miRNA) regulate physiologic and pathologic processes, and they have been postulated as promising diagnostic markers. The main objectives of this study were to characterize the human miRNA profile during anaphylaxis and to assess their capacity as diagnostic markers and determine their participation in the molecular mechanisms of this event.
Rising trend in p​ediatric eosinophilic esophagitis incidence in Spain: Results of a prospective study 2014–16
Enrique La Orden Izquierdo,Ignacio Mahillo-Fern??ndez,Sonia Fern??ndez Fern??ndez,Josefa Barrio Torres,Enriqueta Rom??n Riechmann,Carolina Guti?©rrez Junquera,Working group on Eosinophilic esophagitis of the “Gastrosuroeste groupâ€� in Madrid
doi : 10.1111/pai.13528
Volume 32, Issue 6 p. 1307-1315
The rate of eosinophilic esophagitis (EoE) diagnosis is increasing. This study aims to determine the incidence of EoE in the pediatric population residing in the southwestern Madrid and to analyze whether absolute monthly pollen counts, modified or not by the principal atmospheric pollutants, are associated with it.
The spectrum of ATM gene mutations in Iranian patients with ataxia-telangiectasia
Parisa Amirifar,Mohammad Reza Ranjouri,Salar Pashangzadeh,Martin Lavin,Reza Yazdani,Tannaz Moeini Shad,Mahya Mehrmohamadi,Fereshte Salami,Samaneh Delavari,Soraya Moamer,Asghar Aghamohammadi,Seyed Mohammad Akrami,Hassan Abolhassani
doi : 10.1111/pai.13461
Volume 32, Issue 6 p. 1316-1326
Ataxia-telangiectasia (A-T) is a rare genetic disorder characterized by a distinct range of clinical manifestations, including progressive ataxia, immunodeficiency, and radiosensitivity.
Selective IgM deficiency: Follow-up and outcome
Canan Caka,Ozlem Cimen,Pinar Kahyao??lu,?°lhan Tezcan,Deniz Cagdas
doi : 10.1111/pai.13497
Volume 32, Issue 6 p. 1327-1334
Selective IgM deficiency (sIgMD) is classified under primary immunodeficiencies (PID). This study aimed to define the clinical and immunologic features of sIgMD.
Autoimmune manifestations among 461 patients with monogenic inborn errors of immunity
Gholamreza Azizi,Marzieh Tavakol,Reza Yazdani,Samaneh Delavari,Tannaz Moeini Shad,Seyed Erfan Rasouli,Mahnaz Jamee,Salar Pashangzadeh,Arash Kalantari,Mansoureh Shariat,Alireza Shafiei,Javad Mohammadi,Gholamreza Hassanpour,Zahra Chavoshzadeh,Seyed Alireza Mahdaviani,Tooba Momen,Nasrin Behniafard,Mohammad Nabavi,Mohammad Hassan Bemanian,Saba Arshi,Rasol Molatefi,Roya Sherkat,Afshin Shirkani,Soheila Alyasin,Farahzad Jabbari-Azad,Javad Ghaffari,Mehrnaz Mesdaghi,Hamid Ahanchian,Maryam Khoshkhui,Mohammad Hossein Eslamian,Taher Cheraghi,Abbas Dabbaghzadeh,Rasoul Nasiri Kalmarzi,Hossein Esmaeilzadeh,Javad Tafaroji,Abbas Khalili,Mahnaz Sadeghi-Shabestari,Sepideh Darougar,Mojgan Moghtaderi,Akefeh Ahmadiafshar,Behzad Shakerian,Marzieh Heidarzadeh,Babak Ghalebaghi,Seyed Mohammad Fathi,Behzad Darabi,Morteza Fallahpour,Azam Mohsenzadeh,Sarehsadat Ebrahimi,Samin Sharafian,Ahmad Vosughimotlagh,Mitra Tafakoridelbari,Maziyar Rahimi Haji-Abadi,Parisa Ashournia,Anahita Razaghian,Arezou Rezaei,Fereshte Salami,Paniz Shirmast,Nasrin Bazargan,Setareh Mamishi,Hossein Ali Khazaei,Babak Negahdari,Sima Shokri,Seyed Hesamedin Nabavizadeh,Saeed Bazregari,Ramin Ghasemi,Shiva Bayat,Hamid Eshaghi,Nima Rezaei,Hassan Abolhassani,Asghar Aghamohammadi
doi : 10.1111/pai.13510
Volume 32, Issue 6 p. 1335-1348
The inborn errors of immunity (IEIs) are a group of heterogeneous disorders mainly characterized by severe and recurrent infections besides other complications including autoimmune and inflammatory diseases. In this study, we aim to evaluate clinical, immunologic, and molecular data of monogenic IEI patients with and without autoimmune manifestations.
Predictive value of coagulation profiles for both initial and repeated immunoglobulin resistance in Kawasaki disease: A prospective cohort study
Shuran Shao,Lixia Yang,Xiaoliang Liu,Lei Liu,Mei Wu,Yuxin Deng,Hongyu Duan,Yifei Li,Yimin Hua,Lili Luo,Kaiyu Zhou,Chuan Wang
doi : 10.1111/pai.13495
Volume 32, Issue 6 p. 1349-1359
Intravenous immunoglobulin (IVIG) resistance prediction remains substantial in Kawasaki disease (KD), with limited data on the predictive value of coagulation profile for IVIG resistance, particularly for repeated IVIG resistance. Therefore, the aim of our study was to testify the predictive validity of coagulation profile for both initial IVIG resistance and repeated IVIG resistance in KD.
Increased Th22 cell numbers in a general pediatric population with filaggrin haploinsufficiency: The Generation R Study
Kirsten I. M. Looman,Minke M. F. van Mierlo,Menno C. van Zelm,Chen Hu,Liesbeth Duijts,Johan C. de Jongste,Tamar Nijsten,Luba M. Pardo,Jessica C. Kiefte-de Jong,Henriëtte A. Moll,Suzanne G. M. A. Pasmans
doi : 10.1111/pai.13502
Volume 32, Issue 6 p. 1360-1368
Mutations in the filaggrin gene (FLG) affect epidermal barrier function and increase the risk of atopic dermatitis (AD). We hypothesized that FLG mutations affect immune cell composition in a general pediatric population. Therefore, we investigated whether school-aged children with and without FLG mutations have differences in T- and B-cell subsets.
Predictors of atopic disease in children of women with asthma
Zarqa Ali,Simon Francis Thomsen,Charlotte Suppli Ulrik
doi : 10.1111/pai.13521
Volume 32, Issue 6 p. 1369-1373
Age trends in direct medical costs of pediatric asthma: A population study
Wenjia Chen,Hamid Tavakoli,J. Mark FitzGerald,Padmaja Subbarao,Stuart E. Turvey,Mohsen Sadatsafavi
doi : 10.1111/pai.13515
Volume 32, Issue 6 p. 1374-1377
Treatment-requiring accidental ingestion and risk factors among nursery children with food allergy
Noriyuki Yanagida,Motohiro Ebisawa,Toshio Katsunuma,Jyoji Yoshizawa
doi : 10.1111/pai.13505
Volume 32, Issue 6 p. 1377-1380
Pediatric blinded food challenges: Validating reduced salt and refined sugar recipes
Viktorija Kaminskaite,Harriet Mitchell-Riall,Susie Costelloe,Siân Ludman
doi : 10.1111/pai.13506
Volume 32, Issue 6 p. 1380-1384
Parental intentions regarding introduction of common food allergens during complimentary feeding
Ailish Breathnach,Rosemary Geoghegan,Edina Moylett
doi : 10.1111/pai.13512
Volume 32, Issue 6 p. 1384-1387
Desensitization to carboplatin in low-grade glioma. A revision of 100 treatments in children
Josefina Cernadas,Maria Jo?£o Vasconcelos,Ana Paula Fernandes,Leonor Carneiro-Le?£o,Maria Jo?£o Gil-da-Costa
doi : 10.1111/pai.13525
Volume 32, Issue 6 p. 1388-1391
Continued icatibant use across recurrent attacks in adolescents with hereditary angioedema
Henriette Farkas,Avner Reshef,Teresa Caballero,Mar?a C. Ortega L?pez,Aharon Kessel,Moshe Vardi,James Hao,Werner Aberer
doi : 10.1111/pai.13519
Volume 32, Issue 6 p. 1392-1396
