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Addressing Insulin Access and Affordability: An Endocrine Society Position Statement
The Endocrine Society
doi : 10.1210/clinem/dgaa817
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 4, April 2021, Pages 935–941
Rising costs have made access to affordable insulin far more difficult for people with diabetes, especially low-income individuals, those on high deductible health plans, beneficiaries using Medicare Part B to cover insulin delivered via pump, Medicare beneficiaries in the Part D donut hole, and those who turn 26 and must transition from their parents’ insurance, to manage their diabetes and avoid unnecessary complications and hospitalizations. For many patients with diabetes, insulin is a life-saving medication. Policymakers should immediately address drivers of rising insulin prices and implement solutions that would reduce high out-of-pocket expenditures for patients. The Endocrine Society recommends policy options to expand access to lower cost insulin in this paper.
Efficacy of Micronized Progesterone for Sleep: A Systematic Review and Meta-analysis of Randomized Controlled Trial Data
Brendan J Nolan, Bonnie Liang, Ada S Cheung
doi : 10.1210/clinem/dgaa873
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 4, April 2021, Pages 942–951
Preclinical data has shown progesterone metabolites improve sleep parameters through positive allosteric modulation of the ?-aminobutyric acid type A receptor. We undertook a systematic review and meta-analysis of randomized controlled trials to assess micronized progesterone treatment on sleep outcomes.
Type 1 Diabetes: Management in Women From Preconception to Postpartum
Elizabeth O Buschur, Sarit Polsky
doi : 10.1210/clinem/dgaa931
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 4, April 2021, Pages 952–967
This review presents an up-to-date summary on management of type 1 diabetes mellitus (T1DM) among women of reproductive age and covers the following time periods: preconception, gestation, and postpartum.
Prevalence and Spectrum of DICER1 Mutations in Adult-onset Thyroid Nodules with Indeterminate Cytology
Anne-Sophie Chong, Yuri E Nikiforov, Vincenzo Condello, Abigail I Wald, Marina N Nikiforova, William D Foulkes, Barbara Rivera
doi : 10.1210/clinem/dgab025
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 4, April 2021, Pages 968–977
DICER1 mutations are found in multinodular goiter and differentiated thyroid carcinoma in children, and can be a manifestation of DICER1 syndrome, but the prevalence of DICER1 mutations and their significance in adult-onset thyroid nodules is unknown.
Stuttering and Incident Type 2 Diabetes: A Population-Based Study of 2.2 Million Adolescents
Avishai M Tsur, Shir Hershkovich, Inbar Zucker, Miri Lutski, Orit Pinhas-Hamiel, Asaf Vivante, Maya Fischman, Ofer Amir, Jacob Rotchild, Hertzel C Gerstein, Tali Cukierman-Yaffe, Limor Friedensohn, Ofri Mosenzon, Estela Derazne, Dorit Tzur, Amir Tirosh, Arnon Afek, Itamar Raz, Gilad Twig
doi : 10.1210/clinem/dgaa988
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 4, April 2021, Pages 978–987
To investigate the association between stuttering in adolescence and incident type 2 diabetes in young adulthood.
Novel Recurrent Altered Genes in Chinese Patients With Anaplastic Thyroid Cancer
Lingyun Zhang, Zhixiang Ren, Zhengzheng Su, Yang Liu, Tian Yang, Minyuan Cao, Yong Jiang, Ying Tang, Haining Chen, Weihan Zhang, Rixiang Gong, Tao Wei, Yong Peng, Bo Liu, Wei Zhang, Li Yang, Yiguo Hu, Zhihui Li, Jingqiang Zhu, Heng Xu, Yang Shu, Han Luo
doi : 10.1210/clinem/dgab014
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 4, April 2021, Pages 988–998
Anaplastic thyroid cancer (ATC) is a rare but lethal malignancy, and few systematic investigations on genomic profiles of ATC have been performed in Chinese patients.
Plasma Lipidomic Profiles and Risk of Diabetes: 2 Prospective Cohorts of HIV-Infected and HIV-Uninfected Individuals
Eric Zhang, Jin Choul Chai, Amy A Deik, Simin Hua, Anjali Sharma, Michael F Schneider, Deborah Gustafson, David B Hanna, Jordan E Lake, Leah H Rubin, Wendy S Post, Kathryn Anastos, Todd Brown, Clary B Clish, Robert C Kaplan, Qibin Qi
doi : 10.1210/clinem/dgab011
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 4, April 2021, Pages 999–1010
Antiretroviral therapy (ART) use is associated with disrupted lipid and glucose metabolism in people with HIV infection. We aimed to identify plasma lipid species associated with risk of diabetes in the context of HIV infection.
DNA Methylation Haplotype Block Markers Efficiently Discriminate Follicular Thyroid Carcinoma from Follicular Adenoma
Hui Zhang, Zhenzhen Zhang, Xiaoding Liu, Huanli Duan, Tianmin Xiang, Qiye He, Zhixi Su, Huanwen Wu, Zhiyong Liang
doi : 10.1210/clinem/dgaa950
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 4, April 2021, Pages 1011–1021
Follicular thyroid carcinoma (FTC) is the second most common type of thyroid carcinoma and must be pathologically distinguished from benign follicular adenoma (FA). Additionally, the clinical assessment of thyroid tumors with uncertain malignant potential (TT-UMP) demands effective indicators.
TLR4-Associated IRF-7 and NF?B Signaling Act as a Molecular Link Between Androgen and Metformin Activities and Cytokine Synthesis in the PCOS Endometrium
Min Hu, Yuehui Zhang, Xin Li, Peng Cui, Amanda Nancy Sferruzzi-Perri, Mats Br?nnstr?m, Linus R Shao, H?kan Billig
doi : 10.1210/clinem/dgaa951
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 4, April 2021, Pages 1022–1040
Low-grade chronic inflammation is commonly seen in polycystic ovary syndrome (PCOS) patients with elevated levels of inflammatory cytokines in the endometrium.
Genotype–Phenotype Correlations in Central Precocious Puberty Caused by MKRN3 Mutations
Carlos Eduardo Seraphim, Ana Pinheiro Machado Canton, Luciana Montenegro, Maiara Ribeiro Piovesan, Delanie B Macedo, Marina Cunha, Aline Guimaraes, Carolina Oliveira Ramos, Anna Flavia Figueiredo Benedetti, Andrea de Castro Leal, Priscila C Gagliardi, Sonir R Antonini, Mirta Gryngarten, Andrea J Arcari, Ana Paula Abreu, Ursula B Kaiser, Leandro Soriano-Guillén, Arancha Escribano-Mu?oz, Raquel Corripio, José I Labarta, Lourdes Travieso-Su?rez, Nelmar Valentina Ortiz-Cabrera, Jes?s Argente, Berenice B Mendonca, Vinicius N Brito, Ana Claudia Latronico
doi : 10.1210/clinem/dgaa955
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 4, April 2021, Pages 1041–1050
Loss-of-function mutations of makorin RING finger protein 3 (MKRN3) are the most common monogenic cause of familial central precocious puberty (CPP).
A Novel Type of Extreme Insulin Resistance: Nonhypoglycemic Insulin Autoimmune Syndrome
He Liu, Siyu Liang, Yu Li, Junling Fu, Shi Chen, Ming Li, Huijuan Zhu, Hui Pan, Ou Wang, Tao Yuan, Jiangfeng Mao, Yan Qin, Yuxiu Li
doi : 10.1210/clinem/dgaa911
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 4, April 2021, Pages 1051–1061
Extreme insulin resistance is caused by genetic defects intersecting with the insulin action pathway or by the insulin receptor antibodies. Insulin autoimmune syndrome (IAS) is not considered one of the causes of extreme insulin resistance.
Reduced Muscle Strength Is Associated With Insulin Resistance in Type 2 Diabetes Patients With Osteoarthritis
Oana Patricia Zaharia, Dominik Hans Pesta, Pavel Bobrov, Yuliya Kupriyanova, Christian Herder, Yanislava Karusheva, K?lm?n B?dis, Gidon Josia B?nhof, Johannes Knitza, David Simon, Arnd Kleyer, Jong-Hee Hwang, Karsten Müssig, Dan Ziegler, Volker Burkart, Georg Schett, Michael Roden, Julia Szendroedi
doi : 10.1210/clinem/dgaa912
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 4, April 2021, Pages 1062–1073
Type 2 diabetes is associated with a greater risk for musculoskeletal disorders, yet its impact on joint function remains unclear.
Early Decline of Androgen Levels in Healthy Adult Men: An Effect of Aging Per Se? A Prospective Cohort Study
Thiberiu Banica, Charlotte Verroken, Tim Reyns, Ahmed Mahmoud, Guy T’Sjoen, Tom Fiers, Jean-Marc Kaufman, Bruno Lapauw
doi : 10.1210/clinem/dgaa915
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 4, April 2021, Pages 1074–1083
Androgen levels have been shown to decline in aging men. However, there is no consensus on the effect of aging, (changes in) body mass index (BMI), lifestyle factors, and intercurrent disease.
Congenital Glucagon-like Peptide-1 Deficiency in the Pathogenesis of Protracted Diarrhea in Mitchell–Riley Syndrome
Sara N?brega, Mariana P Monteiro, Lu?s Pereira-da-Silva, Sofia S Pereira, Bolette Hartmann, Jens J Holst, Raul Barbosa Silva, Gonçalo Cordeiro-Ferreira
doi : 10.1210/clinem/dgaa916
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 4, April 2021, Pages 1084–1090
Mitchell–Riley syndrome due to RFX6 gene mutations is characterized by neonatal diabetes and protracted diarrhea. The RFX6 gene encodes a transcription factor involved in enteroendocrine cell differentiation required for beta-cell maturation. In contrast to the pathway by which RFX6 mutations leads to diabetes, the mechanisms underlying protracted diarrhea are unknown.
S-glutathionylation of the Na+-K+ Pump: A Novel Redox Mechanism in Preeclampsia
Chia-Chi Liu, YunJia Zhang, Angela Makris, Helge H Rasmussen, Annemarie Hennessy
doi : 10.1210/clinem/dgaa918
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 4, April 2021, Pages 1091–1100
Reduced Na+-K+ pump activity is widely reported in preeclampsia and may be caused by a reversible oxidative modification that is a novel pathological feature of preeclampsia.
Limited Genetic Overlap Between Overt Hashimoto’s Thyroiditis and Graves’ Disease in Twins: A Population-based Study
Jakob Skov, Jan Calissendorff, Daniel Eriksson, Patrik Magnusson, Olle K?mpe, Sophie Bensing, Ralf Kuja-Halkola
doi : 10.1210/clinem/dgaa956
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 4, April 2021, Pages 1101–1110
Hashimoto’s thyroiditis (HT) and Graves’ disease (GD) are known to coaggregate in families, but the magnitude and nature of a shared etiology is unknown.
Targeted Metabolomics as a Tool in Discriminating Endocrine From Primary Hypertension
Zoran Erlic, Parminder Reel, Smarti Reel, Laurence Amar, Alessio Pecori, Casper K Larsen, Martina Tetti, Christina Pamporaki, Cornelia Prehn, Jerzy Adamski, Aleksander Prejbisz, Filippo Ceccato, Carla Scaroni, Matthias Kroiss, Michael C Dennedy, Jaap Deinum, Katharina Langton, Paolo Mulatero, Martin Reincke, Livia Lenzini, Anne-Paule Gimenez-Roqueplo, Guillaume Assié, Anne Blanchard, Maria Christina Zennaro, Emily Jefferson, Felix Beuschlein
doi : 10.1210/clinem/dgaa954
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 4, April 2021, Pages 1111–1128
Identification of patients with endocrine forms of hypertension (EHT) (primary hyperaldosteronism [PA], pheochromocytoma/paraganglioma [PPGL], and Cushing syndrome [CS]) provides the basis to implement individualized therapeutic strategies. Targeted metabolomics (TM) have revealed promising results in profiling cardiovascular diseases and endocrine conditions associated with hypertension.
Pitfalls in RET Fusion Detection Using Break-Apart FISH Probes in Papillary Thyroid Carcinoma
Yuanyuan Liu, Shafei Wu, Liangrui Zhou, Yong Guo, Xuan Zeng
doi : 10.1210/clinem/dgaa913
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 4, April 2021, Pages 1129–1138
A standardized procedure of fused REarranged during Transfection (RET) gene detection using fluorescence in situ hybridization (FISH) remains to be established in papillary thyroid carcinoma (PTC). Our purpose was to investigate false-negative and false-positive events and their FISH signal characteristics.
Association of Cognitive Function and Retinal Neural and Vascular Structure in Type 1 Diabetes
Ward Fickweiler, Emily A Wolfson, Samantha M Paniagua, Marc Gregory Yu, Atif Adam, Vanessa Bahnam, Konstantina Sampani, I-Hsien Wu, Gail Musen, Lloyd P Aiello, Hetal Shah, Jennifer K Sun, George L King
doi : 10.1210/clinem/dgaa921
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 4, April 2021, Pages 1139–1149
Cognitive dysfunction is a growing and understudied public health issue in the aging type 1 diabetic population and is difficult and time-consuming to diagnose. Studies in long duration type 1 diabetes have reported the presence of proliferative diabetic retinopathy was associated with cognitive dysfunction.
Fasting Glucose Variation Predicts Microvascular Risk in ACCORD and VADT
Jin J Zhou, Juraj Koska, Gideon Bahn, Peter Reaven for the VADT Investigators
doi : 10.1210/clinem/dgaa941
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 4, April 2021, Pages 1150–1162
The association of glycemic variability with microvascular disease complications in type 2 diabetes (T2D) has been under-studied and remains unclear. We investigated this relationship using both Action to Control Cardiovascular Risk in Diabetes (ACCORD) and the Veteran Affairs Diabetes Trial (VADT).
Multiple Endocrine Tumors Associated with Germline MAX Mutations: Multiple Endocrine Neoplasia Type 5?
Amanda J Seabrook, Jessica E Harris, Sofia B Velosa, Edward Kim, Aideen M McInerney-Leo, Trisha Dwight, Jason I Hockings, Nicholas G Hockings, Judy Kirk, Paul J Leo, Amanda J Love, Catherine Luxford, Mhairi Marshall, Ozgur Mete, David J Pennisi, Matthew A Brown, Anthony J Gill, Gregory I Hockings, Roderick J Clifton-Bligh, Emma L Duncan
doi : 10.1210/clinem/dgaa957
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 4, April 2021, Pages 1163–1182
Pathogenic germline MAX variants are associated with pheochromocytoma and paraganglioma (PPGL), pituitary neuroendocrine tumors and, possibly, other endocrine and nonendocrine tumors.
Corticotroph Aggressive Pituitary Tumors and Carcinomas Frequently Harbor ATRX Mutations
Olivera Casar-Borota, Henning?Bünsow Boldt, Britt?Edén Engstr?m, Marianne Skovsager Andersen, Bertrand Baussart, Daniel Bengtsson, Katarina Berinder, Bertil Ekman, Ulla Feldt-Rasmussen, Charlotte H?ybye, Jens Otto L J?rgensen, Anders Jensen Kolnes, M?rta Korbonits, ?se Krogh Rasmussen, John R Lindsay, Paul Benjamin Loughrey, Dominique Maiter, Emilija Manojlovic-Gacic, Jens Pahnke, Pietro Luigi Poliani, Vera Popovic, Oskar Ragnarsson, Camilla Schalin-J?ntti, David Scheie, Mikl?s T?th, Chiara Villa, Martin Wirenfeldt, Jacek Kunicki, Pia Burman
doi : 10.1210/clinem/dgaa749
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 4, April 2021, Pages 1183–1194
Aggressive pituitary tumors (APTs) are characterized by unusually rapid growth and lack of response to standard treatment. About 1% to 2% develop metastases being classified as pituitary carcinomas (PCs). For unknown reasons, the corticotroph tumors are overrepresented among APTs and PCs. Mutations in the alpha thalassemia/mental retardation syndrome X-linked (ATRX) gene, regulating chromatin remodeling and telomere maintenance, have been implicated in the development of several cancer types, including neuroendocrine tumors.
Approach to the Patient with Primary Aldosteronism: Utility and Limitations of Adrenal Vein Sampling
Adina F Turcu, Richard Auchus
doi : 10.1210/clinem/dgaa952
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 4, April 2021, Pages 1195–1208
Several studies over the past 3 decades document a higher prevalence of primary aldosteronism (PA) among hypertensive patients than generally presumed. PA exists as a spectrum from mild to severe aldosterone excess. Although a variety of PA subtypes exist, the 2 most common are aldosterone-producing adenomas (APAs) and bilateral hyperaldosteronism (BHA). The distinction is important, because APA—and other subtypes, with aldosterone production mostly from 1 adrenal—can be cured surgically, and BHA should be treated medically with mineralocorticoid-receptor antagonists (MRAs). The major shortcomings in the tailored management of patients with possible PA are the low rates of screening for case identification and the expensive and technically challenging imaging and interventional procedures required to distinguish APA from BHA, especially adrenal vein sampling (AVS). When AVS identifies an APA and allows the patient to be cured surgically, the procedure is of great value. In contrast, the patient with BHA is treated with MRA whether AVS is performed or not. Consequently, it is prudent to gauge how likely it is to benefit from imaging and AVS in each case prior to embarking on these studies. The explosion of information about PA in the past decade, including predictors of APA and of surgical benefit, are useful in limiting the evaluation for some patients with a positive PA screening test. This article will review our suggestions for approaching these patients in a pragmatic style, recognizing the limitations to even the best resources and facilities.
Preoperative Vitamin D Deficiency is a Risk Factor for Postthyroidectomy Hypoparathyroidism: A Systematic Review and Meta-Analysis of Observational Studies
Konstantina D Vaitsi, Panagiotis Anagnostis, Stavroula Veneti, Theodosios S Papavramidis, Dimitrios G Goulis
doi : 10.1210/clinem/dgab039
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 4, April 2021, Pages 1209–1224
Whether preoperative vitamin D deficiency (VDD) contributes to postoperative hypoparathyroidism (hypoPT) risk is unknown.
Microvascular Benefits of New Antidiabetic Agents: A Systematic Review and Network Meta-Analysis of Kidney Outcomes
Ashley S Cha, Yilin Chen, Katherine Fazioli, Matthew B Rivara, Emily Beth Devine
doi : 10.1210/clinem/dgaa894
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 4, April 2021, Pages 1225–1234
Diabetic kidney disease affects nearly one-third of US adults with prevalent type 2 diabetes mellitus (T2DM). The use of new antidiabetic medications in the prevention and treatment of diabetic kidney disease is a growing area of research interest.
Improving Science by Overcoming Laboratory Pitfalls With Hormone Measurements
Jacquelien J Hillebrand, Wjera V Wickenhagen, Annemieke C Heijboer
doi : 10.1210/clinem/dgaa923
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 4, April 2021, Pages e1504–e1512
Despite all the effort taken, there is often surprisingly little attention paid to the hormone analyses involved in research studies. Thinking carefully about the quality of the hormone measurements in these studies is, however, of major importance, as this attention to methods may prevent false conclusions and inappropriate follow-up studies. We discuss issues regarding hormone measurements that one should consider, ideally prior to starting, or otherwise, as they arise during a scientific study: quality of the technique, expertise, matrices, timing and storage conditions, freeze-thaw cycles, lot-to-lot and day-to-day variation, analyses per batch or sample-wise, singlicate or duplicate measurements, combining methods, and standardization. This article and the examples mentioned herein aim to clarify the need to pay attention to the hormone analyses, and to help in making decisions. In addition, these examples help editors and reviewers of scientific journals to pay attention to the methods section in the submitted manuscripts and ask the right critical questions when needed.
Digital Coaching Strategies to Facilitate Behavioral Change in Type 2 Diabetes: A Systematic Review
Bradley D Gershkowitz, Conor J Hillert, Bradley H Crotty
doi : 10.1210/clinem/dgaa850
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 4, April 2021, Pages e1513–e1520
In this systematic review, we focus on the clinical impact of digital tools for providing health coaching, education, and facilitating behavior in patients with prediabetes or type 2 diabetes. Our approach was designed to provide insights for clinicians and health care systems that are considering adopting such digital tools.
The Relationship Between Glucose Control and Cognitive Function in People With Diabetes After a Lacunar Stroke
Tali Cukierman-Yaffe, Leslie A McClure, Thomas Risoli, Jackie Bosch, Mike Sharma, Hertzel C Gerstein, Oscar Benavente
doi : 10.1210/clinem/dgab022
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 4, April 2021, Pages e1521–e1528
Lacunar strokes and diabetes are risk factors for cognitive dysfunction. Elucidating modifiable risk factors for cognitive dysfunction has great public health implications. One factor may be glycemic status, as measured by glycated hemoglobin (A1c).
Islet Function and Insulin Sensitivity in Latent Autoimmune Diabetes in Adults Taking Sitagliptin: A Randomized Trial
Lin Yang, Huiying Liang, Xinyuan Liu, Xia Wang, Ying Cheng, Yunjuan Zhao, Lingjiao Liu, Gan Huang, Xiangbing Wang, Zhiguang Zhou
doi : 10.1210/clinem/dgab026
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 4, April 2021, Pages e1529–e1541
The long-term effects of dipeptidyl peptidase-4 inhibitors on ?-cell function and insulin sensitivity in latent autoimmune diabetes in adults (LADA) are unclear.
Long-Term Outcome and Treatment in Persistent and Transient Congenital Hyperinsulinism: A Finnish Population-Based Study
Jonna M E M?nnist?, Jarmo J??skel?inen, Timo Otonkoski, Hanna Huopio
doi : 10.1210/clinem/dgab024
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 4, April 2021, Pages e1542–e1551
The management of congenital hyperinsulinism (CHI) has improved.
Insulin-like Growth Factor-1, Bone Mineral Density, and Fracture: A Mendelian Randomization Study
Shuai Yuan, Zi-Hao Wan, Shi-Le Cheng, Karl Michaëlsson, Susanna C Larsson
doi : 10.1210/clinem/dgaa963
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 4, April 2021, Pages e1552–e1558
The associations of circulating insulin-like growth factor-1 (IGF-1) levels with bone mineral density and fracture risk are inconclusive in observational studies.
Iron Overload in Functional Hyperandrogenism: In a Randomized Trial, Bloodletting Does Not Improve Metabolic Outcomes
Andrés E Ortiz-Flores, Mar?a ?ngeles Mart?nez-Garc?a, L?a Nattero-Ch?vez, Francisco ?lvarez-Blasco, Elena Fern?ndez-Dur?n, Alejandra Quintero-Tobar, Héctor F Escobar-Morreale, Manuel Luque-Ram?rez
doi : 10.1210/clinem/dgaa978
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 4, April 2021, Pages e1559–e1573
Functional hyperandrogenism may be associated with a mild increase in body iron stores. Iron depletion exerts a beneficial effect on metabolic endpoints in other iron overload states.
Insulin Resistance in Congenital Adrenal Hyperplasia is Compensated for by Reduced Insulin Clearance
Daniel Minutti de Oliveira, Andrea Tura, Ana Carolina Junqueira Vasques, Daniella Fernandes Camilo, Marcelo Miranda Lima, Sofia Helena Valente de Lemos-Marini, Ezequiel Moreira Goncalves, Gil Guerra-Junior, Bruno Geloneze
doi : 10.1210/clinem/dgab010
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 4, April 2021, Pages e1574–e1585
Congenital adrenal hyperplasia (CAH) patients have potential normal longevity. However, a greater risk for cardiovascular disease has been reported. Insulin resistance and hyperinsulinemia have been described in CAH patients, whereas the prevalence of overt type 2 diabetes is not higher in CAH than in normal population.
No Venous Thromboembolism Increase Among Transgender Female Patients Remaining on Estrogen for Gender-Affirming Surgery
Aki Kozato, G W Conner Fox, Patrick C Yong, Sangyoon J Shin, Bella K Avanessian, Jess Ting, Yiwei Ling, Subha Karim, Joshua D Safer, John Henry Pang
doi : 10.1210/clinem/dgaa966
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 4, April 2021, Pages e1586–e1590
Both surgery and exogenous estrogen use are associated with increased risk of venous thromboembolism (VTE). However, it is not known whether estrogen hormone therapy (HT) exacerbates the surgery-associated risk among transgender and gender nonbinary (TGNB) individuals. The lack of published data has contributed to heterogeneity in perioperative protocols regarding estrogen HT administration for TGNB patients undergoing gender-affirming surgery.
Body Habitus Across the Lifespan and Risk of Pituitary Adenoma
David J Cote, Timothy R Smith, Ursula B Kaiser, Edward R Laws, Jr, Meir J Stampfer
doi : 10.1210/clinem/dgaa987
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 4, April 2021, Pages e1591–e1602
No studies have examined the association between body habitus and incidence of pituitary adenoma.
Preoperative BMI Predicts Postoperative Weight Gain in Adult-onset Craniopharyngioma
Daisy Duan, Leen Wehbeh, Debraj Mukherjee, Amir H Hamrahian, Fausto J Rodriguez, Sachin Gujar, Adham M Khalafallah, Camille Hage, Patrizio Caturegli, Gary L Gallia, Rexford S Ahima, Nisa M Maruthur, Roberto Salvatori
doi : 10.1210/clinem/dgaa985
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 4, April 2021, Pages e1603–e1617
Craniopharyngiomas, while benign, have the highest morbidity of all nonmalignant sellar tumors. Studies on weight and metabolic outcomes in adult-onset craniopharyngioma (AOCP) remain sparse.
Levoketoconazole, the 2S,4R Enantiomer of Ketoconazole, a New Steroidogenesis Inhibitor for Cushing’s Syndrome Treatment
Sara G Creemers, Richard A Feelders, Frank H de Jong, Gaston J H Franssen, Yolanda B de Rijke, Peter M van Koetsveld, Leo J Hofland
doi : 10.1210/clinem/dgaa989
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 4, April 2021, Pages e1618–e1630
Racemic ketoconazole (RK) is a steroidogenesis inhibitor used for treatment of Cushing’s syndrome. Levoketoconazole (COR-003), the pure 2S,4R enantiomer, is potentially more potent and safe compared to RK. We compared in vitro effects of levoketoconazole and RK on adrenocortical and pituitary adenoma cells.
Insulin-Stimulated Muscle Glucose Uptake and Insulin Signaling in Lean and Obese Humans
Paola A Ramos, Kelli A Lytle, Danae Delivanis, S?ren Nielsen, Nathan K LeBrasseur, Michael D Jensen
doi : 10.1210/clinem/dgaa919
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 4, April 2021, Pages e1631–e1646
Skeletal muscle is the primary site for insulin-stimulated glucose disposal, and muscle insulin resistance is central to abnormal glucose metabolism in obesity. Whether muscle insulin signaling to the level of Akt/AS160 is intact in insulin-resistant obese humans is controversial.
A Panel of 6 Biomarkers Significantly Improves the Prediction of Type 2 Diabetes in the MONICA/KORA Study Population
Barbara Thorand, Astrid Zierer, Mustafa Büyük?zkan, Jan Krumsiek, Alina Bauer, Florian Schederecker, Julie Sudduth-Klinger, Christa Meisinger, Harald Grallert, Wolfgang Rathmann, Michael Roden, Annette Peters, Wolfgang Koenig, Christian Herder, Cornelia Huth
doi : 10.1210/clinem/dgaa953
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 4, April 2021, Pages e1647–e1659
Improved strategies to identify persons at high risk of type 2 diabetes are important to target costly preventive efforts to those who will benefit most.
Procoagulant Imbalance in Klinefelter Syndrome Assessed by Thrombin Generation Assay and Whole-Blood Thromboelastometry
Rita Indirli, Emanuele Ferrante, Erica Scalambrino, Eriselda Profka, Marigrazia Clerici, Tommaso Lettera, Andreea Liliana Serban, Walter Vena, Alessandro Pizzocaro, Marco Bonomi, Biagio Cangiano, Giulia Carosi, Gherardo Mazziotti, Luca Persani, Andrea Lania, Maura Arosio, Flora Peyvandi, Giovanna Mantovani, Armando Tripodi
doi : 10.1210/clinem/dgaa936
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 4, April 2021, Pages e1660–e1672
Klinefelter syndrome (KS) is a condition at increased risk of thrombosis compared to 46,XY men.
Plasmatic and Urinary 5-Hydroxyindolacetic Acid Measurements in Patients With Midgut Neuroendocrine Tumors: A GTE Study
Louis de Mestier, Frédérique Savagner, Hedia Brixi, Christine Do Cao, Sophie Dominguez-Tinajero, Guillaume Roquin, Bernard Goichot, Olivia Hentic, Olivier Dubreuil, Vincent Hautefeuille, Thomas Walter, Guillaume Cadiot
doi : 10.1210/clinem/dgaa924
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 4, April 2021, Pages e1673–e1682
Although 24-hour urinary 5-hydroxyindolacetic acid (24u5HIAA) is a key biomarker in midgut neuroendocrine tumors (NETs), it may be inaccurate and inconvenient.
Distant Metastases From Childhood Differentiated Thyroid Carcinoma: Clinical Course and Mutational Landscape
Marloes Nies, Rena Vassilopoulou-Sellin, Roland L Bassett, Sireesha Yedururi, Mark E Zafereo, Maria E Cabanillas, Steven I Sherman, Thera P Links, Steven G Waguespack
doi : 10.1210/clinem/dgaa935
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 4, April 2021, Pages e1683–e1697
Distant metastases (DM) from childhood differentiated thyroid carcinoma (DTC) are uncommon and published studies are limited.
IGF-I/IGFBP3/ALS Deficiency in Sarcopenia: Low GHBP Suggests GH Resistance in a Subgroup of Geriatric Patients
Uta Ferrari, Ralf Schmidmaier, Theresa Jung, Martin Reincke, Sebastian Martini, Benedikt Schoser, Martin Bidlingmaier, Michael Drey
doi : 10.1210/clinem/dgaa972
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 4, April 2021, Pages e1698–e1707
Definition of etiological subgroups of sarcopenia may help to develop targeted treatments. insulin like growth factor-I (IGF-I), Insulinlike growth factor binding protein 3 (IGFBP3), and acid labile subunit (ALS) build a ternary complex that mediates growth hormone (GH) effects on peripheral organs, such as muscle. Low GH binding protein (GHBP) as a marker of GH receptor number would hint toward GH resistance.
Development of a Prediction Score to Avoid Confirmatory Testing in Patients With Suspected Primary Aldosteronism
Jacopo Burrello, Martina Amongero, Fabrizio Buffolo, Elisa Sconfienza, Vittorio Forestiero, Alessio Burrello, Christian Adolf, Laura Handgriff, Martin Reincke, Franco Veglio, Tracy Ann Williams, Silvia Monticone, Paolo Mulatero
doi : 10.1210/clinem/dgaa974
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 4, April 2021, Pages e1708–e1716
The diagnostic work-up of primary aldosteronism (PA) includes screening and confirmation steps. Case confirmation is time-consuming, expensive, and there is no consensus on tests and thresholds to be used. Diagnostic algorithms to avoid confirmatory testing may be useful for the management of patients with PA.
Selective Use of Radioactive Iodine Therapy for Papillary Thyroid Cancers With Low or Lower-Intermediate Recurrence Risk
Giorgio Grani, Livia Lamartina, Marco Alf?, Valeria Ramundo, Rosa Falcone, Laura Giacomelli, Marco Biffoni, Sebastiano Filetti, Cosimo Durante
doi : 10.1210/clinem/dgaa973
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 4, April 2021, Pages e1717–e1727
Current guidelines recommend a selective use of radioiodine treatment (RAI) for papillary thyroid cancer (PTC).
Adoption of Active Surveillance for Very Low-Risk Differentiated Thyroid Cancer in the United States: A National Survey
Susan C Pitt, Nan Yang, Megan C Saucke, Nicholas Marka, Bret Hanlon, Kristin L Long, Alexandria D McDow, J P Brito, Benjamin R Roman
doi : 10.1210/clinem/dgaa942
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 4, April 2021, Pages e1728–e1737
Active surveillance (AS) of thyroid cancer with serial ultrasounds is a newer management option in the United States.
14-Day Ketone Supplementation Lowers Glucose and Improves Vascular Function in Obesity: A Randomized Crossover Trial
Jeremy J Walsh, Helena Neudorf, Jonathan P Little
doi : 10.1210/clinem/dgaa925
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 4, April 2021, Pages e1738–e1754
Postprandial hyperglycemia increases systemic inflammation and is a risk factor for cardiovascular disease. A ketone monoester (KME) drink containing ?-hydroxybutyrate (?-OHB) rapidly lowers plasma glucose, which may be a strategy protecting against postprandial hyperglycemia.
Inequities in Diabetic Ketoacidosis Among Patients With Type 1 Diabetes and COVID-19: Data From 52 US Clinical Centers
Osagie Ebekozien, Shivani Agarwal, Nudrat Noor, Anastasia Albanese-O’Neill, Jenise C Wong, Tossaporn Seeherunvong, Janine Sanchez, Daniel DeSalvo, Sarah K Lyons, Shideh Majidi, Jamie R Wood, Runa Acharya, Grazia Aleppo, Kathryn M Sumpter, Anna Cymbaluk, Nirali A Shah, Michelle Van Name, Lisa Cruz-Aviles, Guy Todd Alonso, Mary Pat Gallagher, Srinath Sanda, Alexis Jamie Feuer, Kristina Cossen, Nicole Rioles, Nana-Hawa Yayah Jones, Manmohan K Kamboj, Irl B Hirsch
doi : 10.1210/clinem/dgaa920
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 4, April 2021, Pages e1755–e1762
We examined whether diabetic ketoacidosis (DKA), a serious complication of type 1 diabetes (T1D) was more prevalent among Non-Hispanic (NH) Black and Hispanic patients with T1D and laboratory-confirmed coronavirus disease 2019 (COVID-19) compared with NH Whites.
HLA Class I Upregulation and Antiviral Immune Responses in Graves Disease
Therese Weider, Sarah J Richardson, Noel G Morgan, Trond H Paulsen, Knut Dahl-J?rgensen, Sara Salehi Hammerstad
doi : 10.1210/clinem/dgaa958
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 4, April 2021, Pages e1763–e1774
The origin of Graves disease (GD) remains elusive. However, evidence of an association between GD and viral infections is emerging. Human leukocyte antigen (HLA) class I presents viral antigens to circulating immune cells and plays a crucial role in the defense against viral infections.
The Calcium-Sensing Receptor Is Essential for Calcium and Bicarbonate Sensitivity in Human Spermatozoa
Ida Marie Boisen, Anders Rehfeld, Iris Mos, Nadia Nicholine Poulsen, John Erik Nielsen, Peter Schwarz, Lars Rejnmark, Steen Dissing, Pernille Bach-Mortensen, Anders Juul, Hans Br?uner-Osborne, Beate Lanske, Martin Blomberg Jensen
doi : 10.1210/clinem/dgaa937
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 4, April 2021, Pages e1775–e1792
The calcium-sensing receptor (CaSR) is essential to maintain a stable calcium concentration in serum. Spermatozoa are exposed to immense changes in concentrations of CaSR ligands such as calcium, magnesium, and spermine during epididymal maturation, in the ejaculate, and in the female reproductive environment. However, the role of CaSR in human spermatozoa is unknown.
Glucose Tolerance Stages in Cystic Fibrosis Are Identified by a Unique Pattern of Defects of Beta-Cell Function
Claudia Piona, Sonia Volpi, Chiara Zusi, Enza Mozzillo, Antonella Tosco, Adriana Franzese, Valeria Raia, Maria Linda Boselli, Maddalena Trombetta, Marco Cipolli, Riccardo C Bonadonna, Claudio Maffeis
doi : 10.1210/clinem/dgaa932
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 4, April 2021, Pages e1793–e1802
We aimed to assess the order of severity of the defects of 3 direct determinants of glucose regulation—beta-cell function, insulin clearance, and insulin sensitivity—in patients with cystic fibrosis (CF), categorized according their glucose tolerance status, including early elevation of mid-level oral glucose tolerance test (OGTT) glucose values (>140 and <200 mg/dL), referred to as AGT140.
Testicular Testosterone and Estradiol Concentrations and Aromatase Expression in Men with Nonobstructive Azoospermia
Koji Shiraishi, Shintaro Oka, Hideyasu Matsuyama
doi : 10.1210/clinem/dgaa860
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 4, April 2021, Pages e1803–e1815
Spermatogenesis is strictly regulated by the intratesticular hormonal milieu, in which testosterone (T) and estradiol (E2) play pivotal roles. However, the optimal expression of aromatase and intratesticular T (ITT) and E2 (ITE2) levels are unknown.
Molecular Imaging Targeting Corticotropin-releasing Hormone Receptor for Corticotropinoma: A Changing Paradigm
Rama Walia, Rahul Gupta, Anil Bhansali, Rosario Pivonello, Rajender Kumar, Harmandeep Singh, Chirag Ahuja, Rajesh Chhabra, Apinderpreet Singh, Sivashanmugam Dhandapani, Sushant Sahoo, Nivedita Rana, Rakhee Vatsa, Pinaki Dutta, Sanjay Kumar Bhadada, Naresh Sachdeva, B R Mittal, Uma Nahar, Jaya Shukla
doi : 10.1210/clinem/dgaa755
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 4, April 2021, Pages e1816–e1826
Corticotrophin-releasing hormone (CRH) is the major regulator of adrenocorticotrophic hormone (ACTH) secretion from the anterior pituitary and acts via CRH-1 receptors (CRH-1R). Corticotropinoma though autonomous, still retain their responsiveness to CRH and hence, we hypothesize that in vivo detection of CRH-1 receptors on pituitary adenoma using Gallium-68 (68Ga)-tagged CRH can indicate the functionality of adenoma, and combining it with positron emission tomography-computed tomography (PET-CT) can provide requisite anatomical information.
Elevated Plasma Branched-Chain Amino Acid Levels Correlate With Type 2 Diabetes–Related Metabolic Disturbances
Froukje Vanweert, Marlies de Ligt, Joris Hoeks, Matthijs K C Hesselink, Patrick Schrauwen, Esther Phielix
doi : 10.1210/clinem/dgaa751
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 4, April 2021, Pages e1827–e1836
Patients with type 2 diabetes mellitus (T2DM) have elevated plasma branched-chain amino acid (BCAA) levels. The underlying cause, however, is not known. Low mitochondrial oxidation of BCAA levels could contribute to higher plasma BCAA levels.
The Effects of Kisspeptin on Brain Response to Food Images and Psychometric Parameters of Appetite in Healthy Men
Lisa Yang, Lysia Demetriou, Matthew B Wall, Edouard G Mills, Victoria C Wing, Layla Thurston, Caroline N Schaufelberger, Bryn M Owen, Ali Abbara, Eugenii A Rabiner, Alexander N Comninos, Waljit S Dhillo
doi : 10.1210/clinem/dgaa746
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 4, April 2021, Pages e1837–e1848
The hormone kisspeptin has crucial and well-characterized roles in reproduction. Emerging data from animal models also suggest that kisspeptin has important metabolic effects including modulation of food intake. However, to date there have been no studies exploring the effects of kisspeptin on brain responses to food stimuli in humans.
Treatment of Gestational Diabetes Mellitus and Offspring Early Childhood Growth
Maisa Feghali, Jacqueline Atlass, Kaleab Z Abebe, Diane Comer, Janet Catov, Steve Caritis, Silva Arslanian, Christina Scifres
doi : 10.1210/clinem/dgaa742
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 4, April 2021, Pages e1849–e1858
Gestational diabetes mellitus (GDM) is associated with fetal overgrowth, and certain treatments are associated with an increased risk of macrosomia. However, there are limited data about the long-term effect of GDM treatment on childhood growth.
Subclinical Hypothyroidism as an Independent Determinant of Left Atrial Dysfunction in the General Population
Koki Nakanishi, Masao Daimon, Yuriko Yoshida, Naoko Sawada, Kazutoshi Hirose, Kentaro Iwama, Yuko Yamamoto, Jumpei Ishiwata, Megumi Hirokawa, Hidehiro Kaneko, Tomoko Nakao, Yoshiko Mizuno, Hiroyuki Morita, Marco R Di Tullio, Shunichi Homma, Issei Komuro
doi : 10.1210/clinem/dgaa730
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 4, April 2021, Pages e1859–e1867
Although subclinical hypothyroidism (SCH) is a common clinical entity and carries independent risk for incident heart failure (HF), its possible association with subclinical cardiac dysfunction is unclear. Left ventricular global longitudinal strain (LVGLS) and left atrial (LA) phasic strain can unmask subclinical left heart abnormalities and are excellent predictors for HF. This study aimed to investigate the association between the presence of SCH and subclinical left heart dysfunction in a sample of the general population without overt cardiac disease.
Long-term Bone Loss and Deterioration of Microarchitecture After Gastric Bypass in African American and Latina Women
Alexandra Krez, Sanchita Agarwal, Mariana Bucovsky, Donald J McMahon, Yizhong Hu, Marc Bessler, Beth Schrope, Angela Carrelli, Shannon Clare, Xiang-Dong Edward Guo, Shonni J Silverberg, Emily M Stein
doi : 10.1210/clinem/dgaa654
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 4, April 2021, Pages e1868–e1879
The prevalence of obesity is burgeoning among African American and Latina women; however, few studies investigating the skeletal effects of bariatric surgery have focused on these groups.
Maternal Obesity Influences Placental Nutrient Transport, Inflammatory Status, and Morphology in Human Term Placenta
Perrine Nogues, Esther Dos Santos, Anne Couturier-Tarrade, Paul Berveiller, Lucie Arnould, Elodie Lamy, Stanislas Grassin-Delyle, François Vialard, Marie-Noëlle Dieudonne
doi : 10.1210/clinem/dgaa660
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 4, April 2021, Pages e1880–e1896
Maternal obesity has a significant impact on placental development. However, this impact on the placenta’s structure and function (ie, nutrient transport and hormone and cytokine production) is a controversial subject.
Insulin Resistance and Hyperinsulinemia: the Egg and the Chicken
Muhammad Abdul-Ghani, Ralph A DeFronzo
doi : 10.1210/clinem/dgaa364
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 4, April 2021, Pages e1897–e1899
Diet and Fat Metabolism—Uncovering Key Determinants of Diabetes Risk Prediction in Populations of African Descent
Amber B Courville, Stephanie T Chung
doi : 10.1210/clinem/dgaa914
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 4, April 2021, Pages e1900–e1901
CRH-Receptor Molecular Imaging Reveals the Intimacy of Corticotroph Adenomas
Jérôme Bertherat
doi : 10.1210/clinem/dgaa883
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 4, April 2021, Pages e1902–e1904
A Window into Understanding the Lasting Impact of the Nutritional Milieu in Adolescents: Anorexia Nervosa as a Model
Jennifer M Barker
doi : 10.1210/clinem/dgaa667
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 4, April 2021, Pages e1905–e1906
Slit2 Regulation of Hyaluronan and Cytokine Synthesis in Fibrocytes in Thyroid-associated Ophthalmopathy
Alessandro Antonelli, Silvia Martina Ferrari, Poupak Fallahi
doi : 10.1210/clinem/dgaa959
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 4, April 2021, Pages e1907–e1908
Casting a Health Equity Lens on Endocrinology and Diabetes
Sherita Hill Golden, Joshua J Joseph, Felicia Hill-Briggs
doi : 10.1210/clinem/dgaa938
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 4, April 2021, Pages e1909–e1916
As endocrinologists we have focused on biological contributors to disparities in diabetes, obesity and other endocrine disorders. Given that diabetes is an exemplar health disparity condition, we, as a specialty, are also positioned to view the contributing factors and solutions more broadly. This will give us agency in contributing to health system, public health, and policy-level interventions to address the structural and institutional racism embedded in our medical and social systems. A history of unconsented medical and research experimentation on vulnerable groups and perpetuation of eugenics theory in the early 20th century have resulted in residual health care provider biases toward minority patients and patient distrust of medical systems, leading to poor quality of care. Historical discriminatory housing and lending policies resulted in racial residential segregation and neighborhoods with inadequate housing, healthy food access, and educational resources, setting the foundation for the social determinants of health (SDOH) contributing to present-day disparities. To reduce these disparities we need to ensure our health systems are implementing the National Standards for Culturally and Linguistically Appropriate Services in Health and Health Care to promote health equity. Because of racial biases inherent in our medical systems due to historical unethical practices in minority communities, health care provider training should incorporate awareness of unconscious bias, antiracism, and the value of diversity. Finally, we must also address poverty-related SDOH (eg, food and housing insecurity) by integrating social needs into medical care and using our voices to advocate for social policies that redress SDOH and restore environmental justice.
Letter to the Editor: “Lipid Management in Patients with Endocrine Disorders: An Endocrine Society Clinical Practice Guideline”
Susan R Davis, Bronwyn G A Stuckey, Karen S Magraith, Rodney J Baber
doi : 10.1210/clinem/dgaa968
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 4, April 2021, Pages e1917–e1918
Letter to the Editor from Candemir et al: “Prevalence and Incidence of Atrial Fibrillation in a Large Cohort of Adrenal Incidentalomas: A Long- Term Study”
Burcu Candemir, Cem Haymana, Mustafa Candemir
doi : 10.1210/clinem/dgab031
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 4, April 2021, Page e1919
Letter to the Editor from Dreyer, et al: “Osteoporosis in Premenopausal Women: A Clinical Narrative Review by the ECTS and the IOF”
Patricia Dreyer, Telma Palomo, Cynthia M A Brand?o, Jose G H Vieira, E Michael Lewiecki
doi : 10.1210/clinem/dgaa984
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 4, April 2021, Pages e1920–e1921
Letter to the Editor from Dalan: “Vitamin D Supplementation for Prevention of Type 2 Diabetes Mellitus: To D or Not to D?”
Rinkoo Dalan
doi : 10.1210/clinem/dgaa967
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 4, April 2021, Pages e1922–e1923
Response to Letter to the Editor from Candemir et al: “Prevalence and Incidence of Atrial Fibrillation in a Large Cohort of Adrenal Incidentalomas: A Long-Term Study”
Guido Di Dalmazi, Uberto Pagotto
doi : 10.1210/clinem/dgab032
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 4, April 2021, Pages e1924–e1925
Response to Letter to the Editor: “Lipid Management in Patients With Endocrine Disorders: An Endocrine Society Clinical Practice Guideline”
Connie Newman, Lisa R Tannock, Ira Goldberg
doi : 10.1210/clinem/dgaa970
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 4, April 2021, Pages e1926–e1927
Response to Letter to the Editor from Dalan: “Vitamin D Supplementation for Prevention of Type 2 Diabetes Mellitus: To D or Not to D?”
Anastassios G Pittas, Rolf Jorde, Tetsuya Kawahara, Bess Dawson-Hughes
doi : 10.1210/clinem/dgaa971
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 4, April 2021, Pages e1928–e1929
Corrigendum to: “Quality of Life in Patients with Neuroendocrine Neoplasms: The Role of Severity, Clinical Heterogeneity, and Resilience”
doi : 10.1210/clinem/dgab017
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 4, April 2021, Page e1930
Corrigendum to: “Osteoporosis in Premenopausal Women: A Clinical Narrative Review by the ECTS and the IOF”
doi : 10.1210/clinem/dgaa947
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 4, April 2021, Page e1931
Corrigendum to: “Safety of High-Dose Vitamin D Supplementation: Secondary Analysis of a Randomized Controlled Trial”
doi : 10.1210/clinem/dgaa886
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 4, April 2021, Page e1932
Corrigendum to: “Effects of Levothyroxine on Pregnant Women with Subclinical Hypothyroidism, Negative for Thyroid Peroxidase Antibodies”
doi : 10.1210/clinem/dgaa946
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 4, April 2021, Page e1933
ERRATUM FOR: “Classic and Nonclassic Apparent Mineralocorticoid Excess Syndrome”
doi : 10.1210/clinem/dgaa272
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 4, April 2021, Page e1934
Erratum to: “Metformin Biodistribution: A Key to Mechanisms of Action?”
doi : 10.1210/clinem/dgaa907
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 4, April 2021, Page e1935
Erratum to: “Reproduction Function in Male Patients With Bardet Biedl Syndrome”
doi : 10.1210/clinem/dgaa897
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 4, April 2021, Page e1936
