Journal of Clinical Endocrinology and Metabolism : JCEM




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سفارش

New Horizon: Exercise and a Focus on Tissue-Brain Crosstalk

Logan K Townsend, Rebecca E K MacPherson, David C Wright

doi : 10.1210/clinem/dgab333

The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 8, August 2021, Pages 2147–2163

The world population is aging, leading to increased rates of neurodegenerative disorders. Exercise has countless health benefits and has consistently been shown to improve brain health and cognitive function. The purpose of this review is to provide an overview of exercise-induced adaptations in the brain with a focus on crosstalk between peripheral tissues and the brain. We highlight recent investigations into exercise-induced circulating factors, or exerkines, including irisin, cathepsin B, GPLD1, and ketones and the mechanisms mediating their effects in the brain.

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Expression of Cholecystokinin and its Receptors in the Intestinal Tract of Type 2 Diabetes Patients and Healthy Controls

Hannah Gilliam-Vigh, Tina Jorsal, Jens F Rehfeld, Jens Pedersen, Steen S Poulsen, Tina Vilsb?ll, Filip K Knop

doi : 10.1210/clinem/dgab367

The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 8, August 2021, Pages 2164–2170

Cholecystokinin (CCK) is a gut hormone originally known for its effects on gallbladder contraction and release of digestive enzymes. CCK, however, also mediates satiety and stimulate insulin secretion. Knowledge of the distribution of CCK-producing enteroendocrine cells (I cells) in humans is sparse. The general notion, based on animal data, is that I cells are present mainly in the proximal small intestine. We examined the occurrence of I cells (immunohistochemically) and the expression of CCK messenger RNA (mRNA) as well as CCK1 and CCK2 receptor mRNA along the intestines in healthy individuals and patients with type 2 diabetes.

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A Selective Androgen Receptor Modulator (OPK-88004) in Prostate Cancer Survivors: A Randomized Trial

Karol M Pencina, Arthur L Burnett, Thomas W Storer, Wen Guo, Zhuoying Li, Adam S Kibel, Grace Huang, Michelle Blouin, Donna L Berry, Shehzad Basaria, Shalender Bhasin

doi : 10.1210/clinem/dgab361

The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 8, August 2021, Pages 2171–2186

Androgen deficiency is common among prostate cancer survivors, but many guidelines consider history of prostate cancer a contraindication for testosterone replacement. We determined the safety and efficacy of a selective androgen receptor modulator (OPK-88004) in symptomatic, testosterone-deficient men who had undergone radical prostatectomy for low-grade, organ-confined prostate cancer.

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Time-Series Analysis of Continuous Glucose Monitoring Data to Predict Treatment Efficacy in Patients with T2DM

Li Li, Jie Sun, Liemin Ruan, Qifa Song

doi : 10.1210/clinem/dgab356

The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 8, August 2021, Pages 2187–2197

There is a challenge to predict treatment effects in patients with type 2 diabetes mellitus (T2DM).

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Afirma Genomic Sequencing Classifier and Xpression Atlas Molecular Findings in Consecutive Bethesda III-VI Thyroid Nodules 

Mimi I Hu, Steven G Waguespack, Chrysoula Dosiou, Paul W Ladenson, Masha J Livhits, Lori J Wirth, Peter M Sadow, Jeffrey F Krane, Brendan C Stack, Mark E Zafereo, Syed Z Ali, Steven P Weitzman, Yangyang Hao, Joshua E Babiarz, Giulia C Kennedy, Richard T Kloos

doi : 10.1210/clinem/dgab304

The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 8, August 2021, Pages 2198–2207

Investigate the molecular findings across a large, real-world cohort of thyroid fine-needle aspiration (FNA) samples.

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Normal Adrenal and Thyroid Function in Patients Who Survive COVID-19 Infection 

Sophie A Clarke, Maria Phylactou, Bijal Patel, Edouard G Mills, Beatrice Muzi, Chioma Izzi-Engbeaya, Sirazum Choudhury, Bernard Khoo, Karim Meeran, Alexander N Comninos, Ali Abbara, Tricia Tan, Waljit S Dhillo

doi : 10.1210/clinem/dgab349

The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 8, August 2021, Pages 2208–2220

The COVID-19 pandemic continues to exert an immense burden on global health services. Moreover, up to 63% of patients experience persistent symptoms, including fatigue, after acute illness. Endocrine systems are vulnerable to the effects of COVID-19 as many glands express the ACE2 receptor, used by the SARS-CoV-2 virion for cellular access. However, the effects of COVID-19 on adrenal and thyroid gland function after acute COVID-19 remain unknown.

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G Protein–coupled Receptors in Radioiodine-refractory Thyroid Cancer in the Era of Precision Medicine

Valentine Suteau, Valérie Seegers, Mathilde Munier, Rym Ben Boubaker, Cécile Reyes, David Gentien, Méline Wery, Anne Croué, Frédéric Illouz, Antoine Hamy, Patrice Rodien, Claire Briet

doi : 10.1210/clinem/dgab343

The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 8, August 2021, Pages 2221–2232

Radioiodine-refractory thyroid cancers have poor outcomes and limited therapeutic options (tyrosine kinase inhibitors) due to transient efficacy and toxicity of treatments. Therefore, combinatorial treatments with new therapeutic approaches are needed. Many studies link G protein–coupled receptors (GPCRs) to cancer cell biology.

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MRI-based Texture Analysis of Trabecular Bone for Opportunistic Screening of Skeletal Fragility

Caroline Zaworski, Jonathan Cheah, Matthew F Koff, Ryan Breighner, Bin Lin, Jonathan Harrison, Eve Donnelly, Emily M Stein

doi : 10.1210/clinem/dgab342

The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 8, August 2021, Pages 2233–2241

Many individuals at high risk for osteoporosis and fragility fracture are never screened by traditional methods. Opportunistic use of imaging obtained for other clinical purposes is required to foster identification of these patients.

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Mortality Risk in Patients With Adrenal Insufficiency Using Prednisolone or Hydrocortisone: A Retrospective Cohort Study

Kanchana Ngaosuwan, Desmond G Johnston, Ian F Godsland, Jeremy Cox, Azeem Majeed, Jennifer K Quint, Nick Oliver, Stephen Robinson

doi : 10.1210/clinem/dgab347

The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 8, August 2021, Pages 2242–2251

Prednisolone has been recommended rather than hydrocortisone for glucocorticoid replacement in adrenal insufficiency due its longer duration of action and lower cost.

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Sex Differences in the Effect of Testosterone on Adipose Tissue Insulin Resistance From Overweight to Obese Adults

Xiaohui Li, Jia Liu, Biao Zhou, Yinhui Li, Zhengyu Wu, Hua Meng, Guang Wang

doi : 10.1210/clinem/dgab325

The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 8, August 2021, Pages 2252–2263

Adipose tissue distribution and glucose metabolism differ between men and women. Few studies have investigated sex differences in adipose tissue insulin resistance (adipose-IR). Herein, we investigated sex differences in adipose-IR in adults ranging from overweight to obese and the potential factors associated with sex differences in adipose-IR.

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Clinical and Genetic Analysis of KATP Variants With Heart Failure Risk in Patients With Decreased Serum ApoA-I Levels

Cheng Liu, Yanxian Lai, Jingxian Pei, Huiling Huang, Junfang Zhan, Songsong Ying, Yan Shen

doi : 10.1210/clinem/dgab336

The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 8, August 2021, Pages 2264–2278

Lower serum concentration of apolipoprotein A-I (ApoA-I) is causally associated with heart failure (HF) risk. Adenosine triphosphate–sensitive potassium channels (KATP), as gating channels coupling vascular reactivity and metabolism with ischemic protection, become a new potential target of management for HF. The KATP gene sequence is highly polymorphic and has a high degree of genetic heterogeneity.

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Maternal Glycemia During Pregnancy and Early Offspring Development: A Prospective Birth Cohort Study

Peng Wang, Jun Xie, Xue-Chun Jiao, Shuang-Shuang Ma, Yang Liu, Wan-Jun Yin, Rui-Xue Tao, Hong-Lin Hu, Ying Zhang, Xian-Xia Chen, Fang-Biao Tao, Peng Zhu

doi : 10.1210/clinem/dgab331

The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 8, August 2021, Pages 2279–2290

The association of maternal gestational diabetes mellitus (GDM) with neurodevelopmental outcomes remains controversial and evidence that maternal increasing levels of glucose during pregnancy associated with the risk for impaired neurodevelopment were limited.

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Glycemic Patterns Are Distinct in Post-Bariatric Hypoglycemia After Gastric Bypass (PBH-RYGB)

Daniel Lee, Jonathan M Dreyfuss, Amanda Sheehan, Alexa Puleio, Christopher M Mulla, Mary Elizabeth Patti

doi : 10.1210/clinem/dgab323

The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 8, August 2021, Pages 2291–2303

To quantify glycemia, glycemic variability, and magnitude/duration of low sensor glucose (SG) values in patients with PBH after Roux-en-Y gastric bypass (PBH-RYGB).

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DXA-Based Bone Strain Index: A New Tool to Evaluate Bone Quality in Primary Hyperparathyroidism

Gaia Tabacco, Anda M Naciu, Carmelo Messina, Gianfranco Sanson, Luca Rinaudo, Roberto Cesareo, Stefania Falcone, Silvia Manfrini, Nicola Napoli, John P Bilezikian, Fabio M Ulivieri, Andrea Palermo

doi : 10.1210/clinem/dgab317

The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 8, August 2021, Pages 2304–2312

To assess the lumbar spine (LS), femoral neck (FN), and total hip (TH) BSI in PHPT patients compared with controls and to investigate the association of BSI with vertebral fractures (VFs) in PHPT.

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Deciphering the Role of PGRMC1 During Human Decidualization Using an In Vitro Approach

Stefania Salsano, Roberto Gonz?lez-Mart?n, Alicia Qui?onero, Silvia Pérez-Debén, Francisco Dom?nguez

doi : 10.1210/clinem/dgab303

The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 8, August 2021, Pages 2313–2327

To determine PGRMC1 and mPRs signaling role during decidualization.

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Randomized Controlled Trial Evaluating the Use of Zoledronic Acid in Duchenne Muscular Dystrophy

Margaret Zacharin, Angelina Lim, James Gryllakis, Aris Siafarikas, Craig Jefferies, Julie Briody, Natasha Heather, Janne Pitkin, Jaiman Emmanuel, Katherine J Lee, Xiaofang Wang, Peter J Simm, Craig F Munns

doi : 10.1210/clinem/dgab302

The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 8, August 2021, Pages 2328–2342

To investigate use of zoledronic acid (ZA) in DMD in improving BMD.

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National Trends in Pediatric Admissions for Diabetic Ketoacidosis, 2006–2016

Estelle M Everett, Timothy P Copeland, Tannaz Moin, Lauren E Wisk

doi : 10.1210/clinem/dgab287

The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 8, August 2021, Pages 2343–2354

Diabetic ketoacidosis (DKA) rates in the United States are rising. Prior studies suggest higher rates in younger populations, but no studies have evaluated national trends in pediatric populations and differences by subgroups. As such, we sought to examine national trends in pediatric DKA.

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[18F]-FDG-PET/CT Correlates With the Response of Radiorefractory Thyroid Cancer to Lenvatinib and Patient Survival

Laura Valerio, Federica Guidoccio, Carlotta Giani, Elisa Tardelli, Giulia Puccini, Luciana Puleo, Elisa Minaldi, Giuseppe Boni, Rossella Elisei, Duccio Volterrani

doi : 10.1210/clinem/dgab278

The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 8, August 2021, Pages 2355–2366

We investigated the role of [18F]-FDG-PET/CT in the evaluation of metabolic response and prediction of the outcome of RAI-R DTC patients treated with lenvatinib.

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Ovarian Hyperandrogenism and Response to Gonadotropin-releasing Hormone Analogues in Primary Severe Insulin Resistance 

Isabel Huang-Doran, Alexandra B Kinzer, Mercedes Jimenez-Linan, Kerrie Thackray, Julie Harris, Claire L Adams, Marc de Kerdanet, Anna Stears, Stephen O’Rahilly, David B Savage, Phillip Gorden, Rebecca J Brown, Robert K Semple

doi : 10.1210/clinem/dgab275

The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 8, August 2021, Pages 2367–2383

To characterize hyperandrogenemia and ovarian pathology in primary severe IR (SIR), using IR of defined molecular etiology to interrogate disease mechanism. To extend evaluation of gonadotropin-releasing hormone (GnRH) analogue therapy in SIR.

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Association of Genetic Variants for Plasma LRG1 With Rapid Decline in Kidney Function in Patients With Type 2 Diabetes

Resham Lal Gurung, Rajkumar Dorajoo, Yiamunaa M, Jian-Jun Liu, Sharon Li Ting Pek, Jiexun Wang, Ling Wang, Xueling Sim, Sylvia Liu, Yi-Ming Shao, Keven Ang, Tavintharan Subramaniam, Wern Ee Tang, Chee Fang Sum, Jian-Jun Liu, Su Chi Lim

doi : 10.1210/clinem/dgab268

The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 8, August 2021, Pages 2384–2394

To identify genetic variants associated with plasma LRG1 levels and determine whether genetically predicted plasma LRG1 contributes to a rapid decline in kidney function (RDKF) in patients with T2D.

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Life-course Exposure to Perfluoroalkyl Substances in Relation to Markers of Glucose Homeostasis in Early Adulthood

Damaskini Valvi, Kurt H?jlund, Brent A Coull, Flemming Nielsen, Pal Weihe, Philippe Grandjean

doi : 10.1210/clinem/dgab267

The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 8, August 2021, Pages 2495–2504

To investigate the prospective associations of life-course perfluoroalkyl substances (PFASs) exposure with glucose homeostasis at adulthood.

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Impaired Function and Altered Morphology in the Skeletal Muscles of Adult Men and Women With Type 1 Diabetes

Athan G Dial, Cynthia M F Monaco, Grace K Grafham, Tirth P Patel, Mark A Tarnopolsky, Thomas J Hawke

doi : 10.1210/clinem/dgab261

The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 8, August 2021, Pages 2405–2422

To investigate skeletal muscle function and morphology across the adult lifespan in those with and without T1D.

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Performance of the Aldosterone to Renin Ratio as a Screening Test for Primary Aldosteronism

Annie Hung, Sumaiya Ahmed, Ankur Gupta, Alexandra Davis, Gregory A Kline, Alexander A Leung, Marcel Ruzicka, Swapnil Hiremath, Gregory L Hundemer

doi : 10.1210/clinem/dgab348

The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 8, August 2021, Pages 2423–2435

To evaluate the sensitivity and specificity of the ARR as a screening test for primary aldosteronism.

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Clinical Practice Guidelines on the Diagnosis and Management of Polycystic Ovary Syndrome: A Systematic Review and Quality Assessment Study

Bassel H Al Wattar, Maria Fisher, Laura Bevington, Vikram Talaulikar, Melanie Davies, Gerrad Conway, Ephia Yasmin

doi : 10.1210/clinem/dgab232

The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 8, August 2021, Pages 2436–2446

We searched MEDLINE, EMBASE, and CENTRAL until December 2020 for all evidence-based CPGs and consensus statements on PCOS. We extracted data in duplicate to map clinical recommendations across prespecified disease domains and assessed CPGs methodological quality of using the Appraisal of Guidelines, Research & Evaluation II tool.

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NAFLD and Liver Fibrosis Are Not Associated With Reduced Femoral Bone Mineral Density in the General US Population

Stefano Ciardullo, Emanuele Muraca, Francesca Zerbini, Giuseppina Manzoni, Gianluca Perseghin

doi : 10.1210/clinem/dgab262

The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 8, August 2021, Pages e2856–e2865

To assess whether liver steatosis and fibrosis are associated with reduced BMD in the general US population.

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LncRNA LPAL2/miR-1287-5p/EGFR Axis Modulates TED-Derived Orbital Fibroblast Activation Through Cell Adhesion Factors

Nuo Wang, Shi-ying Hou, Xin Qi, Mi Deng, Jia-min Cao, Bo-Ding Tong, Wei Xiong

doi : 10.1210/clinem/dgab256

The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 8, August 2021, Pages e2866–e2886

We aimed to investigate the mechanism of TED orbital fibroblast activation from the perspective of noncoding RNA regulation.

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Soluble Alpha Klotho in Acromegaly: Comparison With Traditional Markers of Disease Activity 

J?nia R O L Schweizer, Katharina Schilbach, Michael Haenelt, Alexandre V Giannetti, Mariana F Bizzi, Beatriz S Soares, Eduardo Paulino, Jr, Jochen Schopohl, Sylvère St?rmann, Antônio Ribeiro-Oliveira, Jr, Martin Bidlingmaier

doi : 10.1210/clinem/dgab257

The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 8, August 2021, Pages e2887–e2899

To evaluate the potential of s?KL to aid classification of disease activity.

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Properly Collected Plasma Metanephrines Excludes PPGL After False-Positive Screening Tests

Gregory A Kline, Jessica Boyd, Brenda Polzin, Adrian Harvey, Janice L Pasieka, Hossein S M Sadrzadeh, Alexander A Leung

doi : 10.1210/clinem/dgab241

The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 8, August 2021, Pages e2900–e2906

Determine the correlation between screening urine and seated plasma metanephrines in outpatients where PPGL was absent, compared to meticulously prepared and supine-collected plasma metanephrines with age-adjusted references.

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Preoperative Amlodipine Is Efficacious in Preventing Intraoperative HDI in Pheochromocytoma: Pilot RCT

Sanjeet Kumar Jaiswal, Saba Samad Memon, Anurag Lila, Vijaya Sarathi, Manjunath Goroshi, Robin Garg, Rohit Barnabas, Indrani Hemantkumar, Rajendra D Patel, Shrikanta Oak, Abhay Dalvi, Mahadeo Garale, Virendra Patil, Nalini S Shah, Tushar Bandgar

doi : 10.1210/clinem/dgab231

The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 8, August 2021, Pages e2907–e2918

We aimed to compare the efficacy of CCB and ?-blockers on intraoperative hemodynamic instability (HDI) in PPGL.

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Adolescent Tri-ponderal Mass Index Growth Trajectories and Incident Diabetes Mellitus in Early Adulthood

Yi-Fan Wu, Hsien-Yu Fan, Yang-Ching Chen, Kuan-Liang Kuo, Kuo-Liong Chien

doi : 10.1210/clinem/dgab235

The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 8, August 2021, Pages e2919–e2927

Studies have reported the influence of adolescent obesity on development of adult diabetes, but the effect of the growth pattern during this period has rarely been explored. Also, the tri-ponderal mass index (TMI) was thought to be a better estimation of adolescent body fat levels than the body mass index (BMI), so we sought to investigate whether growth trajectories derived by these two indices could predict incident diabetes.

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HDL Containing Apolipoprotein C-III is Associated with Insulin Sensitivity: A Multicenter Cohort Study

Rain Yamamoto, Majken K Jensen, Sarah Aroner, Jeremy D Furtado, Bernard Rosner, Frank B Hu, Beverley Balkau, Andrea Natali, Ele Ferrannini, Simona Baldi, Frank M Sacks

doi : 10.1210/clinem/dgab234

The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 8, August 2021, Pages e2928–e2940

We investigated the prospective associations between HDL subspecies containing and lacking apolipoprotein (apo) C-III at baseline and insulin sensitivity at year 3.

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Maternal Adiposity and Energy Balance After Normotensive and Preeclamptic Pregnancies 

Sarah L McLennan, Amanda Henry, Lynne M Roberts, Sai S Siritharan, Melissa Ojurovic, Amanda Yao, Gregory K Davis, George Mangos, Franziska Pettit, Mark A Brown, Anthony J O’Sullivan

doi : 10.1210/clinem/dgab223

The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 8, August 2021, Pages e2941–e2952

Preeclampsia is a major pregnancy complication associated with long-term maternal cardiometabolic disease. Research generally is focused on metabolic and pathophysiological changes during pregnancy; however, there is much less focus on the early postpartum period in subjects who suffered preeclampsia. The aim of this study was to (1) characterize energy intake and expenditure 6 months following normotensive and preeclamptic pregnancies and (2) examine associations between energy balance, body composition, insulin resistance measures (HOMA-IR), and clinical characteristics.

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Effect of Leptin Therapy on Survival in Generalized and Partial Lipodystrophy: A Matched Cohort Analysis 

Keziah Cook, Omer Ali, Baris Akinci, Maria Cristina Foss de Freitas, Renan Magalh?es Montenegro, Jr, Virginia Oliveira Fernandes, Deepshekhar Gupta, Kai-Jye Lou, Edward Tuttle, Elif A Oral, Rebecca J Brown

doi : 10.1210/clinem/dgab216

The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 8, August 2021, Pages e2953–e2967

This study aimed to estimate the treatment effect of metreleptin on survival in patients with GL and PL.

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Exceptionality of Distant Metastasis in Node-Negative Hereditary and Sporadic Medullary Thyroid Cancer: Lessons Learned

Andreas Machens, Kerstin Lorenz, Frank Weber, Henning Dralle

doi : 10.1210/clinem/dgab214

The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 8, August 2021, Pages e2968–e2979

This comprehensive investigation aimed to explore risk factors of lymph node and distant metastases and interdependencies between age at thyroidectomy, primary tumor size, lymph node metastasis, and distant metastasis in patients with hereditary and sporadic MTC.

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Denosumab Reduces Lesional Fluoride Skeletal Burden on Na[18F]F PET-CT in Patients With Fibrous Dysplasia/McCune–Albright Syndrome 

Wouter van der Bruggen, Dennis Vriens, Maartje E Meier, Frits Smit, Elizabeth M Winter, Lioe-Fee de Geus-Oei, Natasha M Appelman-Dijkstra

doi : 10.1210/clinem/dgab212

The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 8, August 2021, Pages e2980–e2994

To investigate treatment response measurements in patients with FD/MAS who underwent Na[18F]F-PET-CT and treatment with antiresorptives.

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Population Vitamin D Stores Are Increasing in Tasmania, and This Is Associated With Less BMD Loss Over 10 Years

Michael Thompson, Dawn Aitken, Saliu Balogun, Flavia Cicuttini, Graeme Jones

doi : 10.1210/clinem/dgab197

The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 8, August 2021, Pages e2995–e3004

There are limited data that examine the longitudinal change in population 25-hydroxyvitamin D (25[OH]D) and none that evaluate the long-term skeletal outcomes of longitudinal vitamin D status.

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Pseudohypoparathyroidism: Focus on Cerebral and Renal Calcifications

Laura Mazoni, Matteo Apicella, Federica Saponaro, Giovanna Mantovani, Francesca M Elli, Simona Borsari, Elena Pardi, Paolo Piaggi, Claudio Marcocci, Filomena Cetani

doi : 10.1210/clinem/dgab208

The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 8, August 2021, Pages e3005–e3020

To describe a cohort of 26 patients with PHP followed in a single tertiary center.

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PRL Mutation Causing Alactogenesis: Insights Into Prolactin Structure and Function Relationships

Mika Moriwaki, Corrine K Welt

doi : 10.1210/clinem/dgab201

The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 8, August 2021, Pages e3021–e3026

We hypothesized a heterozygous genetic mutation.

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Long-Term Results of a Phase II Trial of Apatinib for Progressive Radioiodine Refractory Differentiated Thyroid Cancer

Yan-Song Lin, Xin Zhang, Chen Wang, Yan-Qing Liu, Wen-Min Guan, Jun Liang

doi : 10.1210/clinem/dgab196

The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 8, August 2021, Pages e3027–e3036

We report here the long-term results of the phase II clinical trial of apatinib, an anti-angiogenic tyrosine kinase inhibitor, for RAIR-DTC.

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Diabetes Knowledge and Metabolic Control in Type 1 Diabetes Starting With Continuous Glucose Monitoring: FUTURE-PEAK

Ben Broos, Sara Charleer, Nancy Bolsens, Carolien Moyson, Chantal Mathieu, Pieter Gillard, Christophe De Block

doi : 10.1210/clinem/dgab188

The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 8, August 2021, Pages e3037–e3048

To investigate whether diabetes knowledge and health literacy impact glycemic control after 1 year of intermittently scanned continuous glucose monitoring (isCGM) in people with type 1 diabetes ???16 years.

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Cord Blood IGF-I, Proinsulin, Leptin, HMW Adiponectin, and Ghrelin in Short or Skinny Small-for-Gestational-Age Infants

Hua He, Wen-Ting Zhu, Anne Monique Nuyt, Isabelle Marc, Pierre Julien, Rong Huang, Lise Dubois, Shu-Qin Wei, Jun Zhang, Emile Levy, William D Fraser, Zhong-Cheng Luo

doi : 10.1210/clinem/dgab178

The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 8, August 2021, Pages e3049–e3057

This work aimed to assess whether SGA infants with stunting or wasting have similar alterations in neonatal endocrine metabolic health biomarkers.

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Testosterone Therapy Effects on Bone Mass and Turnover in Hypogonadal Men with Type 2 Diabetes

Georgia Colleluori, Lina Aguirre, Nicola Napoli, Clifford Qualls, Dennis T Villareal, Reina Armamento-Villareal

doi : 10.1210/clinem/dgab181

The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 8, August 2021, Pages e3058–e3068

Evaluate the skeletal response to testosterone therapy in hypogonadal men with T2D compared with hypogonadal men without T2D.

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Radiomics With Ensemble Machine Learning Predicts Dopamine Agonist Response in Patients With Prolactinoma

Yae Won Park, Jihwan Eom, Sooyon Kim, Hwiyoung Kim, Sung Soo Ahn, Cheol Ryong Ku, Eui Hyun Kim, Eun Jig Lee, Sun Ho Kim, Seung-Koo Lee

doi : 10.1210/clinem/dgab159

The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 8, August 2021, Pages e3069–e3077

To develop a radiomics model using an ensemble machine learning classifier with conventional magnetic resonance images (MRIs) to predict the DA response in prolactinoma patients.

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Association of Genetically Predicted Serum Estradiol With Risk of Thromboembolism in Men: A Mendelian Randomization Study 

Maria Nethander, Johan Quester, Liesbeth Vandenput, Claes Ohlsson

doi : 10.1210/clinem/dgab164

The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 8, August 2021, Pages e3078–e3086

This work aimed to determine whether endogenous estradiol has a causal role in thromboembolism in men.

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Metabolic and Psychological Features are Associated with Weight Loss 12 Months After Sleeve Gastrectomy

Emanuele Muraca, Alice Oltolini, Alberto Binda, Mattia Pizzi, Stefano Ciardullo, Giuseppina Manzoni, Francesca Zerbini, Eleonora Bianconi, Rosa Cannistraci, Silvia Perra, Pietro Pizzi, Guido Lattuada, Gianluca Perseghin, Matteo Villa

doi : 10.1210/clinem/dgab161

The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 8, August 2021, Pages e3087–e3097

To establish the association of baseline anthropometric, metabolic, and psychologic features with the percent total weight loss (%TWL) and percent excess weight loss (%EWL) 12 months after surgery.

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Characterizing a Common CERS2 Polymorphism in a Mouse Model of Metabolic Disease and in Subjects from the Utah CAD Study

Rebekah J Nicholson, Annelise M Poss, J Alan Maschek, James E Cox, Paul N Hopkins, Steven C Hunt, Mary C Playdon, William L Holland, Scott A Summers

doi : 10.1210/clinem/dgab155

The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 8, August 2021, Pages e3098–e3109

The studies described herein aimed to characterize the effects of rs267738 on CERS2 enzyme activity, sphingolipid profiles, and metabolic outcomes.

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Antenatal Depression and Risk of Gestational Diabetes, Adverse Pregnancy Outcomes, and Postpartum Quality of Life

Caro Minschart, Kyara De Weerdt, Astrid Elegeert, Paul Van Crombrugge, Carolien Moyson, Johan Verhaeghe, Sofie Vandeginste, Hilde Verlaenen, Chris Vercammen, Toon Maes, Els Dufraimont, Christophe De Block, Yves Jacquemyn, Farah Mekahli, Katrien De Clippel, Annick Van Den Bruel, Anne Loccufier, Annouschka Laenen, Roland Devlieger, Chantal Mathieu, Katrien Benhalima

doi : 10.1210/clinem/dgab156

The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 8, August 2021, Pages e3110–e3124

To determine the impact of depressive symptoms on pregnancy outcomes and postpartum quality of life in women with gestational diabetes mellitus (GDM) and normal glucose tolerance (NGT).

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IL-38 Exerts Anti-Inflammatory and Antifibrotic Effects in Thyroid-Associated Ophthalmopathy

Lu Shi, Huijing Ye, Jun Huang, Yanbing Li, Xing Wang, Zhihui Xu, Jingqiao Chen, Wei Xiao, Rongxin Chen, Huasheng Yang

doi : 10.1210/clinem/dgab154

The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 8, August 2021, Pages e3125–e3142

We aimed to evaluate the relationship between IL-38 and TAO disease activity and its role in inflammation and fibrosis in TAO.

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Effect of Testosterone Treatment on Bone Microarchitecture and Bone Mineral Density in Men: A 2-Year RCT

Mark Ng Tang Fui, Rudolf Hoermann, Karen Bracken, David J Handelsman, Warrick J Inder, Bronwyn G A Stuckey, Bu B Yeap, Ali Ghasem-Zadeh, Kristy P Robledo, David Jesudason, Jeffrey D Zajac, Gary A Wittert, Mathis Grossmann

doi : 10.1210/clinem/dgab149

The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 8, August 2021, Pages e3143–e3158

We aimed to determine the effect of testosterone treatment on bone microarchitecture using high resolution–peripheral quantitative computed tomography (HR-pQCT).

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Identification and Functional Characterization of Metabolites for Bone Mass in Peri- and Postmenopausal Chinese Women

Rui Gong, Hong-Mei Xiao, Yin-Hua Zhang, Qi Zhao, Kuan-Jui Su, Xu Lin, Cheng-Lin Mo, Qiang Zhang, Ya-Ting Du, Feng-Ye Lyu, Yuan-Cheng Chen, Cheng Peng, Hui-Min Liu, Shi-Di Hu, Dao-Yan Pan, Zhi Chen, Zhang-Fang Li, Rou Zhou, Xia-Fang Wang, Jun-Min Lu, Zeng-Xin Ao, Yu-Qian Song, Chan-Yan Weng, Qing Tian, Martin R Schiller, Christopher J Papasian, Marco Brotto, Hui Shen, Jie Shen, Hong-Wen Deng

doi : 10.1210/clinem/dgab146

The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 8, August 2021, Pages e3159–e3177

We aimed to systematically identify metabolites associated with BMD variation and their potential functional mechanisms in peri- and postmenopausal women.

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Circulating Galectin-3 Levels Are Not Associated With Nonalcoholic Fatty Liver Disease: A Mendelian Randomization Study

Maxime Tremblay, Nicolas Perrot, Nooshin Ghodsian, ?milie Gobeil, Christian Couture, Patricia L Mitchell, Sébastien Thériault, Benoit J Arsenault

doi : 10.1210/clinem/dgab144

The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 8, August 2021, Pages e3178–e3184

To evaluate the causal effect of circulating galectin-3 levels on NAFLD as well as >800 other human diseases.

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Pregnancy Does not Affect the Prognoses of Differentiated Thyroid Cancer Patients With Lung Metastases

Chuang Xi, Qian Zhang, Hong-Jun Song, Chen-Tian Shen, Guo-Qiang Zhang, Jian-Wen Sun, Zhong-Ling Qiu, Quan-Yong Luo

doi : 10.1210/clinem/dgab111

The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 8, August 2021, Pages e3185–e3197

To assess the impact of pregnancy on DTC-LM through the comparison of prognoses between female patients with DTC-LM who did and did not become pregnant after surgery and radioiodine therapy.

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Lifestyle Intervention Improves Prothrombotic Coagulation Profile in Individuals at High Risk for Type 2 Diabetes

Sebastian H?rber, Rainer Lehmann, Louise Fritsche, Jürgen Machann, Andreas L Birkenfeld, Hans-Ulrich H?ring, Norbert Stefan, Martin Heni, Andreas Fritsche, Andreas Peter

doi : 10.1210/clinem/dgab124

The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 8, August 2021, Pages e3198–e3207

The present study addressed whether this is reversible by lifestyle intervention and elucidated potential underlying associations.

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A 4 Gene-based Immune Signature Predicts Dedifferentiation and Immune Exhaustion in Thyroid Cancer

Cui-Wei Li, Xiao Shi, Ben Ma, Yu-Long Wang, Zhong-Wu Lu, Tian Liao, Yu Wang, Qing-Hai Ji, Wen-Jun Wei

doi : 10.1210/clinem/dgab132

The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 8, August 2021, Pages e3208–e3220

To construct a significant IRG-based signature indicative of dedifferentiation and immune exhaustion in thyroid cancer.

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Elinzanetant (NT-814), a Neurokinin 1,3 Receptor Antagonist, Reduces Estradiol and Progesterone in Healthy Women 

Steve Pawsey, Edouard Gregory Mills, Elizabeth Ballantyne, Kirsteen Donaldson, Mary Kerr, Mike Trower, Waljit Singh Dhillo

doi : 10.1210/clinem/dgab108

The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 8, August 2021, Pages e3221–e3234

This work aimed to assess the effects of the novel NK1,3 antagonist elinzanetant on reproductive hormone levels in healthy women.

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PREVENT: A Randomized, Placebo-controlled Crossover Trial of Avexitide for Treatment of Postbariatric Hypoglycemia 

Colleen M Craig, Helen Margaret Lawler, Clare Jung Eun Lee, Marilyn Tan, Dawn Belt Davis, Jenny Tong, Michele Glodowski, Elisa Rogowitz, Rowan Karaman, Tracey L McLaughlin, Lisa Porter

doi : 10.1210/clinem/dgab103

The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 8, August 2021, Pages e3235–e3248

To evaluate efficacy and safety of avexitide [exendin (9-39)], a glucagon-like peptide-1 antagonist, for treatment of PBH.

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Metabolic Signatures of Genetically Elevated Vitamin D Among Chinese: Observational and Mendelian Randomization Study

Zhenhuang Zhuang, Canqing Yu, Yu Guo, Zheng Bian, Ling Yang, Iona Y Millwood, Robin G Walters, Yiping Chen, Qinai Xu, Mingyuan Zou, Junshi Chen, Zhengming Chen, Jun Lv, Tao Huang, Liming Li

doi : 10.1210/clinem/dgab097

The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 8, August 2021, Pages e3249–e3260

We aimed to investigate the causal effect of elevated 25(OH)D with a detailed systemic metabolite profile in Chinese adults.

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Developmental Patterns of Glycemic Control in T1D and Their Association With Demographic and Clinical Variables

Leon S Farhy

doi : 10.1210/clinem/dgab271

The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 8, August 2021, Pages e3261–e3263

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A New Potential Treatment for Postprandial Hypoglycemia Following Bariatric Surgery

Sophia M R?ssner, Daniel P Andersson

doi : 10.1210/clinem/dgab264

The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 8, August 2021, Pages e3264–e3265

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Searching for Monogenic Diabetes in a High-risk Autoimmune Diabetes Cohort: Needles in a Paperclip Stack 

Daniel Gamu, William T Gibson

doi : 10.1210/clinem/dgab244

The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 8, August 2021, Pages e3266–e3268

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T4DM Trial and its T4Bone Substudy Shed Further Light on Effects of Testosterone Treatment in Middle-Aged and Older Men 

Shalender Bhasin, Peter J Snyder

doi : 10.1210/clinem/dgab246

The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 8, August 2021, Pages e3269–e3271

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Higher-level Modulation of GnRH Secretion: Progress Toward Next-generation Reproductive Treatments?

Christopher R McCartney

doi : 10.1210/clinem/dgab242

The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 8, August 2021, Pages e3272–e3274

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Rates of Conversion of Testosterone to Estradiol May Influence Risk of Venous Thromboembolism in Men

Bu B Yeap

doi : 10.1210/clinem/dgab226

The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 8, August 2021, Pages e3275–e3277

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Lean (Pre)Diabetes – Underestimated and Underexplored 

Andreas F H Pfeiffer, Stefan Kabisch

doi : 10.1210/clinem/dgab198

The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 8, August 2021, Pages e3278–e3280

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Letter to the Editor from Brunerov? et al: “Association of Cognitive Function and Retinal Neural and Vascular Structure in Type 1 Diabetes”

Ludmila Brunerov?, Jaroslava Raudensk?, Richard Sotorn?k, Elena ?ilhov?, Pavel ?krha, Miroslav Veith, Adam Ernest, Alena Jav?rkov?

doi : 10.1210/clinem/dgab350

The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 8, August 2021, Pages e3281–e3282

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Letter to the Editor From Lukas Andereggen: “Pitfalls in Performing and Interpreting Inferior Petrosal Sinus Sampling: Personal Experience and Literature Review”

Lukas Andereggen, Jürgen Beck, Jan Gralla, Markus M Luedi, Emanuel Christ

doi : 10.1210/clinem/dgab329

The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 8, August 2021, Pages e3283–e3284

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Letter to the Editor From Helene Lasolle and Gérald Raverot: “USP8 and TP53 Drivers Are Associated With CNV in a Corticotroph Adenoma Cohort Enriched for Aggressive Tumors”

Hélène Lasolle, Gérald Raverot

doi : 10.1210/clinem/dgab217

The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 8, August 2021, Pages e3285–e3286

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Letter to the Editor from William J. Malone et al: “Proper Care of Transgender and Gender-diverse Persons in the Setting of Proposed Discrimination: A Policy Perspective” 

William J Malone, Paul W Hruz, Julia W Mason, Stephen Beck

doi : 10.1210/clinem/dgab205

The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 8, August 2021, Pages e3287–e3288

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Letter to the Editor from Bello-Chavolla et al: “Are the Different Diabetes Subgroups Correlated With All-Cause, Cancer-related, and Cardiovascular-related Mortality?”

Omar Yaxmehen Bello-Chavolla, Neftali Eduardo Antonio-Villa, Luisa Fern?ndez-Chirino, Arsenio Vargas-V?zquez, Jessica Paola Bahena-L?pez

doi : 10.1210/clinem/dgab173

The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 8, August 2021, Pages e3289–e3290

خرید پکیج و مشاهده آنلاین مقاله


Response to Letter to the Editor From Lukas Andereggen: “Pitfalls in Performing and Interpreting Inferior Petrosal Sinus Sampling: Personal Experience and Literature Review”

Jordan E Perlman, Robert J Weil, Ferdinand Hui, Pablo F Recinos, Gary Gallia, Debraj Mukherjee, Roberto Salvatori, Laurence Kennedy, Amir H Hamrahian

doi : 10.1210/clinem/dgab330

The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 8, August 2021, Pages e3291–e3292

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Response to Letter to the Editor from Lasolle and Raverot: “USP8 and TP53 Drivers Are Associated with CNV in a Corticotroph Adenoma Cohort Enriched for Aggressive Tumors” 

Andrew V Uzilov, Eliza B Geer

doi : 10.1210/clinem/dgab218

The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 8, August 2021, Pages e3293–e3294

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Response to Letter to the Editor from Malone: “Proper Care of Transgender and Gender Diverse Persons in the Setting of Proposed Discrimination: A Policy Perspective”

Abby Walch, Caroline Davidge-Pitts, Ximena Lopez, Vin Tangpricha, Sean J Iwamoto, Joshua D Safer

doi : 10.1210/clinem/dgab206

The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 8, August 2021, Pages e3295–e3296

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Response to Letter to the Editor from Bello-Chavolla et al: “Are the Different Diabetes Subgroups Correlated With All-cause, Cancer-related, and Cardiovascular-related Mortality?”

Peng-Fei Li, Wei-Liang Chen

doi : 10.1210/clinem/dgab174

The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 8, August 2021, Pages e3297–e3298

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ERRATUM to: “Association Between Maternal Normal Range HbA1c Values and Adverse Birth Outcomes” 

doi : 10.1210/clinem/dgab233

The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 8, August 2021, Page e3299

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