Mickael Vourc’h, MD1; Charlotte Garret, MD2; Arnaud Gacouin, MD3; Jean-Claude Lacherade, MD4; Maud Jonas, MD5; Kada Klouche, MD6; Martine Ferrandiere, MD7; Samir Jaber, MD8; Laurent Flet, PharmD9; Eric Dailly, PharmD10; Caroline Pouplet, MD4; Adel Maamar, MD3; Jean Reignier, MD2; Antoine Roquilly, MD1; Fanny Feuillet, PhD11,12; Pierre-Joachim Mahe, MD1; Karim Asehnoune, MD1; for the BACLOREA study group
doi : 10.1001/jama.2021.0658
JAMA. 2021;325(8):732-741
To assess whether high-dose baclofen reduces agitation-related events compared with placebo in patients with unhealthy alcohol use receiving mechanical ventilation.
Jonathan E. Sevransky, MD, MHS1,2; Richard E. Rothman, MD, PhD3; David N. Hager, MD, PhD4; Gordon R. Bernard, MD5; Samuel M. Brown, MD6; Timothy G. Buchman, PhD, MD2,7; Laurence W. Busse, MD, MBA1,2; Craig M. Coopersmith, MD2,7; Christine DeWilde, PhD8; E. Wesley Ely, MD, PhD5,9,10; Lindsay M. Eyzaguirre, MS11; Alpha A. Fowler, MD8; David F. Gaieski, MD12; Michelle N. Gong, MD13; Alex Hall, DHSc, MS14; Jeremiah S. Hinson, MD, PhD3; Michael H. Hooper, MD15; Gabor D. Kelen, MD3; Akram Khan, MD16; Mark A. Levine, MD17; Roger J. Lewis, MD, PhD18,19,20,21; Chris J. Lindsell, PhD22; Jessica S. Marlin, CCRP23; Anna McGlothlin, PhD19; Brooks L. Moore, MD14; Katherine L. Nugent, MD14; Samuel Nwosu, MS22; Carmen C. Polito, MD, MSc1,2; Todd W. Rice, MD, MSc5; Erin P. Ricketts, MSPH3; Caroline C. Rudolph, MBA14; Fred Sanfilippo, MD, PhD24; Kert Viele, PhD19,25; Greg S. Martin, MD, MSc1,2; David W. Wright, MD14; for the VICTAS Investigators
doi : 10.1001/jama.2020.24505
JAMA. 2021;325(8):742-750
Sepsis is a common syndrome with substantial morbidity and mortality. A combination of vitamin C, thiamine, and corticosteroids has been proposed as a potential treatment for patients with sepsis.
The Genetics of Exfoliation Syndrome Partnership
doi : 10.1001/jama.2021.0507
JAMA. 2021;325(8):753-764
Exfoliation syndrome is a systemic disorder characterized by progressive accumulation of abnormal fibrillar protein aggregates manifesting clinically in the anterior chamber of the eye. This disorder is the most commonly known cause of glaucoma and a major cause of irreversible blindness.
Jeremy Samuel Faust, MD, MS1; Harlan M. Krumholz, MD, SM2; Chengan Du, PhD3; Katherine Dickerson Mayes, MD, PhD4; Zhenqiu Lin, PhD3; Cleavon Gilman, MD5; Rochelle P. Walensky, MD, MPH6
doi : 10.1001/jama.2020.24243
JAMA. 2021;325(8):785-787
Carrie Colla, PhD1
doi : 10.1001/jama.2020.26779
JAMA. 2021;325(8):715-716
Julia Adler-Milstein, PhD1
doi : 10.1001/jama.2020.27014
JAMA. 2021;325(8):717-718
Leo Lopez III, MD, MHS1; Louis H. Hart III, MD1; Mitchell H. Katz, MD1
doi : 10.1001/jama.2020.26443
JAMA. 2021;325(8):719-720
H. Cody Meissner, MD1
doi : 10.1001/jama.2020.26792
JAMA. 2021;325(8):721-722
Philip A. Pizzo, MD1; David Spiegel, MD2; Michelle M. Mello, JD, PhD3,4
doi : 10.1001/jama.2021.0122
JAMA. 2021;325(8):723-724
Lisa M. Meeks, PhD1
doi : 10.1001/jama.2021.0119
JAMA. 2021;325(8):725-726
Michael C. Reade, MBBS, DPhil1,2,3
doi : 10.1001/jama.2021.0597
JAMA. 2021;325(8):727-729
Kristin L. Walter, MD, MS1; Christopher W. Seymour, MD, MSc2,3,4
doi : 10.1001/jama.2020.26029
JAMA. 2021;325(8):730-731
Marisa P. McGinley, DO1; Carolyn H. Goldschmidt, DO1; Alexander D. Rae-Grant, MD1,2
doi : 10.1001/jama.2020.26858
JAMA. 2021;325(8):765-779
Multiple sclerosis (MS) is an autoimmune-mediated neurodegenerative disease of the central nervous system characterized by inflammatory demyelination with axonal transection. MS affects an estimated 900?000 people in the US. MS typically presents in young adults (mean age of onset, 20-30 years) and can lead to physical disability, cognitive impairment, and decreased quality of life. This review summarizes current evidence regarding diagnosis and treatment of MS.
Tom Shimabukuro, MD, MPH, MBA1; Narayan Nair, MD2
doi : 10.1001/jama.2021.0600
JAMA. 2021;325(8):780-781
Kevin D. He, MD1; Ken He, MD2,3; Paul B. Cornia, MD2,3
doi : 10.1001/jama.2020.19186
JAMA. 2021;325(8):782-783
Howard Bauchner, MD1; Phil B. Fontanarosa, MD, MBA2; Robert M. Golub, MD3
doi : 10.1001/jama.2020.25952
JAMA. 2021;325(8):751-752
Anita Slomski, MA
doi : 10.1001/jama.2020.25840
JAMA. 2021;325(8):707-709
Dave A. Chokshi, MD, MSc1
doi : 10.1001/jama.2020.24936
JAMA. 2021;325(8):710-711
Bridget M. Kuehn, MSJ
doi : 10.1001/jama.2021.0621
JAMA. 2021;325(8):714
Bridget M. Kuehn, MSJ
doi : 10.1001/jama.2021.1031
JAMA. 2021;325(8):714
Anita Slomski, MA
doi : 10.1001/jama.2021.0651
JAMA. 2021;325(8):713
Anita Slomski, MA
doi : 10.1001/jama.2021.1255
JAMA. 2021;325(8):713
Anita Slomski, MA
doi : 10.1001/jama.2021.1257
JAMA. 2021;325(8):713
Anita Slomski, MA
doi : 10.1001/jama.2021.1259
JAMA. 2021;325(8):713
Anita Slomski, MA
doi : 10.1001/jama.2021.1261
JAMA. 2021;325(8):713
Rita Rubin, MA
doi : 10.1001/jama.2021.0791
JAMA. 2021;325(8):712
Rita Rubin, MA
doi : 10.1001/jama.2021.1228
JAMA. 2021;325(8):712
Rita Rubin, MA
doi : 10.1001/jama.2021.1230
JAMA. 2021;325(8):712
Malcolm M. Kates, BS, BA1; Casey J. Beal, MD1
doi : 10.1001/jama.2020.3911
JAMA. 2021;325(8):798
Tao Xu, PhD1; You Wang, MD1; Yangmei Chen, PhD1
doi : 10.1001/jama.2020.24595
JAMA. 2021;325(8):787
Chloe Kimi Nobuhara, BS1; Miles Berger, MD, PhD2
doi : 10.1001/jama.2020.24601
JAMA. 2021;325(8):787-788
Jacob Bodilsen, MD, PhD1; Henrik Nielsen, MD, DMSci1
doi : 10.1001/jama.2020.24607
JAMA. 2021;325(8):788
Vanessa Alderman, MBBS1; Joshua Agbetile, MD1
doi : 10.1001/jama.2020.25121
JAMA. 2021;325(8):788-789
Stuart MacKay, MD1; R. Doug McEvoy, MD2; Edward M. Weaver, MD, MPH3
doi : 10.1001/jama.2020.25124
JAMA. 2021;325(8):789-790
Miriam Cremer, MD, MPH1; Karla Alfaro, MD, MPH2; Rachel Masch, MD, MPH3
doi : 10.1001/jama.2020.25214
JAMA. 2021;325(8):790
Pascal Geldsetzer, MBChB, ScD, MPH1; Julia M. Lemp, MSc2
doi : 10.1001/jama.2020.25217
JAMA. 2021;325(8):790-791
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