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Stony the road we trod: towards racial justice in kidney care
O. N. Ray Bignall II & Deidra C. Crews
doi : 10.1038/s41581-020-00389-w
Volume 17, Issue 2, February 2021, Published 17 December 2020
The COVID-19 pandemic and the Movement for Black Lives have focused attention on racial disparities in kidney health outcomes. In 2020, kidney professionals highlighted threats posed by racism and other negative social drivers of kidney health, and proposed solutions to address these issues through scholarship and advocacy for social justice.
The COVID-19 pandemic: consequences for nephrology
Annette Bruchfeld
doi : 10.1038/s41581-020-00381-4
Volume 17, Issue 2, February 2021, Published 30 November 2020
The COVID-19 pandemic: consequences for nephrology
SGLT2 inhibitors may offer benefit beyond diabetes
Amy Kang & Meg J. Jardine
doi : 10.1038/s41581-020-00391-2
Volume 17, Issue 2, February 2021, Published 23 December 2020
Sodium–glucose co-transporter 2 inhibitors offer impressive cardiac and kidney outcome benefits to people with type 2 diabetes mellitus (T2DM). These benefits now appear to extend to people without T2DM, according to three trials published in 2020.
New genetic insights into kidney physiology and disease
Anna K?ttgen & Krzysztof Kiryluk
doi : 10.1038/s41581-020-00383-2
Volume 17, Issue 2, February 2021, Published 03 December 2020
Genetic research in nephrology is rapidly advancing. Key studies published in 2020 demonstrate that genetic findings can provide new tools for patient diagnosis and risk stratification as well as important insights into kidney physiology and disease mechanisms that could potentially lead to novel therapies.
Tackling AKI: prevention, timing of dialysis and follow-up
Anitha Vijayan
doi : 10.1038/s41581-020-00390-3
Volume 17, Issue 2, February 2021, Published 17 December 2020
Timely diagnosis and dialytic treatment of acute kidney injury (AKI) came to the forefront at the height of the coronavirus disease 2019 pandemic as admissions surged in intensive care units. Research on early diagnosis, timing of initiation of kidney replacement therapy, and appropriate post-hospitalization patient care remains essential to tackling the burden of AKI.
Advances in ANCA-associated vasculitis and lupus nephritis
Isabelle Ayoub & Patrick H. Nachman
doi : 10.1038/s41581-020-00388-x
Volume 17, Issue 2, February 2021, Published 11 December 2020
In 2020 a number of clinical trials have provided insights into therapeutic approaches for the treatment of anti-neutrophil cytoplasmic autoantibody (ANCA)-associated vasculitis and lupus nephritis. Moreover, mechanistic insights have potential to open new therapeutic strategies in the future.
Immunopathophysiology of trauma-related acute kidney injury
David A. C. Messerer, Rebecca Halbgebauer, Bo Nilsson, Hermann Pavenst?dt, Peter Radermacher & Markus Huber-Lang
doi : 10.1038/s41581-020-00344-9
Volume 17, Issue 2, February 2021, Published 21 September 2020
Acute kidney injury is a common complication of trauma. Here, the authors examine how, in addition to direct trauma to the kidneys, the pathophysiological responses to traumatic injuries in distant organs, including immune responses, can result in kidney dysfunction.
Complexities of the glomerular basement membrane
Richard W. Naylor, Mychel R. P. T. Morais & Rachel Lennon
doi : 10.1038/s41581-020-0329-y
Volume 17, Issue 2, February 2021, Published 24 August 2020
The glomerular basement membrane (GBM) is essential for kidney filtration. This Review describes how studies of GBM composition and structure have provided insights into GBM assembly, its developmental transitions and its role in glomerular filtration. The authors also discuss GBM-associated diseases and current and potential future treatments for these disorders.
Advances in fluorescence microscopy techniques to study kidney function
Suman Ranjit, Luca Lanzan?, Andrew E. Libby, Enrico Gratton & Moshe Levi
doi : 10.1038/s41581-020-00337-8
Volume 17, Issue 2, February 2021, Published 18 September 2020
This Review provides an overview of fluorescence-based microscopy techniques that have been used to study molecular processes within the kidney. The authors describe how the development of cutting-edge technologies has enabled high spatiotemporal resolution of molecular interactions and processes, and how these approaches have aided our understanding of kidney dynamics.
