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COVID-19 vaccines and kidney disease
Martin Windpessl, Annette Bruchfeld, Hans-Joachim Anders, Holly Kramer, Meryl Waldman, Laurent Renia, Lisa F. P. Ng, Zhou Xing & Andreas Kronbichler
doi : 10.1038/s41581-021-00406-6
Volume 17, Issue 5, May 2021, Published 08 February 2021
Patients with kidney diseases should be prioritized for COVID-19 vaccination and the available data suggest that replication-defective viral-vectored vaccines and mRNA vaccines are safe to use. As vaccine responses are likely to be lower in patients with kidney diseases than in the general population, highly potent vaccines should be preferred.
The impact of climate change on kidney health
Matthew A. Borg & Peng Bi
doi : 10.1038/s41581-020-00365-4
Volume 17, Issue 5, May 2021, Published 15 October 2020
The incidence of kidney diseases from communicable and non-communicable causes is expected to increase globally — especially in low and middle-income countries — as a consequence of global warming. As this increase could lead to overburdening of health-care systems, action is crucial to minimize the negative impacts of climate change on kidney health.
Blocking glucose to reduce drug-induced lipotoxicity
Monica Wang
doi : 10.1038/s41581-021-00416-4
Volume 17, Issue 5, May 2021, Published 17 March 2021
A SOX-9–NAV3–YAP1 axis in kidney fibrosis
Susan Allison
doi : 10.1038/s41581-021-00419-1
Volume 17, Issue 5, May 2021, Published 22 March 2021
A nanoparticle approach to prevent AVF failure
Susan Allison
doi : 10.1038/s41581-021-00420-8
Volume 17, Issue 5, May 2021, Published 22 March 2021
ER-associated degradation of nephrin
Susan Allison
doi : 10.1038/s41581-021-00421-7
Volume 17, Issue 5, May 2021, Published 22 March 2021
Soluble ACE2 in SARS-CoV-2 infection
Susan Allison
doi : 10.1038/s41581-021-00422-6
Volume 17, Issue 5, May 2021, Published 23 March 2021
Mitochondrial quality control in kidney injury and repair
Chengyuan Tang, Juan Cai, Xiao-Ming Yin, Joel M. Weinberg, Manjeri A. Venkatachalam & Zheng Dong
doi : 10.1038/s41581-020-00369-0
Volume 17, Issue 5, May 2021, Published 24 November 2020
Mitochondrial dysfunction has roles in acute kidney injury, chronic kidney disease and abnormal kidney repair. Here, the authors discuss the role of mitochondrial quality control mechanisms in kidney injury and repair and highlight their potential as therapeutic targets.
Pathophysiology of diabetic kidney disease: impact of SGLT2 inhibitors
Ralph A. DeFronzo, W. Brian Reeves & Alaa S. Awad
doi : 10.1038/s41581-021-00393-8
Volume 17, Issue 5, May 2021, Published 05 February 2021
Multiple pathophysiological disturbances contribute to the onset and progression of diabetic kidney disease (DKD). This Review describes these pathogenic processes and discusses the ability of sodium–glucose co-transporter 2 (SGLT2) inhibitors to correct or improve many of these processes, which are likely to underlie the ability of these agents to slow progression of established diabetic kidney disease.
Kidney physiology and susceptibility to acute kidney injury: implications for renoprotection
Holger Scholz, Felix J. Boivin, Kai M. Schmidt-Ott, Sebastian Bachmann, Kai-Uwe Eckardt, Ute I. Scholl & Pontus B. Persson
doi : 10.1038/s41581-021-00394-7
Volume 17, Issue 5, May 2021, Published 05 February 2021
In this Review, the authors examine the physiological heterogeneity of different kidney compartments and consider how the local oxygen supply and the capacity for metabolic adaptation of different nephron segments might influence their response to changes in oxygen availability and their susceptibility to injury.
Kidney and epigenetic mechanisms of salt-sensitive hypertension
Wakako Kawarazaki & Toshiro Fujita
doi : 10.1038/s41581-021-00399-2
Volume 17, Issue 5, May 2021, Published 24 February 2021
In this Review, the authors discuss the renal mechanism of salt-sensitive hypertension induced by malnutrition during pregnancy, obesity in adult life and ageing. They also describe the epigenetic mechanisms that potentially contribute to the development of salt-sensitive hypertension in these settings.
