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Mapping the musculoskeletal system one cell at a time
Mathew J. Baldwin, Adam P. Cribbs, Farshid Guilak & Sarah J. B. Snelling
doi : 10.1038/s41584-021-00600-7
Volume 17, Issue 5, May 2021, Published 12 March 2021
The Human Cell Atlas (HCA) project aims to map tissues and organs during development, maturation and pathology at single cell resolution. The musculoskeletal HCA network is a community for fostering collaboration and shared expertise to help develop the therapeutic approaches needed to address the high global burden of musculoskeletal disorders.
Avacopan offers alternative to steroids for ANCA-associated vasculitis
Sarah Onuora
doi : 10.1038/s41584-021-00615-0
Volume 17, Issue 5, May 2021, Published 12 April 2021
aPL target links coagulation and autoimmunity
Jessica McHugh
doi : 10.1038/s41584-021-00613-2
Volume 17, Issue 5, May 2021, Published 07 April 2021
Bone stresses out cartilage in OA
Joanna Clarke
doi : 10.1038/s41584-021-00612-3
Volume 17, Issue 5, May 2021, Published 07 April 2021
Platelets highlighted as a potential source of autoantigens in SLE
Jessica McHugh
doi : 10.1038/s41584-021-00609-y
Volume 17, Issue 5, May 2021, Published 26 March 2021
LACC1-associated JIA linked to autophagy defects in macrophages
Joanna Clarke
doi : 10.1038/s41584-021-00607-0
Volume 17, Issue 5, May 2021, Published 24 March 2021
Skin–kidney crosstalk in SLE
Antonios G. A. Kolios & George C. Tsokos
doi : 10.1038/s41584-021-00588-0
Volume 17, Issue 5, May 2021, Published 25 February 2021
A multitude of factors contribute to the development and progression of systemic lupus erythematosus (SLE) through their effects on immune cells and tissue resident cells. Ultraviolet light instigates skin inflammation in SLE, and now new findings suggest that neutrophils in the inflamed skin migrate to the kidneys, spreading the inflammatory response.
Slicing and dicing myositis for cures and prevention
Frederick W. Miller
doi : 10.1038/s41584-021-00592-4
Volume 17, Issue 5, May 2021, Published 11 March 2021
Myositis is a group of conditions that vary greatly in risk factors, clinical manifestations, laboratory markers, presumed pathogenetic mechanisms, treatment responses and prognoses. Approaches to divide myositis into mutually exclusive and stable phenotypes are being considered, but are we thinking comprehensively enough in our attempts at classification?
Biological classification of childhood arthritis: roadmap to a molecular nomenclature
Peter A. Nigrovic, Robert A. Colbert, V. Michael Holers, Seza Ozen, Nicolino Ruperto, Susan D. Thompson, Lucy R. Wedderburn, Rae S. M. Yeung & Alberto Martini
doi : 10.1038/s41584-021-00590-6
Volume 17, Issue 5, May 2021, Published 17 March 2021
Childhood-onset arthritis has historically been treated as a separate entity to adult-onset arthritis, with its own nomenclature and classification system. Biological evidence has revealed the limitations of the current approach, necessitating a fresh look at the classification of paediatric arthritis.
Cardiovascular effects of approved drugs for rheumatoid arthritis
Fabiola Atzeni, Javier Rodr?guez-Carrio, C?lin D. Popa, Michael T. Nurmohamed, Gabriella Sz?cs & Zolt?n Szekanecz
doi : 10.1038/s41584-021-00593-3
Volume 17, Issue 5, May 2021, Published 08 April 2021
Various drugs used in rheumatoid arthritis management have anti-inflammatory effects that can hinder atherosclerosis development and progression. However, these drugs can also concurrently have different pro-atherogenic effects, complicating the relationship between these drugs and cardiovascular involvement in rheumatoid arthritis.
Immunological memory in rheumatic inflammation — a roadblock to tolerance induction
Patrick Maschmeyer, Hyun-Dong Chang, Qingyu Cheng, Mir-Farzin Mashreghi, Falk Hiepe, Tobias Alexander & Andreas Radbruch
doi : 10.1038/s41584-021-00601-6
Volume 17, Issue 5, May 2021, Published 06 April 2021
Pathogenic, long-lived memory cells of the immune system present a barrier to resolution of chronic inflammatory rheumatic diseases. Approaches to selectively eliminate these cells while sparing protective immune memory cells could restore immunological tolerance and achieve treatment-free remission.
Publisher Correction: Biological classification of childhood arthritis: roadmap to a molecular nomenclature
Peter A. Nigrovic, Robert A. Colbert, V. Michael Holers, Seza Ozen, Nicolino Ruperto, Susan D. Thompson, Lucy R. Wedderburn, Rae S. M. Yeung & Alberto Martini
doi : 10.1038/s41584-021-00610-5
Volume 17, Issue 5, May 2021, Published 29 March 2021
Publisher Correction: Cardiovascular effects of approved drugs for rheumatoid arthritis
Fabiola Atzeni, Javier Rodr?guez-Carrio, C?lin D. Popa, Michael T. Nurmohamed, Gabriella Sz?cs & Zolt?n Szekanecz
doi : 10.1038/s41584-021-00616-z
Volume 17, Issue 5, May 2021, Published 16 April 2021
