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Further evidence that MRI based measurement of midbrain neuromelanin may serve as a proxy measure of brain dopamine activity in psychiatric disorders
Cameron S. Carter
doi : 10.1038/s41386-020-00944-w
Neuropsychopharmacology volume 46, pages1231–1232 (2021)
Association between neuromelanin-sensitive MRI signal and psychomotor slowing in late-life depression
Kenneth WenglerBrandon K. AshinoffBret R. Rutherford
doi : 10.1038/s41386-020-00860-z
Neuropsychopharmacology volume 46, pages1233–1239 (2021)
Late-life depression (LLD) is a prevalent and disabling condition in older adults that is often accompanied by slowed processing and gait speed. These symptoms are related to impaired dopamine function and sometimes remedied by levodopa (L-DOPA).
Medial orbitofrontal cortex dopamine D1/D2 receptors differentially modulate distinct forms of probabilistic decision-making
Nicole L. JenniYi Tao Li and Stan B. Floresco
doi : 10.1038/s41386-020-00931-1
Neuropsychopharmacology volume 46, pages1240–1251 (2021)
Efficient decision-making involves weighing the costs and benefits associated with different actions and outcomes to maximize long-term utility. The medial orbitofrontal cortex (mOFC) has been implicated in guiding choice in situations involving reward uncertainty, as inactivation in rats alters choice involving probabilistic rewards.
Concordant neurophysiological signatures of cognitive control in humans and rats
Mykel A. Robble, Hans S. Schroder, Brian D. Kangas, Stefanie Nickels, Micah Breiger, Ann M. Iturra-Mena, Sarah Perlo, Emilia Cardenas, Andre Der-Avakian, Samuel A. Barnes, Stefan Leutgeb, Victoria B. Risbrough, Gordana Vitaliano, Jack Bergman, William A. Carlezon Jr. & Diego A. Pizzagalli
doi : 10.1038/s41386-021-00998-4
Neuropsychopharmacology volume 46, pages1252–1262 (2021)
Progress towards understanding neural mechanisms in humans relevant to psychiatric conditions has been hindered by a lack of translationally-relevant cognitive tasks for laboratory animals.
Prognostic neuroimaging biomarkers of trauma-related psychopathology: resting-state fMRI shortly after trauma predicts future PTSD and depression symptoms in the AURORA study
Nathaniel G. Harnett, Sanne J. H. van Rooij,Jennifer S. Stevens
doi : 10.1038/s41386-020-00946-8
Neuropsychopharmacology volume 46, pages1263–1271 (2021)
Neurobiological markers of future susceptibility to posttraumatic stress disorder (PTSD) may facilitate identification of vulnerable individuals in the early aftermath of trauma. Variability in resting-state networks (RSNs), patterns of intrinsic functional connectivity across the brain, has previously been linked to PTSD, and may thus be informative of PTSD susceptibility.
Prediction of short-term antidepressant response using probabilistic graphical models with replication across multiple drugs and treatment settings
Arjun P. Athreya, Tanja Brückl, Elisabeth B. Binder, A. John Rush, Joanna Biernacka, Mark A. Frye, Drew Neavin, Michelle Skime, Ditlev Monrad, Ravishankar K. Iyer, Taryn Mayes, Madhukar Trivedi, Rickey E. Carter, Liewei Wang, Richard M. Weinshilboum, Paul E. Croarkin & William V. Bobo
doi : 10.1038/s41386-020-00943-x
Neuropsychopharmacology volume 46, pages1272–1282 (2021)
Heterogeneity in the clinical presentation of major depressive disorder and response to antidepressants limits clinicians’ ability to accurately predict a specific patient’s eventual response to therapy.
Larger dentate gyrus volume as predisposing resilience factor for the development of trauma-related symptoms
Saskia B. J. Koch, Vanessa A. van Ast, Reinoud Kaldewaij, Mahur M. Hashemi, Wei Zhang, Floris Klumpers & Karin Roelofs
doi : 10.1038/s41386-020-00947-7
Neuropsychopharmacology volume 46, pages1283–1292 (2021)
Early interventions to improve resilience require the identification of objective risk biomarkers for PTSD symptom development. Although altered hippocampal and amygdala volumes are consistently observed in PTSD, it remains currently unknown whether they represent a predisposing vulnerability factor for PTSD symptom development or an acquired consequence of trauma exposure and/or the disorder.
Predictors of change in suicidal ideation across treatment phases of major depressive disorder: analysis of the STAR*D data
Cory R. Weissman, Itay Hadas, Dengdeng Yu, Brett Jones, Dehan Kong, Benoit H. Mulsant, Daniel M. Blumberger & Zafiris J. Daskalakis
doi : 10.1038/s41386-020-00953-9
Neuropsychopharmacology volume 46, pages1293–1299 (2021)
The effects of common antidepressants on suicidal ideation (SI) is unclear. In the landmark STAR*D trial antidepressants were effective for Major Depressive Disorder (MDD) in early treatment phases, but less effective in later phases.
Functional connectivity during frustration: a preliminary study of predictive modeling of irritability in youth
Dustin Scheinost, Javid Dadashkarimi, Emily S. Finn, Caroline G. Wambach, Caroline MacGillivray, Alexandra L. Roule, Tara A. Niendam, Daniel S. Pine, Melissa A. Brotman, Ellen Leibenluft & Wan-Ling Tseng
doi : 10.1038/s41386-020-00954-8
Neuropsychopharmacology volume 46, pages1300–1306 (2021)
Irritability cuts across many pediatric disorders and is a common presenting complaint in child psychiatry; however, its neural mechanisms remain unclear.
The clinical effectiveness of using a predictive algorithm to guide antidepressant treatment in primary care (PReDicT): an open-label, randomised controlled trial
Michael Browning, Amy C. Bilderbeck, Rebecca Dias, Colin T. Dourish, Jonathan Kingslake, Jürgen Deckert, Guy M. Goodwin, Philip Gorwood, Boliang Guo, Catherine J. Harmer, Richard Morriss, Andreas Reif, Henricus G. Ruhe, Anneke van Schaik, Judit Simon, Victor Perez Sola, Dick J. Veltman, Matilde Elices, Anne G. Lever, Andreas Menke, Elisabetta Scanferla, Michael St?blein & Gerard R. Dawson
doi : 10.1038/s41386-021-00981-z
Neuropsychopharmacology volume 46, pages1307–1314 (2021)
Depressed patients often do not respond to the first antidepressant prescribed, resulting in sequential trials of different medications.
Changes in the brain structural connectome after a prospective randomized clinical trial of lithium and quetiapine treatment in youth with bipolar disorder
Du Lei, Wenbin Li, Maxwell J. Tallman, L. Rodrigo Patino, Robert K. McNamara, Jeffrey R. Strawn, Christina C. Klein, Fabiano G. Nery, David E. Fleck, Kun Qin, Yuan Ai, Jing Yang, Wenjing Zhang, Su Lui, Qiyong Gong, Caleb M. Adler, John A. Sweeney & Melissa P. DelBello
doi : 10.1038/s41386-021-00989-5
Neuropsychopharmacology volume 46, pages1315–1323 (2021)
The goals of the current study were to determine whether topological organization of brain structural networks is altered in youth with bipolar disorder, whether such alterations predict treatment outcomes, and whether they are normalized by treatment. Youth with bipolar disorder were randomized to double-blind treatment with quetiapine or lithium and assessed weekly.
A large-scale genome-wide gene expression analysis in peripheral blood identifies very few differentially expressed genes related to antidepressant treatment and response in patients with major depressive disorder
Anne Krogh N?hr, Morten Lindow, Annika Forsingdal, Samuel Demharter, Troels Nielsen, Raimund Buller, Ida Moltke, Morana Vitezic & Anders Albrechtsen
doi : 10.1038/s41386-021-01002-9
Neuropsychopharmacology volume 46, pages1324–1332 (2021)
A better understanding of the biological factors underlying antidepressant treatment in patients with major depressive disorder (MDD) is needed.
Association of gray matter volumes with general and specific dimensions of psychopathology in children
E. Leighton Durham, Hee Jung Jeong, Tyler M. Moore, Randolph M. Dupont, Carlos Cardenas-Iniguez, Zaixu Cui, Farrah E. Stone, Marc G. Berman, Benjamin B. Lahey & Antonia N. Kaczkurkin
doi : 10.1038/s41386-020-00952-w
Neuropsychopharmacology volume 46, pages1333–1339 (2021)
Childhood is an important time for the manifestation of psychopathology. Psychopathology is characterized by considerable comorbidity which is mirrored in the underlying neural correlates of psychopathology.
Neural function during emotion regulation and future depressive symptoms in youth at risk for affective disorders
Jay C. Fournier, Michele Bertocci, Cecile D. Ladouceur, Lisa Bonar, Kelly Monk, Halimah Abdul-Waalee, Amelia Versace, Jo?o Paulo Lima Santos, Satish Iyengar, Boris Birmaher & Mary L. Phillips
doi : 10.1038/s41386-021-01001-w
Neuropsychopharmacology volume 46, pages1340–1347 (2021)
Affective disorders (AD, including bipolar disorder, BD, and major depressive disorder) are severe recurrent illnesses.
Long-term effects of intermittent early life stress on primate prefrontal–subcortical functional connectivity
Rui Yuan, Jordan M. Nechvatal, Christine L. Buckmaster, Sarah Ayash, Karen J. Parker, Alan F. Schatzberg, David M. Lyons & Vinod Menon
doi : 10.1038/s41386-021-00956-0
Neuropsychopharmacology volume 46, pages1348–1356 (2021)
Correlational studies of humans suggest that exposure to early life stress has long-term effects on neural circuits involved in vulnerability and resilience to mental health disorders. Stress-related mental health disorders are more prevalent in women than in men.
Salivary beta-endorphin in nonsuicidal self-injury: an ambulatory assessment study
Lisa M. St?rkel, Alexander Karabatsiakis, Johanna Hepp, Iris-Tatjana Kolassa, Christian Schmahl & Inga Niedtfeld
doi : 10.1038/s41386-020-00914-2
Neuropsychopharmacology volume 46, pages1357–1363 (2021)
Nonsuicidal self-injury (NSSI) is a prevalent and impairing behavior, affecting individuals with and without additional psychopathology. To shed further light on biological processes that precede and result from NSSI acts, we built on previous cross-sectional evidence suggesting that the endogenous opioid system, and especially ?-endorphin, is involved in the psychopathology of NSSI.
Deep transcriptome sequencing of subgenual anterior cingulate cortex reveals cross-diagnostic and diagnosis-specific RNA expression changes in major psychiatric disorders
Nirmala Akula, Stefano Marenco, Kory Johnson, Ningping Feng, Kevin Zhu, Anton Schulmann, Winston Corona, Xueying Jiang, Joanna Cross, Bryce England, Aparna Nathan, Sevilla Detera-Wadleigh, Qing Xu, Pavan K. Auluck, Kwangmi An, Robin Kramer, Jose Apud, Brent T. Harris, C. Harker Rhodes, Barbara K. Lipska & Francis J. McMahon
doi : 10.1038/s41386-020-00949-5
Neuropsychopharmacology volume 46, pages1364–1372 (2021)
Despite strong evidence of heritability and growing discovery of genetic markers for major mental illness, little is known about how gene expression in the brain differs across psychiatric diagnoses, or how known genetic risk factors shape these differences.
Facilitating mGluR4 activity reverses the long-term deleterious consequences of chronic morphine exposure in male mice
Jerome A. J. Becker, Lucie P. Pellissier, Yannick Corde, Thibaut Laboute, Audrey Léauté, Jorge Gand?a & Julie Le Merrer
doi : 10.1038/s41386-020-00927-x
Neuropsychopharmacology volume 46, pages1373–1385 (2021)
Understanding the neurobiological underpinnings of abstinence from drugs of abuse is critical to allow better recovery and ensure relapse prevention in addicted subjects.
The anterior retrosplenial cortex encodes event-related information and the posterior retrosplenial cortex encodes context-related information during memory formation
Sydney Trask, Shane E. Pullins, Nicole C. Ferrara & Fred J. Helmstetter
doi : 10.1038/s41386-021-00959-x
Neuropsychopharmacology volume 46, pages1386–1392 (2021)
The retrosplenial cortex (RSC) is extensively interconnected with the dorsal hippocampus and has several important roles in learning and memory. Recent work has demonstrated that certain types of context-dependent learning are selectively impaired when the posterior, but not the anterior, region of the RSC is damaged, suggesting that the role of the RSC in memory formation may not be uniform along its rostro-caudal axis.
Correction to: Elevated fatty acid amide hydrolase in the prefrontal cortex of borderline personality disorder: a [11C] CURB positron emission tomography study
J. Kolla Nathan, R. Mizrahi, K. Karas, C. Wang, R. M. Bagby, S. McMain, A. I. Simpson, P. M. Rusjan, R. Tyndale, S. Houle & I. Boileau
doi : 10.1038/s41386-021-00992-w
Neuropsychopharmacology volume 46, page1393 (2021)
In memoriam-Larry J. Siever, M.D
Kenneth L. Davis, René S. Kahn, Antonia New & Andrew Aronson
doi : 10.1038/s41386-021-00999-3
Neuropsychopharmacology volume 46, page1394 (2021)
