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Rheumatology During a Pandemic: Science and Resilience
Ellen M. Gravallese
doi : 10.1002/art.41756
Volume 73, Issue 6 p. 903-907
American College of Rheumatology, American Academy of Dermatology, Rheumatologic Dermatology Society, and American Academy of Ophthalmology 2020 Joint Statement on Hydroxychloroquine Use With Respect to Retinal Toxicity
James T. Rosenbaum,Karen H. Costenbader,Julianna Desmarais,Ellen M. Ginzler,Nicole Fett,Susan M. Goodman … See all authors
doi : 10.1002/art.41683
Volume 73, Issue 6 p. 908-911
Four major medical societies involved with hydroxychloroquine (HCQ) therapy concur on the need for common principles and cooperation to minimize the risk of ocular toxicity. At a daily dosage of ?5 mg/kg/day actual body weight, the risk of retinal toxicity from HCQ is <2% for usage up to 10 years. Widespread adoption of more sensitive testing techniques, such as optical coherence tomography and automated visual fields, by eye care providers will allow the detection of early toxicity and thus preserve the patient’s visual function. Baseline testing is advised to rule out confounding disease when a patient is started on HCQ.
A Picture Is Worth a Thousand Words, But Only If It Is a Good Picture
Daniel H. Solomon,Bryce A. Binstadt,David T. Felson,Peter A. Nigrovic
doi : 10.1002/art.41682
Volume 73, Issue 6 p. 912-913
no abstract
COVID-19 Outcomes in Patients With Systemic Autoimmune Rheumatic Diseases Compared to the General Population: A US Multicenter, Comparative Cohort Study
Kristin M. D’Silva,April Jorge,Andrew Cohen,Natalie McCormick,Yuqing Zhang,Zachary S. Wallace,Hyon K. Choi
doi : 10.1002/art.41619
Volume 73, Issue 6 p. 914-920
Patients with systemic autoimmune rheumatic diseases (ARDs) continue to be concerned about risks of severe coronavirus disease 2019 (COVID-19) outcomes. This study was undertaken to evaluate the risks of severe outcomes in COVID-19 patients with systemic ARDs compared to COVID-19 patients without systemic ARDs.
Association Between Bone Mineral Density and Autoantibodies in Patients With Rheumatoid Arthritis
Josephine A. M. P. Amkreutz,Emma C. de Moel,Lisa Theander,Minna Willim,Lotte Heimans,Jan-?ke Nilsson,Magnus K. Karlsson … See all authors
doi : 10.1002/art.41623
Volume 73, Issue 6 p. 921-930
Autoantibodies, such as anti–citrullinated protein antibodies (ACPAs), have been described as inducing bone loss in rheumatoid arthritis (RA), which can also be reflected by bone mineral density (BMD). We therefore examined the association between osteoporosis and autoantibodies in two independent RA cohorts.
The Pretreatment Gut Microbiome Is Associated With Lack of Response to Methotrexate in New-Onset Rheumatoid Arthritis
Alejandro Artacho,Sandrine Isaac,Renuka Nayak,Alejandra Flor-Duro,Margaret Alexander,Imhoi Koo,Julia Manasson … See all authors
doi : 10.1002/art.41622
Volume 73, Issue 6 p. 931-942
Although oral methotrexate (MTX) remains the anchor drug for rheumatoid arthritis (RA), up to 50% of patients do not achieve a clinically adequate outcome. In addition, there is a lack of prognostic tools for treatment response prior to drug initiation. This study was undertaken to investigate whether interindividual differences in the human gut microbiome can aid in the prediction of MTX efficacy in new-onset RA.
Regulation of Synovial Inflammation and Tissue Destruction by Guanylate Binding Protein 5 in Synovial Fibroblasts From Patients With Rheumatoid Arthritis and Rats With Adjuvant-Induced Arthritis
Mahamudul Haque,Anil K. Singh,Madhu M. Ouseph,Salahuddin Ahmed
doi : 10.1002/art.41611
Volume 73, Issue 6 p. 943-954
Rheumatoid arthritis synovial fibroblasts (RASFs) are crucial mediators of synovial inflammation and joint destruction. However, their intrinsic immunoregulatory mechanisms under chronic inflammation remain unclear. Thus, the present study was undertaken to understand the role of a newly identified GTPase, guanylate binding protein 5 (GBP-5), in RA pathogenesis.
Association of Lipid Mediators With Development of Future Incident Inflammatory Arthritis in an Anti–Citrullinated Protein Antibody–Positive Population
Kristen J. Polinski,Elizabeth A. Bemis,Fan Yang,Tessa Crume,M. Kristen Demoruelle,Marie Feser,Jennifer Seifert … See all authors
doi : 10.1002/art.41631
Volume 73, Issue 6 p. 955-962
To determine the association of polyunsaturated fatty acid (PUFA)–derived lipid mediators with progression from rheumatoid arthritis (RA)–related autoimmunity to inflammatory arthritis (IA).
HLA–B*08 Identified as the Most Prominently Associated Major Histocompatibility Complex Locus for Anti–Carbamylated Protein Antibody–Positive/Anti–Cyclic Citrullinated Peptide–Negative Rheumatoid Arthritis
Cristina Regueiro,Desire Casares-Marfil,Karin Lundberg,Rachel Knevel,Marialbert Acosta-Herrera,Luis Rodriguez-Rodriguez,Raquel Lopez-Mejias,Eva Perez-Pampin,Ana Triguero-Martinez,Laura Nu?o,Ivan Ferraz-Amaro,Javier Rodriguez-Carrio,Rosario Lopez-Pedrera,Montse Robustillo-Villarino,Santos Casta?eda,Sara Remuzgo-Martinez,Mercedes Alperi,Juan J. Alegre-Sancho,Alejandro Balsa,Isidoro Gonzalez-Alvaro,Antonio Mera,Benjamin Fernandez-Gutierrez,Miguel A. Gonzalez-Gay,Leendert A. Trouw,Caroline Gr?nwall,Leonid Padyukov,Javier Martin,Antonio Gonzalez
doi : 10.1002/art.41630
Volume 73, Issue 6 p. 963-969
Previously, only the HLA–DRB1 alleles have been assessed in rheumatoid arthritis (RA). The aim of the present study was to identify the key major histocompatibility complex (MHC) susceptibility factors showing a significant association with anti–carbamylated protein antibody–positive (anti-CarP+) RA.
Divergence of Cardiovascular Biomarkers of Lipids and Subclinical Myocardial Injury Among Rheumatoid Arthritis Patients With Increased Inflammation
Brittany Weber,Zeling He,Nicole Yang,Martin P. Playford,Dana Weisenfeld,Christine Iannaccone,Jonathan Coblyn,Michael Weinblatt,Nancy Shadick,Marcelo Di Carli,Nehal N. Mehta,Jorge Plutzky,Katherine P. Liao
doi : 10.1002/art.41613
Volume 73, Issue 6 p. 970-979
Patients with rheumatoid arthritis (RA) are 1.5 times more likely to develop cardiovascular disease (CVD) attributed to chronic inflammation. A decrease in inflammation in patients with RA is associated with increased low-density lipoprotein (LDL) cholesterol. This study was undertaken to prospectively evaluate the changes in lipid levels among RA patients experiencing changes in inflammation and determine the association with concomitant temporal patterns in markers of myocardial injury.
Functional Genomic Analysis of a RUNX3 Polymorphism Associated With Ankylosing Spondylitis
Matteo Vecellio,Liye Chen,Carla J. Cohen,Adrian Cortes,Yan Li,Sarah Bonham,Carlo Selmi,Matthew A. Brown,Roman Fischer,Julian C. Knight,B. Paul Wordsworth
doi : 10.1002/art.41628
Volume 73, Issue 6 p. 980-990
To investigate the functional consequences of the single-nucleotide polymorphism rs4648889 in a putative enhancer upstream of the RUNX3 promoter associated with susceptibility to ankylosing spondylitis (AS).
Prevalence of Systemic Lupus Erythematosus in the United States: Estimates From a Meta-Analysis of the Centers for Disease Control and Prevention National Lupus Registries
Peter M. Izmirly,Hilary Parton,Lu Wang,W. Joseph McCune,S. Sam Lim,Cristina Drenkard,Elizabeth D. Ferucci,Maria Dall'Era,Caroline Gordon,Charles G. Helmick,Emily C. Somers
doi : 10.1002/art.41632
Volume 73, Issue 6 p. 991-996
Epidemiologic data on systemic lupus erythematosus (SLE) are limited, particularly for racial/ethnic subpopulations in the US. This meta-analysis leveraged data from the Centers for Disease Control and Prevention (CDC) National Lupus Registry network of population-based SLE registries to estimate the overall prevalence of SLE in the US.
Association of Higher Hydroxychloroquine Blood Levels With Reduced Thrombosis Risk in Systemic Lupus Erythematosus
Michelle Petri,Maximilian F. Konig,Jessica Li,Daniel W. Goldman
doi : 10.1002/art.41632
Volume 73, Issue 6 p. 997-1004
Hydroxychloroquine (HCQ) has a primary role in the prophylaxis and treatment of systemic lupus erythematosus (SLE) and may be protective against thrombosis in SLE. Optimal weight-based dosing of HCQ is unknown. This study was undertaken to examine the usefulness of HCQ blood monitoring in predicting thrombosis risk in a longitudinal SLE cohort.
Lindsay’s Nails in Early Limited Cutaneous Systemic Sclerosis With Severe Digital Vasculopathy
Jessica C. Ellis,John D. Pauling
doi : 10.1002/art.41621
Volume 73, Issue 6 p. 1004-1004
Predictive Significance of Serum Interferon-Inducible Protein Score for Response to Treatment in Systemic Sclerosis–Related Interstitial Lung Disease
Shervin Assassi,Ning Li,Elizabeth R. Volkmann,Maureen D. Mayes,Dennis Rünger,Jun Ying,Michael D. Roth,Monique Hinchcliff,Dinesh Khanna,Tracy Frech,Philip J. Clements,Daniel E. Furst,Jonathan Goldin,Elana J. Bernstein,Flavia V. Castelino,Robyn T. Domsic,Jessica K. Gordon,Faye N. Hant,Ami A. Shah,Victoria K. Shanmugam,Virginia D. Steen,Robert M. Elashoff,Donald P. Tashkin
doi : 10.1002/art.41658
Volume 73, Issue 6 p. 1005-1013
Response to immunosuppression is highly variable in systemic sclerosis (SSc)–related interstitial lung disease (ILD). This study was undertaken to determine whether a composite serum interferon (IFN)–inducible protein score exhibits predictive significance for the response to immunosuppression in SSc-ILD.
Effects of Dietary Patterns on Serum Urate: Results From a Randomized Trial of the Effects of Diet on Hypertension
Stephen P. Juraschek,Chio Yokose,Natalie McCormick,Edgar R. Miller III,Lawrence J. Appel,Hyon K. Choi
doi : 10.1002/art.41614
Volume 73, Issue 6 p. 1014-1020
To determine whether the Dietary Approaches to Stop Hypertension (DASH) diet or an alternative, simplified diet, emphasizing high-fiber fruits and vegetables (the FV diet), lowers serum urate levels.
Novel Majeed Syndrome–Causing LPIN2 Mutations Link Bone Inflammation to Inflammatory M2 Macrophages and Accelerated Osteoclastogenesis
Farzana Bhuyan,Adriana A. de Jesus,Jacob Mitchell,Evgenia Leikina,Rachel VanTries,Ronit Herzog,Karen B. Onel,Andrew Oler,Gina A. Montealegre Sanchez,Kim A. Johnson,Lena Bichell,Bernadette Marrero,Luis Fernandez De Castro,Yan Huang,Katherine R. Calvo,Michael T. Collins,Sundar Ganesan,Leonid V. Chernomordik,Polly J. Ferguson,Raphaela Goldbach-Mansky
doi : 10.1002/art.41624
Volume 73, Issue 6 p. 1021-1032
To identify novel heterozygous LPIN2 mutations in a patient with Majeed syndrome and characterize the pathomechanisms that lead to the development of sterile osteomyelitis.
Association of the Leukocyte Immunoglobulin-like Receptor A3 Gene With Neutrophil Activation and Disease Susceptibility in Adult-Onset Still’s Disease
Mengyan Wang,Mengru Liu,Jinchao Jia,Hui Shi,Jialin Teng,Honglei Liu,Yue Sun,Xiaobing Cheng,Junna Ye,Yutong Su,Huihui Chi,Tingting Liu,Zhihong Wang,Liyan Wan,Jianfen Meng,Yuning Ma,Chengde Yang,Qiongyi Hu
doi : 10.1002/art.41635
Volume 73, Issue 6 p. 1033-1043
Adult-onset Still’s disease (AOSD) is a severe autoinflammatory disease. Neutrophil activation with enhanced neutrophil extracellular trap (NET) formation is involved in the pathogenesis of AOSD. Functional leukocyte immunoglobulin-like receptor A3 (LIR-A3; gene name LILRA3) has been reported to be associated with many autoimmune diseases. We aimed to investigate the association of LILRA3 with disease susceptibility and neutrophil activation in AOSD.
From Diagnosis to Prognosis: Revisiting the Meaning of Muscle ISG15 Overexpression in Juvenile Inflammatory Myopathies
Cyrielle Hou,Chloé Durrleman,Baptiste Periou,Christine Barnerias,Christine Bodemer,Isabelle Desguerre,Pierre Quartier,Isabelle Melki,Gillian I. Rice,Mathieu P. Rodero,Jean-Luc Charuel,Fréderic Relaix,Brigitte Bader-Meunier,FrançoisJérôme Authier,Cyril Gitiaux
doi : 10.1002/art.41625
Volume 73, Issue 6 p. 1044-1052
Juvenile idiopathic inflammatory/immune myopathies (IIMs) constitute a highly heterogeneous group of disorders with diagnostic difficulties and prognostic uncertainties. Circulating myositis-specific autoantibodies (MSAs) have been recognized as reliable tools for patient substratification. Considering the key role of type I interferon (IFN) up-regulation in juvenile IIM, we undertook the present study to investigate whether IFN-induced 15-kd protein (ISG-15) could be a reliable biomarker for stratification and diagnosis and to better elucidate its role in juvenile IIM pathophysiology.
Early Treatment and IL1RN Single-Nucleotide Polymorphisms Affect Response to Anakinra in Systemic Juvenile Idiopathic Arthritis
Manuela Pardeo,Marianna Nicoletta Rossi,Denise Pires Marafon,Emanuela Sacco,Claudia Bracaglia,Chiara Passarelli,Ivan Caiello,Giulia Marucci,Antonella Insalaco,Chiara Perrone,Anna Tulone,Giusi Prencipe,Fabrizio De Benedetti
doi : 10.1002/art.41612
Volume 73, Issue 6 p. 1053-1061
To evaluate the impact of early treatment and IL1RN genetic variants on the response to anakinra in systemic juvenile idiopathic arthritis (JIA).
Comparison of Lesional Juvenile Myositis and Lupus Skin Reveals Overlapping Yet Unique Disease Pathophysiology
Jessica L. Turnier,Lauren M. Pachman,Lori Lowe,Lam C. Tsoi,Sultan Elhaj,Rajasree Menon,Maria C. Amoruso,Gabrielle A. Morgan,Johann E. Gudjonsson,Celine C. Berthier,J. Michelle Kahlenberg
doi : 10.1002/art.41615
Volume 73, Issue 6 p. 1062-1072
Skin inflammation heralds systemic disease in juvenile myositis, yet we lack an understanding of pathogenic mechanisms driving skin inflammation in this disease. We undertook this study to define cutaneous gene expression signatures in juvenile myositis and identify key genes and pathways that differentiate skin disease in juvenile myositis from childhood-onset systemic lupus erythematosus (SLE).
Integrative Analysis Reveals a Molecular Stratification of Systemic Autoimmune Diseases
Guillermo Barturen,Sepideh Babaei,Francesc Català-Moll,Manuel Mart?nez-Bueno,Zuzanna Makowska
doi : 10.1002/art.41610
Volume 73, Issue 6 p. 1073-1085
Clinical heterogeneity, a hallmark of systemic autoimmune diseases, impedes early diagnosis and effective treatment, issues that may be addressed if patients could be classified into groups defined by molecular pattern. This study was undertaken to identify molecular clusters for reclassifying systemic autoimmune diseases independently of clinical diagnosis.
Validation of a Bioassay for Predicting Response to Tumor Necrosis Factor Inhibitors in Rheumatoid Arthritis
Ching-Huang Ho,Andrea A. Silva,Jon T. Giles,Joan M. Bathon,Daniel H. Solomon,Katherine P. Liao,I-Cheng Ho
doi : 10.1002/art.41645
Volume 73, Issue 6 p. 1086-1087
Panniculitis As the First Clinical Manifestation of Myeloperoxidase–Positive Perinuclear Antineutrophil Cytoplasmic Antibody–Associated Vasculitis: Comment on the Article by Micheletti et al
D. Deleersnijder,P. De Haes,L. Peperstraete,J. Buelens,A. Betrains,D. Blockmans
doi : 10.1002/art.41662
Volume 73, Issue 6 p. 1088-1089
Reply
Robert G. Micheletti, Zelma Chiesa Fuxench, Anthea Craven, Raashid A. Luqmani, Richard A. Watts, Peter A. Merkel, for the Diagnostic and Classification Criteria in Vasculitis Study Investigators
doi : 10.1002/art.41661
Volume 73, Issue 6 p. 1089-1089
Who Has the Final Say on the Dose of Acupuncture? Comment on the Article by Tu et al
Yong Ming Li
doi : 10.1002/art.41664
Volume 73, Issue 6 p. 1089-1090
Reply
Jian-Feng Tu,Guang-Xia Shi,Jing-Wen Yang,Li-Qiong Wang,Shi-Yan Yan,Cun-Zhi Liu
doi : 10.1002/art.41661
Volume 73, Issue 6 p. 1090-1091
COVID-19 Reinfection in a Patient Receiving Immunosuppressive Treatment for Antineutrophil Cytoplasmic Antibody–Associated Vasculitis
Kavita Gulati,Maria Prendecki,Candice Clarke,Michelle Willicombe,Stephen McAdoo
doi : 10.1002/art.41671
Volume 73, Issue 6 p. 1091-1092
