دسترسی یکساله به بیش از ۵۰۰ ژورنال روز جهان موجود در سامانه
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American College of Rheumatology Guidance for COVID-19 Vaccination in Patients With Rheumatic and Musculoskeletal Diseases: Version 1
Jeffrey R. Curtis, Sindhu R. Johnson, Donald D. Anthony, Reuben J. Arasaratnam, Lindsey R. Baden, Anne R. Bass, Cassandra Calabrese, Ellen M. Gravallese, Rafael Harpaz, Rebecca E. Sadun, Amy S. Turner, Eleanor Anderson Williams, Ted R. Mikuls
doi : 10.1002/art.41734
Volume 73, Issue 7 p. 1093-1107
To provide guidance to rheumatology providers on the use of coronavirus disease 2019 (COVID-19) vaccines for patients with rheumatic and musculoskeletal diseases (RMDs).
2021 American College of Rheumatology Guideline for the Treatment of Rheumatoid Arthritis
Liana Fraenkel, Joan M. Bathon, Bryant R. England, E. William St. Clair, Thurayya Arayssi, Kristine Carandang, Kevin D. Deane, Mark Genovese, Kent Kwas Huston, Gail Kerr, Joel Kremer, Mary C. Nakamura, Linda A. Russell, Jasvinder A. Singh, Benjamin J. Smith, Jeffrey A. Sparks, Shilpa Venkatachalam, Michael E. Weinblatt, Mounir Al-Gibbawi, Joshua F. Baker, Kamil E. Barbour, Jennifer L. Barton, Laura Cappelli, Fatimah Chamseddine, Michael George, Sindhu R. Johnson, Lara Kahale, Basil S. Karam, Assem M. Khamis, Iris Navarro-Mill?n, Reza Mirza, Pascale Schwab, Namrata Singh, Marat Turgunbaev, Amy S. Turner, Sally Yaacoub, Elie A. Akl
doi : 10.1002/art.41752
Volume 73, Issue 7 p. 1108-1123
To develop updated guidelines for the pharmacologic management of rheumatoid arthritis.
Current Treatment Strategies in Rheumatoid Arthritis After Methotrexate Are Not Enough to Maintain Sustained Remission: There Is No Holy Grail!
Janet E. Pope, Peter Nash, Roy Fleischmann
doi : 10.1002/art.41746
Volume 73, Issue 7 p. 1124-1126
A Good Detective Never Misses a Clue: Why the Epidemiology of Scleritis Deserves Our Attention
Matthew A. Turk, James T. Rosenbaum
doi : 10.1002/art.41724
Volume 73, Issue 7 p. 1127-1128
Risk Factors for COVID-19 and Rheumatic Disease Flare in a US Cohort of Latino Patients
Alice Fike, Julia Hartman, Christopher Redmond, Sandra G. Williams, Yanira Ruiz-Perdomo, Jun Chu, Sarfaraz Hasni, Michael M. Ward, James D. Katz, Pravitt Gourh
doi : 10.1002/art.41656
Volume 73, Issue 7 p. 1129-1134
Latino patients are overrepresented among cases of coronavirus disease 2019 (COVID-19) and are at an increased risk of severe disease. Prevalence of COVID-19 in Latinos with rheumatic diseases is poorly reported. This study was undertaken to characterize COVID-19 clinical features and outcomes in Latino patients with rheumatic diseases.
Sustained Remission in Patients With Rheumatoid Arthritis Receiving Triple Therapy Compared to Biologic Therapy: A Swedish Nationwide Register Study
Hanna K?llmark, Jon T. Einarsson, Jan-?ke Nilsson, Tor Olofsson, Tore Saxne, Pierre Geborek, Meliha C. Kapetanovic
doi : 10.1002/art.41720
Volume 73, Issue 7 p. 1135-1144
To compare the real-life effectiveness of biologic therapy (a biologic disease-modifying antirheumatic drug plus methotrexate [MTX]) versus triple therapy (MTX plus sulfasalazine plus hydroxychloroquine/chloroquine) for sustained remission of rheumatoid arthritis (RA).
Characterization and Function of Tumor Necrosis Factor and Interleukin-6–Induced Osteoclasts in Rheumatoid Arthritis
Kazuhiro Yokota, Kojiro Sato, Takashi Miyazaki, Yoshimi Aizaki, Shinya Tanaka, Miyoko Sekikawa, Noritsune Kozu, Yuho Kadono, Hiromi Oda, Toshihide Mimura
doi : 10.1002/art.41666
Volume 73, Issue 7 p. 1145-1154
We have previously reported that stimulation of mouse bone marrow–derived macrophages with tumor necrosis factor (TNF) and interleukin-6 (IL-6) induces differentiation of osteoclast-like cells. We undertook this study to clarify the characterization and function of human TNF and IL-6–induced osteoclasts using peripheral blood collected from patients with rheumatoid arthritis (RA) and healthy donors.
Contribution of a European-Prevalent Variant near CD83 and an East Asian–Prevalent Variant near IL17RB to Herpes Zoster Risk in Tofacitinib Treatment: Results of Genome-Wide Association Study Meta-Analyses
Nan Bing, Huanyu Zhou, Xing Chen, Tomohiro Hirose, Yuta Kochi, Yumi Tsuchida, Kazuyoshi Ishigaki, Shuji Sumitomo, Keishi Fujio, Baohong Zhang, Hernan Valdez, Michael S. Vincent, David Martin, James D. Clark
doi : 10.1002/art.41655
Volume 73, Issue 7 p. 1155-1166
Tofacitinib is an oral JAK inhibitor for the treatment of rheumatoid arthritis (RA), psoriatic arthritis, and ulcerative colitis, and has been previously investigated for psoriasis (PsO). This meta-analysis of genome-wide association studies (GWAS) was performed to identify genetic factors associated with increased risk/faster onset of herpes zoster (HZ) in subjects with RA or PsO receiving tofacitinib treatment, and to determine potential mechanisms that could be attributed to the varying rates of HZ across ethnicities.
Long-Term Safety and Efficacy of Subcutaneous Tanezumab Versus Nonsteroidal Antiinflammatory Drugs for Hip or Knee Osteoarthritis: A Randomized Trial
Marc C. Hochberg, John A. Carrino, Thomas J. Schnitzer, Ali Guermazi, David A. Walsh, Alexander White, Satoru Nakajo, Robert J. Fountaine, Anne Hickman, Glenn Pixton, Lars Viktrup, Mark T. Brown, Christine R. West, Kenneth M. Verburg
doi : 10.1002/art.41674
Volume 73, Issue 7 p. 1167-1177
To assess the long-term safety and 16-week efficacy of subcutaneous tanezumab in patients with hip or knee osteoarthritis (OA).
Global Deletion of Pannexin 3 Resulting in Accelerated Development of Aging-Induced Osteoarthritis in Mice
P. M. Moon, Z. Y. Shao, G. Wambiekele, C. T. G. Appleton, D. W. Laird, S. Penuela, F. Beier
doi : 10.1002/art.41651
Volume 73, Issue 7 p. 1178-1188
Osteoarthritis (OA) results in pathologic changes in the joint tissue. The mechanisms driving disease progression remain largely unclear, and thus disease-modifying treatments are lacking. Pannexin 3 (Panx3) was identified as a potential mediator of cartilage degeneration in OA, and our previous study in mice indicated that deletion of the Panx3 gene delayed surgically induced cartilage degeneration. This study was undertaken to examine the role of Panx3 in other OA subtypes, particularly primary OA during aging, in a mouse model of aging-induced OA.
Inflammasome Activation in Ankylosing Spondylitis Is Associated With Gut Dysbiosis
Giuliana Guggino, Daniele Mauro, Aroldo Rizzo, Riccardo Alessandro, Stefania Raimondo, Anne-Sophie Bergot, M. Arifur Rahman, Jonathan J. Ellis, Simon Milling, Rik Lories, Dirk Elewaut, Matthew A. Brown, Ranjeny Thomas, Francesco Ciccia
doi : 10.1002/art.41644
Volume 73, Issue 7 p. 1189-1199
We undertook this study to evaluate the activation and functional relevance of inflammasome pathways in ankylosing spondylitis (AS) patients and rodent models and their relationship to dysbiosis.
Mediation of Interleukin-23 and Tumor Necrosis Factor–Driven Reactive Arthritis by Chlamydia-Infected Macrophages in SKG Mice
Xavier Romand, Xiao Liu, M. Arifur Rahman, Zaied Ahmed Bhuyan, Claire Douillard, Reena Arora Kedia, Nathan Stone, Dominique Roest, Zi Huai Chew, Amy J. Cameron, Linda M. Rehaume, Aurélie Bozon, Mohammed Habib, Charles W. Armitage, Minh Vu Chuong Nguyen, Bertrand Favier, Kenneth Beagley, Max Maurin, Philippe Gaudin, Ranjeny Thomas, Timothy J. Wells, Athan Baillet
doi : 10.1002/art.41653
Volume 73, Issue 7 p. 1200-1210
ZAP-70W163C BALB/c (SKG) mice develop reactive arthritis (ReA) following infection with Chlamydia muridarum. Since intracellular pathogens enhance their replicative fitness in stressed host cells, we examined how myeloid cells infected with C muridarum drive arthritis.
Tumor Necrosis Factor Inhibitors Reduce Spinal Radiographic Progression in Patients With Radiographic Axial Spondyloarthritis: A Longitudinal Analysis From the Alberta Prospective Cohort
Alexandre Sepriano, Sofia Ramiro, Stephanie Wichuk, Praveena Chiowchanwisawakit, Joel Paschke, Désirée van der Heijde, Robert Landewé, Walter P. Maksymowych
doi : 10.1002/art.41667
Volume 73, Issue 7 p. 1211-1219
To investigate whether tumor necrosis factor inhibitors (TNFi) impact spinal radiographic progression in patients with axial spondyloarthritis (SpA) and whether this is coupled to their effect on inflammation.
Tissue-Resident Memory CD8+ T Cells From Skin Differentiate Psoriatic Arthritis From Psoriasis
Emmerik F. Leijten, Tessa S. van Kempen, Michel A. Olde Nordkamp, Juliette N. Pouw, Nienke J. Kleinrensink, Nanette L. Vincken, Jorre Mertens, Deepak M. W. Balak, Fleurieke H. Verhagen, Sarita A. Hartgring, Erik Lubberts, Janneke Tekstra, Aridaman Pandit, Timothy R. Radstake, Marianne Boes
doi : 10.1002/art.41652
Volume 73, Issue 7 p. 1220-1232
To compare immune cell phenotype and function in psoriatic arthritis (PsA) versus psoriasis in order to better understand the pathogenesis of PsA.
Specific Follicular Helper T Cell Signature in Takayasu Arteritis
A. C. Desbois, P. Régnier, V. Quiniou, A. Lejoncour, A. Maciejewski-Duval, C. Comarmond, H. Vallet, M. Rosenzwag, G. Darrasse-Jèze, N. Derian, J. Pouchot, M. Samson, B. Bienvenu, P. Fouret, F. Koskas, M. Garrido, D. Sène, P. Bruneval, P. Cacoub, D. Klatzmann, D. Saadoun
doi : 10.1002/art.41672
Volume 73, Issue 7 p. 1233-1243
Our aim was to compare transcriptome and phenotype profiles of CD4+ T cells and CD19+ B cells in patients with Takayasu arteritis (TAK), patients with giant cell arteritis (GCA), and healthy donors.
Genetic Association of a Gain-of-Function IFNGR1 Polymorphism and the Intergenic Region LNCAROD/DKK1 With Behçet’s Disease
Lourdes Ortiz Fern?ndez, Patrick Coit, Vuslat Yilmaz, Sibel P. Yentür, Fatma Alibaz-Oner, Kenan Aksu, Eren Erken, Nursen Düzgün, Gokhan Keser, Ayse Cefle, Ayten Yazici, Andac Ergen, Erkan Alpsoy, Carlo Salvarani, Bruno Casali, Bünyamin K?sac?k, Ina K?tter, J?rg Henes, Muhammet ??nar, Arne Schaefer, Rahime M. Nohutcu, Alexandra Zhernakova, Cisca Wijmenga, Fujio Takeuchi, Shinji Harihara, Toshikatsu Kaburaki, Meriam Messedi, Yeong-Wook Song, Timuçin Ka?ifo?lu, F. David Carmona, Joel M. Guthridge, Judith A. James, Javier Martin, Mar?a Francisca Gonz?lez Escribano, Güher Saruhan-Direskeneli, Haner Direskeneli, Amr H. Sawalha
doi : 10.1002/art.41637
Volume 73, Issue 7 p. 1244-1252
Behçet’s disease is a complex systemic inflammatory vasculitis of incompletely understood etiology. This study was undertaken to investigate genetic associations with Behçet’s disease in a diverse multiethnic population.
The Vasculopathy of Juvenile Dermatomyositis: Endothelial Injury, Hypercoagulability, and Increased Arterial Stiffness
Charalampia Papadopoulou, Ying Hong, Petra Krol, Muthana Al Obaidi, Clarissa Pilkington, Lucy R. Wedderburn, Paul A. Brogan, Despina Eleftheriou
doi : 10.1002/art.41639
Volume 73, Issue 7 p. 1253-1266
Vasculopathy is considered central to the pathogenesis of juvenile dermatomyositis (DM) and is associated with severe extramuscular manifestations. We undertook this study to investigate the hypothesis that the vasculopathy of juvenile DM can be noninvasively tracked by examining biomarkers of endothelial injury, subclinical inflammation, hypercoagulability, and vascular arterial stiffness.
Epidemiology of Scleritis in the United Kingdom From 1997 to 2018: Population-Based Analysis of 11 Million Patients and Association Between Scleritis and Infectious and Immune-Mediated Inflammatory Disease
Tasanee Braithwaite, Nicola J. Adderley, Anuradhaa Subramanian, James Galloway, John H. Kempen, Krishna Gokhale, Andrew P. Cope, Andrew D. Dick, Krishnarajah Nirantharakumar, Alastair K. Denniston
doi : 10.1002/art.41709
Volume 73, Issue 7 p. 1267-1276
To estimate 22-year trends in the prevalence and incidence of scleritis, and the associations of scleritis with infectious and immune-mediated inflammatory diseases (I-IMIDs) in the UK.
Association of Lymphangiogenic Factors With Pulmonary Arterial Hypertension in Systemic Sclerosis
Henriette Didriksen, ?yvind Molberg, H?vard Fretheim, Einar Gude, Suzana Jordan, Cathrine Brunborg, Vyacheslav Palchevskiy, Torhild Garen, ?yvind Midtvedt, Arne K. Andreassen, Oliver Distler, John Belperio, Anna-Maria Hoffmann-Vold
doi : 10.1002/art.41665
Volume 73, Issue 7 p. 1277-1287
Pulmonary arterial hypertension (PAH) is a major complication in systemic sclerosis (SSc), a disease marked by vascular and lymphatic vessel abnormalities. This study was undertaken to assess the role of the lymphangiogenic factors vascular endothelial growth factor C (VEGF-C) and angiopoietin 2 (Ang-2) and the soluble forms of their respective cognate receptors, soluble VEGF receptor 3 (sVEGFR-3) and soluble TIE-2, in patients with SSc, and to evaluate their predictive ability as markers for PAH development in SSc.
Expression Quantitative Trait Locus Analysis in Systemic Sclerosis Identifies New Candidate Genes Associated With Multiple Aspects of Disease Pathology
Martin Kerick, David Gonz?lez-Serna, Elena Carnero-Montoro, Maria Teruel, Marialbert Acosta-Herrera, Zuzanna Makowska, Anne Buttgereit, Sepideh Babaei, Guillermo Barturen, Elena L?pez-Isac, PRECISESADS Clinical Consortium , Ralf Lesche, Lorenzo Beretta, Marta E. Alarcon-Riquelme, Javier Martin
doi : 10.1002/art.41657
Volume 73, Issue 7 p. 1288-1300
To identify the genetic variants that affect gene expression (expression quantitative trait loci [eQTLs]) in systemic sclerosis (SSc) and to investigate their role in the pathogenesis of the disease.
Tocilizumab Prevents Progression of Early Systemic Sclerosis–Associated Interstitial Lung Disease
David Roofeh, Celia J. F. Lin, Jonathan Goldin, Grace Hyun Kim, Daniel E. Furst, Christopher P. Denton, Suiyuan Huang, Dinesh Khanna, the focuSSced Investigators
doi : 10.1002/art.41668
Volume 73, Issue 7 p. 1301-1310
Tocilizumab (TCZ) has demonstrated lung function preservation in 2 randomized controlled trials in early systemic sclerosis (SSc). This effect has yet to be characterized in terms of radiographically evident quantitative lung involvement. We undertook this study to assess the impact of TCZ on lung function preservation in a post hoc analysis, stratifying treatment arms according to the degree of lung involvement.
Dysfunctional Keratinocytes Increase Dermal Inflammation in Systemic Sclerosis: Results From Studies Using Tissue-Engineered Scleroderma Epidermis
Barbara Russo, Julia Borowczyk, Wolf-Henning Boehncke, Marie-Elise Truchetet, Ali Modarressi, Nicol? C. Brembilla, Carlo Chizzolini
doi : 10.1002/art.41659
Volume 73, Issue 7 p. 1311-1317
Evidence suggests that keratinocyte–fibroblast interactions are abnormal in systemic sclerosis (SSc). The present study was undertaken to investigate potential epidermal dysfunction in SSc and its effects on dermal homeostasis.
Greater Somatosensory Afference With Acupuncture Increases Primary Somatosensory Connectivity and Alleviates Fibromyalgia Pain via Insular ?-Aminobutyric Acid: A Randomized Neuroimaging Trial
Ishtiaq Mawla, Eric Ichesco, Helge J. Z?llner, Richard A. E. Edden, Thomas Chenevert, Henry Buchtel, Meagan D. Bretz, Heather Sloan, Chelsea M. Kaplan, Steven E. Harte, George A. Mashour, Daniel J. Clauw, Vitaly Napadow, Richard E. Harris
doi : 10.1002/art.41620
Volume 73, Issue 7 p. 1318-1328
Acupuncture is a complex multicomponent treatment that has shown promise in the treatment of fibromyalgia (FM). However, clinical trials have shown mixed results, possibly due to heterogeneous methodology and lack of understanding of the underlying mechanism of action. The present study was undertaken to understand the specific contribution of somatosensory afference to improvements in clinical pain, and the specific brain circuits involved.
Giant Iliopsoas Bursitis in Systemic Juvenile Idiopathic Arthritis
Asami Shimbo, Yuko Akutsu, Susumu Yamazaki, Masaki Shimizu, Masaaki Mori
doi : 10.1002/art.41692
Volume 73, Issue 7 p. 1328-1328
Anti–Cytosolic 5?-Nucleotidase 1A Autoantibodies Are Absent in Juvenile Dermatomyositis
Anke Rietveld, Judith Wienke, Eline Visser, Wilma Vree Egberts, Wolfgang Schlumberger, Baziel van Engelen, Annet van Royen-Kerkhof, Hui Lu, Lucy Wedderburn, Christiaan Saris, Sarah Tansley, Ger Pruijn, the Juvenile Dermatomyositis Research Group and the Dutch Myositis Consortium
doi : 10.1002/art.41660
Volume 73, Issue 7 p. 1329-1333
To assess anti–cytosolic 5?-nucleotidase 1A (anti–cN-1A) autoantibodies in children with juvenile dermatomyositis (DM) and healthy controls, using 3 different methods of antibody detection, as well as verification of the results in an independent cohort.
Distinct Gene Expression Signatures Characterize Strong Clinical Responders Versus Nonresponders to Canakinumab in Children With Systemic Juvenile Idiopathic Arthritis
Emely L. Verweyen, Alex Pickering, Alexei A. Grom, Grant S. Schulert
doi : 10.1002/art.41640
Volume 73, Issue 7 p. 1334-1340
Canakinumab is a human anti–interleukin-1? (anti–IL-1?) blocking agent that effectively neutralizes IL-1?–mediated signaling for treatment of systemic juvenile idiopathic arthritis (JIA). While many patients have dramatic clinical response to IL-1 blockade, approximately one-third fail to respond, but there are currently no validated clinical or immunologic predictors of response. We undertook this study to characterize distinct gene signatures for treatment response and nonresponse to canakinumab in systemic JIA patients.
Prophylactic Anticoagulation Therapy: Comment on the Article by Henderson et al
Barbara Faganel Kotnik, Mojca Zajc Avramovi?, Lidija Kitanovski, Tadej Av?in
doi : 10.1002/art.41690
Volume 73, Issue 7 p. 1341-1342
Reply
Lauren A. Henderson, Kevin G. Friedman, Mary Beth F. Son, Kate F. Kernan, Scott W. Canna, Mark Gorelik, Sivia K. Lapidus, Anne Ferris, Grant S. Schulert, Philip Seo, Adriana H. Tremoulet, Rae S. M. Yeung, David R. Karp, Hamid Bassiri, Edward M. Behrens, Jay J. Mehta
doi : 10.1002/art.41689
Volume 73, Issue 7 p. 1342-1343
Understanding the Relationships Between Type I Interferon, STAT4, and the Production of Interleukin-21 and Interferon-? by Follicular Helper T Cells in Lupus: Comment on the Article by Dong et al
Caiqun Chen, Yan Liang, Zaixing Yang
doi : 10.1002/art.41715
Volume 73, Issue 7 p. 1343-1344
Temporal Arteritis Revealing Antineutrophil Cytoplasmic Antibody–Associated Vasculitides: Are the Visual Outcomes Different From Giant Cell Arteritis? Comment on the Article by Delaval et al
Joydeep Samanta, GSRSNK Naidu, Sakshi Mittal, Ritambhra Nada, Amanjit Bal, Ramandeep Singh, Vishali Gupta, Amod Gupta, Aman Sharma, Benzeeta Pinto
doi : 10.1002/art.41698
Volume 73, Issue 7 p. 1345-1346
Biologics for Eosinophilic Granulomatosis With Polyangiitis—One Size Does Not Fit All: Comment on the Article by Canzian et al
Marco Caminati, Alessandro Giollo, Gianenrico Senna, Claudio Lunardi
doi : 10.1002/art.41695
Volume 73, Issue 7 p. 1346-1347
Sj?gren’s Disease, Not Syndrome
Alan N. Baer, Katherine M. Hammitt
doi : 10.1002/art.41676
Volume 73, Issue 7 p. 1347-1348
