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A new Editor: A fresh beginning on our 25th anniversary
Robert A. Schwartz
doi : 10.1111/dth.14983
Dermatologic TherapyVolume 34, Issue 3 e14983
Lichen sclerosus successfully treated with baricitinib plus psoralen and ultraviolet A
Jingyi Li, Wen Zheng, Junchi Tang, Bin Yang
doi : 10.1111/dth.14896
Dermatologic TherapyVolume 34, Issue 3 e14896
Granuloma annulare triggered by SARS-CoV-2 infection: Immunohistochemical staining
Juan Monte-Serrano, Miguel Fernando Garc?a-Gil, Mar Garc?a-Garc?a, Inmaculada Casas-Flecha, Cristina Matovelle-Ochoa, Mariano Ara-Mart?n
doi : 10.1111/dth.14897
Dermatologic TherapyVolume 34, Issue 3 e14897
Erythrodermic psoriasis precipitated by B-cell chronic lymphocytic leukemia
Yingyi Li, Yujie Wen, Ran You, Chenxue Qu, Yue Yin, Ping Tu, Yang Wang
doi : 10.1111/dth.14904
Dermatologic TherapyVolume 34, Issue 3 e14904
Acquired digital arteriovenous malformation successfully treated with long-pulsed 1.064 nm neodymium-doped yttrium aluminum garnet (Nd:YAG) laser
Nuria Set?-Torrent, Ana Iglesias-Plaza, M?nica Quintana-Codina, Elisabet Amores-Mart?n, Jes?s Del Pozo-Losada, Montse Salleras-Redonnet
doi : 10.1111/dth.14913
Dermatologic TherapyVolume 34, Issue 3 e14913
Oral evening primrose oil as an adjuvant treatment option in chronic lichenoid dermatitis
Kwang Ho Yoo, Dong Sik Bang, Mi Le Kim, Sung Eun Lee, Kapsok Li, Beom Joon Kim
doi : 10.1111/dth.14914
Dermatologic TherapyVolume 34, Issue 3 e14914
Workforce geography of older dermatologists during the COVID-19 pandemic
David X. Zheng, Tarun K. Jella, Melissa A. Levoska, Anne Y. Ning, Christopher R. Cullison, Bryan T. Carroll, Jeffrey F. Scott
doi : 10.1111/dth.14917
Dermatologic TherapyVolume 34, Issue 3 e14917
Complete remission of Psoriatic erythroderma using modified low dose etanercept in a HIV positive patient: A case report with review of literature
Akash Agarwal, Maitreyee Panda, Arunima Ray
doi : 10.1111/dth.14922
Dermatologic TherapyVolume 34, Issue 3 e14922
Guselkumab in the treatment of severe hidradenitis suppurativa, a promising role?
Lorenza Burzi, Federica Repetto, Alice Ramondetta, Giulia Rozzo, Matteo Licciardello, Simone Ribero, Pietro Quaglino, Paolo Dapavo
doi : 10.1111/dth.14930
Dermatologic TherapyVolume 34, Issue 3 e14930
Paradoxical capillary hemangioma during treatment with ramucirumab
Noelia Moreiras-Arias, V?ctor Cebey, Carlos Aliste, Hugo V?zquez-Veiga, Rafael L?pez- L?pez, Igor V?zquez-Osorio
doi : 10.1111/dth.14938
Dermatologic TherapyVolume 34, Issue 3 e14938
A rare case of early-onset lymphomatoid papulosis refractory to brentuximab vedotin
Martina Ferranti, Roberto Salmaso, Dario Marino, Mauro Alaibac
doi : 10.1111/dth.14943
Dermatologic TherapyVolume 34, Issue 3 e14943
Use of dermoscopy after punch removal of a veiled sea urchin spine
Su Jung Park, Jae Wan Park, Sun Young Choi, Kwang Ho Yoo
doi : 10.1111/dth.14947
Dermatologic TherapyVolume 34, Issue 3 e14947
Management of advanced basal cell carcinoma: Real-life data with sonidegib
Elvira Moscarella, Gabriella Brancaccio, Giulia Briatico, Andrea Ronchi, Pasquale Verolino, Giuseppe Argenziano, Roberto Alfano
doi : 10.1111/dth.14948
Dermatologic TherapyVolume 34, Issue 3 e14948
Romidepsin in combination with low-dose methotrexate in advanced-stage mycosis fungoides and Sézary syndrome
Deysy Elizabeth Cieza-D?az, Salma Machan, Luc?a Prieto-Torres, Luis Requena, Ra?l C?rdoba
doi : 10.1111/dth.14952
Dermatologic TherapyVolume 34, Issue 3 e14952
Prevalence and pattern of acute dermatological manifestations of the novel COVID-19 infection at a COVID-19 treatment center in Sub-Saharan Africa
Ehiaghe L. Anaba
doi : 10.1111/dth.14953
Dermatologic TherapyVolume 34, Issue 3 e14953
Dermatoscopic findings and dermatopathological correlates in clinical variants of actinic keratosis, Bowen's disease, keratoacanthoma, and squamous cell carcinoma
Pelin Ertop Do?an, Bengü Nisa Akay, Aylin Okçu Heper, Cliff Rosendahl, Cengizhan Erdem
doi : 10.1111/dth.14877
Dermatologic TherapyVolume 34, Issue 3 e14877
Non-melanoma skin cancer (NMSC), predominantly squamous cell carcinoma (SCC) and basal cell carcinoma, is increasing worldwide. Dermatoscopy, which is one of the non-invasive diagnostic techniques, is important for early diagnosis of NMSC.
Physical and psychological impacts of handwashing and personal protective equipment usage in the COVID-19 pandemic: A UK based cross-sectional analysis of healthcare workers
Emily S. Burns, Pirunthan Pathmarajah, Vijaytha Muralidharan
doi : 10.1111/dth.14885
Dermatologic TherapyVolume 34, Issue 3 e14885
The COVID-19 pandemic has necessitated intensified handwashing and mask usage for healthcare staff. A retrospective cross-sectional study was performed primarily to investigate the potential skin damage and secondary impacts on wellbeing of staff resulting from these practices. Additionally the availability and uptake of occupational health services and moisturisers in the work place was also assessed.
Botulinum toxin and platelet rich plasma as innovative therapeutic modalities for keloids
Yomna Mazid El-Hamd Neinaa, Toka Ahmad Elsayed, Dareen Ali Mohamed, Nashwa Naeem Elfar
doi : 10.1111/dth.14900
Dermatologic TherapyVolume 34, Issue 3 e14900
Keloids characterize a definitely challenging type of cutaneous scars for which a diversity of therapeutic modalities has been suggested. The aim of this work was to compare the therapeutic efficacy of intralesional injection of botulinum toxin type-A (BTX-A), platelet rich plasma (PRP), and triamcinolone acetonide (TAC) in keloids.
Successful systemic treatment outcomes of lichen planus: A single-center retrospective review
Katherine M. Hunt, Skylar Klager, Young J. Kwak, Naveed Sami
doi : 10.1111/dth.14903
Dermatologic TherapyVolume 34, Issue 3 e14903
Lichen planus (LP) affects up to 4% of adults and can cause significant distress and morbidity, especially to those with persistent disease. As many as 20% of patients with LP may exhibit widespread or recalcitrant disease necessitating systemic treatment options. We sought to evaluate the effectiveness of systemic treatments for severe and recalcitrant LP not responsive to topical corticosteroids or calcineurin inhibitors. Over a 10-year period, 374 patients with cutaneous and mucosal LP were evaluated at a major regional tertiary medical center; 94 qualified for inclusion in the study.
Disease severity and poor mental health are the main predictors of stigmatization in patients with hidradenitis suppurativa
Gulsen Akoglu, Irem Yildiz, Eda Karaismailo?lu, Pelin Esme
doi : 10.1111/dth.14910
Dermatologic TherapyVolume 34, Issue 3 e14910
Hidradenitis suppurativa (HS) causes significant psychological distress in patients. We aimed to investigate the stigmatization level of HS patients and to determine the related physical, social, and psychological factors. A questionnaire with 22 questions about the physical and psychosocial problems related to HS was administered to 29 male and 34 female patients between the ages of 18 and 66 to evaluate the thoughts, emotions, attitudes, and behaviors of patients.
DECISA Project (DErmatology Clinics in Italy: Survey on Alitretinoin): A real-life retrospective cohort multicenter study on 438 subjects with chronic hand eczema
Silvia Ferrucci, Paola Persichini, Massimo Gola, Ilaria Scandagli, Paolo Pigatto, Agostina Legori, Maria Letizia Musumeci, Giuseppe Micali, Elisabetta D'Agata, Donatella Schena, Alan Azzolini, Rosella Gallo, Ilaria Trave, Antonio Cristaudo, Cataldo Patruno, Maddalena Napolitano, Myriam Zucca, Viviana Piras, Luca Stingeni, Leonardo Bianchi, Monica Corazza, Pierantonia Zedde, Caterina Foti, Paolo Romita, Serafinella Patrizia Cannav?, Fabrizio Guarneri
doi : 10.1111/dth.14911
Dermatologic TherapyVolume 34, Issue 3 e14911
Alitretinoin is the only systemic agent approved to treat moderate-severe chronic hand eczema (CHE) unresponsive to potent topical corticosteroids. No nationwide Italian data regarding real-life efficacy, safety, and tolerability of treatment are available. The DECISA project (DErmatology Clinics in Italy: Survey on Alitretinoin) retrospectively examined data from a registry including 15 Dermatology Clinics authorized to prescription of alitretinoin for CHE patients. Disease severity was assessed at baseline, and after 3 and 6 months of treatment, using the 5-point Physician Global Assessment (PGA) and the modified Total Lesion-Symptoms-Severity (mTLSS) scores. Between November 2010 and July 2018, data of 248 male and 190 female patients (mean age 49.71?±?13.20?years) treated with alitretinoin were collected.
Treatments for alopecia areata: A systematic review and network meta-analysis
Takeshi Fukumoto, Rie Fukumoto, Elizabeth Magno, Masahiro Oka, Chikako Nishigori, Nobuyuki Horita
doi : 10.1111/dth.14916
Dermatologic TherapyVolume 34, Issue 3 e14916
Existing guidelines form no consensus for alopecia areata (AA) treatment due to the absence of a universal standard treatment and arbitrary selection of reference arms in randomized control trials (RCTs). The aim is to identify the best treatment and to rank treatments using systematic review and network meta-analysis.
Systemic antibiotics in hidradenitis suppurativa: efficacy and effects of body mass index and smoking pack-year on the response to therapy
Michela Iannone, Agata Janowska, Gianluca Bartolomei, Matteo Puntoni, Teresa Oranges, Marco Romanelli, Valentina Dini
doi : 10.1111/dth.14919
Dermatologic TherapyVolume 34, Issue 3 e14919
The combination of oral clindamycin with rifampicin is recommended by European guidelines as a first-line treatment in moderate-to-severe hidradenitis suppurativa (HS). Recent studies highlight that oral clindamycin in monotherapy (CM) may be a useful alternative treatment.
DEFB1 gene polymorphisms modify vitiligo extent and response to NB-UVB phototherapy
Rehab Mohammed Salem, Amira Mohamed Noureldin Abdelrahman, Heba Mohamed Abd El-Kareem, Marwa Seif
doi : 10.1111/dth.14921
Dermatologic TherapyVolume 34, Issue 3 e14921
Human beta defensin-1(hBD-1); an antimicrobial peptide, has immune regulatory effects which may be involved in autoimmunity. The aims were to evaluate the association between defensin beta 1 (DEFB1) (-44 C/G) and (-20?G/A) gene polymorphisms with the risk of vitiligo development, the extent of the disease and the response to NB-UVB treatment in a sample of Egyptian population.
A20 deficiency in myeloid cells deteriorates the onset of vitiligo in mice
He Li, Congpin Wang, Xiaoqing Li, Yinghui Kong, Weiguo Sun
doi : 10.1111/dth.14923
Dermatologic TherapyVolume 34, Issue 3 e14923
Melanocyte-specific CD8+T cells enrichment correlates with the severity of vitiligo, and the role of A20 derived from myeloid cells in the enrichment of pathogenic T cells is unknown. Premelanosome (PMEL)-specific transgenic CD8+T cells were adoptive transferred into Krt14-Kitl* mice to construct the vitiligo model, which was further mated with A20MKO mice and IKK2fl/fl mice.
The efficacy of oral vs different dilutions of intradermal tranexamic acid microinjections in melasma—A randomized clinical trial
Heba El Hadidi, Rana Mosaad, Nanis Ragab
doi : 10.1111/dth.14924
Dermatologic TherapyVolume 34, Issue 3 e14924
Melasma is a common acquired disorder of pigmentation, remains challenging despite numerous treatment modalities. Tranexamic acid (TXA) has emerged as a potential treatment for melasma. Different forms of TXA (oral, topical, and intradermal microinjections) have shown promising results. To evaluate and compare the efficacy of oral vs different dilutions of intradermal TXA in melasma.
Efficacy and safety of a novel water-soluble herbal patch for acne vulgaris treatment: A randomized, assessor-blinds controlled, intra-individual split-face comparative study
Kulwipapat Jaturapisanukul, Montree Udompataikul, Silada Kanokrungsee, Salinee Rojhirunsakool, Nanticha Kamanamool, Mingkwan Rachpirom, Panupong Puttarak
doi : 10.1111/dth.14925
Dermatologic TherapyVolume 34, Issue 3 e14925
Acne vulgaris is a chronic inflammatory skin disease. Antibiotics, particularly clindamycin and erythromycin, are used for the treatment of acne vulgaris. However, emerging antibiotic-resistant strains have been an important problem. This study aims to evaluate the efficiency and safety of a novel water-soluble herbal acne patch (WHAP) compared with the hydrocolloid acne patch (HAP) in mild to moderate inflammatory acne patients. The randomized, assessor-blind controlled, intra-individual split-face study was performed on 49 acne patients.
Retrospective analysis of nail biopsies performed using the Medicare Provider Utilization and Payment Database 2012 to 2017
Yu Wang, Shari R. Lipner
doi : 10.1111/dth.14928
Dermatologic TherapyVolume 34, Issue 3 e14928
Subungual melanoma (SUM) is subset of acral melanoma that develops within the nail unit and is associated with a poor prognosis. Nail biopsy is the only way to definitively diagnosis SUM. Our objectives were to analyze the Medicare database for nail biopsy utilization and to compare the annual nail biopsy rate with the estimated incidence of SUM in the United States.
Certolizumab pegol in the treatment of psoriasis: Real-life data
Meltem Turkmen, Sinan Dogan
doi : 10.1111/dth.14929
Dermatologic TherapyVolume 34, Issue 3 e14929
Certolizumab pegol (CZP), the only Fc-free, PEGylated anti-tumor necrosis factor biologic agent. This study aims to investigate the effect and safety of CZP in moderate-to-severe chronic plaque psoriasis. We performed a retrospective observational analysis of the moderate-to-severe psoriasis patients under ceratolizumab pegol therapy.
Cutaneous venous malformations as a clue for possible gastrointestinal tract involvement: Diagnosis and treatment of six cases
Andrea Diociaiuti, Roberta Rotunno, Tamara Caldaro, Sabrina Rossi, Claudia Carnevale, Filippo Torroni, Guglielmo Paolantonio, Teresa Capriati, May El Hachem
doi : 10.1111/dth.14932
Dermatologic TherapyVolume 34, Issue 3 e14932
Venous malformation (VM) is the most common type among vascular malformations classified by the International Society for the Study of Vascular Anomalies. Most VMs are sporadic (94%), caused in 40% of cases by somatic mutation of TEK gene. VMs can be cutaneous, visceral, or combined. Visceral involvement is rare, and gastrointestinal (GI) tract is the most common localization. Visceral VMs, usually asymptomatic, may manifest with bleeding, anemia, and consumptive coagulopathy, which sometimes require an emergency treatment. Our aim is to study the possible GI involvement in patients with only one cutaneous VM.
Dupilumab for children and adolescents with atopic dermatitis: An Asian perspective
Shi Yun Chia, Lynette Wei Yi Wee, Mark Jean Aan Koh
doi : 10.1111/dth.14933
Dermatologic TherapyVolume 34, Issue 3 e14933
Atopic dermatitis (AD) is a common, chronic, recurrent inflammatory skin disease. Poorly controlled AD can lead to reduced quality of life (QoL) and psychosocial impairment. Dupilumab is the first approved monoclonal antibody targeting type 2 inflammation, for adolescent and adult patients with moderate-to-severe AD.
Dermatological findings in patients admitting to dermatology clinic after using face masks during Covid-19 pandemia: A new health problem
Esra ?nan Do?an, Ferit Kaya
doi : 10.1111/dth.14934
Dermatologic TherapyVolume 34, Issue 3 e14934
In the present study, the purpose was to evaluate the presence of dermatological symptoms and the effects of mask use on existing dermatological diseases associated with face in patients admitting with any dermatological disease. The present study consisted of 150 patients, including 91 volunteering women and 59 men, admitting to our dermatology clinic with any dermatological symptoms. The presence of symptoms, such as itching, rash, drying and peeling, discomfort, redness, burning, pain, swelling, acne, oily skin symptoms because of mask use, and previous history of facial dermatological disease, whether this disease increased with the use of mask, were questioned.
Propranolol for infantile hemangioma: Evaluating efficacy and predictors of response and rebound growth
Nadav Pam, Khalaf Kridin, Ziad Khamaysi
doi : 10.1111/dth.14936
Dermatologic TherapyVolume 34, Issue 3 e14936
Propranolol emerged as the first-line therapy for infantile hemangioma (IH). Determinants of interindividual variation in drug response and predictors of rebound growth after drug discontinuation are yet to be firmly established. We aimed to evaluate the outcomes of a relatively large cohort of patients with IH treated by propranolol and to determine predictors of (a) an excellent response to treatment (?90 improvement) and (b) of rebound growth after drug cessation.
Stromal vascular fraction and emulsified fat as regenerative tools in rejuvenation of the lower eyelid area
Agnieszka Surowiecka, Miros?aw Piekarski, Hanno Pototschnig
doi : 10.1111/dth.14937
Dermatologic TherapyVolume 34, Issue 3 e14937
In the lower eyelid area, dermal melanocytosis, fine lines, skin atrophy, dryness, and loss of subcutaneous fat tissue represent the initial signs of aging. Beside the addition of volume, adipose tissue injections can also improve pigmentation and skin texture.
Results of low-level laser therapy in the treatment of hair growth: An Egyptian experience
Mohamed Amer, Amany Nassar, Heba Attallah, Amin Amer
doi : 10.1111/dth.14940
Dermatologic TherapyVolume 34, Issue 3 e14940
Recently, low level laser therapy was evaluated as an effective stimulating hair growth. Hair loss is the most common complaint in dermatology (specially females). It causes a significant psychosocial distress and decreased quality of life in affected patients and exists in different types, but the most common types are androgenetic alopecia and telogen effluvium (TE).
Investigation of prevalence of biologic use and discontinuation rates in moderate-to-severe psoriasis patients in Newfoundland and Labrador using real-world data
Susanne R. Gulliver, Wayne Gulliver
doi : 10.1111/dth.14944
Dermatologic TherapyVolume 34, Issue 3 e14944
Real-world data for psoriasis includes registries, and meta-analyses could help guide biologic therapy choice. The objective was to determine the prevalence and reason for discontinuation of biologic or PD4 inhibitor therapy in patients with moderate-to-severe psoriasis in Newfoundland and Labrador, Canada from 2001 to 2017. A retrospective cohort study was conducted on data collected between 2001 and 2017, to determine the type of biologic therapy or PD4 inhibitor, length of treatment, prevalence of and reason for discontinuation.
Evaluation of fecal calprotectin as a marker of gastrointestinal inflammation in rosacea: A case-control study
Asl? Aksu ?erman, Ezgi Akta? Karabay, Hazel Ezgi Kaya, Filiz Türe ?zdemir, Ezgi ?zkur, Yasemin Erdem, ?lknur K?vanç Altunay
doi : 10.1111/dth.14946
Dermatologic TherapyVolume 34, Issue 3 e14946
A higher incidence of gastrointestinal diseases has been well established in patients with rosacea. However, no screening tool has been introduced for gastrointestinal disease development in rosacea. Fecal calprotectin (FC) is a calcium-binding protein, mainly derived from polymorpho-nuclear cells, such as neutrophils.
Satisfaction and attitudes toward systemic treatments for psoriasis: A cross-sectional study
Maria Esposito, Alessandro Giunta, Paolo Gisondi, Sara Tambone, Marco Rovaris, Valeria Manfreda, Federico Pirro, Cristina Pellegrini, Maria Concetta Fargnoli, Luca Bianchi, Ketty Peris, Giampiero Girolomoni
doi : 10.1111/dth.14949
Dermatologic TherapyVolume 34, Issue 3 e14949
In psoriasis patients, satisfaction and patients' attitude toward treatment are heterogeneous depending on several factors and remain poorly investigated, although the availability of several new targeted therapeutic options. A multicentre cross-sectional investigation was conducted to estimate treatment satisfaction and attitudes (awareness, trust, and therapeutic alliance) in a large population of adult psoriasis patients undergoing a systemic biologic or non-biologic agent for moderate-to-severe plaque-type psoriasis. Patients' satisfaction was measured using the Treatment Satisfaction Questionnaire for Medication II questionnaire an
Dermatology outpatient clinic outcomes after COVID-19 outbreak: What is new normal?
Ceyda ?aytemel, Ozan Erdem, ?enay A??rg?l, Zafer Türko?lu
doi : 10.1111/dth.14950
Dermatologic TherapyVolume 34, Issue 3 e14950
Coronavirus disease-2019 (COVID-19), which emerged in late 2019 and caused a pandemic, has significantly affected outpatient admissions to dermatology outpatient clinics. There have been changes in the number and composition of the patients who applied to the outpatient clinics.
Idiopathic perniosis presenting as acral purpuric lesions: Clustering of cases before COVID-19 pandemic and their comparison with chilblain like lesions reported in the literature
Rashmi Jindal, Payal Chauhan, Dikshita Goyal, Nadia Shirazi
doi : 10.1111/dth.14951
Dermatologic TherapyVolume 34, Issue 3 e14951
Perniosis/chilblains are the acral inflammatory skin lesions developing in susceptible individuals as an abnormal reaction to cold. In the absence of a discernible cause, it is labeled as idiopathic perniosis (IP). With the ongoing COVID-19 pandemic, there was an upsurge of reports of chilblain like lesions (CLL) especially in young patients possibly implicated to the SARS-CoV-2 virus.
African black soap: Physiochemical, phytochemical properties, and uses
Adebola Ogunbiyi, Nkechi A. Enechukwu
doi : 10.1111/dth.14870
Dermatologic TherapyVolume 34, Issue 3 e14870
The African black soap is popular for its cleansing and medicinal properties particularly amongst those of African descent. The “traditional” African black soap” refers to soaps made from the ash-derived alkali from agricultural waste and oil extracted from vegetable matter without the addition of cosmetic enhancing products. Production of black soap has been traced to west Africa especially Nigeria and Ghana.
Ustekinumab for the treatment of paradoxical skin reactions and cutaneous manifestations of inflammatory bowel diseases
Jessica Wu, Jan Smogorzewski
doi : 10.1111/dth.14883
Dermatologic TherapyVolume 34, Issue 3 e14883
Ustekinumab (STELARA), a human monoclonal antibody directed against IL-12 and IL-23, is FDA-approved to treat psoriasis, psoriatic arthritis, Crohn's disease, and ulcerative colitis. Increasing recognition of paradoxical skin reactions induced by older biologic therapies used for inflammatory bowel diseases (IBD), such as, adalimumab and infliximab, has led to the investigation of ustekinumab for the treatment of the cutaneous and gastrointestinal manifestations of IBD.
Oral nicotinamide: The role in skin cancer chemoprevention
Serena Giacalone, Cristina B. Spigariolo, Paolo Bortoluzzi, Gianluca Nazzaro
doi : 10.1111/dth.14892
Dermatologic TherapyVolume 34, Issue 3 e14892
The incidence of skin cancer has gradually increased in the last years and exposition to ultraviolet radiation remains the main risk factor. We performed a comprehensive review on the role of nicotinamide (NAM) in the chemoprevention of skin cancers.
Parotid metastases of cutaneous squamous cell carcinoma in renal transplant recipients: Case series and literature review
Mislav Mokos, Nikolina Ba?i?-Juki?
doi : 10.1111/dth.14907
Dermatologic TherapyVolume 34, Issue 3 e14907
Cutaneous squamous cell skin carcinoma (cSCC) is the most common skin cancer in renal transplant recipients (RTR). Metastatic potential of cSCC is significantly higher in RTR than in the general population. Parotid metastases (PM) of cSCC are rare, but their prognosis is poor. The present study aimed to investigate the frequency and characteristics of PM of cSCC in our renal transplant cohort. Among 1610 patients who received kidney allografts at our institution in the period from January 1999 to December 2019, 84 patients (5.2%) developed at least one cSCC.
Purse-string suture versus full-thickness skin graft: An efficacy and safety comparison study
Edoardo Cammarata, Elisa Zavattaro, Stefano Astolfi, Chiara Airoldi, Roberto Giorgione, Paolo Boggio, Paola Savoia
doi : 10.1111/dth.14909
Dermatologic TherapyVolume 34, Issue 3 e14909
Purse-string suture (PSS) and full-thickness skin graft (FTSG) are two different approaches to the closure of circular skin defects. In this study, we compare the feasibility and the aesthetic outcome of these two techniques in high operatory risk non-melanoma skin cancer (NMSC) patients.
A systematic review of N-acetylcysteine for treatment of acne vulgaris and acne-related associations and consequences: Focus on clinical studies
Nafiseh Mardani, Samaneh Mozafarpoor, Azadeh Goodarzi, Farahnaz Nikkhah
doi : 10.1111/dth.14915
Dermatologic TherapyVolume 34, Issue 3 e14915
Acne vulgaris is one of the most common dermatologic disorders affects people of all races and ethnicities and has many adverse effects on the quality of life. The increased bacterial resistance to antibiotics has reduced the effectiveness of treatment with these agents.
Are biologics combined with methotrexate better than biologics monotherapy in psoriasis and psoriatic arthritis: A meta-analysis of randomized controlled trials
Yan Xie, Yang Liu, Yi Liu
doi : 10.1111/dth.14926
Dermatologic TherapyVolume 34, Issue 3 e14926
To investigate if the combination of biologics with methotrexate (MTX) would have better performance than biological monotherapy in clinical efficiency and safety for the treatment of psoriasis and psoriatic arthritis (PsA)? a systematic review of randomized controlled trials (RCTs) searched from the Pubmed, Cochrane Library, and Embase was conducted.
The efficacy of energy-based devices combination therapy for melasma
Behzad Iranmanesh, Maryam Khalili, Saman Mohammadi, Rezvan Amiri, Mahin Aflatoonian
doi : 10.1111/dth.14927
Dermatologic TherapyVolume 34, Issue 3 e14927
Melasma is a recalcitrant pigmentary disease with a complex pathogenesis. Monotherapy often results in unsatisfactory results with high recurrence rate. In this review article, we evaluate efficacy of energy-based devices combination therapy for melasma. We reviewed published literature since 2010 up to November 2020 regarding adjuvant therapy of energy-based devices with other treatment modalities in the treatment of melasma.
JAK-inhibitors for dermatomyositis: A concise literature review
Aliza Paudyal, Ming Zheng, Ling Lyu, Christina Thapa, Shirui Gong, Yao Yang, Xiaoyan Lyu
doi : 10.1111/dth.14939
Dermatologic TherapyVolume 34, Issue 3 e14939
Refractory dermatomyositis (DM) is defined as cases that do not show improvement after initial treatment with two different immunosuppressives combined with corticosteroids with or without intravenous immunoglobulins. In recent years, few studies have reported a positive response to the use of Janus kinase inhibitors (JAK-inhibitors) for the treatment of refractory DM.
What level of photoprotection can be obtained using facial mask? Determining effectiveness using an in vitro method
Céline Couteau, Eva Paparis, Laurence Coiffard
doi : 10.1111/dth.14837
Dermatologic TherapyVolume 34, Issue 3 e14837
It has become a general practice worldwide to wear a face mask serving as a barrier against the transmission of pathogens. This has prompted us to investigate whether masks could also protect our skin from UV radiation. We have studied eight masks, four surgical and four “homemade” using an in vitro method. The study demonstrated that they all offered protection against both UVB and UVA radiation.
A preliminary clinical trial comparing wet silver dressings versus wet-to-dry povidone-iodine dressings for wound healing in pemphigus vulgaris patients
JiHui Chen, Qin Zou, Michael R. Hamblin, Xiang Wen
doi : 10.1111/dth.14906
Dermatologic TherapyVolume 34, Issue 3 e14906
There is insufficient evidence concerning the efficacy of wet silver-containing dressings for wound healing in pemphigus vulgaris (PV). In this randomized, controlled clinical trial, 58 patients with PV skin erosions (10%-70% body surface area) were assigned to receive either wet silver-containing dressings (n = 28) or wet to dry povidone-iodine dressings as a control (n = 30).
Management of melanoma patients during COVID-19 pandemic in an Italian skin unit
Angela Filoni, Paolo Del Fiore, Rocco Cappellesso, Luigi Dall'Olmo, Nick Salimian, Romina Spina, Saveria Tropea, Marco Rastrelli, Francesco Russano, Mattia D'Amico, Alessandra Collodetto, Carlo Riccardo Rossi, Alessandra Buja, Antonella Vecchiato, Mauro Alaibac, Simone Mocellin
doi : 10.1111/dth.14908
Dermatologic TherapyVolume 34, Issue 3 e14908
Due to the COVID-19 crisis, many scheduled medical and surgical activities have been suspended. This interruption to the healthcare system can negatively affect the diagnosis and management of melanoma. Neglecting melanoma throughout the outbreak may be associated with increased rates of mortality, morbidity, and healthcare expenses.
Photothermal therapy using gold nanoparticles for acne in Asian patients: A preliminary study
Dong Hye Suh, Tae Jun Park, Jae Yeong Jeong, Ko Eun Kim, Jong Heon Park, Sang Jun Lee, Hyun Joo Kim, Hwa Jung Ryu
doi : 10.1111/dth.14918
Dermatologic TherapyVolume 34, Issue 3 e14918
Acne is a common skin disease that occurs in pilosebaceous units and is often prevalent in adolescence. There are many acne treatments, but they are associated with side effects, such as antibiotic resistance, teratogenicity, and irritation. Therefore, it is necessary to develop a more effective and safe alternative treatment for managing acne in patients of all ages. This study aimed to confirm the effect of gold photothermal therapy for acne.
Erythema-directed digital photography and colorimeter scores correlate with rosacea erythema evaluation in patients under treatment with topical ivermectin
Federica Dall'Oglio, Francesco Lacarrubba, Giuseppe Micali
doi : 10.1111/dth.14920
Dermatologic TherapyVolume 34, Issue 3 e14920
Inflammatory rosacea is clinically characterized by persistent erythema and inflammatory lesions. Its severity is generally based on clinical observation that may be cumbersome. The aim of this study was to assess if erythema-directed digital photography (EEDP) and colorimeter (COL) correlate and are concordant with clinical evaluation of erythema degree of rosacea under topical treatment.
Considerations on inhibition of IL-23 in psoriatic women of childbearing potential
Roberto Russo, Giulia Gasparini, Emanuele Cozzani, Martina Burlando, Aurora Parodi
doi : 10.1111/dth.14931
Dermatologic TherapyVolume 34, Issue 3 e14931
Lack of safety data on pregnant women determines difficulty in choosing the correct biologic agent to treat psoriasis in women of childbearing potential. Studies have postulated a role of IL-23 in unexplained recurrent spontaneous abortions. This gives rise to consideration about use of anti-IL-23 drugs in treatment of psoriasis in women of childbearing potential.
Chitin-lipid interactions and the potential relationship between Demodex and SARS-CoV-2
Alin Laurentiu Tatu, Thomas Nadasdy, Lawrence Chukwudi Nwabudike
doi : 10.1111/dth.14935
Dermatologic TherapyVolume 34, Issue 3 e14935
Already from the early days of the COVID-19 pandemic, regulatory agencies have attempted to ascertain the possible routes of SARS-CoV-2 viral transmission. It is hypothesized that the lipid bilayer that surrounds the SARS-CoV-2 improves its ability to remain stable on sebum-rich skin and serves as another possible route of contracting the virus.
Treatment challenges in clinically amyopathic dermatomyositis: A case series and review of new therapeutic options for skin involvement
Andrea Rodr?guez-Tejero, Beatriz L?pez-Espadafor, Trinidad Montero-V?lchez, Manuel S?nchez-D?az, Salvador Arias-Santiago, Alejandro Molina-Leyva
doi : 10.1111/dth.14942
Dermatologic TherapyVolume 34, Issue 3 e14942
The term clinically amyopathic dermatomyositis (CADM) is used to represent a subgroup of patients with the typical cutaneous features of dermatomyositis (DM) in the absence of muscle involvement. Similar to classic DM, CADM can be associated with other connective tissue disorders and systemic manifestations such as interstitial lung disease and malignancy.
A case of giant condyloma acuminatum (Buschke-Lowenstein tumor) successfully treated with acitretin
Si-Qi Long, Chang-Qiang Li
doi : 10.1111/dth.14905
Dermatologic TherapyVolume 34, Issue 3 e14905
Transparent film as an alternative to face mask for decreasing the risk of coronavirus disease transmission during head and neck surgery
Jee-Woo Kim, Chang-Hun Huh, Je-Ho Mun
doi : 10.1111/dth.14945
Dermatologic TherapyVolume 34, Issue 3 e14945
Our experience in the treatment of hemangioma with intense pulsed light laser: A 10 year study in Albania
Vladimir Filaj, Etleva Jorgaqi, Mirela Byzhyti
doi : 10.1111/dth.14880
Dermatologic TherapyVolume 34, Issue 3 e14880
Laser treatment brought an innovation in the treatment of hemangiomas and vascular anomalies. The range of superficial vascular lesions that can be treated with laser continues to expand. In our country laser device date relatively late, since then these technologies have facilitated the treatment of many skin condition.
Can intermittent, time-restricted circadian fasting modulate cutaneous severity of dermatological disorders? Insights from a multicenter, observational, prospective study
Nicola Luigi Bragazzi, Khaled Trabelsi, Sergio Garbarino, Achraf Ammar, Hamdi Chtourou, Alessia Pacifico, Piergiorgio Malagoli, Hristina Kocic, Rosalynn R. Z. Conic, Young Dermatologists Italian Network , Khalaf Kridin, Paolo Daniele Maria Pigatto, Giovanni Damiani
doi : 10.1111/dth.14912
Dermatologic TherapyVolume 34, Issue 3 e14912
The impact of intermittent circadian fasting (ICF) on skin disorders is far to be plenty deciphered. However, the circadian rhythm seems to exert a modulation on dermatoses severity, drug-response, and drug-related side effects. We aimed to evaluate ICF effect in the daily management of dermatological diseases. In this multicenter, prospective observational study we enrolled patients willing to undergo the 2018 ICF (from May 16 to June 14).
