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Spotlight on protein structure design
doi : 10.1038/s41587-024-02150-1
Volume 42 Issue 2, February 2024
Can single-cell biology realize the promise of precision medicine?
Cormac SheridanÂÂ
What does it take for an ‘AlphaFold Moment’ in functional protein engineering and design?
Roberto A. Chica & Noelia FerruzÂ
Contracts and intellectual property rights in translational R&D: furthering safeguards in the public interest
Mark Anderson, Naomi Hawkins & Alison SladeÂ
Boosting circulating tumor DNA to improve liquid biopsies
Iris MarchalÂÂ
Perfecting antibodies with language models
Carlos Outeiral & Charlotte M. DeaneÂ
An optimized toolkit for prime editing
Ryan M. Marks, Ori Scott, Evgueni A. Ivakine & Ronald D. CohnÂ
Integration of multi-modal single-cell data
Michelle Y. Y. Lee & Mingyao LiÂ
Sampling techniques and microbial concentration measurements influence the results of microbiome studies
Generative models for protein structures and sequences
Chloe Hsu, Clara Fannjiang & Jennifer ListgartenÂ
Designing proteins with language models
Jeffrey A. Ruffolo & Ali MadaniÂ
Sparks of function by de novo protein design
Alexander E. Chu, Tianyu Lu & Po-Ssu HuangÂ
Machine learning for functional protein design
Pascal Notin, Nathan Rollins, Yarin Gal, Chris Sander & Debora MarksÂ
Computational drug development for membrane protein targets
Haijian Li, Xiaolin Sun, Wenqiang Cui, Marc Xu, Junlin Dong, Babatunde Edukpe Ekundayo, Dongchun Ni, Zhili Rao, Liwei Guo, Henning Stahlberg, Shuguang Yuan & Horst VogelÂ
Fast and accurate protein structure search with Foldseek
Michel van Kempen, Stephanie S. Kim, Charlotte Tumescheit, Milot Mirdita, Jeongjae Lee, Cameron L. M. Gilchrist, Johannes Söding & Martin SteineggerÂ
scDesign3 generates realistic in silico data for multimodal single-cell and spatial omics
Dongyuan Song, Qingyang Wang, Guanao Yan, Tianyang Liu, Tianyi Sun & Jingyi Jessica LiÂ
Efficient prime editing in mouse brain, liver and heart with dual AAVs
Jessie R. Davis, Samagya Banskota, Jonathan M. Levy, Gregory A. Newby, Xiao Wang, Andrew V. Anzalone, Andrew T. Nelson, Peter J. Chen, Andrew D. Hennes, Meirui An, Heejin Roh, Peyton B. Randolph, Kiran Musunuru & David R. LiuÂ
Engineered phage with antibacterial CRISPR–Cas selectively reduce E. coli burden in mice
Yilmaz Emre Gencay, Džiuginta JasinskytÄ—, Camille Robert, Szabolcs Semsey, Virginia MartÃÂnez, Anders Østergaard Petersen, Katja Brunner, Ana de Santiago Torio, Alex Salazar, Iszabela Cristiana Turcu, Melissa Kviesgaard Eriksen, Lev Koval, Adam Takos, Ricardo Pascal, Thea Staffeldt Schou, Lone Bayer, Tina Bryde, Katja Chandelle Johansen, Emilie Glad Bak, Frenk Smrekar, Timothy B. Doyle, Michael J. Satlin, Aurelie Gram, Joana Carvalho, Lene Jessen, Björn Hallström, Jonas Hink, Birgitte Damholt, Alice Troy, Mette Grove, Jasper Clube, Christian Grøndahl, Jakob Krause Haaber, Eric van der Helm, Milan Zdravkovic & Morten Otto Alexander SommerÂ
Efficient evolution of human antibodies from general protein language models
Brian L. Hie, Varun R. Shanker, Duo Xu, Theodora U. J. Bruun, Payton A. Weidenbacher, Shaogeng Tang, Wesley Wu, John E. Pak & Peter S. KimÂ
Stabilized mosaic single-cell data integration using unshared features
Shila Ghazanfar, Carolina Guibentif & John C. MarioniÂ
Dictionary learning for integrative, multimodal and scalable single-cell analysis
Yuhan Hao, Tim Stuart, Madeline H. Kowalski, Saket Choudhary, Paul Hoffman, Austin Hartman, Avi Srivastava, Gesmira Molla, Shaista Madad, Carlos Fernandez-Granda & Rahul SatijaÂ
Efficient engineering of human and mouse primary cells using peptide-assisted genome editing
Zhen Zhang, Amy E. Baxter, Diqiu Ren, Kunhua Qin, Zeyu Chen, Sierra M. Collins, Hua Huang, Chad A. Komar, Peter F. Bailer, Jared B. Parker, Gerd A. Blobel, Rahul M. Kohli, E. John Wherry, Shelley L. Berger & Junwei ShiÂ
Precise integration of large DNA sequences in plant genomes using PrimeRoot editors
Chao Sun, Yuan Lei, Boshu Li, Qiang Gao, Yunjia Li, Wen Cao, Chao Yang, Hongchao Li, Zhiwei Wang, Yan Li, Yanpeng Wang, Jun Liu, Kevin Tianmeng Zhao & Caixia GaoÂ
Quantifying bias introduced by sample collection in relative and absolute microbiome measurements
Dylan G. Maghini, Mai Dvorak, Alex Dahlen, Morgan Roos, Scott Kuersten & Ami S. BhattÂ
SPARKing academic technologies across the valley of death
Jeewon Sylvia Kim, Stephen Kargotich, Sophia H. Lee, Rieko Yajima, Adriana Ann Garcia, Gretchen Ehrenkaufer, Mary Romeo, Peter Santa Maria, Kevin V. Grimes & Daria Mochly-RosenÂ
