دسترسی یکساله به بیش از ۵۰۰ ژورنال روز جهان موجود در سامانه
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A Systematic Review and Meta-Analysis of the Association Between Perceived Injustice and Depression
Julie Lynch, Susan Fox, Paul D'Alton, Keith Gaynor
doi : 10.1016/j.jpain.2020.12.009
Volume 22, Issue 6, June 2021, Pages 643-654
Perceived injustice is increasingly recognized as a risk factor for problematic recovery, with a growing body of evidence documenting its association with heightened pain, disability, medication use, anger and post-traumatic stress. The aim of this paper was to systematically review and critically appraise the association between perceived injustice and depressive symptomatology across a wide range of medical and mental health populations, including acute and chronic pain samples. A search of published, English language studies in the PubMed, EMBASE, CINAHL, and PsycINFO databases from 1990 to June 2020 was performed.
Optimization of Spinal Manipulative Therapy Protocols: A Factorial Randomized Trial Within a Multiphase Optimization Framework
Julie M. Fritz, Jason Sharpe, Tom Greene, Elizabeth Lane, ... Gregory Kawchuk
doi : 10.1016/j.jpain.2020.11.008
Volume 22, Issue 6, June 2021, Pages 655-668
Spinal manipulative therapy (SMT) is a common nonpharmacological treatment for low back pain (LBP). Although generally supported by systematic reviews and practice guidelines, clinical trials evaluating SMT have been characterized by small effect sizes. This study adopts a Multiphase Optimization Strategy framework to examine individual components of an SMT delivery protocol using a single-blind trial with the goal of identifying and optimizing a multicomponent SMT protocol.
Sensory and Psychological Factors Predict Exercise-Induced Shoulder Injury Responses in a High-Risk Phenotype Cohort
Katie A. Butera, Mark D. Bishop, Warren H. Greenfield, Roland Staud, ... Steven Z. George
doi : 10.1016/j.jpain.2020.12.002
Volume 22, Issue 6, June 2021, Pages 669-679
Our prior studies identified a high-risk phenotype (ie, high pain sensitivity variant of the catechol-O-methyltransferase gene (Single Nucleotide Polymorphism [SNP] rs6269) and pain catastrophizing scores) for shoulder pain. The current study identified sensory and psychological predictors of heightened pain responses following exercise-induced shoulder injury.
Modifications in fMRI Representation of Mental Rotation Following a 6 Week Graded Motor Imagery Training in Chronic CRPS Patients
Sebastian Strauss, Silke Barby, Jonas H?rtner, Nicola Neumann, ... Martin Lotze
doi : 10.1016/j.jpain.2020.12.003
Volume 22, Issue 6, June 2021, Pages 680-691
Complex regional pain syndrome (CRPS) is a neuropathic pain condition that is difficult to treat. For behavioral interventions, graded motor imagery (GMI) showed relevant effects, but underlying neural substrates in patient groups have not been investigated yet.
A Role for Protease Activated Receptor Type 3 (PAR3) in Nociception Demonstrated Through Development of a Novel Peptide Agonist
Juliet Mwirigi, Moeno Kume, Shayne N. Hassler, Ayesha Ahmad, ... Theodore J. Price
doi : 10.1016/j.jpain.2020.12.006
Volume 22, Issue 6, June 2021, Pages 692-706
The protease activated receptor (PAR) family is a group of G-protein coupled receptors (GPCRs) activated by proteolytic cleavage of the extracellular domain. PARs are expressed in a variety of cell types with crucial roles in homeostasis, immune responses, inflammation, and pain.
Exposure to an Immersive Virtual Reality Environment can Modulate Perceptual Correlates of Endogenous Analgesia and Central Sensitization in Healthy Volunteers
Erzsebet Mehesz, Hajer Karoui, Paul H. Strutton, Sam W. Hughes
doi : 10.1016/j.jpain.2020.12.007
Volume 22, Issue 6, June 2021, Pages 707-714
Virtual reality (VR) has been shown to produce analgesic effects during different experimental and clinical pain states. Despite this, the top-down mechanisms are still poorly understood. In this study, we examined the influence of both a real and sham (ie, the same images in 2D) immersive arctic VR environment on conditioned pain modulation (CPM) and in a human surrogate model of central sensitization in 38 healthy volunteers. CPM and acute heat pain thresholds were assessed before and during VR/sham exposure in the absence of any sensitization. In a follow-on study, we used the cutaneous high frequency stimulation model of central sensitization and measured changes in mechanical pain sensitivity in an area of heterotopic sensitization before and during VR/sham exposure. There was an increase in CPM efficiency during the VR condition compared to baseline (P < .01).
Serotonin Plays a Key Role in the Development of Opioid-Induced Hyperalgesia in Mice
Mika Sasaki, Yoshinori Kamiya, Keiko Bamba, Takeshi Onishi, ... Harue Yanagimura
doi : 10.1016/j.jpain.2020.12.008
Volume 22, Issue 6, June 2021, Pages 715-729
Opioid usage for pain therapy is limited by its undesirable clinical effects, including paradoxical hyperalgesia, also known as opioid-induced hyperalgesia (OIH). However, the mechanisms associated with the development and maintenance of OIH remain unclear. Here, we investigated the effect of serotonin inhibition by the 5-HT3 receptor antagonist, ondansetron (OND), as well as serotonin deprivation via its synthesis inhibitor para-chlorophenylalanine, on mouse OIH models, with particular focus on astrocyte activation. Co-administering of OND and morphine, in combination with serotonin depletion, inhibited mechanical hyperalgesia and astrocyte activation in the spinal dorsal horn of mouse OIH models.
Desire to Receive More Pain Treatment – A Relevant Patient-Reported Outcome Measure to Assess Quality of Post-Operative Pain Management? Results From 79,996 Patients Enrolled in the Pain Registry QUIPS from 2016 to 2019
Marcus Komann, Philipp Baumbach, Ulrike M. Stamer, Claudia Weinmann, ... Winfried Mei?ner
doi : 10.1016/j.jpain.2021.01.002
Volume 22, Issue 6, June 2021, Pages 730-738
Acute postoperative pain is frequently evaluated by pain intensity scores. However, interpretation of the results is difficult and thresholds requiring treatment are not well defined. Additional patient-reported outcome measures (PROMs) might be helpful to better understand individual pain experience and quality of pain management after surgery. We used data from the QUIPS pain registry for a cross-sectional study in order to investigate associations between the desire to receive more pain treatment (D2RMPT) with pain intensity ratings and other PROMs.
Gray Matter Brain Alterations in Temporomandibular Disorder Tested in a Population Cohort and Three Clinical Samples
Martin Domin, Nikolai K. Grimm, Kai Klepzig, Carsten O. Schmidt, ... Martin Lotze
doi : 10.1016/j.jpain.2021.01.003
Volume 22, Issue 6, June 2021, Pages 739-747
Temporomandibular pain (TMD) is a frequent symptom comprising pain around the mandibular jaw with a high dependence on stressors. Chronic pain has been associated with changes of the brains gray matter volume (GMV), but previous studies on GMV alterations associated with TMD have yielded contradictory results.
Imprecise Visual Feedback About Hand Location Increases a Classically Conditioned Pain Expectancy Effect
Thais Cristina Chaves, Tasha R. Stanton, Ashley Grant, Brian W. Pulling, ... G. Lorimer Moseley
doi : 10.1016/j.jpain.2021.01.004
Volume 22, Issue 6, June 2021, Pages 748-761
We tested the hypotheses that rendering sensory input about hand location imprecise increases a classically conditioned pain expectancy effect, increases generalization of the effect to novel locations and reduces extinction of the effect. Forty healthy volunteers performed movements with their right hand along predefined paths.
