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Associate Editorial Board
doi : 10.1016/S0007-0912(21)00057-X
Volume 126, Issue 3, March 2021, Page ii
Patient-centric goal-oriented perioperative care
Geoffrey P. Roberts, Nicholas Levy, Dileep N. Lobo
doi : 10.1016/j.bja.2020.12.004
Volume 126, Issue 3, March 2021, Pages 559-564
What is the true worth of a P-value? Time for a change
George Hadjipavlou, Richard Siviter, Birte Feix
doi : 10.1016/j.bja.2020.10.042
Volume 126, Issue 3, March 2021, Pages 564-567
Preoperative considerations of new long-acting glucagon-like peptide-1 receptor agonists in diabetes mellitus
Abraham H. Hulst, Jorinde A.W. Polderman, Sarah E. Siegelaar, Daniel H. van Raalte, ... Jeroen Hermanides
doi : 10.1016/j.bja.2020.10.023
Volume 126, Issue 3, March 2021, Pages 567-571
Supraglottic airway versus tracheal intubation and the risk of postoperative pulmonary complications
Jennifer M. Hunter, Michael F. Aziz
doi : 10.1016/j.bja.2020.12.015
Volume 126, Issue 3, March 2021, Pages 571-574
Detrimental effects of general anaesthesia on young primates: are we closer to understanding the link?
Vesna Jevtovic-Todorovic
doi : 10.1016/j.bja.2020.12.019
Volume 126, Issue 3, March 2021, Pages 575-577
Clinically applicable approach for predicting mechanical ventilation in patients with COVID-19
Nicholas J. Douville, Christopher B. Douville, Graciela Mentz, Michael R. Mathis, ... Milo Engoren
doi : 10.1016/j.bja.2020.11.034
Volume 126, Issue 3, March 2021, Pages 578-589
Patients with coronavirus disease 2019 (COVID-19) requiring mechanical ventilation have high mortality and resource utilisation. The ability to predict which patients may require mechanical ventilation allows increased acuity of care and targeted interventions to potentially mitigate deterioration.
Impaired fibrinolysis in critically ill COVID-19 patients
Mirjam Bachler, Johannes B?sch, Daniel P. Stürzel, Tobias Hell, ... Dietmar Fries
doi : 10.1016/j.bja.2020.12.010
Volume 126, Issue 3, March 2021, Pages 590-598
Critically ill coronavirus disease 2019 (COVID-19) patients present with a hypercoagulable state with high rates of macrovascular and microvascular thrombosis, for which hypofibrinolysis might be an important contributing factor.
Intraoperative venous congestion and acute kidney injury in cardiac surgery: an observational cohort study
Marcos G. Lopez, Matthew S. Shotwell, Jennifer Morse, Yafen Liang, ... Frederic T. Billings
doi : 10.1016/j.bja.2020.12.028
Volume 126, Issue 3, March 2021, Pages 599-607
Increased intravascular volume has been associated with protection from acute kidney injury (AKI), but in patients with congestive heart failure, venous congestion is associated with increased AKI. We tested the hypothesis that intraoperative venous congestion is associated with AKI after cardiac surgery.
Reducing the dose of neuromuscular blocking agents with adjuncts: a systematic review and meta-analysis
Valentin Weber, Tom E.F. Abbott, Gareth L. Ackland
doi : 10.1016/j.bja.2020.09.048
Volume 126, Issue 3, March 2021, Pages 608-621
Acute global shortages of neuromuscular blocking agents (NMBA) threaten to impact adversely on perioperative and critical care. The use of pharmacological adjuncts may reduce NMBA dose. However, the magnitude of any putative effects remains unclear.
Effects of perioperative oxygen concentration on oxidative stress in adult surgical patients: a systematic review
Alexander H. Oldman, Daniel S. Martin, Martin Feelisch, Michael P.W. Grocott, Andrew F. Cumpstey
doi : 10.1016/j.bja.2020.09.050
Volume 126, Issue 3, March 2021, Pages 622-632
The fraction of inspired oxygen (FiO2) administered during general anaesthesia varies widely despite international recommendations to administer FiO2 0.8 to all anaesthetised patients to reduce surgical site infections (SSIs). Anaesthetists remain concerned that high FiO2 administration intraoperatively may increase harm, possibly through increased oxidative damage and inflammation, resulting in more complications and worse outcomes. In previous systematic reviews associations between FiO2 and SSIs have been inconsistent, but none have examined how FiO2 affects perioperative oxidative stress. We aimed to address this uncertainty by reviewing the available literature.
Observational study of anaesthesia workflow to evaluate physical workspace design and layout
Katherina A. Jurewicz, David M. Neyens, Ken Catchpole, Anjali Joseph, ... James H. Abernathy
doi : 10.1016/j.bja.2020.08.063
Volume 126, Issue 3, March 2021, Pages 633-641
The safety and efficiency of anaesthesia care depend on the design of the physical workspace. However, little is known about the influence that workspace design has on the ability to perform complex operating theatre (OT) work. The aim of this study was to observe the relationship between task switching and physical layout, and then use the data collected to design and assess different anaesthesia workspace layouts.
Socioeconomic deprivation and long-term outcomes after elective surgery: analysis of prospective data from two observational studies
Yize I. Wan, Dermot McGuckin, Alexander J. Fowler, John R. Prowle, ... S. Ramani Moonesinghe
doi : 10.1016/j.bja.2020.10.019
Volume 126, Issue 3, March 2021, Pages 642-651
Socioeconomic deprivation is associated with health inequalities. We explored relationships between socioeconomic group and outcomes after elective surgery in the UK National Health Service (NHS).
Phenylephrine impairs host defence mechanisms to infection: a combined laboratory study in mice and translational human study
Roeland F. Stolk, Flavia Naumann, Eva van der Pasch, Joost Schouwstra, ... Matthijs Kox
doi : 10.1016/j.bja.2020.11.040
Volume 126, Issue 3, March 2021, Pages 652-664
Immunosuppression after surgery is associated with postoperative complications, mediated in part by catecholamines that exert anti-inflammatory effects via the ?-adrenergic receptor. Phenylephrine, generally regarded as a selective ?-adrenergic agonist, is frequently used to treat perioperative hypotension. However, phenylephrine may impair host defence through ?-adrenergic affinity.
Propofol plus low-dose dexmedetomidine infusion and postoperative delirium in older patients undergoing cardiac surgery
Mona Momeni, Céline Khalifa, Guillaume Lemaire, Christine Watremez, ... Luc-Marie Jacquet
doi : 10.1016/j.bja.2020.10.041
Volume 126, Issue 3, March 2021, Pages 665-673
Postoperative delirium (POD) is a frequent complication in older patients. Dexmedetomidine might be effective in decreasing the incidence of POD. We hypothesised that adding low-dose rate dexmedetomidine infusion to a propofol sedation regimen would have fewer side-effects and would counteract the possible delirium producing properties of propofol, resulting in a lower risk of POD than propofol with placebo.
Inhibition of a tonic inhibitory conductance in mouse hippocampal neurones by negative allosteric modulators of ?5 subunit-containing ?-aminobutyric acid type A receptors: implications for treating cognitive deficits
Marc A. Manzo, Dian-Shi Wang, Winston W. Li, Arsène Pinguelo, ... Beverley A. Orser
doi : 10.1016/j.bja.2020.11.032
Volume 126, Issue 3, March 2021, Pages 674-683
Multiple cognitive and psychiatric disorders are associated with an increased tonic inhibitory conductance that is generated by ?5 subunit-containing ?-aminobutyric acid type A (?5 GABAA) receptors. Negative allosteric modulators that inhibit ?5 GABAA receptors (?5-NAMs) are being developed as treatments for these disorders. The effects of ?5-NAMs have been studied on recombinant GABAA receptors expressed in non-neuronal cells; however, no study has compared drug effects on the tonic conductance generated by native GABAA receptors in neurones, which was the goal of this study.
Determination of the ED95 of a single bolus dose of dexmedetomidine for adequate sedation in obese or nonobese children and adolescents
Bin Wu, Jiaqi Shan, Quanhong Zhou, Li Wang
doi : 10.1016/j.bja.2020.11.037
Volume 126, Issue 3, March 2021, Pages 684-691
With the increasing prevalence of children who are overweight and with obesity, anaesthesiologists must determine the optimal dosing of medications given the altered pharmacokinetics and pharmacodynamics in this population. We therefore determined the single dose of dexmedetomidine that provided sufficient sedation in 95% (ED95) of children with and without obesity as measured by a minimum Ramsay sedation score (RSS) of 4.
Multicentre randomised controlled clinical trial of electroacupuncture with usual care for patients with non-acute pain after back surgery
In Heo, Byung-Cheul Shin, Jae-Heung Cho, In-Hyuk Ha, ... Kyung-Min Shin
doi : 10.1016/j.bja.2020.10.038
Volume 126, Issue 3, March 2021, Pages 692-699
The purpose of this study was to investigate the effectiveness and safety between electroacupuncture (EA) combined with usual care (UC) and UC alone for pain reduction and functional improvement in patients with non-acute low back pain (LBP) after back surgery.
Perioperative use of physostigmine to reduce opioid consumption and peri-incisional hyperalgesia: a randomised controlled trial
Christoph Klivinyi, Gudrun Rumpold-Seitlinger, Christian Dorn, Larissa Sampl, ... Helmar Bornemann-Cimenti
doi : 10.1016/j.bja.2020.10.039
Volume 126, Issue 3, March 2021, Pages 700-705
Several studies have shown that cholinergic mechanisms play a pivotal role in the anti-nociceptive system by acting synergistically with morphine and reducing postoperative opioid consumption. In addition, the anti-cholinesterase drug physostigmine that increases synaptic acetylcholine concentrations has anti-inflammatory effects.
Eukaryotic initiation factor 4 gamma 2 contributes to neuropathic pain through down-regulation of Kv1.2 and the mu opioid receptor in mouse primary sensory neurones
Zhen Zhang, Bixin Zheng, Shibin Du, Guang Han, ... Yuan-Xiang Tao
doi : 10.1016/j.bja.2020.10.032
Volume 126, Issue 3, March 2021, Pages 706-719
Nerve injury-induced changes in gene expression in the dorsal root ganglion (DRG) contribute to neuropathic pain genesis. Eukaryotic initiation factor 4 gamma 2 (eIF4G2) is a general repressor of cap-dependent mRNA translation. Whether DRG eIF4G2 participates in nerve injury-induced alternations in gene expression and nociceptive hypersensitivity is unknown.
Association between perioperative fluid management and patient outcomes: a multicentre retrospective study
Timothy E. Miller, Monty Mythen, Andrew D. Shaw, Seungyoung Hwang, ... Charles Hunley
doi : 10.1016/j.bja.2020.10.031
Volume 126, Issue 3, March 2021, Pages 720-729
Postoperative complications increase hospital length of stay and patient mortality. Optimal perioperative fluid management should decrease patient complications. This study examined associations between fluid volume and noncardiac surgery patient outcomes within a large multicentre US surgical cohort.
Association between early postoperative nutritional supplement utilisation and length of stay in malnourished hip fracture patients
David G.A. Williams, Tetsu Ohnuma, Krista L. Haines, Vijay Krishnamoorthy, ... Paul E. Wischmeyer
doi : 10.1016/j.bja.2020.12.026
Volume 126, Issue 3, March 2021, Pages 730-737
Malnutrition in older hip fracture patients is associated with increased complication rates and mortality. As postoperative nutrition delivery is essential to surgical recovery, postoperative nutritional supplements including oral nutritional supplements or tube feeding formulas can improve postoperative outcomes in malnourished hip/femur fracture patients. The association between early postoperative nutritional supplements utilisation and hospital length of stay was assessed in malnourished hip/femur fracture patients.
Supraglottic airway device versus tracheal intubation and the risk of emergent postoperative intubation after general anaesthesia in adults: a retrospective cohort study
Maximilian Hammer, Peter Santer, Maximilian S. Schaefer, Friederike C. Althoff, ... Philipp Fassbender
doi : 10.1016/j.bja.2020.10.040
Volume 126, Issue 3, March 2021, Pages 738-745
We examined the association between emergent postoperative tracheal intubation and the use of supraglottic airway devices (SGAs) vs tracheal tubes.
MINS and postoperative haemoglobin: statistics versus reality?
Henrik Kehlet
doi : 10.1016/j.bja.2020.11.017
Volume 126, Issue 3, March 2021, Page e83
Reality supported by statistics. Comment on Br J Anaesth 2021; 126: e83
Alparslan Turan, Daniel I. Sessler
doi : 10.1016/j.bja.2020.11.030
Volume 126, Issue 3, March 2021, Pages e83-e84
Surgeons' view of the PREVENTT trial. Comment on Br J Anaesth 2021; 126: 9–11
Jeremy Meyer, Salomone Di Saverio, Frédéric Ris, Richard J. Davies
doi : 10.1016/j.bja.2020.11.025
Volume 126, Issue 3, March 2021, Pages e84-e86
Bleeding Independently associated with Mortality after noncardiac Surgery (BIMS). Comment on Br J Anaesth 2021; 126: 163–71
Tobias Resa, Pedro Lopez-Ayala, Noemi Glarner, Melissa Amrein, ... Christian Mueller
doi : 10.1016/j.bja.2020.11.028
Volume 126, Issue 3, March 2021, Pages e86-e87
Ringer's acetate solution-induced precipitation of remimazolam
Haruka Sasaki, Hiroshi Hoshijima, Kentaro Mizuta
doi : 10.1016/j.bja.2020.11.021
Volume 126, Issue 3, March 2021, Pages e87-e89
Prescription for unguided mobile health applications
Rajat N. Moman, W. Michael Hooten
doi : 10.1016/j.bja.2020.11.022
Volume 126, Issue 3, March 2021, Pages e89-e92
Thresholds of functional capacity using the four-question (modified) Duke Activity Status Index (M-DASI-4Q) as a screening tool: observations from the Measurement of Exercise Tolerance Before Surgery (METS) study
Chun H.A. Lee, Hilmy Ismail, Kwok M. Ho, Bernhard Riedel, Robert Schier
doi : 10.1016/j.bja.2020.11.023
Volume 126, Issue 3, March 2021, Pages e92-e94
Impact of intraoperative goal-directed fluid therapy in patients undergoing transthoracic oesophagectomy. Comment on Br J Anaesth 2020; 125: 953–61
Stefano Turi, Marilena Marmiere, Luigi Beretta
doi : 10.1016/j.bja.2020.11.024
Volume 126, Issue 3, March 2021, Pages e94-e95
Increasing intraoperative hydromorphone does not decrease postoperative pain: a retrospective observational study
Craig S. Curry, Wendy Y. Craig, Janelle M. Richard, Denham S. Ward
doi : 10.1016/j.bja.2020.11.026
Volume 126, Issue 3, March 2021, Pages e95-e97
The importance of perfusion pressure in estimating oxygen delivery and extraction. Comment on Br J Anaesth 2020; 124: 395–402
Marceli Lukaszewski, Kinga Kosiorowska
doi : 10.1016/j.bja.2020.12.005
Volume 126, Issue 3, March 2021, Pages e97-e99
The superficial femoral artery for arterial access. Comment on Br J Anaesth 2020; 125: e453–e455
Graham Walker
doi : 10.1016/j.bja.2020.12.008
Volume 126, Issue 3, March 2021, Page e99
Graphing causation: getting a clearer picture or fuzzy logic? Comment on Br J Anaesth 2020: 125: 393–97
Nick Barnett
doi : 10.1016/j.bja.2020.12.014
Volume 126, Issue 3, March 2021, Pages e100-e101
Pitfalls in the assessment of ventriculo-arterial coupling from peripheral waveform analysis in septic shock. Comment on Br J Anaesth 2020; 125: 1018–1024
Lorenzo Giosa, Mattia Busana, Didier Payen
doi : 10.1016/j.bja.2020.12.016
Volume 126, Issue 3, March 2021, Pages e101-e102
Routine neuromuscular monitoring before succinylcholine. Comment on Br J Anaesth 2020; 125: 629–36
Denis Schmartz, Thomas Fuchs-Buder
doi : 10.1016/j.bja.2020.12.022
Volume 126, Issue 3, March 2021, Pages e103-e104
Reproducibility and transparency in anaesthesiology research. Comment on Br J Anaesth 2020; 125: 835–42
Danny J.N. Wong, Edward Palmer
doi : 10.1016/j.bja.2020.12.024
Volume 126, Issue 3, March 2021, Pages e104-e105
Anaphylaxis to the first COVID-19 vaccine: is polyethylene glycol (PEG) the culprit?
Lene H. Garvey, Shuaib Nasser
doi : 10.1016/j.bja.2020.12.020
Volume 126, Issue 3, March 2021, Pages e106-e108
Association of frailty and mortality in patients with COVID-19: a meta-analysis
Chia S. Kow, Syed S. Hasan, Kaeshaelya Thiruchelvam, Mamoon Aldeyab
doi : 10.1016/j.bja.2020.12.002
Volume 126, Issue 3, March 2021, Pages e108-e110
Quality of life, functional status, and persistent symptoms after intensive care of COVID-19 patients
Manuel Taboada, Esther Moreno, Agust?n Cari?ena, Teresa Rey, ... Teresa Seoane-Pillado
doi : 10.1016/j.bja.2020.12.007
Volume 126, Issue 3, March 2021, Pages e110-e113
Impending cognitive and functional decline in COVID-19 survivors. Comment on Br J Anaesth 2021; 126: 44–7
Rohan Magoon
doi : 10.1016/j.bja.2020.12.009
Volume 126, Issue 3, March 2021, Pages e113-e114
Does opioid substitution treatment have a protective effect on the clinical manifestations of COVID-19? Comment on Br J Anaesth 2020; 125: e382–3
Marie Eagleton, Siobhan Stokes, Fiona Fenton, Eamon Keenan
doi : 10.1016/j.bja.2020.11.027
Volume 126, Issue 3, March 2021, Pages e114-e116
Craving togetherness: planning and replanning a national society hybrid conference during the COVID-19 pandemic
Carolyn F. Weiniger, Idit Matot
doi : 10.1016/j.bja.2020.11.029
Volume 126, Issue 3, March 2021, Pages e116-e118
Effects of the COVID-19 pandemic on environmental sustainability in anaesthesia. Comment on Br J Anaesth 2020; 125: 680-92
Stuart M. White, Clifford L. Shelton
doi : 10.1016/j.bja.2020.12.003
Volume 126, Issue 3, March 2021, Pages e118-e119
Effects of the COVID-19 pandemic on environmental sustainability in anaesthesia. Response to Br J Anaesth 2021;126:e118–e119
Forbes McGain, Jane Muret, Cathy Lawson, Jodi D. Sherman
doi : 10.1016/j.bja.2020.11.031
Volume 126, Issue 3, March 2021, Pages e119-e122
Impact of an aerosol box on time to tracheal intubation: systematic review and meta-analysis
Zheng Jie Lim, Mallikarjuna Ponnapa Reddy, Dharshi Karalapillai, Kiran Shekar, Ashwin Subramaniam
doi : 10.1016/j.bja.2020.11.036
Volume 126, Issue 3, March 2021, Pages e122-e125
Repeated vaporised hydrogen peroxide disinfection of 3M 1860 N95 mask respirators does not degrade quantitative fit performance
Phillip Moschella, Wesley Liao, Alain Litwin, Jonn Foulk, ... Christine Cole
doi : 10.1016/j.bja.2020.12.021
Volume 126, Issue 3, March 2021, Pages e125-e127
Association between inflammation, angiopoietins, and disease severity in critically ill COVID-19 patients: a prospective study
Osama Abou-Arab, Youssef Bennis, Pierre Gauthier, Cedric Boudot, ... Yazine Mahjoub
doi : 10.1016/j.bja.2020.12.017
Volume 126, Issue 3, March 2021, Pages e127-e130
Phenotypes of severe COVID-19 ARDS receiving extracorporeal membrane oxygenation
Joe Zhang, Stephen F. Whebell, Barney Sanderson, Andrew Retter, ... Luigi Camporota
doi : 10.1016/j.bja.2020.12.023
Volume 126, Issue 3, March 2021, Pages e130-e132
Anatomy for the FRCA, J. Bowness, A. Taylor, Cambridge University Press, Cambridge, UK (2019), Pp. 180. Price £21.30. ISBN 978-1-108-70188-4
Charlotte L. Smith, Danny J.N. Wong, Huw Thomas
doi : 10.1016/j.bja.2020.12.012
Volume 126, Issue 3, March 2021, Pages 746-747
Corrigendum to ‘Mast cell activation test in chlorhexidine allergy: a proof of concept’ (Br J Anaesth 2020; 125: 970–5)
Jessy Elst, Marie-Line M. van der Poorten, Margaretha A. Faber, Athina L. Van Gasse, ... Didier G. Ebo
doi : 10.1016/j.bja.2020.12.001
Volume 126, Issue 3, March 2021, Pages 748-749
