دسترسی یکساله به بیش از ۵۰۰ ژورنال روز جهان موجود در سامانه
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Assessing the Role of Rare Genetic Variation in Patients With Heart Failure
Gundula Povysil, MD, PhD1; Olympe Chazara, PhD2; Keren J. Carss, PhD2; Sri V. V. Deevi, PhD2; Quanli Wang, MSc2; Javier Armisen, PhD2; Dirk S. Paul, PhD2; Christopher B. Granger, MD3; John Kjekshus, MD, PhD4; Vimla Aggarwal, MBBS1,5; Carolina Haefliger, MD2; David B. Goldstein, PhD1
doi : 10.1001/jamacardio.2020.6500
JAMA Cardiol. 2021;6(4):379-386
Importance Sequencing studies have identified causal genetic variants for distinct subtypes of heart failure (HF) such as hypertrophic or dilated cardiomyopathy. However, the role of rare, high-impact variants in HF, for which ischemic heart disease is the leading cause, has not been systematically investigated.
Association of Genetic West African Ancestry, Blood Pressure Response to Therapy, and Cardiovascular Risk Among Self-reported Black Individuals in the Systolic Blood Pressure Reduction Intervention Trial (SPRINT)
Shreya Rao, MD, MPH1; Matthew W. Segar, MD, MS1; Adam P. Bress, PharmD, MS2; Pankaj Arora, MD3; Wanpen Vongpatanasin, MD1; Vijay Agusala, MD, MBA1; Utibe R. Essien, MD4; Adolfo Correa, MD5; Alanna A. Morris, MD6; James A. de Lemos, MD1; Ambarish Pandey, MD, MSCS1
doi : 10.1001/jamacardio.2020.6566
JAMA Cardiol. 2021;6(4):388-398
Importance Self-identified Black race is associated with higher hypertension prevalence and worse blood pressure (BP) control compared with other race/ethnic groups. The contribution of genetic West African ancestry to these racial disparities appears not to have been completely determined.
Differences in Long-term Outcomes After Coronary Artery Bypass Grafting Using Single vs Multiple Arterial Grafts and the Association With Sex
Mario Gaudino, MD, MSCE1; Zaza Samadashvili, MD2; Irbaz Hameed, MD1,3; Joanna Chikwe, MD4; Leonard N. Girardi, MD1; Edward L. Hannan, PhD2
doi : 10.1001/jamacardio.2020.6585
JAMA Cardiol. 2021;6(4):401-409
Importance Sex-related differences in the outcome of using multiple arterial grafts during coronary artery bypass grafting (CABG) remain uncertain.
Assessing the Risks of Bleeding vs Thrombotic Events in Patients at High Bleeding Risk After Coronary Stent Implantation
Philip Urban, MD1; John Gregson, PhD2; Ruth Owen, MSc2; Roxana Mehran, MD3; Stephan Windecker, MD4; Marco Valgimigli, MD, PhD4; Olivier Varenne, MD, PhD5,6; Mitchell Krucoff, MD7; Shigeru Saito, MD8; Usman Baber, MD, MSc3; Bernard Chevalier, MD9; Davide Capodanno, MD, PhD10,11; Marie-Claude Morice, MD12; Stuart Pocock, MSc, PhD2
doi : 10.1001/jamacardio.2020.6814
JAMA Cardiol. 2021;6(4):410-419
Importance Patients who are candidates for percutaneous coronary intervention (PCI) and are at high bleeding risk constitute a therapeutic challenge because they often also face an increased risk of thrombotic complications.
Effectiveness of Systematic Echocardiographic Screening for Rheumatic Heart Disease in Nepalese Schoolchildren
Prahlad Karki, MD1; Surendra Uranw, MPH1; Santosh Bastola, MSc1; Rajan Mahato, MD1; Nikesh Raj Shrestha, MD2; Kunjang Sherpa, MD1; Sahadeb Dhungana, MD3; Ayodele Odutayo, MD, DPhil4; Keshar Gurung, MD2; Naveen Pandey, MD1; Krishna Agrawal, MD1; Prashant Shah, MD1; Martina Rothenbühler, PhD5; Peter Jüni, MD4; Thomas Pilgrim, MD, MSc5
doi : 10.1001/jamacardio.2020.7050
JAMA Cardiol. 2021;6(4):420-426
Importance Echocardiographic screening allows for early detection of subclinical stages of rheumatic heart disease among children in endemic regions.
Association of Effective Regurgitation Orifice Area to Left Ventricular End-Diastolic Volume Ratio With Transcatheter Mitral Valve Repair Outcomes
JoAnn Lindenfeld, MD1; William T. Abraham, MD2; Paul A. Grayburn, MD3; Saibal Kar, MD4; Federico M. Asch, MD5; D. Scott Lim, MD6; Hong Nie, PhD7; Pooja Singhal, PhD7; Kartik S. Sundareswaran, PhD7; Neil J. Weissman, MD8; Michael J. Mack, MD9; Gregg W. Stone, MD10; for the Cardiovascular Outcomes Assessment of the MitraClip Percutaneous Therapy for Heart Failure Patients With Functional Mitral Regurgitation (COAPT) Investigators
doi : 10.1001/jamacardio.2020.7200
JAMA Cardiol. 2021;6(4):427-436
Importance Transcatheter mitral valve repair (TMVr) plus maximally tolerated guideline-directed medical therapy (GDMT) reduced heart failure (HF) hospitalizations (HFHs) and all-cause mortality (ACM) in symptomatic patients with HF and secondary mitral regurgitation (SMR) compared with GDMT alone in the Cardiovascular Outcomes Assessment of the MitraClip Percutaneous Therapy for Heart Failure Patients With Functional Mitral Regurgitation (COAPT) trial but not in a similar trial, Multicenter Study of Percutaneous Mitral Valve Repair MitraClip Device in Patients With Severe Secondary Mitral Regurgitation (MITRA-FR), possibly because the degree of SMR relative to the left ventricular end-diastolic volume index (LVEDVi) was substantially lower.
Association of Lipid, Inflammatory, and Metabolic Biomarkers With Age at Onset for Incident Coronary Heart Disease in Women
Sagar B. Dugani, MD, PhD1,2; M. Vinayaga Moorthy, PhD1,3; Chunying Li, MPH1,3; Olga V. Demler, PhD1,3; Alawi A. Alsheikh-Ali, MD, MSc4; Paul M Ridker, MD, MPH3,5; Robert J. Glynn, PhD1,3; Samia Mora, MD, MHS1,3,5
doi : 10.1001/jamacardio.2020.7073
JAMA Cardiol. 2021;6(4):437-447
Importance Risk profiles for premature coronary heart disease (CHD) are unclear.
Association of Global Longitudinal Strain With Clinical Status and Mortality in Patients With Chronic Heart Failure
Sven-Oliver Tr?bs, MD1,2; Jürgen H. Prochaska, MD2,3,4; S?ren Schwuchow-Thonke, MD, MHBA1,2; Andreas Schulz, PhD3; Felix Müller, MD2,3; Marc William Heidorn, MD2,3; Sebastian G?bel, MD1,2; Simon Diestelmeier, MD1,2; Jaume Lerma Monteverde, MD1; Karl J. Lackner, MD2,5; Tommaso Gori, MD, PhD1,2; Thomas Münzel, MD1,2,4; Philipp S. Wild, MD, MSc2,3,4
doi : 10.1001/jamacardio.2020.7184
JAMA Cardiol. 2021;6(4):448-456
Importance Global longitudinal strain (GLS) is an emerging echocardiographic biomarker of cardiac function in heart failure (HF). Evidence from large-scale studies comprehensively investigating GLS for its association with clinical phenotypes and mortality in asymptomatic and symptomatic chronic HF is limited.
Association of Damaging Variants in Genes With Increased Cancer Risk Among Patients With Congenital Heart Disease
Sarah U. Morton, MD, PhD1,2; Akiko Shimamura, MD, PhD3,4; Peter E. Newburger, MD5,6; Alexander R. Opotowsky, MD, MMSC7,8,9; Daniel Quiat, MD, PhD7,9; Alexandre C. Pereira, MD, PhD10; Sheng Chih Jin, PhD11,12; Michelle Gurvitz, MD7,9; Martina Brueckner, MD11,12; Wendy K. Chung, MD, PhD13,14; Yufeng Shen, PhD15,16; Daniel Bernstein, MD17; Bruce D. Gelb, MD18; Alessandro Giardini, MD, PhD19; Elizabeth Goldmuntz, MD20; Richard W. Kim, MD21; Richard P. Lifton, MD, PhD22; George A. Porter Jr, MD, PhD23; Deepak Srivastava, MD, PhD24; Martin Tristani-Firouzi, MD25; Jane W. Newburger, MD, MPH7,9; J. G. Seidman, PhD26; Christine E. Seidman, MD8,10,26
doi : 10.1001/jamacardio.2020.4947
JAMA Cardiol. 2021;6(4):457-462
Importance Patients with congenital heart disease (CHD), the most common birth defect, have increased risks for cancer. Identification of the variables that contribute to cancer risk is essential for recognizing patients with CHD who warrant longitudinal surveillance and early interventions.
Effectiveness of Home-Based Mobile Guided Cardiac Rehabilitation as Alternative Strategy for Nonparticipation in Clinic-Based Cardiac Rehabilitation Among Elderly Patients in Europe
Johan A. Snoek, MD, MSc1,2; Eva I. Prescott, MD, PhD3; Astrid E. van der Velde, PhD1; Thijs M. H. Eijsvogels, PhD4; Nicolai Mikkelsen, PhD3; Leonie F. Prins, MSc5; Wendy Bruins, PhD; Esther Meindersma, MD, MSc6; José R. Gonz?lez-Juanatey, MD, PhD7; Carlos Pe?a-Gil, MD, PhD7; Violeta Gonz?lez-Salvado, MD, PhD7; Feriel Moatemri, MD8; Marie-Christine Iliou, MD, PhD8; Thimo Marcin, PhD9; Prisca Eser, PhD9; Matthias Wilhelm, MD, PhD9; Arnoud W.J. Van’t Hof, MD, PhD10,11; Ed P. de Kluiver, PhD1
doi : 10.1001/jamacardio.2020.5218
JAMA Cardiol. 2021;6(4):463-468
Importance Although nonparticipation in cardiac rehabilitation is known to increase cardiovascular mortality and hospital readmissions, more than half of patients with coronary artery disease in Europe are not participating in cardiac rehabilitation.
Assessment of Neutrophil Extracellular Traps in Coronary Thrombus of a Case Series of Patients With COVID-19 and Myocardial Infarction
Ana Blasco, MD, PhD1; Mar?a-José Coronado, PhD2; Fernando Hern?ndez-Terciado, MD1; Paloma Mart?n, MD, PhD3,4; Ana Royuela, PhD5,6; Elvira Ramil, PhD7; Diego Garc?a, MLT3; Javier Goicolea, MD1; Mar?a Del Trigo, MD, PhD1; Javier Ortega, MD1; Juan M. Escudier, MD, PhD1; Lorenzo Silva, MD1; Carmen Bellas, MD, PhD3,4
doi : 10.1001/jamacardio.2020.7308
JAMA Cardiol. 2021;6(4):469-474
Importance Severe coronavirus disease 2019 (COVID-19) is characterized by the intense formation of neutrophil extracellular traps (NETs), leading to the occlusion of microvessels, as shown in pulmonary samples. The occurrence of ST-elevated myocardial infarction (STEMI) is a serious cardiac manifestation of COVID-19; the intrinsic mechanism of coronary thrombosis appears to still be unknown.
Variability in Reported Percutaneous Coronary Intervention Mortality Among Physicians Practicing at Multiple Sites in New York State
Nancy Yang, BA1; Peter W. Groeneveld, MD, MS2,3,4,5; Sameed Ahmed Mustafa Khatana, MD, MPH2,3,6; Jay Giri, MD, MPH2,3,5,6; Alexander C. Fanaroff, MD, MHS2,3,6; Ashwin S. Nathan, MD2,3,6
doi : 10.1001/jamacardio.2020.6717
JAMA Cardiol. 2021;6(4):477-478
Screening for Rheumatic Heart Disease—Quo Vadis?
Kumar Narayanan, MD, DM1,2; Xavier Jouven, MD, PhD1,3; Eloi Marijon, MD, PhD1,3
doi : 10.1001/jamacardio.2020.7063
JAMA Cardiol. 2021;6(4):375-376
Reconciling COAPT and Mitra-FR Results Based on Mitral Regurgitation Severity and Left Ventricular Size
Linda D. Gillam, MD, MPH1
doi : 10.1001/jamacardio.2020.7214
JAMA Cardiol. 2021;6(4):376-378
Unusual Wide QRS Complex Rhythm in a Teenager
Nicolas Combes, MD, MSc1,2,3; Alice Maltret, MD3; Victor Waldmann, MD, PhD4,5,6
doi : 10.1001/jamacardio.2020.7091
JAMA Cardiol. 2021;6(4):475-476
Causative Mechanism of Constrictive Pericarditis Diagnosed by Fluoroscopy
Harpreet S. Bhatia, MD1; Ryan R. Reeves, MD1
doi : 10.1001/jamacardio.2021.0616
JAMA Cardiol. 2021;6(4):e210616
Return-to-Play Guidelines for Athletes After COVID-19 Infection
Diana Santos-Ferreira, MD, MMed, IOC Dip Sp Phy1,2; Rita Tom?s, MD, MS, IOC Dip Sp Phy3,4; Hélder Dores, PhD1,2,5
doi : 10.1001/jamacardio.2020.5345
JAMA Cardiol. 2021;6(4):478-479
Return-to-Play Guidelines for Athletes After COVID-19 Infection
Dina N. Greene, PhD1; Alan H. B. Wu, PhD2; Allan S. Jaffe, MD3,4
doi : 10.1001/jamacardio.2020.5348
JAMA Cardiol. 2021;6(4):479
Return-to-Play Guidelines for Athletes After COVID-19 Infection—Reply
Dermot Phelan, MD, PhD1; Jonathan H. Kim, MD, MSc2; Eugene H. Chung, MD, MSc3
doi : 10.1001/jamacardio.2020.5351
JAMA Cardiol. 2021;6(4):479-480
PCSK9 Inhibition—A Tale of 2 Potential Treatment Opportunities
Angel Lopez-Candales, MD1; Srikanth Vallurupalli, MD1
doi : 10.1001/jamacardio.2020.5606
JAMA Cardiol. 2021;6(4):480-481
PCSK9 Inhibition—A Tale of 2 Potential Treatment Opportunities—Reply
Brian A. Bergmark, MD1; Marc S. Sabatine, MD, MPH1,2
doi : 10.1001/jamacardio.2020.5613
JAMA Cardiol. 2021;6(4):481
The 70/30 Rule Between Men and Women—Disparity or Opportunity?
Aldo P. Maggioni, MD1; Susanna Grego, MD2
doi : 10.1001/jamacardio.2020.6118
JAMA Cardiol. 2021;6(4):481-482
The 70/30 Rule Between Men and Women—Disparity or Opportunity?—Reply
Jaya Chandrasekhar, MBBS, MS, PhD1,2; Marie-Claude Morice, MD3; Roxana Mehran, MD1,4
doi : 10.1001/jamacardio.2020.6136
JAMA Cardiol. 2021;6(4):482-483
Consistency and Generalizability of Trials for Coronary Computed Tomography Angiography
David E. Newby, DM, PhD1; Philip D. Adamson, MBChB, PhD2; Leslee J. Shaw, PhD3
doi : 10.1001/jamacardio.2020.6124
JAMA Cardiol. 2021;6(4):483-484
Consistency and Generalizability of Trials for Coronary Computed Tomography Angiography—Reply
Raymond J. Gibbons, MD, MSc1
doi : 10.1001/jamacardio.2020.6133
JAMA Cardiol. 2021;6(4):484
Genetic Contribution to Common Heart Failure—Not So Rare?
Elizabeth M. McNally, MD, PhD1,2; Christopher J. O’Donnell, MD, MPH3,4,5
doi : 10.1001/jamacardio.2020.6508
JAMA Cardiol. 2021;6(4):387
Reporting Genetic Markers and the Social Determinants of Health in Clinical Cardiovascular Research—It Is Time to Recalibrate the Use of Race
Clyde W. Yancy, MD, MSc1,2; Elizabeth McNally, MD, PhD1,3
doi : 10.1001/jamacardio.2020.6576
JAMA Cardiol. 2021;6(4):400
Disentangling Ancestry From Social Determinants of Health in Hypertension Disparities—An Important Step Forward
Tiffany M. Powell-Wiley, MD, MPH1,2
doi : 10.1001/jamacardio.2020.6573
JAMA Cardiol. 2021;6(4):398-399
