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Editorial Board
doi : 10.1016/S0167-8140(21)06152-1
EDITORIAL BOARD| VOLUME 156, PII, MARCH 01, 2021
Meta-analysis of chemotherapy in head and neck cancer (MACH-NC): An update on 107 randomized trials and 19,805 patients, on behalf of MACH-NC Group
Benjamin Lacas,Alexandra Carmel,Cécile Landais,Pierre Blanchard,Jean-Pierre Pignonon behalf of the MACH-NC Collaborative Group
doi : 10.1016/j.radonc.2021.01.013
ORIGINAL ARTICLE| VOLUME 156, P281-293, MARCH 01, 2021
The Meta-Analysis of Chemotherapy in squamous cell Head and Neck Cancer (MACH-NC) demonstrated that concomitant chemotherapy (CT) improved overall survival (OS) in patients without distant metastasis. We report the updated results.
The role of the gut microbiome on radiation therapy efficacy and gastrointestinal complications: A systematic review
Marion Tonneau,Arielle Elkrief,David Pasquier,Mathias Chamaillard,Houda Bahig,Bertrand Routy
doi : 10.1016/j.radonc.2020.10.033
SYSTEMATIC REVIEW| VOLUME 156, P1-9, MARCH 01, 2021
Radiation therapy (RT) is an essential component of therapy either curative or palliative armamentarium in oncology, but its efficacy varies considerably among patients through many extrinsic and intrinsic mechanisms of the tumour, which are beginning to be better understood. Recent studies have shown that the gut microbiome represents a key factor in the modulation of the systemic immune response and consequently on patients’ outcome. Moreover, the emergence of biomarkers that are derived from the gut microbiota has fuelled the development of adjuvant strategies for patients treated with immunotherapy in combination or not with RT. Despite progress in development of more precise radiotherapy techniques, almost all patients undergoing RT to the abdomen, pelvis, or rectum develop acute adverse events as a consequence of several dose-limiting parameters such as the location of irradiation that may subsequently damage normal tissue including the intestinal epithelium. Several lines of evidence in preclinical models identified that vancomycin improves RT-induced gastrointestinal toxicities such as diarrhea and oral mucositis. In order to gain further insight into this rapidly evolving field, we have systematically reviewed the studies that have described how the gut microbiome may directly or indirectly modulate RT efficacy and its gastro-intestinal toxicities. Lastly, we outline current knowledge gaps and discuss potentially more satisfactory therapeutic options to restore the functionality of the gut microbiome of patients treated with RT.
ESTRO ACROP guideline for target volume delineation of skull base tumors
Stephanie E. Combs,Brigitta G. Baumert,Martin Bendszus,Damien Charles Weber,Claus Belka,Giuseppe Minniti
doi : 10.1016/j.radonc.2020.11.014
ORIGINAL ARTICLE| VOLUME 156, P80-94, MARCH 01, 2021
For skull base tumors, target definition is the key to safe high-dose treatments because surrounding normal tissues are very sensitive to radiation. In the present work we established a joint ESTRO ACROP guideline for the target volume definition of skull base tumors.
Prostate high dose-rate brachytherapy as monotherapy for prostate cancer: Late toxicity and patient reported outcomes from a randomized phase II clinical trial
Mark Corkum,Andrew Loblaw,Yaser Hasan,Liying Zhang,Alexandre Mamedov,Gerard Morton
doi : 10.1016/j.radonc.2020.12.021
ORIGINAL ARTICLE| VOLUME 156, P160-165, MARCH 01, 2021
Long-term toxicity of high dose-rate brachytherapy as monotherapy for prostate cancer is not well defined. We report late toxicity and health related quality of life (HRQOL) changes from a randomized phase II clinical trial of two different fractionation schemes.
Clinical oncology module for the ESTRO core curriculum
Kim Benstead,Pedro C. Lara,Yannick Eller,Icro Meattini,Ingvil Mjaaland,Raphael Pfeffer
doi : 10.1016/j.radonc.2020.11.029
ORIGINAL ARTICLE| VOLUME 156, P19-22, MARCH 01, 2021
Clinical oncologists are physicians with the competencies to manage cancer patients through the entire disease pathway combining the competencies of radiation and medical oncologists. The 4th edition of the European Society for Radiotherapy and Oncology Core Curriculum for Radiation Oncology/Radiotherapy (ESTRO curriculum) has received wide support by the clinical oncology community. The aim was to develop a clinical oncology module that could be combined with the ESTRO curriculum to enable clinical oncology trainees to follow a single curriculum.
A case-control study to identify molecular risk factors for local recurrence in young breast cancer patients
Sophie C.J. Bosma,Marlous Hoogstraat,Erik van Werkhoven,Harry Bartelink,Marc J. van de VijverYoung Boost Trial research group
doi : 10.1016/j.radonc.2020.11.025
ORIGINAL ARTICLE| VOLUME 156, P127-135, MARCH 01, 2021
To investigate risk factors for local recurrence (LR) after breast conserving therapy in young breast cancer patients randomized in the “Young Boost Trial”.
Three large trials on radiotherapy for early breast cancer: What did we learn?
L.J. Boersma,L.H.P. Murrer
doi : 10.1016/j.radonc.2020.12.018
SHORT COMMUNICATION| VOLUME 156, P239-243, MARCH 01, 2021
A graded prognostic model for patients surviving 3?years or more (GPM???3Ys) after stereotactic radiosurgery for brain metastasis
Yasunori Sato,Masaaki Yamamoto,Toru Serizawa,Kei-ichiro Yamada,Yoshinori Higuchi,Hidetoshi Kasuya
doi : 10.1016/j.radonc.2020.11.024
ORIGINAL ARTICLE| VOLUME 156, P29-35, MARCH 01, 2021
As more cancer patients with brain metastases (BMs) are surviving longer due to recent advancements in various treatment modalities, we developed a grading system for stereotactic radiosurgery (SRS)-treated BM patients with long survival. This is a Graded Prognostic Model for Patients Surviving 3 Years or More (GPM???3Ys).
Pattern of failure in IDH mutated, low grade glioma after radiotherapy – Implications for margin reduction
J.P.M. Jaspers,A. Méndez Romero,R. Wiggenraad,D.B.P. Eekers,R.A. Nout,M. van den Bent
doi : 10.1016/j.radonc.2020.11.019
ORIGINAL ARTICLE| VOLUME 156, P43-48, MARCH 01, 2021
no abstract
The 70-year-old newly diagnosed glioblastoma patients are older than the 65-year-old? Outcome evaluation of the two categories in a matched case control study with propensity score balancing
Pierina Navarria,Federico Pessina,Ciro Franzese,Zefferino Rossini,Armando Santoro,Marta Scorsetti
doi : 10.1016/j.radonc.2020.11.022
ORIGINAL ARTICLE| VOLUME 156, P49-55, MARCH 01, 2021
The standard of care for elderly, newly-diagnosed glioblastoma patients consists, if feasible, of surgical resection followed by a short course of radiation therapy (RT) with concomitant and adjuvant temozolomide chemotherapy (TMZCHT). To date, the literature lacks of consistence in the definition of elderly, if older than 65 years, or 70 years. Aim of this study was to explore whether differences exist between these two cohorts, comparing outcomes using a propensity score matched analysis (PSM).
Patterns of palliative radiotherapy fractionation for brain metastases patients in New South Wales, Australia
V. Batumalai,J. Descallar,G.P. Delaney,J. Shafiq,S.K. Vinod,M.B. Barton
doi : 10.1016/j.radonc.2020.12.020
ORIGINAL ARTICLE| VOLUME 156, P174-180, MARCH 01, 2021
There is a paucity of studies examining variation in the use of palliative radiation therapy (RT) fractionation for brain metastases. The aim of this study is to assess variation in palliative RT fractionation given for brain metastases in New South Wales (NSW), Australia, and identify factors associated with variation.
Dosimetric predictors of symptomatic radiation necrosis after five-fraction radiosurgery for brain metastases
Neal Andruska,William R. Kennedy,Liberty Bonestroo,Keith M. Rich,Christopher Spencer,Jiayi Huang
doi : 10.1016/j.radonc.2020.12.011
ORIGINAL ARTICLE| VOLUME 156, P181-187, MARCH 01, 2021
To identify factors predictive of developing symptomatic radiation necrosis (sRN) among patients with either intact or resected brain metastases undergoing five-fraction stereotactic radiosurgery (5fSRS).
Intravoxel incoherent motion (IVIM) modeling of diffusion MRI during chemoradiation predicts therapeutic response in IDH wildtype glioblastoma
Pejman Jabehdar Maralani,Sten Myrehaug,Hatef Mehrabian,James Perry,Greg Stanisz,Arjun Sahgal
doi : 10.1016/j.radonc.2020.12.037
ORIGINAL ARTICLE| VOLUME 156, P258-265, MARCH 01, 2021
Prediction of early progression in glioblastoma may provide an opportunity to personalize treatment. Simplified intravoxel incoherent motion (IVIM) MRI offers quantitative estimates of diffusion and perfusion metrics. We investigated whether these metrics, during chemoradiation, could predict treatment outcome.
Proposal for the delineation of neoadjuvant target volumes in oesophageal cancer
Melissa Thomas,Hanna R. Mortensen,Lone Hoffmann,Philippe Nafteux,Marianne Nordsmark,Karin Haustermans
doi : 10.1016/j.radonc.2020.11.032
ORIGINAL ARTICLE| VOLUME 156, P102-112, MARCH 01, 2021
To define instructions for delineation of target volumes in the neoadjuvant setting in oesophageal cancer.
Stereotactic body radiation therapy for hepatocellular carcinoma with Macrovascular invasion
Pablo Munoz-Schuffenegger,Aisling Barry,Eshetu G. Atenafu,Tae Kyoung Kim,Gonzalo Sapisochin,Laura A. Dawson
doi : 10.1016/j.radonc.2020.11.033
ORIGINAL ARTICLE| VOLUME 156, P120-126, MARCH 01, 2021
In patients with hepatocellular carcinoma (HCC), macrovascular invasion (MVI) is associated with a poor prognosis. The purpose of this study is to describe long-term outcomes of patients with HCC and MVI treated with stereotactic body radiation therapy (SBRT).
Consequential late effects up to >10 years following primary and postoperative radiotherapy for prostate cancer
Friederike Leufgens,Amr Gharib,Marsha Schlenter,Ludmila Timm,Michael Pinkawa
doi : 10.1016/j.radonc.2020.12.017
ORIGINAL ARTICLE| VOLUME 156, P188-192, MARCH 01, 2021
no abstract
Pelvic insufficiency fractures following carbon-ion radiotherapy for uterine carcinomas
Yuhei Miyasaka,Noriyuki Okonogi,Mai Fukahori,Tatsuya Ohno,Takashi Nakano,Hiroshi Tsuji
doi : 10.1016/j.radonc.2020.11.030
ORIGINAL ARTICLE| VOLUME 156, P56-61, MARCH 01, 2021
There is growing evidence on the role of carbon-ion radiotherapy (C-ion RT) for gynaecological tumours. Pelvic insufficiency fracture (PIF) decreases the quality of life after photon beam radiotherapy (RT). However, there is little information on PIF after C-ion RT. This study retrospectively assessed incidence of PIF after C-ion RT for uterine carcinomas (UCs) and the associations of clinical and dosimetric parameters with PIF incidence.
Healthcare resource utilization following unilateral versus bilateral radiation therapy for oropharyngeal carcinoma
Ali Hosni,Shao Hui Huang,Wei Xu,David P. Goldstein,John Waldron,John R. de Almeida
doi : 10.1016/j.radonc.2020.11.028
ORIGINAL ARTICLE| VOLUME 156, P95-101, MARCH 01, 2021
To describe differences in healthcare resource utilization between patients treated with bilateral vs. unilateral neck radiation therapy (RT) for lateralized oropharyngeal cancer.
Prognostic influence of prevertebral space involvement in nasopharyngeal carcinoma: A retrospective study
Shao-Bo Liang,Lu-Si Chen,Hai-Yang Chen,Chuan-Bo Xie,Li-Zhi Liu,Xiang-Ying Xu
doi : 10.1016/j.radonc.2020.12.012
ORIGINAL ARTICLE| VOLUME 156, P113-119, MARCH 01, 2021
To evaluate how prevertebral space involvement (PSI) and degree of tumor extension within the space affects prognosis in nasopharyngeal carcinoma (NPC).
Prolongation of definitive head and neck cancer radiotherapy: Survival impact and predisposing factors
Michael Xiang,Michael F. Gensheimer,Erqi L. Pollom,Alexander D. Colevas,Quynh-Thu Le,Beth M. Beadle
doi : 10.1016/j.radonc.2020.12.025
ORIGINAL ARTICLE| VOLUME 156, P201-208, MARCH 01, 2021
To quantify the survival impact of prolongation of definitive radiotherapy (RT) for head and neck cancer in a national, modern cohort, and to identify predictive factors for prolongation.
The use of pentoxifylline, tocopherol and clodronate in the management of osteoradionecrosis of the jaws
Sagar Patel,Nisma Patel,Isabel Sassoon,Vinod Patel
doi : 10.1016/j.radonc.2020.12.027
ORIGINAL ARTICLE| VOLUME 156, P209-216, MARCH 01, 2021
Medical management of osteoradionecrosis (ORN) via pentoxifylline, tocopherol (PENTO) and clodronate (PENTOCLO) has shown both promise and early positive outcomes. We aimed to determine clinical outcomes for patients with established ORN managed solely via PENTO or PENTOCLO.
Prognostic value of radiologic extranodal extension in patients with hypopharyngeal cancer treated with primary chemoradiation
Kang-Hsing Fan,Chih-Hua Yeh,Sheng-Ping Hung,Ann-Joy Cheng,Shu-Hang Ng,Joseph Tung-Chieh Chang
doi : 10.1016/j.radonc.2020.12.028
ORIGINAL ARTICLE| VOLUME 156, P217-222, MARCH 01, 2021
We aimed to evaluate the prognostic value of radiologic extranodal extension (rENE) in patients with hypopharyngeal cancer (HPC) treated with primary chemoradiation.
Modified reduced-volume intensity-modulated radiation therapy in non-metastatic nasopharyngeal carcinoma: A prospective observation series
Qiaojuan Guo,Yahan Zheng,Jinyong Lin,Youping Xiao,Jianji Pan,Shaojun Lin
doi : 10.1016/j.radonc.2020.12.035
ORIGINAL ARTICLE| VOLUME 156, P251-257, MARCH 01, 2021
Although the efficacy of “reduced-volume intensity-modulated radiation therapy (IMRT)” in nasopharyngeal carcinoma (NPC) has been confirmed, two issues regarding the necessity of clinical target volume 1(CTV1) delineation and the optimal margin of CTV2 remained undetermined. The current series, utilized de-intensification technique that omitted the contouring of CTV1 and narrowed the margin of CTV2 from 10 mm to 8 mm, namely “modified reduced-volume IMRT” was initiated to evaluate the efficacy and feasibility of this renew technique in a prospective series.
Treatment outcomes of elderly salivary gland cancer patients undergoing radiotherapy – Results from a large multicenter analysis
Sati Akbaba,Alexander Rühle,Sofie Rothhaar,Jürgen Debus,Tilman Bostel,Nils H. Nicolay
doi : 10.1016/j.radonc.2020.12.024
ORIGINAL ARTICLE| VOLUME 156, P266-274, MARCH 01, 2021
To evaluate oncological outcomes and treatment-related toxicities of elderly salivary gland cancer patients undergoing (chemo)radiotherapy.
Assessment of jaw osteonecrosis diagnostic criteria in cancer patients with a history of radiation therapy and exposure to bone-modifying agents
Yehuda Zadik,Yotam Ganor,Ori Rimon,Evgeniya Bersudski,Amichay Meirovitz
doi : 10.1016/j.radonc.2020.12.026
ORIGINAL ARTICLE| VOLUME 156, P275-280, MARCH 01, 2021
Osteoradionecrosis (ORN) of the jaw is currently defined by the development of osteonecrosis in head/neck irradiated patients, regardless of lesion exposure. To diagnose medication-related osteonecrosis of the jaw (MRONJ), a history of any radiation therapy to the jaw region must be ruled out. The aim of this study was to assess the accuracy of current osteonecrosis criteria, while introducing new modifications for improved diagnosis and treatment.
Clinical and dosimetric predictors of radiation pneumonitis in early-stage lung cancer treated with Stereotactic Ablative radiotherapy (SABR) – An analysis of UK’s largest cohort of lung SABR patients
Animesh Saha,Matthew Beasley,Nathaniel Hatton,Mark Teo,Patrick Murray,John Lilley
doi : 10.1016/j.radonc.2020.12.015
ORIGINAL ARTICLE| VOLUME 156, P153-159, MARCH 01, 2021
Stereotactic Ablative Radiotherapy (SABR) is the standard treatment for early-stage medically inoperable lung cancer. Predictors of radiation pneumonitis (RP) in patients treated with SABR are poorly defined. In this study, we investigate clinical and dosimetric parameters, which can predict symptomatic RP in early-stage lung cancer patients treated with SABR.
Proton beam therapy reduces the risk of severe radiation-induced lymphopenia during chemoradiotherapy for locally advanced non-small cell lung cancer: A comparative analysis of proton versus photon therapy
Nalee Kim,Jae Myoung Noh,Woojin Lee,Heejoo Park,Ji Young Park,Hongryull Pyo
doi : 10.1016/j.radonc.2020.12.019
ORIGINAL ARTICLE| VOLUME 156, P166-173, MARCH 01, 2021
We investigated differences in severe radiation-induced lymphopenia (SRL) after pencil beam scanning proton therapy (PBSPT) or intensity-modulated (photon) radiotherapy (IMRT) for patients with locally advanced non-small cell lung cancer.
Safety of lung stereotactic ablative radiotherapy for the functioning of cardiac implantable electronic devices
Mario Levis,Alessandro Andreis,Serena Badellino,Francesca R. Giglioli,Gaetano M. De Ferrari,Umberto Ricardi
doi : 10.1016/j.radonc.2020.12.029
ORIGINAL ARTICLE| VOLUME 156, P193-198, MARCH 01, 2021
The prevalence of patients with a cardiac implantable device (CIED) developing cancer and requiring a course of radiotherapy (RT) is increasing remarkably. Previously published reports agree that standard and conventionally fractionated RT is usually safe for CIEDs, but no “in-vivo” reports are available on the potential effects of thoracic stereotactic ablative radiotherapy (SABR) regimens to CIEDs functioning. The purpose of our study is therefore to evaluate the effects of SABR on CIEDs (pacemakers [PM] or implantable cardiac defibrillators [ICD]) in a cohort of patients affected by primary or metastatic lung lesions.
The development and external validation of an overall survival nomogram in medically inoperable centrally located early-stage non-small cell lung carcinoma
M. Duijm,E. Oomen-de Hoop,N. van Voort van der Zyp,M. Hoogeman,S. Senan,J. Nuyttens
doi : 10.1016/j.radonc.2020.12.038
ORIGINAL ARTICLE| VOLUME 156, P223-230, MARCH 01, 2021
Current nomograms predicting survival prognosis after stereotactic body radiation therapy (SBRT) in non-small cell lung cancer (NSCLC) are based on peripherally located tumors. However, patients with a central lung tumor tend to be older, the tumor is often larger and fraction-schedules are risk-adapted. Therefore, we developed and externally validated a nomogram to predict overall survival (OS) in patients having centrally located early-stage NSCLC treated with SBRT.
Risk factors for symptomatic radiation pneumonitis after stereotactic body radiation therapy (SBRT) in patients with non-small cell lung cancer
Yongmei Liu,Weili Wang,Kevin Shiue,Pingfu Fu,Tim Lautenschlaeger,Feng-Ming (Spring) Kong
doi : 10.1016/j.radonc.2020.10.015
ORIGINAL ARTICLE| VOLUME 156, P231-238, MARCH 01, 2021
Radiation pneumonitis (RP) can be a potential fatal toxicity of stereotactic body radiation therapy (SBRT) for medically inoperable non-small cell lung cancer (NSCLC). This study aimed to examine the risk factors that predict RP and explore dosimetric tolerance for safe practice in a large institutional series of NSCLC patients.
A validation study on the lung immune prognostic index for prognostic value in patients with locally advanced non–small cell lung cancer
Tao Zhang,Wenji Xue,Daquan Wang,Jie Wang,Nan Bi,Luhua Wang
doi : 10.1016/j.radonc.2020.12.039
ORIGINAL ARTICLE| VOLUME 156, P244-250, MARCH 01, 2021
Baseline lung immune prognostic index (LIPI) was reported as a potential predictive biomarker of immune checkpoint inhibitor treatment and a prognostic biomarker for metastatic non-small cell lung cancer (NSCLC). However, it remains unclear whether LIPI is associated with outcomes in locally advanced NSCLC (LA-NSCLC).
Deep learning prediction of proton and photon dose distributions for paediatric abdominal tumours
F. Guerreiro,E. Seravalli,G.O. Janssens,J.A. Langendijk,B.W. Raaymakers,C. Kontaxis
doi : 10.1016/j.radonc.2020.11.026
ORIGINAL ARTICLE| VOLUME 156, P36-42, MARCH 01, 2021
Dose prediction using deep learning networks prior to radiotherapy might lead tomore efficient modality selections. The study goal was to predict proton and photon dose distributions based on the patient-specific anatomy and to assess their clinical usage for paediatric abdominal tumours.
The contribution of surgical clips for optimizing highly-conformal image-guided flank irradiation in pediatric renal tumors: A single center experience
Joeri Mul,Cornelis P. van de Ven,Enrica Seravalli,Martine van Grotel,Marry M. van den Heuvel-Eibrink,Geert O. Janssens
doi : 10.1016/j.radonc.2020.12.010
ORIGINAL ARTICLE| VOLUME 156, P62-68, MARCH 01, 2021
Two-opposing photon beams are considered standard of care for flank irradiation in pediatric patients with renal tumors. Nowadays, Image-Guided Radiotherapy (IGRT) techniques allow high-precision dose delivery to complex flank target volumes taking into account postoperative organ shifts and tumor bed motion. This study examines the contribution of a lateral and superior surgical clip on flank target volume delineation intended for IGRT.
Dosimetric impact of intrafraction prostate rotation and accuracy of gating, multi-leaf collimator tracking and couch tracking to manage rotation: An end-to-end validation using volumetric film measurements
Robin De Roover,Rune Hansen,Wouter Crijns,Karin Haustermans,Per Rugaard Poulsen,Tom Depuydt
doi : 10.1016/j.radonc.2020.11.031
ORIGINAL ARTICLE| VOLUME 156, P10-18, MARCH 01, 2021
Both gating and tracking can mitigate the deteriorating dosimetric impact of intrafraction translation during prostate stereotactic body radiotherapy (SBRT). However, their ability to manage intrafraction rotation has not yet been thoroughly investigated. The dosimetric accuracy of gating, MLC tracking and couch tracking to manage intrafraction prostate rotation was investigated.
Multicentre, deep learning, synthetic-CT generation for ano-rectal MR-only radiotherapy treatment planning
David Bird,Michael G. Nix,Hazel McCallum,Richard Speight,Bashar Al-Qaisieh,Ann M. Henry
doi : 10.1016/j.radonc.2020.11.027
ORIGINAL ARTICLE| VOLUME 156, P23-28, MARCH 01, 2021
Comprehensive dosimetric analysis is required prior to the clinical implementation of pelvic MR-only sites, other than prostate, due to the limited number of site specific synthetic-CT (sCT) dosimetric assessments in the literature. This study aims to provide a comprehensive assessment of a deep learning-based, conditional generative adversarial network (cGAN) model for a large ano-rectal cancer cohort. The following challenges were investigated; T2-SPACE MR sequences, patient data from multiple centres and the impact of sex and cancer site on sCT quality.
Normal tissue complication probability (NTCP) models of acute urinary toxicity (AUT) following carbon ion radiotherapy (CIRT) for prostate cancer
Yongqiang Li,Ping Li,Wenchien Hsi,Zhengshan Hong,Shen Fu,Qing Zhang
doi : 10.1016/j.radonc.2020.12.009
ORIGINAL ARTICLE| VOLUME 156, P69-79, MARCH 01, 2021
To estimate the Lyman Kutcher Burman (LKB) and multivariate NTCP models predicting the AUT of prostate cancer treated with CIRT.
Single-fraction prostate stereotactic body radiotherapy: Dose reconstruction with electromagnetic intrafraction motion tracking
Maud Jaccard,Stefanie Ehrbar,Raymond Miralbell,Pelagia Tsoutsou,Matthias Guckenberger,Thomas Zilli
doi : 10.1016/j.radonc.2020.12.013
ORIGINAL ARTICLE| VOLUME 156, P145-152, MARCH 01, 2021
To reconstruct the dose delivered during single-fraction urethra-sparing prostate stereotactic body radiotherapy (SBRT) accounting for intrafraction motion monitored by intraprostatic electromagnetic transponders (EMT).
p38? (MAPK11) mediates gemcitabine-associated radiosensitivity in sarcoma experimental models
R. Pascual-Serra,D.M. Fern?ndez-Aroca,S. Sabater,B. Belandia,M.J. Ruiz-Hidalgo,R. S?nchez-Prieto
doi : 10.1016/j.radonc.2020.12.008
ORIGINAL ARTICLE| VOLUME 156, P136-144, MARCH 01, 2021
Gemcitabine is an antitumour agent currently used in the treatment of several types of cancer with known properties as a radiosensitizer. p38MAPK signalling pathway has been shown to be a major determinant in the cellular response to gemcitabine in different experimental models. However, the molecular mechanism implicated in gemcitabine-associated radiosensitivity remains unknown.
Detection of an asymptomatic Covid-19 patient on CBCT-imaging
Rémy Kinj,Alexander Bennassi,Edouard Romano,Nathaniel Scher,Jean Bourhis,Mahmut Ozsahin
doi : 10.1016/j.radonc.2020.12.030
LETTER TO THE EDITOR| VOLUME 156, P199-200, MARCH 01, 2021
