دسترسی یکساله به بیش از ۵۰۰ ژورنال روز جهان موجود در سامانه
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Assessment of extracranial metastatic disease in patients with brain metastases: How much effort is needed in the context of evolving survival prediction models?
Carsten Nieder,Minesh P. Mehta,Matthias Guckenberger,...Arjun Sahgal,Anca L. Grosu,Dirk De Ruysscher
doi : 10.1016/j.radonc.2021.02.038
VOLUME 159, P17-20, JUNE 01, 2021
Survival prediction models may serve as decision-support tools for clinicians who have to assign the right treatment to each patient, in a manner whereby harmful over- or undertreatment is avoided as much as possible. Current models differ regarding their components, the overall number of components and the weighting of individual components
Deciphering the epigenetic network in cancer radioresistance
Ariana Cabrera-Licona,Isidro X. Pérez-A?orve,Mauricio Flores-Fortis,...Rocio Su?rez-S?nchez,Margarita Ch?vez-Salda?a,Elena Aréchaga-Ocampo
doi : 10.1016/j.radonc.2021.03.012
VOLUME 159, P48-59, JUNE 01, 2021
Radiotherapy, in addition to surgery and systemic chemotherapy, remains the core of the current clinical management of cancer.
Report dose-to-medium in clinical trials where available; a consensus from the Global Harmonisation Group to maximize consistency
Stephen F. Kry,Jessica Lye,Catharine H. Clark,...Karen Venables,Ying Xiao,Joerg Lehmann
doi : 10.1016/j.radonc.2021.03.006
VOLUME 159, P106-111, JUNE 01, 2021
To promote consistency in clinical trials by recommending a uniform framework as it relates to radiation transport and dose calculation in water versus in medium.
ESTRO-ACROP recommendations on the clinical implementation of hybrid MR-linac systems in radiation oncology
Stefanie Corradini,Filippo Alongi,Nicolaus Andratschke,...Lotte Wilke,Daniel Zips,Claus Belka
doi : 10.1016/j.radonc.2021.03.025
VOLUME 159, P146-154, JUNE 01, 2021
Online magnetic resonance-guided radiotherapy (oMRgRT) represents one of the most innovative applications of current image-guided radiation therapy (IGRT).
First experience of autonomous, un-supervised treatment planning integrated in adaptive MR-guided radiotherapy and delivered to a patient with prostate cancer
Luise A. Künzel,Marcel Nachbar,Markus Hagmüller,...Simon Boeke,Daniel Zips,Daniela Thorwarth
doi : 10.1016/j.radonc.2021.03.032
VOLUME 159, P197-201, JUNE 01, 2021
Currently clinical radiotherapy (RT) planning consists of a multi-step routine procedure requiring human interaction which often results in a time-consuming and fragmented process with limited robustness.
The role of combined ion-beam radiotherapy (CIBRT) with protons and carbon ions in a multimodal treatment strategy of inoperable osteosarcoma
Katharina Seidensaal,Matthias Mattke,Sabine Haufe,...Jürgen Debus,Matthias Uhl,Semi B. Harrabi
doi : 10.1016/j.radonc.2021.01.029
VOLUME 159, P8-16, JUNE 01, 2021
To investigate the role of combined ion-beam radiotherapy (CIBRT) with protons and carbon ions in a multimodal treatment strategy of inoperable osteosarcoma; final analysis of a one-armed, single center phase I/II trial.
Single dose high-dose-rate brachytherapy with focal dose escalation for prostate cancer: Mature results of a phase 2 clinical trial
Shreya Armstrong,Stephanie Brown,May Stancliffe,...Robert Hughes,Peter Hoskin,Roberto Alonzi
doi : 10.1016/j.radonc.2021.03.018
VOLUME 159, P67-74, JUNE 01, 2021
The dominant intraprostatic lesion (DIL) is the commonest site of relapse after single dose high-dose-rate brachytherapy (HDR-BT) for localised prostate cancer. This study investigated toxicity and clinical outcomes of focal dose escalation to the DIL with dose de-escalation to the remaining prostate.
Head and neck cancer patients under (chemo-)radiotherapy undergoing nutritional intervention: Results from the prospective randomized HEADNUT-trial
Anastassia L?ser,Jakob Abel,Laura Magdalena Kutz,...Andreas Krüll,Cordula Petersen,Cedric Oliver Carl
doi : 10.1016/j.radonc.2021.03.019
VOLUME 159, P82-90, JUNE 01, 2021
Patients with squamous cell carcinoma of the head and neck undergoing (chemo-)radiotherapy are at high risk of malnutrition. Nevertheless, there is still a lack of prospective, randomized trials investigating the influence of nutritional status on therapy-related toxicity and patients’ outcome.
Deep regional hyperthermia with preoperative radiochemotherapy in locally advanced rectal cancer, a prospective phase II trial
Cihan Gani,Ulf Lamprecht,Alexander Ziegler,...Alfred K?nigsrainer,Michael Bitzer,Daniel Zips
doi : 10.1016/j.radonc.2021.03.011
VOLUME 159, P155-160, JUNE 01, 2021
The goal of the present study was to investigate the effect of deep regional hyperthermia on early and long-term oncological outcomes in the context of preoperative radiochemotherapy in rectal cancer.
Neoadjuvant hypofractionated radiotherapy and chemotherapy for extremity soft tissue sarcomas: Safety, feasibility, and early oncologic outcomes of a phase 2 trial
Maria Leticia Gobo Silva,Celso Abdon Lopes de Mello,Samuel Aguiar Junior,Bruna Elisa Catin Kupper,Antonio Cassio De Assis Pellizzon,Ademar Lopes
doi : 10.1016/j.radonc.2021.03.033
VOLUME 159, P161-167, JUNE 01, 2021
Optimal treatment of extremity soft tissue sarcomas (ESTS) is controversial. The aim of this study was to evaluate neoadjuvant chemotherapy (ChT) plus concomitant hypofractionated RT (hypo-RT) in local and distant disease relapse. Here we report safety, feasibility and early outcomes.
Long-term follow-up of a phase I/II trial of radiation dose escalation by simultaneous integrated boost for locally advanced esophageal squamous cell carcinoma
Ying Zhang,Wen Feng,Lan-Ting Gao,...Zheng-Fei Zhu,Xiao-Long Fu,Wen Yu
doi : 10.1016/j.radonc.2021.03.031
VOLUME 159, P190-196, JUNE 01, 2021
To observe the long-term survival and late adverse events in a phase ?/? trial (NCT01843049) of dose escalation for thoracic esophageal squamous cell carcinoma (ESCC) with simultaneous integrated boost (SIB) technique.
How do patient-reported outcomes compare with clinician assessments? A prospective study of radiation dermatitis in breast cancer
Tara Behroozian,Lauren Milton,Liying Zhang,...Gina Wong,Ewa Szumacher,Edward Chow
doi : 10.1016/j.radonc.2021.03.020
VOLUME 159, P98-105, JUNE 01, 2021
Breast cancer patients frequently develop radiation dermatitis (RD) when undergoing post-operative radiation therapy (RT). Traditional RD assessment methods measure clinician-reported outcomes (CROs), but patient-reported outcomes (PROs) have gained recent popularity. The purpose of this prospective analysis was to compare PROs with CROs of breast RD.
Intrafraction motion during partial breast irradiation depends on treatment time
Nienke Hoekstra,Steven Habraken,Annemarie Swaak-Kragten,Mischa Hoogeman,Jean-Philippe Pignol
doi : 10.1016/j.radonc.2021.03.029
VOLUME 159, P176-182, JUNE 01, 2021
As the prognosis of early-stage breast cancer patients is excellent, prevention of radiation-induced toxicity has become crucial. Reduction of margins compensating for intrafraction motion reduces non-target dose. We assessed motion of the tumor bed throughout APBI treatment fractions and calculated CTV-PTV margins for breathing and drift.
Prognostic impact of radiation therapy in tubular carcinoma of the breast
Jessica Stauber,Neil Chevli,Waqar Haque,...Sandra Hatch,E. Brian Butler,Bin S. The
doi : 10.1016/j.radonc.2021.03.009
VOLUME 159, P202-208, JUNE 01, 2021
Tubular carcinoma (TC) is an invasive breast cancer with favorable prognosis. While pathology-specific guidelines exist for TC regarding adjuvant chemotherapy and endocrine therapy, no recommendations exist regarding locoregional treatment based on tumor histology. Prognostic impact of radiotherapy for patients with TC remains unclear.
Distance to isocenter is not associated with an increased risk for local failure in LINAC-based single-isocenter SRS or SRT for multiple brain metastases
Johannes Kraft,Janita E. van Timmeren,Michael Mayinger,...Matthias Guckenberger,Stephanie Tanadini-Lang,Nicolaus Andratschke
doi : 10.1016/j.radonc.2021.03.022
VOLUME 159, P168-175, JUNE 01, 2021
To evaluate the impact of the distance between treatment isocenter and brain metastases on local failure in patients treated with a frameless linear-accelerator-based single-isocenter volumetric modulated arc (VMAT) SRS/SRT for multiple brain metastases.
Clinical selection strategy for and evaluation of intra-operative brachytherapy in patients with locally advanced and recurrent rectal cancer
Esmée A. Dijkstra,Véronique E.M. Mul,Patrick H.J. Hemmer,...Mostafa El Moumni,Christina T. Muijs,Boudewijn van Etten
doi : 10.1016/j.radonc.2021.03.010
VOLUME 159, P91-97, JUNE 01, 2021
A radical resection of locally advanced rectal cancer (LARC) or recurrent rectal cancer (RRC) can be challenging. In case of increased risk of an R1 resection, intra-operative brachytherapy (IOBT) can be applied. We evaluated the clinical selection strategy for IOBT.
Bioelectrical impedance analysis as a quantitative measure of sarcopenia in head and neck cancer patients treated with radiotherapy
Aaron J. Grossberg,Crosby D. Rock,Jared Edwards,...Adam S. Garden,Clifton D. Fuller,David I. Rosenthal
doi : 10.1016/j.radonc.2021.03.005
VOLUME 159, P21-27, JUNE 01, 2021
Sarcopenia is associated with decreased survival in head and neck cancer patients treated with radiotherapy. This study sought to determine whether in-clinic multifrequency bioelectrical impedance analysis (BIA) can identify survival-associated sarcopenia in patients with head and neck cancer.
Immunohistochemistry-based hypoxia-immune prognostic classifier for head-and-neck cancer patients undergoing chemoradiation – Post-hoc analysis from a prospective imaging trial
Alexander Rühle,Anca-L. Grosu,Nicole Wiedenmann,...Martin Werner,Gian Kayser,Nils H. Nicolay
doi : 10.1016/j.radonc.2021.03.014
VOLUME 159, P75-81, JUNE 01, 2021
As both tumor hypoxia and an immunosuppressing tumor microenvironment hamper the anti-tumor activity of radiotherapy in head-and-neck squamous cell carcinoma (HNSCC), we aimed to develop an immunohistochemistry-based hypoxia-immune classifier.
Standard radiotherapy for patients with nasopharyngeal carcinoma results in progressive tract-specific brain white matter alterations: A one-year follow-up via diffusion tensor imaging
Yingwei Qiu,Zheng Guo,Xiaoshan Lin,...Lujun Han,Yadi Yang,Xiaofei Lv
doi : 10.1016/j.radonc.2021.03.039
VOLUME 159, P255-264, JUNE 01, 2021
Radiation therapy (RT)-induced neurocognitive disability may be mediated by brain tissue damage. The aim of the present study was to investigate the effects of standard RT on normal brain tissue via in vivo neuroimaging in patients with nasopharyngeal carcinoma (NPC).
Impact of dose to lung outside the planning target volume on distant metastasis or progression after SBRT for early-stage non-small cell lung cancer
Ryan T. Hughes,Cole R. Steber,Travis J. Jacobson,Michael K. Farris
doi : 10.1016/j.radonc.2021.03.004
VOLUME 159, P28-32, JUNE 01, 2021
no abstract
MRI and CBCT for lymph node identification and registration in patients with NSCLC undergoing radical radiotherapy
Michael Dubec,Sean Brown,Robert Chuter.Marcel van Herk,Corinne Faivre-Finn,David Cobben
doi : 10.1016/j.radonc.2021.03.015
VOLUME 159, P112-118, JUNE 01, 2021
This study compared MRI to CBCT for the identification and registration of lymph nodes (LN) in patients with locally advanced (LA)-NSCLC, to assess the suitability of targeting LNs in future MR-image guided radiotherapy (MRgRT) workflows.
Is a higher estimated dose of radiation to immune cells predictive of survival in patients with locally advanced non-small cell lung cancer treated with thoracic radiotherapy?
Xiaoming Yin,Jing Luo,Cai Xu.Ping Wang,Yunchuan Sun,Lujun Zhao
doi : 10.1016/j.radonc.2021.03.026
VOLUME 159, P218-223, JUNE 01, 2021
In previous studies, the estimated dose of radiation to immune cells (EDRIC) showed a correlation with overall survival (OS) of patients with locally advanced non-small cell lung cancer (LA-NSCLC) who received thoracic radiotherapy. However, several factors such as gross tumor volume (GTV) and lymph node (N) stage may impact EDRIC. The purpose of this study was to identify the factors influencing EDRIC and to further assess the prognostic relevance of EDRIC.
Clinical implementation of deep learning contour autosegmentation for prostate radiotherapy
Elaine Cha,Sharif Elguindi,Ifeanyirochukwu Onochie,...Joseph O. Deasy,Michael Zelefsky,Erin F. Gillespie
doi : 10.1016/j.radonc.2021.02.040
VOLUME 159, P1-7, JUNE 01, 2021
Artificial intelligence advances have stimulated a new generation of autosegmentation, however clinical evaluations of these algorithms are lacking. This study assesses the clinical utility of deep learning-based autosegmentation for MR-based prostate radiotherapy planning.
Predictors for post-treatment biopsy outcomes after prostate stereotactic body radiotherapy
Michael J. Zelefsky,Debra A. Goldman,Margaret Hopkins,...Achiraya Teyateeti,Zhigang Zhang,Marisa A. Kollmeier
doi : 10.1016/j.radonc.2021.02.008
VOLUME 159, P33-38, JUNE 01, 2021
To investigate predictors associated with post-treatment biopsy outcomes after stereotactic body radiotherapy (SBRT) for localized prostate cancer.
Brachytherapy for locally advanced cervical cancer: A survey of UK provision of care and support
Pauline Humphrey,Emma Dures,Peter Hoskin,Fiona Cramp
doi : 10.1016/j.radonc.2021.03.007
VOLUME 159, P60-66, JUNE 01, 2021
Gynaecological brachytherapy can cause anxiety, distress and discomfort. It is not known how variation in delivery impacts women’s experiences. To inform future research an online survey was carried out to identify variations in brachytherapy and support available to women receiving treatment for locally advanced cervical cancer (LACC).
Locoregional control using highly conformal flank target volumes and volumetric-modulated arc therapy in pediatric renal tumors: Results from the Dutch national cohort
Joeri Mul,Martine van Grotel,Enrica Seravalli,Annemieke S. Littooij,Marry M. van den Heuvel-Eibrink,Geert O. Janssens
doi : 10.1016/j.radonc.2021.04.005
VOLUME 159, P249-254, JUNE 01, 2021
In pediatric renal tumors, conventional two opposing photon beams have been used to cover the postoperative flank target volume for decades. This single center study describes the locoregional outcome using highly conformal flank target volumes adjusted for postoperative changes and intra-fraction motion combined with Volumetric-Modulated Arc Therapy (VMAT).
Anatomic changes in head and neck intensity-modulated proton therapy: Comparison between robust optimization and online adaptation
Arthur Lalonde,Mislav Bobi?,Brian Winey,Joost Verburg,Gregory C. Sharp,Harald Paganetti
doi : 10.1016/j.radonc.2021.03.008
VOLUME 159, P39-47, JUNE 01, 2021
Setup variations and anatomical changes can severely affect the quality of head and neck intensity-modulated proton therapy (IMPT) treatments. The impact of these changes can be alleviated by increasing the plan’s robustness a priori, or by adapting the plan online. This work compares these approaches in the context of head and neck IMPT.
Dosimetric influence of deformable image registration uncertainties on propagated structures for online daily adaptive proton therapy of lung cancer patients
Lena Nenoff,Michael Matter,Enrique Javier Amaya,...Damien Charles Weber,Ye Zhang,Francesca Albertini
doi : 10.1016/j.radonc.2021.03.021
VOLUME 159, P136-143, JUNE 01, 2021
A major burden of introducing an online daily adaptive proton therapy (DAPT) workflow is the time and resources needed to correct the daily propagated contours. In this study, we evaluated the dosimetric impact of neglecting the online correction of the propagated contours in a DAPT workflow
Rapid 4D-MRI reconstruction using a deep radial convolutional neural network: Dracula
Joshua N. Freedman,Oliver J. Gurney-Champion,Simeon Nill,...Marc Kachelrie?,Uwe Oelfke,Andreas Wetscherek
doi : 10.1016/j.radonc.2021.03.034
VOLUME 159, P209-217, JUNE 01, 2021
4D and midposition MRI could inform plan adaptation in lung and abdominal MR-guided radiotherapy. We present deep learning-based solutions to overcome long 4D-MRI reconstruction times while maintaining high image quality and short scan times.
Thermoacoustic range verification during pencil beam delivery of a clinical plan to an abdominal imaging phantom
Sarah K. Patch,Chinh Nguyen,Diego Dominguez-Ramirez,...Kevin Souris,Shigeto Ono,Ted Lynch
doi : 10.1016/j.radonc.2021.03.027
VOLUME 159, P224-230, JUNE 01, 2021
The purpose of this phantom study is to demonstrate that thermoacoustic range verification could be performed clinically. Thermoacoustic emissions generated in an anatomical multimodality imaging phantom during delivery of a clinical plan are compared to simulated emissions to estimate range shifts compared to the treatment plan.
Deep learning-based auto-segmentation of organs at risk in high-dose rate brachytherapy of cervical cancer
Reza Mohammadi,Iman Shokatian,Mohammad Salehi,Hossein Arabi,Isaac Shiri,Habib Zaidi
doi : 10.1016/j.radonc.2021.03.030
VOLUME 159, P231-240, JUNE 01, 2021
Delineation of organs at risk (OARs), such as the bladder, rectum and sigmoid, plays an important role in the delivery of optimal absorbed dose to the target owing to the steep gradient in high-dose rate brachytherapy (HDR-BT). In this work, we propose a deep convolutional neural network-based approach for fast and reproducible auto-contouring of OARs in HDR-BT.
Impact of DNA repair and reactive oxygen species levels on radioresistance in pancreatic cancer
Lily Nguyen,Sophie Dobiasch,Günter Schneider,...Thomas E. Schmid,Daniela Schilling,Stephanie E. Combs
doi : 10.1016/j.radonc.2021.03.038
VOLUME 159, P265-276, JUNE 01, 2021
Radioresistance in pancreatic cancer patients remains a critical obstacle to overcome. Understanding the molecular mechanisms underlying radioresistance may achieve better response to radiotherapy and thereby improving the poor treatment outcome. The aim of the present study was to elucidate the mechanisms leading to radioresistance by detailed characterization of isogenic radioresistant and radiosensitive cell lines.
?H2AX foci assay in glioblastoma: Surgical specimen versus corresponding stem cell culture
Andreas Riedel,Lukas Klumpp,Apostolos Menegakis,...Susan Noell,Marcos Tatagiba,Daniel Zips
doi : 10.1016/j.radonc.2021.03.023
VOLUME 159, P119-125, JUNE 01, 2021
To assess radiation response using ?H2AX assay in surgical specimens from glioblastoma (GB) patients and their corresponding primary gliosphere culture. To test the hypothesis that gliospheres (stem cell enriched) are more resistant than specimens (bulky cell dominated) but that the interpatient heterogeneity is similar.
Comprehensive analysis of radiosensitivity in head and neck squamous cell carcinoma
Guangqi Li,Yuanjun Jiang,Guang Li,Qiao Qiao
doi : 10.1016/j.radonc.2021.03.017
VOLUME 159, P126-135, JUNE 01, 2021
Radioresistance is a major barrier to the successful treatment of head and neck squamous cell carcinoma (HNSCC).
Development of a method for generating SNP interaction-aware polygenic risk scores for radiotherapy toxicity
Nicola Rares Franco,Michela Carlotta Massi,Francesca Ieva,...Catharine M.L. West,Tiziana RancatiREQUITE Consortium Collaborators
doi : 10.1016/j.radonc.2021.03.024
VOLUME 159, P241-248, JUNE 01, 2021
To identify the effect of single nucleotide polymorphism (SNP) interactions on the risk of toxicity following radiotherapy (RT) for prostate cancer (PCa) and propose a new method for polygenic risk score incorporating SNP-SNP interactions (PRSi).
Predicting outcomes in anal cancer patients using multi-centre data and distributed learning – A proof-of-concept study
Ananya Choudhury,Stelios Theophanous,Per-Ivar L?nne,Eirik Malinen,Leonard Wee,Ane L. Appelt
doi : 10.1016/j.radonc.2021.03.013
VOLUME 159, P183-189, JUNE 01, 2021
Predicting outcomes is challenging in rare cancers. Single-institutional datasets are often small and multi-institutional data sharing is complex. Distributed learning allows machine learning models to use data from multiple institutions without exchanging individual patient-level data. We demonstrate this technique in a proof-of-concept study of anal cancer patients treated with chemoradiotherapy across multiple European countries.
Treatment and outcome of a patient with radiation-induced organizing pneumonia in the context of coronavirus disease 2019 (COVID-19)
Arnaud Beddok,Augusta D'Huy,Alain Livartowski,Nicolas Girard,Gilles Créhange,Sylvie Helfre
doi : 10.1016/j.radonc.2021.03.028
VOLUME 159, P144-145, JUNE 01, 2021
