دسترسی یکساله به بیش از ۵۰۰ ژورنال روز جهان موجود در سامانه
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قیمت : 3,800,000 تومان- قیمت ویژه : 1,900,000تومان
Nrf2 activation putatively mediates clinical benefits of low-dose radiotherapy in COVID-19 pneumonia and acute respiratory distress syndrome (ARDS): Novel mechanistic considerations
Edward J. Calabrese,Walter J. Kozumbo,Rachna Kapoor,Gaurav Dhawan,Pedro C. Lara,James Giordano
doi : 10.1016/j.radonc.2021.04.015
VOLUME 160, P125-131, JULY 01, 2021
Novel mechanistic insights are discussed herein that link a single, nontoxic, low-dose radiotherapy (LDRT) treatment (0.5–1.0 Gy) to (1) beneficial subcellular effects mediated by the activation of nuclear factor erythroid 2-related transcription factor (Nrf2) and to (2) favorable clinical outcomes for COVID-19 pneumonia patients displaying symptoms of acute respiratory distress syndrome (ARDS).
Metrics to evaluate the performance of auto-segmentation for radiation treatment planning: A critical review
Michael V. ShererMichael V. Sherer¡ Diana Lin¡ Sharif Elguindi¡ Simon Duke¡ Li-Tee Tan ¡Jon Cacicedo ¡Max Dahele ¡Erin F. Gillespie
doi : 10.1016/j.radonc.2021.05.003
VOLUME 160, P185-191, JULY 01, 2021
Advances in artificial intelligence-based methods have led to the development and publication of numerous systems for auto-segmentation in radiotherapy. These systems have the potential to decrease contour variability, which has been associated with poor clinical outcomes and increased efficiency in the treatment planning workflow.
Effects of brain radiotherapy on cognitive performance in adult low-grade glioma patients: A systematic review
Christos Koutsarnakis¡Eleftherios Neromyliotis¡Spyridon Komaitis¡Nektarios Mazarakis¡Daniel J. O'Hara¡Georgios Stranjalis¡Paul Chumas
doi : 10.1016/j.radonc.2021.04.023
VOLUME 160, P202-211, JULY 01, 2021
Grade II gliomas are slow growing tumours that usually affect younger patients. The mainstream treatment modality at present is surgical. The role of radiation therapy in the management of grade II gliomas has been the subject of considerable debate. Radiation therapy has a proven potential to prolong progression free and overall survival in high-risk patients, but may also produce long-term cognitive deficits.
Value-based radiotherapy: A new chapter of the ESTRO-HERO project
Yolande Lievens,Josep-Maria Borras,Cai Grau,Ajay Aggarwal
doi : 10.1016/j.radonc.2021.05.007
VOLUME 160, P236-239, JULY 01, 2021
Radiotherapy interventions are rapidly evolving and improving, holding promise for better patient outcomes, yet at the possible detriment of higher societal costs. The ESTRO-HERO value-based radiotherapy project aims to develop a framework defining and assessing the value of radiotherapy innovations, to support clinical implementation and equitable access, within a sustainable healthcare system.
Recommendations for postoperative radiotherapy in head & neck squamous cell carcinoma in the presence of flaps: A GORTEC internationally-reviewed HNCIG-endorsed consensus
Florent Carsuzaa¡Michel Lapeyre¡Vincent Gregoire¡Philippe MaingonArnaud Beddok¡Pierre-Yves Marcy¡Julia Salleron 1¡Alexandre Coutte¡Severine Racadot¡Yoann Pointreau¡Pierre Graff¡Beth Beadle¡Karen Benezery¡Julian Biau¡Valentin Calugaru¡Joel Castelli¡Melvin Chua¡Alessia Di Rito¡Melanie Dore¡Pirus Ghadjar¡Florence Huguet¡Pauline Jardel¡Jorgen Johansen¡Randall Kimple¡Marco Krengli¡Sarbani Laskar¡Lachlan Mcdowell¡Anthony Nichols¡Silke tribius¡Izaskun Valduvieco¡Chaosu Hu¡Xavier Liem¡Antoine Moya-Plana¡Ida D'onofrio¡Upendra Parvathaneni¡Vinita Takiar¡Ester Orlandi¡Amanda Psyrri¡George Shenouda¡David Sher¡Conor Steuer¡Xu Shan Sun¡Yungan Tao¡David Thomson¡Mu-Hung Tsai¡Noemie Vulquin¡Philippe Gorphe¡Hisham Mehanna¡Sue S. Yom¡Jean Bourhis¡Juliette Thariat¡
doi : 10.1016/j.radonc.2021.04.026
VOLUME 160, P140-147, JULY 01, 2021
Head and neck reconstructive surgery using a flap is increasingly common. Best practices and outcomes for postoperative radiotherapy (poRT) with flaps have not been specified. We aimed to provide consensus recommendations to assist clinical decision-making highlighting areas of uncertainty in the presence of flaps.
IBS-GEC ESTRO-ABS recommendations for CT based contouring in image guided adaptive brachytherapy for cervical cancer
Umesh Mahantshetty¡Richard Poetter¡Sushil Beriwal¡Surbhi Grover¡Gurram Lavanya¡Bhavana Rai¡Primoz Petric¡Kari Tanderup¡Heloisa Carvalho¡Neamat Hegazy¡Sandy Mohamed¡Tatsuya Ohno¡Napapat Amornwichet¡
doi : 10.1016/j.radonc.2021.05.010
VOLUME 160, P273-284, JULY 01, 2021
MR Imaging is regarded as?the gold standard?for Image Gudied Adaptive Brachytherapy (IGABT) for cervical cancer. However, its wide applicability is limited by its availability, logistics and financial implications. Use of alternative imaging like CTand Ultrasound (US) for IGABT has been attempted. In order to arrive at a systematic, uniform and international approach for CT based definition and contouring of target structures, GEC ESTRO, IBS and ABS agreed to jointly develop such recommendations based on the concepts and terms as published in the ICRU Report 89.
Prognostic value of testosterone castration levels following androgen deprivation and high-dose radiotherapy in localized prostate cancer: Results from a phase III trial
Almudena Zapatero¡Ana ?lvarez¡Araceli Guerrero¡Xavier Maldonado¡Carmen Gonz?lez San Segundo¡Mar?a A. Cabeza¡Carmen Mart?n de Vidales¡Josep M. Solé¡Agust? Pedro Olivé¡Francesc Casas¡Ana BoladerasMar?a L. V?zquez de la Torre¡Susana Vara¡Felipe.A. Calvo¡
doi : 10.1016/j.radonc.2021.04.018
VOLUME 160, P115-119, JULY 01, 2021
The optimal prognostic value of testosterone following androgen deprivation therapy (ADT) is controversial. We studied the effect of serum testosterone levels on clinical outcome in localized prostate cancer (PCa) treated with ADT and high-dose radiotherapy (HRT).
Theranostic AGuIX nanoparticles as radiosensitizer: A phase I, dose-escalation study in patients with multiple brain metastases (NANO-RAD trial)
Camille Verry¡Sandrine Dufort¡Julie Villa¡Marylaure Gavard¡Carole Iriart¡Sylvie Grand¡Julie Charles¡Benoit Chovelon¡Jean-Luc Cracowski¡Jean-Louis Quesada¡Christophe Mendoza¡Lucie Sancey¡Audrey Lehmann¡Florence Jover¡Jean-Yves Giraud¡François Lux¡Yannick Crémillieux¡Stephen McMahon¡Petrus J. Pauwels¡Daniel Cagney¡Ross Berbeco¡Ayal Aizer¡Eric Deutsch¡Markus Loeffler¡Géraldine Le Duc¡Olivier Tillement¡Jacques Balosso¡
doi : 10.1016/j.radonc.2021.04.021
VOLUME 160, P159-165, JULY 01, 2021
Brain metastasis impacts greatly on patients’ quality of life and survival. The phase I NANO-RAD trial assessed the safety and maximum tolerated dose of systemic administration of a novel gadolinium-based nanoparticle, AGuIX, in combination with whole brain radiotherapy in patients with multiple brain metastases not suitable for stereotactic radiotherapy.
Watch-and-wait strategy in rectal cancer: Is there a tumour size limit? Results from two pooled prospective studies
Micha? Jankowski¡Lucyna Pietrzak¡Maciej Rupi?ski¡Wojciech Michalski¡Anna Ho?dakowska¡Karol Paciorek¡Andrzej Rutkowski¡Tomasz Olesi?ski¡Anna Cencelewicz¡Marek Szczepkowski¡Wojciech Zegarski¡Joanna Reszke¡Piotr Richter¡Przemys?aw Wawok¡Krzysztof Ma?ecki¡Marek B?benek¡Jolanta Szelachowska¡Marek Mazurek¡Iwona Gisterek¡Wojciech Polkowski¡Malgorzata Jankiewicz¡Roman Styli?ski¡Joanna Socha¡Krzysztof Bujko¡
doi : 10.1016/j.radonc.2021.05.014
VOLUME 160, P229-235, JULY 01, 2021
Frequency and predictive factors for a clinical complete response (cCR) in unselected patients are unclear.
Evolution of the gross tumour volume extent during radiotherapy for glioblastomas
Uffe Bernchou¡Trine Skak Tranemose Arnold¡Brit Axelsen¡Mette Klüver-Kristensen¡Faisal Mahmood¡Frederik Severin Gr?e Harbo¡Jon Thor Asmussen¡Olfred Hansen¡Anders Smedegaard Bertelsen¡Steinbj?rn Hansen¡Carsten Brink¡Rikke Hedegaard Dahlrot¡
doi : 10.1016/j.radonc.2021.04.001
VOLUME 160, P40-46, JULY 01, 2021
Tumour growth during radiotherapy may lead to geographical misses of the target volume. This study investigates the evolution of the tumour extent and evaluates the need for plan adaptation to ensure dose coverage of the target in glioblastoma patients.
Identification of patient benefit from proton beam therapy in brain tumour patients based on dosimetric and NTCP analyses
Almut Dutz¡Armin Lühr¡Esther G.C. Troost¡Linda Agolli¡Rebecca Bütof¡Chiara Valentini¡Michael Baumann¡Xavier Vermeren¡Dirk Geismar¡Beate Timmermann¡ Mechthild Krause¡Steffen L?ck
doi : 10.1016/j.radonc.2021.04.008
VOLUME 160, P69-77, JULY 01, 2021
The limited availability of proton beam therapy (PBT) requires individual treatment selection strategies, such as the model-based approach. In this study, we assessed the dosimetric benefit of PBT compared to photon therapy (XRT), analysed the corresponding changes in normal tissue complication probability (NTCP) on a variety of available models, and illustrated model-based patient selection in an in-silico study for patients with brain tumours.
Deciphering the glioblastoma phenotype by computed tomography radiomics
Inge Compter¡Maikel Verduin¡Zhenwei Shi¡Henry C. Woodruff¡Robert J. Smeenk¡Tom Rozema¡Ralph T.H. Leijenaar¡René Monshouwer¡Daniëlle B.P. Eekers¡Ann Hoeben¡Alida A. Postma¡Andre Dekker¡Dirk De Ruysscher¡Philippe Lambin¡Leonard Wee
doi : 10.1016/j.radonc.2021.05.002
VOLUME 160, P132-139, JULY 01, 2021
Glioblastoma (GBM) is the most common malignant primary brain tumour which has, despite extensive treatment, a median overall survival of 15 months. Radiomics is the high-throughput extraction of large amounts of image features from radiographic images, which allows capturing the tumour phenotype in 3D and in a non-invasive way. In this study we assess the prognostic value of CT radiomics for overall survival in patients with a GBM.
Update of the EPTN atlas for CT- and MR-based contouring in Neuro-Oncology
Daniëlle B.P. Eekers ¡Dario Di Perri ¡Erik Roelofs ¡Alida Postma ¡Jeanette Dijkstra¡ Thankamma Ajithkumar¡ Claire Alapetite ¡Malin Blomstrand ¡Neil G Burnet ¡Valentin Calugaru¡ Inge Compter ¡Ida E.M. Coremans¡ Semi Harrabi ¡Alberto Iannalfi¡ Yvonne L.B. Klaver¡ Maarten Lambrecht ¡Alejandra Méndez Romero¡ Frank Paulsen ¡Beate Timmermann¡ Pavel Vitek ¡Hiske L van der Weide¡ Gillian A Whitfield ¡Petra Witt Nystr?m ¡Jaap Zindler ¡Dirk de Ruysscher¡ Johannes Langendijk¡ Damien C Weber ¡Esther G.C. Troost¡
doi : 10.1016/j.radonc.2021.05.013
VOLUME 160, P259-265, JULY 01, 2021
To update the digital online atlas for organs at risk (OARs) delineation in neuro-oncology based on high-quality computed tomography (CT) and magnetic resonance (MR) imaging with new OARs.
Influence of postoperative radiotherapy target volumes in unilateral head and neck carcinoma of unknown primary: A multicentric study using propensity score
Esteban Brenet.Pierre Philouze.Camille Schiffler.Pascal Pommier.Carole Crozes.Nazim Benzerdjeb.Elodie Monchet.Camille Boulagnon-Rombi.Jean Ton Van.Fabien Podeur.Stéphanie Servagi-Vernat.Xavier Liem.Jean-Claude Merol.Philippe Ceruse.Anne-Agathe Serre.Sylvie Chabaud.Morbize Julieron.Sophie Deneuve.
doi : 10.1016/j.radonc.2021.04.002
VOLUME 160, P1-8, JULY 01, 2021
To compare the impact of two radiation modalities on loco-regional control, survival and tumour emergence, after node dissection for an unilateral head and neck carcinoma of unknown primary (HNCUP).
Development and validation of a normal tissue complication probability model for acquired nasal cavity stenosis and atresia after radical radiotherapy for nasopharyngeal carcinoma
Jin-Jie Yan .Shan-Shan Guo. Da-Feng Lin .Li-Ting Liu.Sai-Lan Liu.Bei-Bei Xiao.Jin-Hao Yang.Dong-Xiang Wen.Zhen-Chong Yang.Yu-Jing Liang.Qing-Nan Tang.Chao Lin.Xiao-Yun L.Xue-Song Sun.Ji-Bin Li.Lin-Quan Tang. Qiu-Yan Chen .Hai-Qiang Mai
doi : 10.1016/j.radonc.2021.03.040
VOLUME 160, P9-17, JULY 01, 2021
Curative radiotherapy for nasopharyngeal carcinoma (NPC) can lead to acquired nasal cavity stenosis and atresia (ANCSA). As the first study to investigate risk factors of ANCSA in a large cohort of NPC patients, this article aims to develop and validate a multivariate normal tissue complication probability (NTCP) model to predict the development of ANCSA and to establish a nomogram for clinical use.
Intensity-modulated proton therapy for oropharyngeal cancer reduces rates of late xerostomia
Jianzhong Cao ¡Xiaodong Zhang¡Bo Jiang¡Jiayun Chen¡Xiaochun Wang¡Li Wang¡Narayan Sahoo¡X. Ronald Zhu¡Rong Ye ¡Pierre Blanchard¡Adam S. Garden¡C. David Fuller¡G. Brandon Gunn¡Steven J. Frank
doi : 10.1016/j.radonc.2021.03.036
VOLUME 160, P32-39, JULY 01, 2021
To determine rates of xerostomia after intensity-modulated radiotherapy (IMRT) or intensity-modulated proton therapy (IMPT) for oropharyngeal cancer (OPC) and identify dosimetric factors associated with xerostomia risk.
Impact of radiation-induced toxicities on quality of life of patients treated for head and neck cancer
Hans Paul van der Laan,Lisa Van den Bosch,Ewoud Schuit,Roel J.H.M. Steenbakkers,Arjen van der Schaaf,Johannes A. Langendijk
doi : 10.1016/j.radonc.2021.04.011
VOLUME 160, P47-53, JULY 01, 2021
The aim of this study is to establish the relative impact of physician-rated toxicities and patient-rated symptoms in head and neck cancer (HNC) on quality of life (QOL) and to weigh the various toxicities and symptoms during treatment plan optimization and selection.
TNM 8 staging is a better prognosticator than TNM 7 for patients with locally advanced oral cavity squamous cell carcinoma treated with surgery and post-operative radiotherapy
Khrishanthne Sambasivan¡Isabel Sassoon¡Selvam Thavaraj¡Robert Kennedy¡Gowardhanan Doss¡Andriana Michaelidou¡Edward Odell¡Ann Sandison¡Gillian Hall¡Peter Morgan¡Lisette Hannah Claire Collins¡Andrew Lyons¡Luke Cascarin¡Alastair Fry¡Richard Oakley¡Ricard Simo¡Jean-Pierre Jeannon¡Imran Petkar¡Miguel Reis Ferreira¡Anthony Kong¡Mary Lei¡Teresa Guerrero Urbano
doi : 10.1016/j.radonc.2021.04.003
VOLUME 160, P54-60, JULY 01, 2021
To assess TNM 8 staging in discriminating overall survival (OS) amongst patients with locally advanced oral cavity squamous cell carcinoma (OCSCC) treated with surgery and post-operative radiotherapy (PORT), compared to TNM 7.
Can 3D pseudo-continuous arterial spin labeling perfusion imaging be applied to predict early response to chemoradiotherapy in patients with advanced nasopharyngeal carcinoma?
Zongqiong Sun,Shudong Hu,Qian Xue,Linfang Jin,Jianfeng Huang,Weiqiang Dou
doi : 10.1016/j.radonc.2021.04.017
VOLUME 160, P97-106, JULY 01, 2021
Chemoradiotherapy (CRT) has been widely applied in patients with advanced nasopharyngeal carcinoma (ANPC). However, limited imaging modality exists on the evaluation of early response to CRT. The purpose of this study was therefore to investigate whether 3D pseudo-continuous arterial spin labeling (3D pCASL) perfusion imaging could predict early response to CRT in ANPC patients.
68Ga-FAPI-PET/CT improves diagnostic staging and radiotherapy planning of adenoid cystic carcinomas – Imaging analysis and histological validation
Manuel R?hrich ¡Mustafa Syed ¡Dawn P. Liew¡Frederik L. Giese¡Jakob Liermann¡Peter L. Choyke¡Annika K. Wefers¡Thomas Ritz¡Marina Szymbara¡Lisa Schillings¡Ulrike Heger¡Hendrik Rathke¡Clemens Kratochwi¡Peter E. Huber¡Andreas von Deimling¡Jürgen Debus¡Hans-Ulrich Kauczor¡Uwe Haberkorn¡Sebastian Adeberg¡
doi : 10.1016/j.radonc.2021.04.016
VOLUME 160, P192-201, JULY 01, 2021
Adenoid cystic carcinomas (ACCs) are rare epithelial tumors mostly situated in the head and neck region and characterized by infiltrative growth. The tumor stroma of ACCs includes cancer-associated fibroblasts (CAFs) expressing Fibroblast Activation Protein (FAP), a new target for positron emission tomography (PET) imaging. Here we describe the value of PET/ computed tomography (PET/CT) imaging using 68Ga-labelled FAP-Inhibitors (68Ga-FAPI-PET/CT) and their clinical potential for staging and radiotherapy planning in 12 ACC patients (7 primary, 5 recurrent).
Extent of paranasal sinus involvement and its prognostic value in nasopharyngeal carcinoma: Proposed modification in the current UICC/AJCC staging system
Xiao-Yi Wang ¡Si-Yu Zhu ¡Wei-Jie WU¡Hao-Jiang Li¡Jiao Li¡Xiao-Feng Lin¡Li Li¡Li-Zhi Liu
doi : 10.1016/j.radonc.2021.04.024
VOLUME 160, P221-227, JULY 01, 2021
This study aimed to evaluate the prognostic value of paranasal sinus involvement (PSI) in NPC and to explore its appropriate position in the current AJCC staging system.
Higher biologically effective dose is associated with improved survival in patients with squamous cell carcinoma of the lung treated with stereotactic body radiation therapy
Jacob S. Parzen ¡Muayad F. Almahariq¡ Thomas J. Quinn¡Zaid A. Siddiqui¡Andrew B. Thompson¡Thomas Guerrero¡Kuei Lee¡Craig Stevens¡Inga S. Grills
doi : 10.1016/j.radonc.2021.04.010
VOLUME 160, P25-31, JULY 01, 2021
Multiple studies have suggested that patients with early-stage SCC of the lung treated with SBRT are more susceptible to local failure compared to other NSCLC histologies. It is unknown if higher BED leads to improved outcomes in this patient population. We evaluated the effect of “high” BED versus “low” BED SBRT on overall survival (OS) in SCC and non-SCC NSCLC patients.
Outcomes of curative-intent radiotherapy in non-small cell lung cancer (NSCLC) patients with chronic obstructive pulmonary disease (COPD) and interstitial lung disease (ILD)
Celion Tang¡Hitesh Mistry¡Neil Bayman¡Clara Chan¡David Cobben¡Corinne Faivre-Finn¡Margaret Harris¡Jason Kennedy¡Laura Pemberton¡Gareth Price¡Hamid Sheikh¡David Woolf¡Joanna Coote¡Ahmed Salem
doi : 10.1016/j.radonc.2021.04.014
VOLUME 160, P78-81, JULY 01, 2021
Outcomes of non-small cell lung cancer (NSCLC) patients with chronic obstructive pulmonary disease (COPD n = 587) and interstitial lung disease (ILD n = 34) treated with curative-intent radiotherapy were retrospectively investigated. Presence of ILD but not decreased forced expiratory volume in 1-second correlated with poor overall survival. Increased breathlessness and oxygen requirements after radiotherapy were observed in severe/very severe COPD and ILD.
The dynamics and prognostic value of FDG PET-metrics in weekly monitoring of (chemo)radiotherapy for NSCLC
Matthew D. La Fontaine¡Natascha M. Bruin¡Simon van Kranen¡Joost L. Knegjens¡Jeroen B. van de Kamer¡Wouter V. Vogel¡Jan-Jakob Sonke
doi : 10.1016/j.radonc.2021.04.009
VOLUME 160, P107-114, JULY 01, 2021
To test if the relative change in FDG-PET SUVmax over the course of treatment was associated with disease progression and overall survival. Additionally, the prognostic values of other first-order PET-metric changes were investigated.
Characterizing spatial differences between SPECT-ventilation and SPECT-perfusion in patients with lung cancer undergoing radiotherapy
Farnoush Forghani¡Taylor Patton¡Jennifer Kwak¡David Thomas¡Quentin Diot¡Chad Rusthoven¡Richard Castillo¡Edward Castillo¡Inga Grills¡Thomas Guerrero¡Moyed Miften¡Yevgeniy Vinogradskiy¡
doi : 10.1016/j.radonc.2021.04.022
VOLUME 160, P120-124, JULY 01, 2021
This study investigates agreement between ventilation and perfusion for lung cancer patients undergoing radiotherapy. Ventilation-perfusion scans of nineteen patients with stage III lung cancer from a prospective protocol were compared using voxel-wise Spearman correlation-coefficients. The presented results show in about 25% of patients, ventilation and perfusion exhibit lower agreement.
Intensity-modulated radiation therapy with concurrent chemotherapy followed by durvalumab for stage III non-small cell lung cancer: A multi-center retrospective study
Yoko Tsukita¡Takaya Yamamoto¡Hiroshi Mayahara¡Akito Hata¡Yuichiro Takeda¡Hidetsugu Nakayama¡Satoshi Tanaka¡Junji Uchida¡Kazuhiro Usui¡Tatsuya Toyoda¡Motohiro Tamiya¡Masahiro Morimoto¡Yuko Oya¡Takeshi Kodaira¡Eisaku Miyauchi¡Keiichi Jingu¡Hisatoshi Sugiura¡
doi : 10.1016/j.radonc.2021.05.016
VOLUME 160, P266-272, JULY 01, 2021
Intensity-modulated radiation therapy (IMRT) is increasingly applied in concurrent chemoradiotherapy (CCRT) for locally-advanced non-small cell lung cancer (NSCLC), with improvement of target coverage and better sparing of normal tissue. IMRT tends to have a larger low-dose irradiation volume than 3D conformal radiotherapy, but the incidence of and risk factors for pneumonitis remain unclear, especially following the approval of durvalumab.
Dosimetric feasibility of hypofractionation for metastatic bone/bone marrow lesions from paediatric solid tumours
Sophie C. Huijskens ¡Filipa Guerreiro ¡Mirjam Bosman¡Geert O. Janssens¡Bianca A. Hoeben¡Raquel D?vila Fajardo¡Petra S. Kroon ¡Enrica Seravall
doi : 10.1016/j.radonc.2021.04.020
VOLUME 160, P166-174, JULY 01, 2021
The aim of this study was to determine the feasibility of hypofractionated schedules for metastatic bone/bone marrow lesions in children and to investigate dosimetric differences to the healthy surrounding tissues compared to conventional schedules.
Plan quality effects of maximum monitor unit constraints in pencil beam scanning proton therapy for central nervous system and skull base tumors
Avani Dholakia Rao¡Kai Sun¡Mingyao Zhu¡Sina Mossahebi¡Pouya Sabouri¡Thomas Houser¡Jenna Jatczak¡Mark Zakhary¡William F. Regine¡Robert C. Miller¡S?ren Bentzen¡Mark V. Mishra
doi : 10.1016/j.radonc.2021.03.016
VOLUME 160, P18-24, JULY 01, 2021
With reports of CNS toxicity in patients treated with proton therapy at doses lower than would be expected based on photon data, it has been proposed that heavy monitor unit (MU) weighting of pencil beam scanning (PBS) proton therapy spots may potentially increase the risk of toxicity. We evaluated the impact of maximum MU weighting per spot (maxMU/spot) restrictions on PBS plan quality, prior to implementing clinic-wide maxMU/spot restrictions.
Development of advanced preselection tools to reduce redundant plan comparisons in model-based selection of head and neck cancer patients for proton therapy
Makbule Tambas¡Hans P. van der Laan¡Wouter Rutgers¡Johanna G.M. van den Hoek¡Edwin Oldehinkel¡Tineke W.H. Meijer¡Arjen van der Schaaf¡Daniel Scandurra¡Jeffrey Free¡Stefan Both¡Roel J.H.M. Steenbakkers¡Johannes A. Langendijk
doi : 10.1016/j.radonc.2021.04.012
VOLUME 160, P61-68, JULY 01, 2021
In the Netherlands, head and neck cancer (HNC) patients are selected for proton therapy (PT) based on estimated normal tissue complication probability differences (?NTCP) between photons and protons, which requires a plan comparison (VMAT vs. IMPT). We aimed to develop tools to improve patient selection for plan comparisons.
Combining rescanning and gating for a time-efficient treatment of mobile tumors using pencil beam scanning proton therapy
Pauline Gut,Miriam Krieger,Tony Lomax,Damien C. Weber,Jan Hrbacek
doi : 10.1016/j.radonc.2021.03.041
VOLUME 160, P82-89, JULY 01, 2021
Respiratory motion during proton therapy can severely degrade dose distributions, particularly due to interplay effects when using pencil beam scanning. Combined rescanning and gating treatments for moving tumors mitigates dose degradation, but at the cost of increased treatment delivery time. The objective of this study was to identify the time efficiency of these dose degradation-motion mitigation strategies for different range of motions.
Verification of field match lines in whole breast radiation therapy using Cherenkov imaging
Rachael Hachadorian¡J. Cedar Farwell¡Petr Bruza¡Michael Jermyn¡David J. Gladstone¡Brian W. Pogue¡Lesley A. Jarvis
doi : 10.1016/j.radonc.2021.04.013
VOLUME 160, P90-96, JULY 01, 2021
In mono-isocentric radiation therapy treatment plans designed to treat the whole breast and supraclavicular lymph nodes, the fields meet at isocenter, forming the match line. Insufficient coverage at the match line can lead to recurrence, and overlap over weeks of treatment can lead to increased risk of healthy tissue toxicity. Cherenkov imaging was used to assess the accuracy of delivery at the match line and identify potential incidents during patient treatments.
Probing thoracic dose patterns associated to pericardial effusion and mortality in patients treated with photons and protons for locally advanced non-small-cell lung cancer
Laura Cella ¡Serena Monti¡Ting Xu¡Raffaele Liuzzi¡Arnaldo Stanzione¡Marco Durante¡Radhe Mohan¡Zhongxing Liao¡Giuseppe Palma¡
doi : 10.1016/j.radonc.2021.04.025
VOLUME 160, P148-158, JULY 01, 2021
To investigate thoracic dose–response patterns for pericardial effusion (PCE) and mortality in patients treated for locally advanced Non-Small-Cell Lung Cancer (NSCLC) by Intensity Modulated RT (IMRT) or Passive-Scattering Proton Therapy (PSPT).
A deep learning-based auto-segmentation system for organs-at-risk on whole-body computed tomography images for radiation therapy
Xuming Chen ¡Shanlin Sun ¡Narisu Bai ¡Kun Han ¡Qianqian Liu¡Shengyu Yao¡Hao Tang¡Chupeng Zhang¡Zhipeng Lu¡Qian Huang¡Guoqi Zhao¡Yi Xu¡Tingfeng Chen¡Xiaohui Xie¡Yong Liu
doi : 10.1016/j.radonc.2021.04.019
VOLUME 160, P175-184, JULY 01, 2021
Delineating organs at risk (OARs) on computed tomography (CT) images is an essential step in radiation therapy; however, it is notoriously time-consuming and prone to inter-observer variation. Herein, we report a deep learning-based automatic segmentation (AS) algorithm (WBNet) that can accurately and efficiently delineate all major OARs in the entire body directly on CT scans.
First experimental evaluation of multi-target multileaf collimator tracking during volumetric modulated arc therapy for locally advanced prostate cancer
Emily A. Hewson¡Andrew Dipuglia¡John Kipritidis¡Yuanyuan Ge¡Ricky O'Brien¡Stephanie Roderick¡Linda Bell¡Per R. Poulsen¡Thomas Eade¡Jeremy T. Booth¡Paul J. Keall¡Doan T. Nguyen¡
doi : 10.1016/j.radonc.2021.05.001
VOLUME 160, P212-220, JULY 01, 2021
Locally advanced and oligometastatic cancer patients require radiotherapy treatment to multiple independently moving targets. There is no existing commercial solution that can simultaneously track and treat multiple targets. This study experimentally implemented and evaluated a real-time multi-target tracking system for locally advanced prostate cancer.
Reproducibility and accuracy of a target motion mitigation technique for dose-escalated prostate stereotactic body radiotherapy
Carlo Greco¡Joep Stroom¡Sandra Vieira¡Dalila Mateus¡Maria Jo?o Cardoso¡Ana Soares¡Oriol Pares¡Nuno Pimentel¡Vasco Louro¡Beatriz Nunes¡Justyna Kociolek¡Zvi Fuks¡
doi : 10.1016/j.radonc.2021.05.004
VOLUME 160, P240-249, JULY 01, 2021
To quantitate the accuracy, reproducibility and prostate motion mitigation efficacy rendered by a target immobilization method used in an intermediate-risk prostate cancer dose-escalated 5×9Gy SBRT study.
Training a deep neural network coping with diversities in abdominal and pelvic images of children and young adults for CBCT-based adaptive proton therapy
Jinsoo Uh,Chuang Wang,Sahaja Acharya,Matthew J. Krasin,Chia-ho Hua
doi : 10.1016/j.radonc.2021.05.006
VOLUME 160, P250-258, JULY 01, 2021
To train a deep neural network for correcting abdominal and pelvic cone-beam computed tomography (CBCT) of children and young adults in the presence of diverse patient size, anatomic extent, and scan parameters.
Corrigendum to “Measurement of circulating free DNA in squamous cell carcinoma of the anus and relation to risk factors and recurrence” [Radiother. Oncol. 150 (2020) 211-216]
Anna Cecilie Lefèvre,Camilla Kronborg,Brita Singers S?rensen,S?ren Rasmus Palmelund Krag,Eva Serup-Hansen,Karen-Lise Garm Spindler
doi : 10.1016/j.radonc.2021.05.008
VOLUME 160, P228, JULY 01, 2021
