American Journal of Gastroenterology

Bonura, Giuliano Francesco MD1; Mandarino, Francesco Vito MD1; Ponz de Leon Pisani, Ruggero MD1; Dell’Anna, Giuseppe MD1; Napolitano, Maria MD1; Esposito, Dario PhD, MD2; Azzolini, Francesco MD2

doi : 10.14309/ajg.0000000000001168

August 2021 - Volume 116 - Issue 8 - p 1581

خرید پکیج و مشاهده آنلاین مقاله

Anchoring Method to Prevent Migration of a Covered, Self-Expanding, Metal Stent Placed for Esophageal Perforation

Inoue, Takahiro MD1; Kanesaka, Takashi MD1,2; Yamamoto, Sachiko MD1; Tani, Yasuhiro MD1; Michida, Tomoki MD, PhD1; Ishihara, Ryu MD, PhD1

doi : 10.14309/ajg.0000000000001303

August 2021 - Volume 116 - Issue 8 - p 1582

خرید پکیج و مشاهده آنلاین مقاله

CME Information

doi : 10.14309/ajg.0000000000001123

August 2021 - Volume 116 - Issue 8 - p 1583-1584

خرید پکیج و مشاهده آنلاین مقاله

Continuing Medical Education Questions: August 2021

Ho, Edith Y. MD

doi : 10.14309/ajg.0000000000001372

August 2021 - Volume 116 - Issue 8 - p 1585

A microsimulation model to determine the cost-effectiveness of treat to target strategies for Crohn's disease

خرید پکیج و مشاهده آنلاین مقاله

Continuing Medical Education Questions: August 2021

Shafi, Mehnaz A. MD, FACG

doi : 10.14309/ajg.0000000000001373

August 2021 - Volume 116 - Issue 8 - p 1586

Antispasmodics for Chronic Abdominal Pain: Analysis of North American Treatment Options

خرید پکیج و مشاهده آنلاین مقاله

Antispasmodics for Chronic Abdominal Pain: Analysis of North American Treatment Options

Brenner, Darren M. MD, FACG1; Lacy, Brian E. MD, PhD, FACG2

doi : 10.14309/ajg.0000000000001266

August 2021 - Volume 116 - Issue 8 - p 1587-1600

Chronic abdominal pain is a common gastrointestinal (GI) symptom that characterizes many functional GI disorders/disorders of gut-brain interaction, including irritable bowel syndrome, functional dyspepsia, and centrally mediated abdominal pain syndrome. The symptoms of abdominal pain in these highly prevalent disorders are often treated with antispasmodic agents. Antispasmodic treatment includes a broad range of therapeutic classes with different mechanisms of action, including anticholinergic/antimuscarinic agents (inhibition of GI smooth muscle contraction), calcium channel inhibitors (inhibition of calcium transport into GI smooth muscle), and direct smooth muscle relaxants (inhibition of sodium and calcium transport). The aim of this review article was to examine the efficacy and safety of antispasmodics available in North America (e.g., alverine, dicyclomine, hyoscine, hyoscyamine, mebeverine, otilonium, pinaverium, and trimebutine) for the treatment of chronic abdominal pain in patients with common disorders of gut-brain interaction. For the agents examined, comparisons of studies are limited by inconsistencies in treatment dosing and duration, patient profiles, and diagnostic criteria employed. Furthermore, variability in study end points limits comparisons. Risk of selection, performance, detection, attrition, and reporting bias also differed among studies, and in many cases, risks were considered “unclear.” The antispasmodics evaluated in this review, which differ in geographic availability, were found to vary dramatically in efficacy and safety. Given these caveats, each agent should be considered on an individual basis, rather than prescribed based on information across the broad class of agents.

خرید پکیج و مشاهده آنلاین مقاله

Tegaserod for Irritable Bowel Syndrome With Constipation in Women Younger Than 65 Years Without Cardiovascular Disease: Pooled Analyses of 4 Controlled Trials

Shah, Eric D. MD, MBA1; Lacy, Brian E. MD, PhD2; Chey, William D. MD3; Chang, Lin MD4; Brenner, Darren M. MD5

doi : 10.14309/ajg.0000000000001313

August 2021 - Volume 116 - Issue 8 - p 1601-1611

Tegaserod was the first US Food and Drug Administration–approved drug for irritable bowel syndrome with constipation (IBS-C) in women and was recently reapproved for use. Recognizing that clinical trials were performed almost 20 years ago, we performed an integrated analysis on patient-reported outcomes relevant to current practice including previously unpublished data.

خرید پکیج و مشاهده آنلاین مقاله

Abdominal Pain and Depression, Not Bowel Habits, Predict Health Care Utilization in Patients With Functional Bowel Disorders

Yu, Vanessa BA1; Ballou, Sarah PhD1; Hassan, Rifu MD1; Singh, Prashant MD; Shah, Eric MD, MBA2; Rangan, Vikram MD1; Iturrino, Johanna MD1; Nee, Judy MD1; Lembo, Anthony MD1

doi : 10.14309/ajg.0000000000001306

August 2021 - Volume 116 - Issue 8 - p 1720-1726

Patients with disorders of gut-brain interaction (DGBIs) are high users of health care. Past studies exploring predictors of utilization have lacked patient-level clinical data. The aim of the current study is to identify demographic, clinical, and psychological predictors of health care utilization in patients with irritable bowel syndrome (IBS), functional constipation (FC), and functional diarrhea (FDr).

خرید پکیج و مشاهده آنلاین مقاله

Exposure to Ranitidine and Risk of Bladder Cancer: A Nested Case-Control Study

Cardwell, Chris R. PhD1; McDowell, Ronald D. PhD1; Hughes, Carmel M. PhD2; Hicks, Bl?naid PhD1; Murchie, Peter MD, PhD3

doi : 10.14309/ajg.0000000000001310

August 2021 - Volume 116 - Issue 8 - p 1612-1619

Ranitidine has been shown to contain the carcinogen N-nitrosodimethylamine and increase urinary N-nitrosodimethylamine in humans. We investigated whether ranitidine use is associated with increased bladder cancer risk.

خرید پکیج و مشاهده آنلاین مقاله

Comparative Cost Effectiveness of Reflux-Based and Reflux-Independent Strategies for Barrett's Esophagus Screening

Sami, Sarmed S. MBBCh, PhD1; Moriarty, James P. MS2; Rosedahl, Jordan K. BS2; Borah, Bijan J. PhD2,3; Katzka, David A. MD4; Wang, Kenneth K. MD4; Kisiel, John B. MD5; Ragunath, Krish MD6; Rubenstein, Joel H. MD7,8; Iyer, Prasad G. MD, MSc4

doi : 10.14309/ajg.0000000000001336

August 2021 - Volume 116 - Issue 8 - p 1620-1631

Minimally invasive tests for Barrett's esophagus (BE) detection have raised the prospect of broader nonreflux-based testing. Cost-effectiveness studies have largely studied men aged 50 years with chronic gastroesophageal reflux disease (GERD) symptoms. We evaluated the comparative cost effectiveness of BE screening tests in GERD-based and GERD-independent testing scenarios.

خرید پکیج و مشاهده آنلاین مقاله

Potent Acid Suppression With Vonoprazan vs Proton Pump Inhibitors Does Not Have Higher Association With Clostridioides difficile Infection

Watanabe, Kenta MD1; Shimodaira, Yosuke MD, PhD1; Takahashi, So MD1; Fukuda, Sho MD, PhD1; Koizumi, Shigeto MD, PhD1; Matsuhashi, Tamotsu MD, PhD1; Iijima, Katsunori MD, PhD1

doi : 10.14309/ajg.0000000000001309

August 2021 - Volume 116 - Issue 8 - p 1632-1637

Proton pump inhibitors (PPIs) are associated with the onset of Clostridioides difficile infection (CDI). Although a new potassium-competitive acid blocker, vonoprazan, consistently shows a more potent acid inhibitory effect in comparison to PPIs, the risk of CDI in vonoprazan-treated patients relative to those treated with PPIs is unknown. In this retrospective case-control study, using a nationwide hospital-based administrative database in Japan, we investigated the association of the onset of CDI in patients treated with vonoprazan.

خرید پکیج و مشاهده آنلاین مقاله

Increased ACE2 Levels and Mortality Risk of Patients With COVID-19 on Proton Pump Inhibitor Therapy

Liu, Julia J. MD, MSc1,2; Sloan, Meredith E. MD3; Owings, Anna H. DO3; Figgins, Erika BS4; Gauthier, Josee PhD5; Gharaibeh, Raad PhD5; Robinson, Tanya PhD3; Williams, Haley MS3; Sindel, Campbell B. MD3; Backus, Fremel MHIIM6; Ayyalasomayajula, Krishna PhD6; Parker, Adam MD3; Senitko, Michal MD7; Abraham, George E. III MD7; Claggett, Brian PhD8; Horwitz, Bruce H. MD, PhD9; Jobin, Christian PhD5; Adelman, Robert M. PhD10; Diamond, Gill PhD4; Glover, Sarah C. DO3

doi : 10.14309/ajg.0000000000001311

August 2021 - Volume 116 - Issue 8 - p 1638-1645

Proton pump inhibitor (PPI) use was recently reported to be associated with increased severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and worse clinical outcomes. The underlying mechanism(s) for this association are unclear.

خرید پکیج و مشاهده آنلاین مقاله

Identifying Gender Barriers for Colorectal Cancer Screening and Assessing the Need for a Multigender Endoscopy Team: A Prospective Multicenter Study

Khara, Harshit S. MD, FACG, FASGE1; Suthar, Darshan DO1; Bergenstock, Marika MD1; Berger, Andrea MAS2; McKee, Jessica L. DO1; Stewart, Dana DO1; Theis, Samuel R. DO1; Komar, Michael MD1; Johal, Amitpal S. MD1; Valencia Chavez, Diego R. MD3; Hale, William B. MD3; Mangla, Rakhee MD3

doi : 10.14309/ajg.0000000000001318

August 2021 - Volume 116 - Issue 8 - p 1646-1656

Gender preferences have been reported as a barrier to colorectal cancer screening, particularly among women. We aim to identify the role of patients' gender preferences for endoscopists and endoscopy team members, with the effect of age-related and regional differences.

خرید پکیج و مشاهده آنلاین مقاله

Prediction of Hepatocellular Carcinoma by On-Therapy Response of Noninvasive Fibrosis Markers in Chronic Hepatitis B

Nam, Heechul MD1,2; Lee, Sung Won MD1,2; Kwon, Jung Hyun MD, PhD1,2; Lee, Hae Lim MD1,2; Yoo, Sun Hong MD, PhD1,2; Kim, Hee Yeon MD, PhD1,2; Song, Do Seon MD, PhD1,2; Sung, Pil Soo MD, PhD1,2; Chang, U Im MD, PhD1,2; Kim, Chang Wook MD, PhD1,2; Nam, Soon Woo MD, PhD1,2; Bae, Si Hyun MD, PhD1,2; Choi, Jong Young MD, PhD1,2; Yoon, Seung Kew MD, PhD1,2; Yang, Jin Mo MD, PhD1,2; Han, Nam Ik MD, PhD1,2; Jang, Jeong Won MD, PhD1,2

doi : 10.14309/ajg.0000000000001219

August 2021 - Volume 116 - Issue 8 - p 1657-1666

Antiviral therapy improves hepatic fibrosis and reduces hepatocellular carcinoma (HCC) incidence. This study aimed to evaluate whether on-therapy changes in scores for fibrosis index based on 4 factors and aspartate aminotransferase-to-platelet ratio index are associated with HCC development and establish an HCC risk score model incorporating noninvasive fibrosis marker (NFM) response.

خرید پکیج و مشاهده آنلاین مقاله

Red Meat Consumption and Risk of Nonalcoholic Fatty Liver Disease in a Population With Low Meat Consumption: The Golestan Cohort Study

Hashemian, Maryam MD, PhD1,2; Merat, Shahin MD3; Poustchi, Hossein MD, PhD3; Jafari, Elham MD, MPH3; Radmard, Amir-Reza MD4; Kamangar, Farin MD, PhD1,5; Freedman, Neal PhD6; Hekmatdoost, Azita MD, PhD7; Sheikh, Mahdi MD, PhD1,8; Boffetta, Paolo MD, PhD9,10; Sinha, Rashmi PhD6; Dawsey, Sanford M. MD6; Abnet, Christian C. PhD, MPH6; Malekzadeh, Reza MD1; Etemadi, Arash MD, PhD1,6

doi : 10.14309/ajg.0000000000001229

August 2021 - Volume 116 - Issue 8 - p 1667-1675

Nonalcoholic fatty liver disease (NAFLD), as the most common liver disease in the world, can range from simple steatosis to steatohepatitis. We evaluated the association between meat consumption and risk of NAFLD in the Golestan Cohort Study (GCS).

خرید پکیج و مشاهده آنلاین مقاله

Unreliable Estimation of Fibrosis Regression During Treatment by Liver Stiffness Measurement in Patients With Chronic Hepatitis B

Ji, Dong MD, PhD1; Chen, Yan MD1; Shang, Qinghua MD2; Liu, Huabao MD3; Tan, Lin MD4; Wang, Jing MD5; Chen, Yongping MD6; Li, Qin MD7; Long, Qinghua MD8; Song, Laicheng MD9; Jiang, Li MD10; Xiao, Guangming MD11; Yu, Zujiang MD12; Chen, Liang MD13; Hu, Xiaoyu MD14; Wang, Xiaodong MD6; Chen, Da MD7; Li, Zhiqin MD12; Dong, Zheng MD1; Chen, Guofeng MD1; Yang, Yongping MD1

doi : 10.14309/ajg.0000000000001239

August 2021 - Volume 116 - Issue 8 - p 1676-1685

Little reliable evidence has been reported regarding usefulness of liver stiffness measurement (LSM) for monitoring the hepatic fibrosis changes during treatment. We aimed to assess the association between changes in LSM and histological outcomes in patients with chronic hepatitis B.

خرید پکیج و مشاهده آنلاین مقاله

Hepatic Steatosis and Steatohepatitis in a Large North American Cohort of Adults With Chronic Hepatitis B

Khalili, Mandana MD1; Kleiner, David E. MD2; King, Wendy C. PhD3; Sterling, Richard K. MD, MSc4; Ghany, Marc G. MD2; Chung, Raymond T. MD5; Bhan, Atul K. MD5,6; Rosenthal, Philip MD1; Lisker-Melman, Mauricio MD7; Ramachandran, Rageshree MD1; Lok, Anna S. MD8; ; and the Hepatitis B Research Network (HBRN)

doi : 10.14309/ajg.0000000000001257

August 2021 - Volume 116 - Issue 8 - p 1686-1697

Fatty liver disease (FLD) influences liver disease progression and liver cancer risk. We investigated the impact of FLD on liver disease severity in a large North American cohort with chronic hepatitis B virus (HBV).

خرید پکیج و مشاهده آنلاین مقاله

Effect of Diameter and Number of Hepatocellular Carcinomas on Survival After Resection, Transarterial Chemoembolization, and Ablation

Kawaguchi, Yoshikuni MD, PhD1,*; Hasegawa, Kiyoshi MD, PhD1,*; Hagiwara, Yasuhiro PhD2,*; De Bellis, Mario MD3; Famularo, Simone MD4,5; Panettieri, Elena MD6; Matsuyama, Yutaka PhD2,*; Tateishi, Ryosuke MD, PhD7,*; Ichikawa, Tomoaki MD, PhD8,*; Kokudo, Takashi MD, PhD1,*; Izumi, Namiki MD, PhD9,*; Kubo, Shoji MD, PhD10,*; Sakamoto, Michiie MD, PhD11,*; Shiina, Shuichiro MD, PhD12,*; Takayama, Tadatoshi MD, PhD13,*; Nakashima, Osamu MD, PhD14,*; Murakami, Takamichi MD, PhD15,*; Vauthey, Jean-Nicolas MD16; Giuliante, Felice MD6; De Carlis, Luciano MD4,17; Romano, Fabrizio MD4,5; Ruzzenente, Andrea MD, PhD3; Guglielmi, Alfredo MD3; Kudo, Masatoshi MD, PhD18,*; Kokudo, Norihiro MD, PhD19,*

doi : 10.14309/ajg.0000000000001256

August 2021 - Volume 116 - Issue 8 - p 1698-1708

Most studies predicting survival after resection, transarterial chemoembolization (TACE), and ablation analyzed diameter and number of hepatocellular carcinomas (HCCs) as dichotomous variables, resulting in an underestimation of risk variation. We aimed to develop and validate a new prognostic model for patients with HCC using largest diameter and number of HCCs as continuous variables.

خرید پکیج و مشاهده آنلاین مقاله

A Microsimulation Model to Determine the Cost-Effectiveness of Treat-to-Target Strategies for Crohn's Disease

Dulai, Parambir S. MD1; Jairath, Vipul MD, PhD2; Narula, Neeraj MD3; Wong, Emily BS3; Kochhar, Gursimran S. MD4; Colombel, Jean-Frederic MD5; Sandborn, William J. MD1

doi : 10.14309/ajg.0000000000001263

August 2021 - Volume 116 - Issue 8 - p 1709-1719

Cost-effectiveness of biomarker- vs endoscopy-based treat-to-target monitoring in Crohn's disease (CD) is unknown.

خرید پکیج و مشاهده آنلاین مقاله

Esophageal Mucosa Innervation in Children With Nonerosive Reflux Disease

Nikaki, Kornilia MD1; Lee, Chung BSc, MSc1; Ustaoglu, Ahsen BSc, MRes1; Alessandrella, Annalisa MD2; Staiano, Annamaria MD2; Woodland, Philip MD, PhD1; Sifrim, Daniel MD, PhD1

doi : 10.14309/ajg.0000000000001286

August 2021 - Volume 116 - Issue 8 - p 1727-1729

Esophageal mucosa innervation in adults with nonerosive reflux disease (NERD) is more superficial compared with healthy volunteers. We delineated the esophageal mucosal innervation in pediatric NERD and controls.

خرید پکیج و مشاهده آنلاین مقاله

Surveillance Cessation for Barrett's Esophagus: A Survey of Gastroenterologists

Ozanne, Elissa M. PhD1; Silver, Elisabeth R. BS2; Saini, Sameer D. MD3,4,5; Rubenstein, Joel H. MD, MSc3,6; Lansdorp-Vogelaar, Iris PhD7; Bowers, Nicole BA4; Tan, Sarah Xinhui BS2; Inadomi, John M. MD8; Hur, Chin MD, MPH2,9,10

doi : 10.14309/ajg.0000000000001323

August 2021 - Volume 116 - Issue 8 - p 1730-1733

Regular endoscopic surveillance is the gold standard Barrett's esophagus (BE) surveillance, yet harms of surveillance for some patients may outweigh the benefits. We sought to characterize physicians' BE surveillance cessation recommendations.

خرید پکیج و مشاهده آنلاین مقاله

Characteristics and Outcomes of Children With Cystic Fibrosis Hospitalized With Cirrhosis in the United States

Thornton, Christina MD, PhD1; Somayaji, Ranjani MD, MPH1,2,3; Parkins, Michael MD, MSc1,2; Swain, Mark G. MD1; Ramos, Kathleen J. MD, MSc4; Goss, Christopher H. MD, MSc4; Shaheen, Abdel A. MD, MSc1,2,3

doi : 10.14309/ajg.0000000000001275

August 2021 - Volume 116 - Issue 8 - p 1734-1737

To describe the characteristics and outcomes of children with cystic fibrosis (CF) hospitalized with cirrhosis in the United States.

خرید پکیج و مشاهده آنلاین مقاله

Impact of COVID-19 on Prescribing Trends of Direct-Acting Antivirals for the Treatment of Hepatitis C in Ontario, Canada

Konstantelos, Natalia BSc1,2; Shakeri, Ahmad MSc1; McCormack, Daniel MSc3; Feld, Jordan J. MD, MPH4,5; Gomes, Tara PhD2,3,6; Tadrous, Mina PharmD, PhD1,2,3

doi : 10.14309/ajg.0000000000001287

August 2021 - Volume 116 - Issue 8 - p 1738-1740

Direct-acting antivirals (DAAs) are curative treatments for hepatitis C. However, initiation of these treatments requires adequate healthcare access. Coronavirus 2019 (COVID-19) resulted in restrictions to healthcare services in March 2020. We examined the impact of COVID-19 on the number of individuals dispensed DAAs.

خرید پکیج و مشاهده آنلاین مقاله

Mortality in Patients With Genetic and Environmental Risk of Liver Disease

Schneider, Carolin V. MD1,2; Fromme, Malin2; Schneider, Kai Markus MD, PhD2,3; Bruns, Tony MD2; Strnad, Pavel MD2

doi : 10.14309/ajg.0000000000001326

August 2021 - Volume 116 - Issue 8 - p 1741-1745

The increasing liver-related mortality calls for hepatic surveillance programs. To design them, factors selectively increasing liver-related vs overall mortality need to be identified.

خرید پکیج و مشاهده آنلاین مقاله

Adverse Events After SARS-CoV-2 mRNA Vaccination Among Patients With Inflammatory Bowel Disease

Botwin, Gregory J. BS1,2; Li, Dalin PhD1,2; Figueiredo, Jane PhD2,3; Cheng, Susan MD, MMSc, MPH4; Braun, Jonathan MD, PhD1,2,5; McGovern, Dermot P. B. MD, PhD1,2,5; Melmed, Gil Y. MD, MS, FACG, AGAF1,2

doi : 10.14309/ajg.0000000000001342

August 2021 - Volume 116 - Issue 8 - p 1746-1751

Patients with immune-mediated inflammatory diseases such as inflammatory bowel disease (IBD) on immunosuppressive and biologic therapies were largely excluded from severe acute respiratory syndrome coronavirus-2 messenger RNA vaccine trials.

خرید پکیج و مشاهده آنلاین مقاله

Decreasing Stigmatization of Persons With Higher Weights: When Words Count

Nassani, Najib MD, MSc1; El-Khoury, Rita MD2,3

doi : 10.14309/ajg.0000000000001249

August 2021 - Volume 116 - Issue 8 - p 1752

خرید پکیج و مشاهده آنلاین مقاله

Ending Obesity Stigma and Discrimination: Starting From Healthcare Professionals

Zhang, Wen RN1; Mahawar, Kamal MD2; Parmar, Chetan MD3,4; Chen, Weiju RN1; Wang, Cunchuan MD, PhD5,6; Yang, Wah MD5,6,7,8, on behalf of Global Bariatric Research Collaborative

doi : 10.14309/ajg.0000000000001269

August 2021 - Volume 116 - Issue 8 - p 1753

خرید پکیج و مشاهده آنلاین مقاله