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Structural and Functional Imaging in Glioma Management
Bledi C Brahimaj, MD, Ryan B Kochanski, MD, John J Pearce, MD, Melike Guryildirim, MD, Carter S Gerard, MD, Mehmet Kocak, MD, Sepehr Sani, MD, Richard W Byrne, MD
doi : 10.1093/neuros/nyaa360
Volume 88, Issue 2, February 2021, Pages 211–221
The goal of glioma surgery is maximal safe resection in order to provide optimal tumor control and survival benefit to the patient. There are multiple imaging modalities beyond traditional contrast-enhanced magnetic resonance imaging (MRI) that have been incorporated into the preoperative workup of patients presenting with gliomas.
Robot-Assisted Stereotaxy Reduces Target Error: A Meta-Analysis and Meta-Regression of 6056 Trajectories
Lucas R Philipp, MD, MPH, Caio M Matias, MD, PhD, Sara Thalheimer, BA, Shyle H Mehta, MA, Ashwini Sharan, MD, Chengyuan Wu, MD, MSBmE
doi : 10.1093/neuros/nyaa428
Volume 88, Issue 2, February 2021, Pages 222–233
The pursuit of improved accuracy for localization and electrode implantation in deep brain stimulation (DBS) and stereoelectroencephalography (sEEG) has fostered an abundance of disparate surgical/stereotactic practices. Specific practices/technologies directly modify implantation accuracy; however, no study has described their respective influence in multivariable context.
Genetic Events and Signaling Mechanisms Underlying Schwann Cell Fate in Development and Cancer
Harish N Vasudevan, MD, PhD, Calixto-Hope G Lucas, MD, Javier E Villanueva-Meyer, MD, Philip V Theodosopoulos, MD, David R Raleigh, MD, PhD
doi : 10.1093/neuros/nyaa455
Volume 88, Issue 2, February 2021, Pages 234–245
In this review, we describe Schwann cell development from embryonic neural crest cells to terminally differentiated myelinated and nonmyelinated mature Schwann cells. We focus on the genetic drivers and signaling mechanisms mediating decisions to proliferate versus differentiate during Schwann cell development, highlighting pathways that overlap with Schwann cell development and are dysregulated in tumorigenesis. We conclude by considering how our knowledge of the events underlying Schwann cell development and mouse models of schwannoma, neurofibroma, and malignant peripheral nerve sheath tumor can inform novel therapeutic strategies for patients with cancers derived from Schwann cell lineages.
Commentary: Genetic Events and Signaling Mechanisms Underlying Schwann Cell Fate in Development and Cancer
Aria M Jamshidi, MD, Anthony Diaz, MS, S Shelby Burks, MD, Allan D Levi, MD, PhD
doi : 10.1093/neuros/nyaa501
Volume 88, Issue 2, February 2021, Pages E128–E129
A Phase II and Pharmacodynamic Trial of RO4929097 for Patients With Recurrent/Progressive Glioblastoma
David M Peereboom, MD, Xiaobu Ye, MD, Tom Mikkelsen, MD, Glenn J Lesser, MD, Frank S Lieberman, MD, H Ian Robins, MD, PhD, Manmeet S Ahluwalia, MD, Andrew E Sloan, MD, Stuart A Grossman, MD
doi : 10.1093/neuros/nyaa412
Volume 88, Issue 2, February 2021, Pages 246–251
Cancer stem-like cells are a major cause of resistance to therapy in patients with glioblastoma (GBM) as well as other cancers. Tumor cells are maintained in a stem-like proliferative state in large part through the Notch signaling pathway. The function of this pathway in turn depends on gamma secretase activity. Inhibition of this enzyme therefore inhibits the Notch pathway and tumor growth as measured by a reduction in the formation of brain tumor neurospheres in murine models. RO4929097 is an oral gamma secretase inhibitor.
Survival, Dependency, and Health-Related Quality of Life in Patients With Ruptured Intracranial Aneurysm: 10-Year Follow-up of the United Kingdom Cohort of the International Subarachnoid Aneurysm Trial
Xinyang Hua, PhD, Alastair Gray, PhD, Jane Wolstenholme, PhD, Philip Clarke, PhD, Andrew J Molyneux, FRCR, Richard S C Kerr, FRCS, Alison Clarke, BA, Mary Sneade, BA, Oliver Rivero-Arias, DPhil
doi : 10.1093/neuros/nyaa454
Volume 88, Issue 2, February 2021, Pages 252–260
Previous analyses of the International Subarachnoid Aneurysm Trial (ISAT) cohort have reported on clinical outcomes after treatment of a ruptured intracranial aneurysm with either neurosurgical clipping or endovascular coiling.
Responsive Neurostimulation of the Mesial Temporal White Matter in Bilateral Temporal Lobe Epilepsy
Ravi S Nunna, MD, Alireza Borghei, MD, Bledi C Brahimaj, MD, Fiona Lynn, NP, Diego Garibay-Pulido, BS, Richard W Byrne, MD, Marvin A Rossi, MD, Sepehr Sani, MD
doi : 10.1093/neuros/nyaa381
Volume 88, Issue 2, February 2021, Pages 261–267
Responsive neuromodulation (RNS) is a treatment option for patients with medically refractory bilateral mesial temporal lobe epilepsy (MTLE). A paucity of data exists on the feasibility and clinical outcome of hippocampal-sparing bilateral RNS depth lead placements within the parahippocampal white matter or temporal stem.
Middle Meningeal Artery Embolization for Chronic Subdural Hematoma: A Multi-Center Experience of 154 Consecutive Embolizations
Peter Kan, MD, MPH, FRCS, Georgios A Maragkos, MD, Aditya Srivatsan, MS, Visish Srinivasan, MD, Jeremiah Johnson, MD, Jan-Karl Burkhardt, MD, Timothy M Robinson, MD, Mohamed M Salem, MD, Stephen Chen, MD, Howard A Riina, MD, Omar Tanweer, MD, Elad I Levy, MD, Alejandro M Spiotta, MD, Sami Al Kasab, MD, Jonathan Lena, MD, Bradley A Gross, MD, Jacob Cherian, MD, C Michael Cawley, MD, Brian M Howard, MD, Alexander A Khalessi, MD, Aditya S Pandey, MD, Andrew J Ringer, MD, Ricardo Hanel, MD, PhD, Rafael A Ortiz, MD, David Langer, MD, Cory M Kelly, MS, Brian T Jankowitz, MD, Christopher S Ogilvy, MD, Justin M Moore, MD, PhD, Michael R Levitt, MD, Mandy Binning, MD, Ramesh Grandhi, MD, MS, Farhan Siddiq, MD, Ajith J Thomas, MD
doi : 10.1093/neuros/nyaa379
Volume 88, Issue 2, February 2021, Pages 268–277
Middle meningeal artery (MMA) embolization has emerged as a promising treatment for chronic subdural hematoma (cSDH).
Commentary: Middle Meningeal Artery Embolization for Chronic Subdural Hematoma: A Multi-Center Experience of 154 Consecutive Embolizations
Tyler Scullen, MD, Mansour Mathkour, MD, John D Nerva, MD, Aaron S Dumont, MD, MBA
doi : 10.1093/neuros/nyaa432
Volume 88, Issue 2, February 2021, Pages E130–E132
Ocular Fundus Abnormalities in Acute Subarachnoid Hemorrhage: The FOTO-ICU Study
Rahul A Sharma, MD, MPH, Philip S Garza, MD, MSc, Valérie Biousse, MD, Owen B Samuels, MD, Nancy J Newman, MD, Beau Benjamin Bruce, MD, PhD
doi : 10.1093/neuros/nyaa411
Volume 88, Issue 2, February 2021, Pages 278–284
Ocular fundus abnormalities, especially intraocular hemorrhage, may represent a clinically useful prognostic marker in patients with acute subarachnoid hemorrhage (SAH).
Mild and Severe Obesity Reduce the Effectiveness of Lumbar Fusions: 1-Year Patient-Reported Outcomes in 8171 Patients
Graham Mulvaney, MD, Olivia M Rice, MD, Vincent Rossi, MD, David Peters, MD, Mark Smith, MD, Joshua Patt, MD, MPH, Deborah Pfortmiller, PhD, Anthony L Asher, MD, Paul Kim, MD, Joe Bernard, MD ... Show more
doi : 10.1093/neuros/nyaa414
Volume 88, Issue 2, February 2021, Pages 285–294
Elevated body mass index (BMI) is a well-known risk factor for surgical complications in lumbar surgery. However, its effect on surgical effectiveness independent of surgical complications is unclear.
Enhanced Recovery After Surgery Reduces Postoperative Opioid Use and 90-Day Readmission Rates After Open Thoracolumbar Fusion for Adult Degenerative Deformity
Emmanuel A Adeyemo, BA, Salah G Aoun, MD, Umaru Barrie, BS, Madelina L Nguyen, BS, Olatunde Badejo, BS, Mark N Pernik, BA, Zachary Christian, BA, Luke J Dosselman, BS, Tarek Y El Ahmadieh, MD, Kristen Hall, BS ... Show more
doi : 10.1093/neuros/nyaa399
Volume 88, Issue 2, February 2021, Pages 295–300
The role of enhanced recovery after surgery (ERAS) pathways implementation has not been previously explored in adult deformity patients.
Commentary: Enhanced Recovery After Surgery Reduces Postoperative Opioid Use and 90-Day Readmission Rates After Open Thoracolumbar Fusion for Adult Degenerative Deformity
Philip K Louie, MD, Sheeraz A Qureshi, MD, MBA
doi : 10.1093/neuros/nyaa405
Volume 88, Issue 2, February 2021, Pages E133–E135
Commentary: Enhanced Recovery After Surgery Reduces Postoperative Opioid Use and 90-Day Readmission Rates After Open Thoracolumbar Fusion for Adult Degenerative Deformity
Marco V Corniola, MD, Enrico Tessitore, MD PD
doi : 10.1093/neuros/nyaa449
Volume 88, Issue 2, February 2021, Pages E136–E137
The Role of Prophylactic Intraventricular Antibiotics in Reducing the Incidence of Infection and Revision Surgery in Pediatric Patients Undergoing Shunt Placement
Nikita Lakomkin, MD, Constantinos G Hadjipanayis, MD, PhD
doi : 10.1093/neuros/nyaa413
Volume 88, Issue 2, February 2021, Pages 301–305
Ventriculoperitoneal shunt placement remains the primary treatment modality for children with hydrocephalus. However, morbidity and revision surgery secondary to infection remains high, even while using antibiotic-impregnated shunts.
Prepontine Shunting for Pseudotumor Cerebri in Previously Failed Shunt Patients: A 5-Year Analysis
Ian White, MD, Megan Tuohy, MD, Michael Turner, MD, Albert Lee, MD
doi : 10.1093/neuros/nyaa417
Volume 88, Issue 2, February 2021, Pages 306–312
Shunting procedures have a high failure rate when used to treat pseudotumor cerebri (PTC) patients who have failed medical therapy. This failure is believed to be attributable to the collapsibility of the ventricular system when exposed to increased differential pressure gradients in the cerebral spinal fluid compartments caused by ventriculoperitoneal shunts (VPS).
Stereotactic Radiosurgery With Versus Without Embolization for Brain Arteriovenous Malformations
Ching-Jen Chen, MD, Dale Ding, MD, Cheng-Chia Lee, MD, PhD, Kathryn N Kearns, BS, I Jonathan Pomeraniec, MD, MBA, Christopher P Cifarelli, MD, PhD, David E Arsanious, MD, Roman Liscak, MD, Jaromir Hanuska, MD, Brian J Williams, MD ... Show more
doi : 10.1093/neuros/nyaa418
Volume 88, Issue 2, February 2021, Pages 313–321
Prior comparisons of brain arteriovenous malformations (AVMs) treated using stereotactic radiosurgery (SRS) with or without embolization were inherently flawed, due to differences in the pretreatment nidus volumes.
Curve Characteristics and Response of Sciatic and Olisthesis Scoliosis Following L5/S1 Transforaminal Lumbar Interbody Fusion in Adolescent Lumbar Spondylolisthesis
Chang-zhi Du, MD, Ze-zhang Zhu, MD, Yu Wang, MD, Song Li, MD, Liang Xu, MD, Bin Wang, MD, Yong Qiu, MD, Xu Sun, MD
doi : 10.1093/neuros/nyaa429
Volume 88, Issue 2, February 2021, Pages 322–331
Lumbosacral spondylolisthesis-induced scoliosis is a rare clinical entity. Sagittal reconstruction and the coronal curve evolution after surgery for spondylolisthesis have not been investigated in depth.
Occipital-Cervical Fusion and Ventral Decompression in the Surgical Management of Chiari-1 Malformation and Syringomyelia: Analysis of Data From the Park-Reeves Syringomyelia Research Consortium
Travis S CreveCoeur, MD, Alexander T Yahanda, MS, Cormac O Maher, MD, Gabrielle W Johnson, BS, Laurie L Ackerman, MD, P David Adelson, MD, Raheel Ahmed, MD, PhD, Gregory W Albert, MD, Phillipp R Aldana, MD, Tord D Alden, MD ... Show more
doi : 10.1093/neuros/nyaa460
Volume 88, Issue 2, February 2021, Pages 332–341
Occipital-cervical fusion (OCF) and ventral decompression (VD) may be used in the treatment of pediatric Chiari-1 malformation (CM-1) with syringomyelia (SM) as adjuncts to posterior fossa decompression (PFD) for complex craniovertebral junction pathology.
A Retrospective Analysis in 1347 Patients Undergoing Cement Augmentation for Osteoporotic Vertebral Compression Fracture: Is the Sandwich Vertebra at a Higher Risk of Further Fracture?
Ping-Yeh Chiu, MD, Fu-Cheng Kao, MD, Ming-Kai Hsieh, MD, Tsung-Ting Tsai, MD, PhD, Wen-Jer Chen, MD, Chi-Chien Niu, MD, Po-Liang Lai, MD, PhD
doi : 10.1093/neuros/nyaa435
Volume 88, Issue 2, February 2021, Pages 342–348
Multiple percutaneous vertebral cement augmentation may create sandwich vertebrae. Whether the sandwich vertebra is at higher risk of further fracture remains unknown.
Three-Tesla Magnetic Resonance Imaging of Patients With Deep Brain Stimulators: Results From a Phantom Study and a Pilot Study in Patients
Benjamin Davidson, MD, Fred Tam, B.Math, Benson Yang, MASc, Ying Meng, MD, Clement Hamani, MD, PhD, Simon J Graham, PhD, Nir Lipsman, MD, PhD
doi : 10.1093/neuros/nyaa439
Volume 88, Issue 2, February 2021, Pages 349–355
Deep brain stimulation (DBS) is a standard of care treatment for multiple neurologic disorders. Although 3-tesla (3T) magnetic resonance imaging (MRI) has become the gold-standard modality for structural and functional imaging, most centers refrain from 3T imaging in patients with DBS devices in place because of safety concerns. 3T MRI could be used not only for structural imaging, but also for functional MRI to study the effects of DBS on neurocircuitry and optimize programming.
Use of Functional MRI to Assess Effects of Deep Brain Stimulation Frequency Changes on Brain Activation in Parkinson Disease
Marisa DiMarzio, PhD, Radhika Madhavan, PhD, Ileana Hancu, PhD, Eric Fiveland, MS, Julia Prusik, MPH, Suresh Joel, PhD, Michael Gillogly, BA/BS, RN, Ilknur Telkes, PhD, Michael D Staudt, MD, MSc, Jennifer Durphy, MD ... Show more
doi : 10.1093/neuros/nyaa397
Volume 88, Issue 2, February 2021, Pages 356–365
Models have been developed for predicting ideal contact and amplitude for subthalamic nucleus (STN) deep brain stimulation (DBS) for Parkinson disease (PD). Pulse-width is generally varied to modulate the size of the energy field produced. Effects of varying frequency in humans have not been systematically evaluated.
Embolization of Brain Arteriovenous Malformations With Versus Without Onyx Before Stereotactic Radiosurgery
Ching-Jen Chen, MD, Dale Ding, MD, Cheng-Chia Lee, MD, PhD, Kathryn N Kearns, BS, I Jonathan Pomeraniec, MD, MBA, Christopher P Cifarelli, MD, PhD, David E Arsanious, MD, Roman Liscak, MD, Jaromir Hanuska, MD, Brian J Williams, MD ... Show more
doi : 10.1093/neuros/nyaa370
Volume 88, Issue 2, February 2021, Pages 366–374
Embolization of brain arteriovenous malformations (AVMs) using ethylene-vinyl alcohol copolymer (Onyx) embolization may influence the treatment effects of stereotactic radiosurgery (SRS) differently than other embolysates.
Long-Term Efficacy of Occipital Nerve Stimulation for Medically Intractable Cluster Headache
Aurélie Leplus, MD, Denys Fontaine, MD, PhD, Anne Donnet, MD, Jean Regis, MD, PhD, Christian Lucas, MD, Nadia Buisset, MD, Serge Blond, MD, Sylvie Raoul, MD, PhD, Evelyne Guegan-Massardier, MD, Stéphane Derrey, MD, PhD ... Show more
doi : 10.1093/neuros/nyaa373
Volume 88, Issue 2, February 2021, Pages 375–383
Occipital nerve stimulation (ONS) has been proposed to treat refractory chronic cluster headache (rCCH) but its efficacy has only been showed in small short-term series.
Focal Cortical Dysplasia IIIa in Hippocampal Sclerosis-Associated Epilepsy: Anatomo-Electro-Clinical Profile and Surgical Results From a Multicentric Retrospective Study
Massimo Cossu, MD, Piergiorgio d'Orio, MD, Carmen Barba, MD, PhD, Sofia Asioli, MD, Francesco Cardinale, MD, PhD, Sara Casciato, MD, Massimo Caulo, MD, Gabriella Colicchio, MD, Alessandro Consales, MD, Alfredo D'Aniello, MD ... Show more
doi : 10.1093/neuros/nyaa369
Volume 88, Issue 2, February 2021, Pages 384–393
Hippocampal sclerosis (HS) may be associated with focal cortical dysplasia IIIa (FCD IIIa) in patients undergoing surgery for temporal lobe epilepsy (TLE).
Conditioning Effect of Inhalational Anesthetics on Delayed Cerebral Ischemia After Aneurysmal Subarachnoid Hemorrhage
Umeshkumar Athiraman, MD, Rajat Dhar, MD, Keshav Jayaraman, BA, Menelaos Karanikolas, MD, Daniel Helsten, MD, Jane Yuan, BA, Abhijit V Lele, MBBS, MD, MS, Girija Prasad Rath, MD, DM, Rene Tempelhoff, MD, Steven Roth, MD ... Show more
doi : 10.1093/neuros/nyaa356
Volume 88, Issue 2, February 2021, Pages 394–401
Delayed cerebral ischemia (DCI) after aneurysmal subarachnoid hemorrhage (SAH) has been identified as an independent predictor of poor outcome in numerous studies.
Survival Trends After Surgery for Spinal Metastatic Tumors: 20-Year Cancer Center Experience
Robert J Rothrock, MD, Ori Barzilai, MD, Anne S Reiner, MPH, Eric Lis, MD, Adam M Schmitt, MD, Daniel S Higginson, MD, Yoshiya Yamada, MD, Mark H Bilsky, MD, Ilya Laufer, MD
doi : 10.1093/neuros/nyaa380
Volume 88, Issue 2, February 2021, Pages 402–412
Over the last 2 decades, advances in systemic therapy have increased the expected overall survival for patients with cancer. It is unclear whether the same survival benefit has been conferred to patients requiring surgery for metastatic spinal disease.
Commentary: Survival Trends After Surgery for Spinal Metastatic Tumors: 20-Year Cancer Center Experience
Dean Chou, MD
doi : 10.1093/neuros/nyaa394
Volume 88, Issue 2, February 2021, Pages E138–E139
Commentary: Survival Trends After Surgery for Spinal Metastatic Tumors: 20-Year Cancer Center Experience
Elie Massaad, MD, Ganesh M Shankar, MD, PhD, John H Shin, MD
doi : 10.1093/neuros/nyaa395
Volume 88, Issue 2, February 2021, Pages E140–E141
Familial Predisposition and Differences in Radiographic Patterns in Spontaneous Nonaneurysmal Subarachnoid Hemorrhage
Pui Man Rosalind Lai, MD, Isaac Ng, BSc, William B Gormley, MD, MPH, Nirav J Patel, MD, Kai U Frerichs, MD, M Ali Aziz-Sultan, MD, Rose Du, MD, PhD
doi : 10.1093/neuros/nyaa396
Volume 88, Issue 2, February 2021, Pages 413–419
Subarachnoid hemorrhage (SAH) from an intracranial aneurysmal rupture is the most common nontraumatic etiology for SAH, but up to 15% of patients with SAH have no identifiable source.
The Effect of Perioperative Adverse Events on Long-Term Patient-Reported Outcomes After Lumbar Spine Surgery
Oliver G S Ayling, MD, Tamir Ailon, MD, John T Street, MD, Nicolas Dea, MD, Greg McIntosh, MSc, Edward Abraham, MD, W Bradly Jacobs, MD, Alex Soroceanu, MD, Michael G Johnson, MD, Jerome Paquet, MD ... Show more
doi : 10.1093/neuros/nyaa427
Volume 88, Issue 2, February 2021, Pages 420–427
Perioperative adverse events (AEs) lead to patient disappointment and greater costs. There is a paucity of data on how AEs affect long-term outcomes.
External Validation of the Timed Up and Go Test as Measure of Objective Functional Impairment in Patients With Lumbar Degenerative Disc Disease
Martin N Stienen, MD, FEBNS, Nicolai Maldaner, MD, Marketa Sosnova, MD, Anna M Zeitlberger, MD, Michal Ziga, MD, Astrid Weyerbrock, MD, Oliver Bozinov, MD, Oliver P Gautschi, MD
doi : 10.1093/neuros/nyaa441
Volume 88, Issue 2, February 2021, Pages E142–E149
The Timed Up and Go (TUG) test is the most commonly applied objective measure of functional impairment in patients with lumbar degenerative disc disease (DDD).
Development of a Complication- and Treatment-Aware Prediction Model for Favorable Functional Outcome in Aneurysmal Subarachnoid Hemorrhage Based on Machine Learning
Nicolai Maldaner, MD, Anna M Zeitlberger, MD/MSc, Marketa Sosnova, MD, Johannes Goldberg, MD, Christian Fung, MD, David Bervini, MD, Adrien May, MD, Philippe Bijlenga, MD, PhD, Karl Schaller, MD, Michel Roethlisberger, MD ... Show more
doi : 10.1093/neuros/nyaa401
Volume 88, Issue 2, February 2021, Pages E150–E157
Current prognostic tools in aneurysmal subarachnoid hemorrhage (aSAH) are constrained by being primarily based on patient and disease characteristics on admission.
Longitudinal Changes After Amygdala Surgery for Intractable Aggressive Behavior: Clinical, Imaging Genetics, and Deformation-Based Morphometry Study—A Case Series
Flavia Venetucci Gouveia, PhD, Jürgen Germann, PhD, Rosa de Morais, MD, Erich Talamoni Fonoff, MD, PhD, Clement Hamani, MD, PhD, Eduardo Joaquim Alho, MD, PhD, Helena Brentani, MD, PhD, Ana Paula Martins, MD, Gabriel Devenyi, PhD, Raihaan Patel, BASc ... Show more
doi : 10.1093/neuros/nyaa378
Volume 88, Issue 2, February 2021, Pages E158–E169
Intractable aggressive behavior (iAB) is a devastating behavioral disorder that may affect psychiatric patients. These patients have reduced quality of life, are more challenging to treat as they impose a high caregiver burden and require specialized care. Neuromodulatory interventions targeting the amygdala, a key hub in the circuitry of aggressive behavior (AB), may provide symptom alleviation.
Low-Profile Visualized Intraluminal Support Jr Braided Stent Versus Atlas Self-Expandable Stent for Treatment of Intracranial Aneurysms: A Single Center Experience
Andre Monteiro, MD, Gustavo M Cortez, MD, Amin Aghaebrahim, MD, Eric Sauvageau, MD, Ricardo A Hanel, MD, PhD
doi : 10.1093/neuros/nyaa458
Volume 88, Issue 2, February 2021, Pages E170–E178
The Neuroform Atlas Stent and Low-profile Visualized Intraluminal Support (LVIS) and LVIS Jr stents are used to treat intracranial aneurysms (IAs), but their safety, performance, and outcomes have not been directly compared.
Ultrashort Echo Time Magnetic Resonance Angiography in Follow-up of Intracranial Aneurysms Treated With Endovascular Coiling: Comparison of Time-of-Flight, Pointwise Encoding Time Reduction With Radial Acquisition, and Contrast-Enhanced Magnetic Resonance Angiography
Sung-Hye You, MD, PhD, Byungjun Kim, MD, PhD, Kyung-Sook Yang, PhD, Bo Kyu Kim, MD, Jaeil Ryu, MD
doi : 10.1093/neuros/nyaa467
Volume 88, Issue 2, February 2021, Pages E179–E189
The optimal magnetic resonance angiography (MRA) sequence for assessing the aneurysm occlusion state or in-stent flow after endovascular coiling is not well established.
Predicting the Extent of Resection in Low-Grade Glioma by Using Intratumoral Tractography to Detect Eloquent Fascicles Within the Tumor
David Mato, MD, PhD, Carlos Velasquez, MD, PhD, Elsa G?mez, ST, Enrique Marco de Lucas, MD, Juan Martino, MD, PhD
doi : 10.1093/neuros/nyaa463
Volume 88, Issue 2, February 2021, Pages E190–E202
An early maximal safe surgical resection is the current treatment paradigm for low-grade glioma (LGG). Nevertheless, there are no reliable methods to accurately predict the axonal intratumoral eloquent areas and, consequently, to predict the extent of resection.
Computational Drug Repositioning Identifies Potentially Active Therapies for Chordoma
Jeffrey I Traylor, BS, Hadley E Sheppard, BS, Visweswaran Ravikumar, MS, Jonathan Breshears, MD, Shaan M Raza, MD, Charles Y Lin, PhD, Shreyaskumar R Patel, MD, Franco DeMonte, MD
doi : 10.1093/neuros/nyaa398
Volume 88, Issue 2, February 2021, Pages 428–436
Chordomas are aggressive bone tumors that often recur despite maximal resection and adjuvant radiation. To date there are no Food and Drug Administration (FDA)-approved chemotherapies. Computational drug repositioning is an expanding approach to identify pharmacotherapies for clinical trials.
Commentary: Computational Drug Repositioning Identifies Potentially Active Therapies for Chordoma
Daniel G Eichberg, MD, Ricardo J Komotar, MD, Michael E Ivan, MD, MBS
doi : 10.1093/neuros/nyaa403
Volume 88, Issue 2, February 2021, Pages E203–E204
No Abstract
Radiotherapy, Temozolomide, and Antiprogrammed Cell Death Protein 1 Treatments Modulate the Immune Microenvironment in Experimental High-Grade Glioma
Matteo Riva, MD, PhD, Roxanne Wouters, MBMS, DS, Edmond Sterpin, MD, PhD, Roberto Giovannoni, PhD, Louis Boon, PhD, Uwe Himmelreich, PhD, Willy Gsell, PhD, Marc Van Ranst, MD, PhD, An Coosemans, MD, PhD
doi : 10.1093/neuros/nyaa421
Volume 88, Issue 2, February 2021, Pages E205–E215
The lack of immune synergy with conventional chemoradiation could explain the failure of checkpoint inhibitors in current clinical trials for high-grade gliomas (HGGs).
Letter: Stem Cell Transplantation for Parkinson Disease: Déjà Vu All Over Again?
Ron L Alterman, MD
doi : 10.1093/neuros/nyaa487
Volume 88, Issue 2, February 2021, Pages E216–E217
