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Novel analysis procedure for red ginseng polysaccharides by matrix-assisted laser desorption/ionization time-of-flight/time-of-flight mass spectrometry
Ye RinJinabMyung JinOhcHeung JooYukaHyun JooAncDong SeonKimab
doi : 10.1016/j.jgr.2021.02.005
Volume 45, Issue 5, September 2021, Pages 539-545
Red ginseng polysaccharides (RGPs) have been acknowledged for their outstanding immunomodulation and anti-tumor activities. However, their studies are still limited by the complexity of their structural features, the absence of purification and enrichment methods, and the rarity of the analytical instruments that apply to the analysis of such macromolecules. Thus, this study is an attempt to establish a new mass spectrometry (MS)-based analysis procedure for RGPs.
Effect of coadministration of enriched Korean Red Ginseng (Panax ginseng) and American ginseng (Panax quinquefolius L) on cardiometabolic outcomes in type-2 diabetes: A randomized controlled trial
ElenaJovanovskiafLeaSmircic-DuvnjakbAllisonKomishonaFei (Rodney)Au-YeungafJohn L.SievenpiperacdefAndreeaZurbauafAlexandra L.JenkinsaMi-KyungSunggRobertJossedfDandanLiafVladimirVuksanacdf
doi : 10.1016/j.jgr.2019.11.005
Volume 45, Issue 5, September 2021, Pages 546-554
Diabetes mellitus and hypertension often occur together, amplifying cardiovascular disease (CVD) risk and emphasizing the need for a multitargeted treatment approach. American ginseng (AG) and Korean Red Ginseng (KRG) species could improve glycemic control via complementary mechanisms. Additionally, a KRG-inherent component, ginsenoside Rg3, may moderate blood pressure (BP). Our objective was to investigate the therapeutic potential of coadministration of Rg3-enriched Korean Red Ginseng (Rg3-KRG) and AG, added to standard of care therapy, in the management of hypertension and cardiometabolic risk factors in type-2 diabetes.
Anti-melanogenic property of ginsenoside Rf from Panax ginseng via inhibition of CREB/MITF pathway in melanocytes and ex vivo human skin
Ha-RiLeeac1Joon MinJungb1Ji-YeonSeoacSung EunChangbc2YoungsupSongac2
doi : 10.1016/j.jgr.2020.11.003
Volume 45, Issue 5, September 2021, Pages 555-564
Ginsenosides of Panax ginseng are used to enhance skin health and beauty. The present study aimed to investigate the potential use of ginsenoside Rf (Rf) from Panax ginseng as a new anti-pigmentation agent.
Saengmaeksan, a traditional herbal formulation consisting of Panax ginseng, ameliorates hyperuricemia by inhibiting xanthine oxidase activity and enhancing urate excretion in rats
Yoon-YoungSungHeung JooYukDong-SeonKim
doi : 10.1016/j.jgr.2021.01.001
Volume 45, Issue 5, September 2021, Pages 565-574
Saengmaeksan (SMS) is a traditional Korean medicine composed of three herbs, Panax ginseng, Schisandra chinensis, and Liriope platyphylla. SMS is used to treat respiratory and cardiovascular disorders. However, whether SMS exerts antihyperuricemic effects is unknown.
Gintonin regulates inflammation in human IL-1?-stimulated fibroblast-like synoviocytes and carrageenan/kaolin-induced arthritis in rats through LPAR2
MijinKimaBongjunSuraTheaVillaaJaesukYunbSeung YeolNahcSeikwanOha
doi : 10.1016/j.jgr.2021.02.001
Volume 45, Issue 5, September 2021, Pages 575-582
In ginseng, there exists a glycolipoprotein complex with a special form of lipid LPAs called Gintonin. The purpose of this study is to show that Gintonin has a therapeutic effect on rheumatoid arthritis through LPA2 receptors.
Effects of Gintonin-enriched fraction on the gene expression of six lysophosphatidic receptor subtypes
RamiLeeaByung-HwanLeeaSun-HyeChoiaYeon-JinChoaHan-SungChoaHyoung-ChunKimbHyewhonRhimcIk-HyunChodMan HeeRheeeSeung-YeolNaha
doi : 10.1016/j.jgr.2021.02.006
Volume 45, Issue 5, September 2021, Pages 583-590
Gintonin, isolated from ginseng, acts as a ginseng-derived lysophosphatidic acid (LPA) receptor ligand and elicits the [Ca2+]i transient through six LPA receptor subtypes (LPARSs). However, the long-term effects of gintonin-enriched fraction (GEF) on the gene expression of six LPARSs remain unknown. We examined changes in the gene expression of six LPA receptors in the mouse whole brain, heart, lungs, liver, kidneys, spleen, small intestine, colon, and testis after long-term oral GEF administration.
The increasing hematopoietic effect of the combined treatment of Korean Red Ginseng and Colla corii asini on cyclophosphamide-induced immunosuppression in mice
Yuan YeeLeeaMuhammadIrfanadYixianQuahaEvelynSababSung-DaeKimaSeung-ChunParkaMyung-GyunJeongcYi-SeongKwakcMan HeeRheea
doi : 10.1016/j.jgr.2021.02.004
Volume 45, Issue 5, September 2021, Pages 591-598
Hematopoiesis is the production of blood cells from hematopoietic stem cells (HSCs) that reside in the bone marrow. Cyclophosphamide (CTX) is a chemotherapy drug that suppresses the immune system. Korean Red Ginseng (KRG) and Colla corii asini (CCA) have been traditionally used for boosting the immune system.
Role of ginseng in the neurovascular unit of neuroinflammatory diseases focused on the blood-brain barrier
MinsuKimHyejungMokWoon-SeokYeoJoong-HoonAhnYoon KyungChoi
doi : 10.1016/j.jgr.2021.02.003
Volume 45, Issue 5, September 2021, Pages 599-609
Ginseng has long been considered as an herbal medicine. Recent data suggest that ginseng has anti-inflammatory properties and can improve learning- and memory-related function in the central nervous system (CNS) following the development of CNS neuroinflammatory diseases such as Alzheimer’s disease, cerebral ischemia, and other neurological disorders. In this review, we discuss the role of ginseng in the neurovascular unit, which is composed of endothelial cells surrounded by astrocytes, pericytes, microglia, neural stem cells, oligodendrocytes, and neurons, especially their blood-brain barrier maintenance, anti-inflammatory effects and regenerative functions. In addition, cell-cell communication enhanced by ginseng may be attributed to regeneration via induction of neurogenesis and angiogenesis in CNS diseases. Thus, ginseng may have therapeutic potential to exert cognitive improvement in neuroinflammatory diseases such as stroke, traumatic brain injury, multiple sclerosis, Parkinson’s disease, and Alzheimer’s disease.
Ginsenoside Rg3 attenuates skin disorders via down-regulation of MDM2/HIF1? signaling pathway
Na-RaHanabSeong-GyuKobcPhil-DongMoondHi-JoonParke
doi : 10.1016/j.jgr.2021.06.008
Volume 45, Issue 5, September 2021, Pages 610-616
Thymic stromal lymphopoietin (TSLP) acts as a master switch for inflammatory responses. Ginsenoside Rg3 (Rg3) which is an active ingredient of Panax ginseng Meyer (Araliaceae) is known to possess various therapeutic effects. However, a modulatory effect of Rg3 on TSLP expression in the inflammatory responses remains poorly understood.
