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Spotlight on the August 24 Issue
Merino, Jose G. MD, MPhil; Editor-in-Chief, Neurology(R)
doi : 10.1212/WNL.0000000000012457
Volume 97(8), 24 August 2021, p 353-354
Hematoma Enlargement as a Target for Treating Intracerebral Hemorrhage: A More Granular View
Grotta, James C. MD
doi : 10.1212/WNL.0000000000012391
Volume 97(8), 24 August 2021, p 355-356
Hematoma Expansion Shift Analysis to Assess Acute Intracerebral Hemorrhage Treatments
Yogendrakumar, Vignan MD Msc; Ramsay, Tim PhD; Menon, Bijoy K. MD MSc; Qureshi, Adnan I. MD; Saver, Jeffrey L. MD; Dowlatshahi, Dar MD PhD
doi : 10.1212/WNL.0000000000012393
Volume 97(8), 24 August 2021, p e755-e764
Safety and Outcomes of Thrombectomy in Ischemic Stroke With vs Without IV Thrombolysis
Ahmed, Niaz MD, PhD; Mazya, Michael MD, PhD; Nunes, Ana Paiva MD; Moreira, Tiago MD, PhD; Ollikainen, Jyrki P. MD; Escudero-Martinez, Irene MD, PhD; Bigliardi, Guido MD; Dorado, Laura MD, PhD; Davalos, Antoni MD, PhD; Egido, Jose A. MD, PhD; Tassi, Rossana MD; Strbian, Daniel MD, PhD; Zini, Andrea MD; Nichelli, Paolo MD; Herzig, Roman MD, PhD; Jurak, Lubomir MD, PhD; Hurtikova, Eva MD; Tsivgoulis, Georgios MD, PhD; Peeters, Andre MD; Nevsimalova, Miroslava MD; Brozman, Miroslav MD, PhD; Cavallo, Roberto MD; Lees, Kennedy R. MD; Mikulik, Robert MD, PhD; Toni, Danilo MD, PhD; Holmin, Staffan MD, PhD
doi : 10.1212/WNL.0000000000012327
Volume 97(8), 24 August 2021, p e765-e776
Hematoma expansion (HE) is commonly analyzed as a dichotomous outcome in intracerebral hemorrhage (ICH) trials. In this proof-of-concept study, we propose an HE shift analysis model as a method to improve the evaluation of candidate ICH therapies.
Utility of Intravenous Alteplase Prior to Endovascular Stroke Treatment: A Systematic Review and Meta-analysis of RCTs
Katsanos, Aristeidis H. MD; Turc, Guillaume MD; Psychogios, Marios MD; Kaesmacher, Johannes MD; Palaiodimou, Lina MD; Stefanou, Maria Ioanna MD; Magoufis, George MD; Shoamanesh, Ashkan MD; Themistocleous, Marios MD; Sacco, Simona MD; Fiehler, Jens MD; Gralla, Jan MD; Strbian, Daniel MD; Alexandrov, Andrei V. MD; Fischer, Urs MD; Tsivgoulis, Georgios MD
doi : 10.1212/WNL.0000000000012390
Volume 97(8), 24 August 2021, p e777-e784
To provide a critical appraisal on the evidence from randomized controlled clinical trials (RCTs) on the utility of direct endovascular treatment (dEVT) compared to the combination of endovascular treatment preceded by IV thrombolysis (bridging therapy [BT]) for patients with acute large vessel occlusion (LVO).
Differentiating Carotid Free-Floating Thrombus From Atheromatous Plaque Using Intraluminal Filling Defect Length on CTA: A Validation Study
Torres, Carlos MD, FRCPC; Lum, Cheemun MD, FRCP; Puac-Polanco, Paulo MD, MSc; Stotts, Grant MD, FRCPC; Shamy, Michel Christopher Frank MD, MA, FRCPC; Blacquiere, Dylan MD, MSc, FRCPC; Lun, Ronda MD; Dave, Prasham MD; Bharatha, Aditya MD, FRCPC; Menon, Bijoy K. MBBS, MD, DM, MSc, FRCPC; Thornhill, Rebecca PhD; Momoli, Franco PhD, MSc; Dowlatshahi, Dar MD, PhD, FRCPC
doi : 10.1212/WNL.0000000000012368
Volume 97(8), 24 August 2021, p e785-e793
To validate a previously proposed filling defect length threshold of >3.8 mm on CT angiography (CTA) to discriminate between free-floating thrombus (FFT) and plaque of atheroma.
Longitudinal Network Changes and Conversion to Cognitive Impairment in Multiple Sclerosis
Huiskamp, Marijn MSc; Eijlers, Anand J.C. MD, PhD; Broeders, Tommy A.A. MSc; Pasteuning, Jasmin BSc; Dekker, Iris MD, PhD; Uitdehaag, Bernard M.J. MD, PhD; Barkhof, Frederik MD, PhD; Wink, Alle-Meije PhD; Geurts, Jeroen J.G. PhD; Hulst, Hanneke E. PhD; Schoonheim, Menno M. PhD
doi : 10.1212/WNL.0000000000012341
Volume 97(8), 24 August 2021, p e794-e802
To characterize functional network changes related to conversion to cognitive impairment in a large sample of patients with multiple sclerosis (MS) over a period of 5 years.
Progressive Neurochemical Abnormalities in Cognitive and Motor Subgroups of Amyotrophic Lateral Sclerosis: A Prospective Multicenter Study
Ta, Daniel BSc; Ishaque, Abdullah PhD; Srivastava, Ojas BSc; Hanstock, Chris PhD; Seres, Peter MSc; Eurich, Dean T. PhD; Luk, Collin MD, PhD; Briemberg, Hannah MD; Frayne, Richard MD, PhD; Genge, Angela L. MD; Graham, Simon J. PhD; Korngut, Lawrence MD; Zinman, Lorne MD; Kalra, Sanjay MD
doi : 10.1212/WNL.0000000000012367
Volume 97(8), 24 August 2021, p e803-e813
To evaluate progressive cerebral degeneration in amyotrophic lateral sclerosis (ALS) by assessing alterations in N-acetylaspartate (NAA) ratios in the motor and prefrontal cortex within clinical subgroups of ALS.
Association of Orthostatic Hypotension With Cerebral Atrophy in Patients With Lewy Body Disorders
Pilotto, Andrea MD; Romagnolo, Alberto MD; Scalvini, Andrea MD; Masellis, Mario MD, PhD; Shimo, Yasushi MD, PhD; Bonanni, Laura MD, PhD; Camicioli, Richard MD; Wang, Lily L. MD; Dwivedi, Alok K. PhD; Longardner, Katherine MD; Rodriguez-Porcel, Federico MD; DiFrancesco, Mark PhD; Vizcarra, Joaquin A. MD; Montanaro, Elisa PsyD; Maule, Simona MD; Lupini, Alessandro MD; Ojeda-Lopez, Carmen MD, MSc; Black, Sandra E. MD, PhD; Delli Pizzi, Stefano PhD; Gee, Myrlene PhD; Tanaka, Ryota MD, PhD; Yamashiro, Kazuo MD, PhD; Hatano, Taku MD, PhD; Borroni, Barbara MD; Gasparotti, Roberto MD; Rizzetti, Maria C. MD, PhD; Hattori, Nobutaka MD, PhD; Lopiano, Leonardo MD, PhD; Litvan, Irene MD, MSc; Espay, Alberto J. MD, MSc; Padovani, Alessandro MD, PhD; Merola, Aristide MD, PhD
doi : 10.1212/WNL.0000000000012342
Volume 97(8), 24 August 2021, p e814-e824
To evaluate whether orthostatic hypotension (OH) or supine hypertension (SH) is associated with brain atrophy and white matter hyperintensities (WMH), we analyzed clinical and radiologic data from a large multicenter consortium of patients with Parkinson disease (PD) and dementia with Lewy bodies (DLB).
Association of Lewy Bodies With Age-Related Clinical Characteristics in Black and White Decedents
Nag, Sukriti MD, PhD; Barnes, Lisa L. PhD; Yu, Lei PhD; Buchman, Aron S. MD; Bennett, David A. MD; Schneider, Julie A. MD, MS; Wilson, Robert S. PhD
doi : 10.1212/WNL.0000000000012324
Volume 97(8), 24 August 2021, p e825-e835
The associations of Lewy bodies (LBs) with olfactory dysfunction, parkinsonism, and higher odds of dementia were assessed in Black and White community-dwelling elders and racial differences in these associations were tested.
Diabetes Mellitus and Cognition: Pathway Analysis in the MEMENTO Cohort
Frison, Eric MD, PhD; Proust-Lima, Cecile PhD; Mangin, Jean-Francois PhD; Habert, Marie-Odile MD, PhD; Bombois, Stephanie MD, PhD; Ousset, Pierre-Jean MD, PhD; Pasquier, Florence MD, PhD; Hanon, Olivier MD, PhD; Paquet, Claire MD, PhD; Gabelle, Audrey MD, PhD; Ceccaldi, Mathieu MD, PhD; Annweiler, Cedric MD, PhD; Krolak-Salmon, Pierre MD, PhD; Bejot, Yannick MD, PhD; Belin, Catherine MD, PhD; Wallon, David MD, PhD; Sauvee, Mathilde MD, PhD; Beaufils, Emilie MD, PhD; Bourdel-Marchasson, Isabelle MD, PhD; Jalenques, Isabelle MD, PhD; Chupin, Marie PhD; Chene, Genevieve MD, PhD*; Dufouil, Carole PhD*; on behalf of the MEMENTO Cohort Study Group; on behalf of the MEMENTO Cohort Study Group; Allard, Michele MD, PhD; Andrieu, Sandrine MD, PhD; Anthony, Pierre MD, PhD; Astier, Christine MD; Augier, Alexandre MD, PhD; Auguste, Nicolas MD; Auriacombe, Sophie MD, PhD; Avet, John MD, PhD; Bailon, Olivier MD, PhD; Barral, Fabrice-Guy MD; Barre, Jean MD; Barthelaix, Annick MD, PhD; Bayle, Catherine MD; Beauchet, Olivier; Belkacem, Samia MD; Ben Salem, Douraied MD, PhD; Bennys, Karim MD; Bera, Geraldine MD; Berger, Eric MD; Berger, Marc G MD, PhD; Bergouin, Emilie MD; Bertin-Hugault, Francois MD; Bertrand, Guillaume MD; Bertrand, Francois-Xavier MD, PhD; Beze, Catherine MD; Boilet, Valerie; Bonafe, Alain MD, PhD; Boudali, Yasmina MD; Bouhladour, Hatem MD, PhD; Boully, Clemence MD; Bouteloup, Vincent PharmD; Boutet, Claire MD; Bracard, Serge MD, PhD; Brangier, Antoine MD; Brillet, Pierre-Yves MD, PhD; Caillard, Laure MD; Calvas, Fabienne MD; Camus, Agnes MD; Camus, Vincent MD, PhD; Canaple, Sandrine MD; Carpentier, Antoine MD, PhD; Cassagnaud, Pascaline MD; Cattin, Francoise MD; Chamard, Ludivine MD; Chanalet, Stephane MD; Chastan, Mathieu MD; Chauvelier, Sophie MD; Chauvire, Valerie MD; Cheriet, Samia MD, PhD; Clotagatide, Anthony MD; Cognat, Emmanuel MD, PhD; Cohen, Lora PhD; Constans, Jean-Marc MD, PhD; Coste, Marie-Helene MD, PhD; Cottier, Jean-Philippe MD, PhD; Cotton, Francois MD, PhD; Couret, Isabelle MD; Couturier, Olivier-Francois MD, PhD; Cowppli-Bony, Pascale MD, PhD; Cressot, Veronique MD; Cretin, Benjamin MD; Danaila, Keren MD; Darcourt, Jacques MD, PhD; Dartigues, Jean-Francois MD, PhD; Dascalita, Ana-Maria MD, PhD; David, Renaud MD, PhD; De Petigny, Xavier MD; De Verbizier-Lonjon, Delphine MD; Decousus, Marielle MD, PhD; Defouilloy, Isabelle MD, PhD; Delmaire, Christine MD, PhD; Delrieu, Julien MD; Demuyinck, Catherine MD; Deramecourt, Vincent MD, PhD; Deramond, Herve MD, PhD; Desmidt, Thomas MD, PhD; Desruet, Marie-Dominique PharmD, PhD; Detour, Julien; Devendeville, Agnes MD; Didic, Mira MD, PhD; Doireau, Maritchu MD; Santos, Antonio Dos MD; Douillet, Patrice MD; Du Boisgueheneuc, Foucaud MD; Dubail, Delphine MD; Ducroq-Ducastaing, Laure MD; Dumurgier, Julien MD, PhD; Dupuy, Diane MD, PhD; Duron, Emmanuelle MD, PhD; Dygai-Cochet, Inna MD, PhD; Eder, Veronique MD, PhD; Epelbaum, Stephane MD, PhD; Etcharry-Bouyx, Frederique MD, PhD; Fagret, Daniel MD, PhD; Faisant, Catherine MD; Farid, Karim MD, PhD; Federico, Denis MD; Felician, Olivier MD, PhD; Fernandez, Philippe MD, PhD; Fosse, Pacome MD; Foubert-Samier, Alexandra MD, PhD; Franck, Isabelle MD; Galitzky, Monique MD; Gallazzini-Crepin, Celine MD; Gantchev, Radka MD; Garbarg-Chenon, Laurence MD; Gautier, Guillaume MD, PhD; Gerardin, Emmanuel MD, PhD; Gervais, Claire MD; Getenet, Jean-Claude MD; Girard, Nadine MD, PhD; Giraud, Fabienne MD; Girtanner, Chantal MD; Gissot, Valerie MD; Grangeon, Caroline PharmD; Grucker, Daniel MD, PhD; Guedj, Eric MD, PhD; Gueriot, Claude MD; Guilhermet, Yves MD; Guillevin, Remy MD, PhD; Haffen, Sophie MD; Hannequin, Didier MD, PhD; Harston, Sandrine MD; Hitzel, Anne MD, PhD; Hommet, Caroline MD, PhD; Hossein-Foucher, Claude MD, PhD; Hubele, Fabrice MD; Jacquin-Piques, Agnes MD, PhD; Jean, Betty MD; Jenn, Joanne MD, PhD; Joly, Laure MD, PhD; Jonveaux, Therese MD; Julian, Adrien MD, PhD; Kas, Aurelie MD, PhD; Kearney-Schwartz, Anna MD; Keles, Alice MD; Kelly, Antony MD; Keromnes, Nathalie MD; Koric, Lejla MD; Krainik, Alexandre MD, PhD; Kremer, Stephane MD; Labouree, Florian MD; Lacoeuille, Franck MD, PhD; Lala, Francoise MD; Lamy, Chantal MD; Laplanche, Jean-Louis PharmD, PhD; Launay, Cyrille MD, PhD; Lehericy, Stephane MD, PhD; Lehmann, Sylvain MD, PhD; Lenoir, Hermine MD, PhD; Levy, Marcel MD, PhD; Libercier, Stephanie MD, PhD; Mackowiak-Cordoliani, Marie-Anne MD; Magnin, Eloi MD; Makaroff, Zaza MD; Marantidou, Athina MD; Marcet, Isabelle MD; Marelli, Cecilia MD, PhD; Marilier, Sophie MD; Martin, Idalie MD; Martinaud, Olivier MD, PhD; Martin-Hunyadi, Catherine MD; Medjoul, Aicha MD; Merlet, Isabelle MD; Mestas, Danielle MD; Meyer, Marc-Etienne MD, PhD; Michel, Jean-Marc MD; Michon, Agnes MD; Migeon-Duballet, Isabelle MD; Mondon, Karl MD, PhD; Morgat, Clement PharmD, PhD; Moullart, Veronique MD; Moussard, Christian MD; Mouton, Aurelie MD, PhD; Namer, Izzie Jacques MD, PhD; Niewiadomski, Georges MD, PhD; Nivaggioni, Guillaume MD; Noblet, Marie MD, PhD; Nonent, Michel MD, PhD; Nourhashemi, Fati MD, PhD; Oesterle, Helene MD; Orvoen, Galdric MD; Pallardy, Amandine MD; Pare, Pierre-Yves MD, PhD; Pasco, Anne MD, PhD; Payoux, Pierre MD, PhD; Pays, Cecile MD, PhD; Pellegrin, Isabelle MD, PhD; Perdrisot, Remy MD, PhD; Perin, Bertille MD, PhD; Perret-Guillaume, Christine MD, PhD; Petyt, Gregory MD; Philippi, Nathalie MD, PhD; Pinganaud, Genevieve MD; Plichart, Matthieu MD; Pop, Gabriel MD, PhD; Puel, Michele MD; Queneau, Mathieu MD, PhD; Querellou, Solene MD; Quillard-Muraine, Muriel MD, PhD; Quipourt, Valerie MD, PhD; Rachez, Chloe MD, PhD; Razzouk-Cadet, Micheline MD; Rigaud, Anne-Sophie MD, PhD; Robin-Ismer, Helene MD; Rodallec, Mathieu MD, PhD; Rolland, Yves MD, PhD; Rollin-Sillaire, Adeline MD, PhD; Rouaud, Olivier MD; Roubaud, Caroline MD, PhD; Rouch, Isabelle MD, PhD; Roux, Julie MD, PhD; Sacco, Guillaume MD, PhD; Salaun, Pierre-Yves MD; Salmon, Francois MD, PhD; Sanchez, Alicia MD; Santiago-Ribeiro, Maria-Joao MD, PhD; Sarciron, Alain MD; Sastre-Hengan, Nathalie MD; Scheiber, Christian MD, PhD; Schneider, Anne-Marie MD, PhD; Semah, Franck MD, PhD; Serra, Amelie MD; Seux, Marie-Laure MD; Sordet-Guepet, Helene MD; Soto, Maria Eugenia MD; Tafani, Mathieu MD; Tanguy, Jean-Yves MD, PhD; Taroux, Michael MD, PhD; Teichmann, Marc MD, PhD; Terrat, Catherine MD, PhD; Thabet, Jamila MD; Thalamas, Claire MD; Thomas-Anterion, Catherine MD, PhD; Troussiere, Anne-Cecile MD; Ursu, Renata MD; Vera, Pierre MD, PhD; Vercelletto, Martine MD; Vercruysse, Olivier MD; Verger, Antoine MD, PhD; Viau, Philippe MD; Videau, Marie-Neige MD; Voisin, Thierry MD; Wagemann, Nathalie MD, PhD; Waissi-Sediq, Aziza MD; Xie, Jing MD, PhD; Yeni, Nathanaelle MD; Zanca, Michel MD, PhD; Zinszner, Jean MD, PhD
doi : 10.1212/WNL.0000000000012440
Volume 97(8), 24 August 2021, p e836-e848
To assess the role of biomarkers of Alzheimer disease (AD), neurodegeneration, and small vessel disease (SVD) as mediators in the association between diabetes mellitus and cognition.
Skeletal Muscle and Peripheral Nerve Histopathology in COVID-19
Suh, Joome MD; Mukerji, Shibani S. MD, PhD; Collens, Sarah I. BS; Padera, Robert F. Jr MD, PhD; Pinkus, Geraldine S. MD; Amato, Anthony A. MD*; Solomon, Isaac H. MD, PhD*
doi : 10.1212/WNL.0000000000012344
Volume 97(8), 24 August 2021, p e849-e858
To explore the spectrum of skeletal muscle and nerve pathology of patients who died after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and to assess for direct viral invasion of these tissues.
Domain-Specific Outcomes for Stroke Clinical Trials: What the Modified Rankin Isn't Ranking
Braun, Robynne G. MD, PhD; Heitsch, Laura MD; Cole, John W. MD, MS; Lindgren, Arne G. MD, PhD; de Havenon, Adam MD; Dude, Jason A. BS; Lohse, Keith R. PhD; Cramer, Steven C. MD; Worrall, Bradford B. MD, MSc; on behalf of the GPAS Collaboration, Phenotyping Core; on behalf of the GPAS Collaboration, Phenotyping Core; Braun, Robynne G. MD, PhD; Heitsch, Laura MD; Cole, John W. MD, MS; Lindgren, Arne G. MD, PhD; de Havenon, Adam MD; Dude, Jason A. BS; Lohse, Keith R. PhD; Cramer, Steven C. MD; Worrall, Bradford B. MD, MSc
doi : 10.1212/WNL.0000000000012231
Volume 97(8), 24 August 2021, p 367-377
Global outcome measures that are widely used in stroke clinical trials, such as the modified Rankin Scale (mRS), lack sufficient detail to detect changes within specific domains (e.g., sensory, motor, visual, linguistic, or cognitive function). Yet such data are vital for understanding stroke recovery and its mechanisms. Poststroke deficits in specific domains differ in their rate and degree of recovery and in their effects on overall independence and quality of life. For example, even in a patient with complete recovery of strength, persistent deficits in the nonmotor domains such as language and cognition may make a return to independent living impossible. In such cases, global measures based solely on the patient's degree of independence would overlook a complete recovery in the motor domain. Capturing these important aspects of recovery demands a domain-specific approach. If stroke outcomes trials are to incorporate finer-grained recovery metrics-which can require substantial time, effort, and expertise to implement-efficiency must be a priority. In this article, we discuss how commonly collected clinical data from the NIH Stroke Scale can guide the judicious selection of relevant recovery domains for more detailed testing. Our overarching goal is to make the implementation of domain-specific testing more feasible for large-scale clinical trials on stroke recovery.
Secondary Progressive Multiple Sclerosis: New Insights
Cree, Bruce A.C. MD, PhD, MAS; Arnold, Douglas L. MD; Chataway, Jeremy PhD, FRCP; Chitnis, Tanuja MD; Fox, Robert J. MD; Pozo Ramajo, Angela PhD; Murphy, Niamh PhD; Lassmann, Hans MD
doi : 10.1212/WNL.0000000000012323
Volume 97(8), 24 August 2021, p 378-388
In most cases, multiple sclerosis (MS) begins with a relapsing-remitting course followed by insidious disability worsening that is independent from clinically apparent relapses and is termed secondary progressive MS (SMPS). Major differences exist between relapsing-remitting MS (RRMS) and SPMS, especially regarding therapeutic response to treatment. This review provides an overview of the pathology, differentiation, and challenges in the diagnosis and treatment of SPMS. We emphasize the criticality of conversion from a relapsing-remitting to a secondary progressive disease course not only because such conversion is evidence of disability progression, but also because, until recently, treatments that effectively reduced disability progression in relapsing MS were not proven to be effective in SPMS. Clear clinical, imaging, immunologic, or pathologic criteria marking the transition from RRMS to SPMS have not yet been established. Early identification of SPMS will require tools that, together with the use of appropriate treatments, may result in better long-term outcomes for the population of patients with SPMS.
Progressive Neurologic Symptoms in the Setting of HIV: A Rare Case of Neurosymptomatic CSF HIV Escape
Eisenmenger, Laura B. MD; Sawatzky, Benjamin D. MD; Manunga, Jesse M. MD; Sosman, James M. MD; Rowley, Howard A. MD; Kuner, Anthony D. MD
doi : 10.1212/WNL.0000000000012238
Volume 97(8), 24 August 2021, p 389-390
Substantia Nigra Involvement: An Unusual Finding in Heat Stroke
Lersy, Francois MD; Merdji, Hamid MD
doi : 10.1212/WNL.0000000000012277
Volume 97(8), 24 August 2021, p 391-392
Education Research: NeuroBytes: A New Rapid, High-Yield e-Learning Platform for Continuing Professional Development in Neurology
Lavette, Laura E.; Miller, Alexandra MD, PhD; Rook, Bobby; London, Zachary MD; Cook, Calli NP, DNP, APRN, FNP-C; Merkler, Alexander E. MD, MS; Santini, Veronica MD, MA; Ruff, Ilana Marie MD; Kraakevik, Jeff MD; Smith, Don MD; Anderson, Wayne E. DO; Johnson, Stacy L. NP; Yan, Peter Z. MD; Sweeney, Joan MD; Chamberlain, Amanda; Rogers-Baggett, Beth; Isaacson, Richard MD; Strowd, Roy E. MEd, MD, MS
doi : 10.1212/WNL.0000000000012133
Volume 97(8), 24 August 2021, p 393-400
To determine whether NeuroBytes is a helpful e-Learning tool in neurology through usage, viewer type, estimated time and cost of development, and postcourse survey responses.
Editors' Note: The Index Vein Pointing to the Origin of the Migraine Aura Symptom: A Case Series
Ganesh, Aravind MD, DPhil, FRCPC; Galetta, Steven MD
doi : 10.1212/WNL.0000000000012456
Volume 97(8), 24 August 2021, p 401
Reader Response: The Index Vein Pointing to the Origin of the Migraine Aura Symptom: A Case Series
Bugnicourt, Jean-Marc; Godefroy, Olivier
doi : 10.1212/WNL.0000000000012455
Volume 97(8), 24 August 2021, p 401-402
Author Response: The Index Vein Pointing to the Origin of the Migraine Aura Symptom: A Case Series
Schankin, Christoph J.; Denier, Niklaus; El-Koussy, Marwan; Wiest, Roland; Kellner-Weldon, Frauke; Fischer, Urs; Slavova, Nedelina
doi : 10.1212/WNL.0000000000012459
Volume 97(8), 24 August 2021, p 402
Editors' Note: Prehospital Midazolam Use and Outcomes Among Patients With Out-of-Hospital Status Epilepticus
Ganesh, Aravind MD, DPhil, FRCPC; Galetta, Steven MD
doi : 10.1212/WNL.0000000000012458
Volume 97(8), 24 August 2021, p 402-403
Reader Response: Prehospital Midazolam Use and Outcomes Among Patients With Out-of-Hospital Status Epilepticus
Kellinghaus, Christoph; Rossetti, Andrea O.; Ruegg, Stephan; Trinka, Eugen; Rosenow, Felix
doi : 10.1212/WNL.0000000000012461
Volume 97(8), 24 August 2021, p 403-404
Author Response: Prehospital Midazolam Use and Outcomes Among Patients With Out-of-Hospital Status Epilepticus
Guterman, Elan L.; Sanford, Joseph K.; Betjemann, John P.; Zhang, Li; Burke, James F.; Lowenstein, Daniel H.; Josephson, S. Andrew; Sporer, Karl A.
doi : 10.1212/WNL.0000000000012460
Volume 97(8), 24 August 2021, p 404
Clinical Reasoning: A 59-Year-Old Woman Presenting With Diplopia, Dysarthria, Right-Sided Weakness, and Encephalopathy
Manzano, Giovanna S. MD; Torre, Matthew MD; Luskin, Marlise R. MD, MSCE; Vaitkevicius, Henrikas MD
doi : 10.1212/WNL.0000000000012151
Volume 97(8), 24 August 2021, p e859-e864
Teaching Video NeuroImage: Abnormal Movements due to Brainstem Release Phenomenon
Ojha, Kshama MD; Gianakon, Julie Grace MD; Ilyas, Mohammed MD
doi : 10.1212/WNL.0000000000012139
Volume 97(8), 24 August 2021, p e865-e866
Teaching Video NeuroImage: Unique Ipsilateral Manual Automatism in Temporal Lobe Epilepsy: Conducting the Orchestra
Mohamed, Alaa S. MD, MSc; Prusinski, Christian C. DO; Ritaccio, Anthony L. MD; Tatum, William O. DO; Feyissa, Anteneh M. MD, MSc
doi : 10.1212/WNL.0000000000012136
Volume 97(8), 24 August 2021, p e867-e868
