New England Journal of Medicine




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سفارش

The Future of Drug-Pricing Transparency

William B. Feldman, M.D., D.Phil., M.P.H., Benjamin N. Rome, M.D., Jerry Avorn, M.D., and Aaron S. Kesselheim, M.D., J.D., M.P.H.

doi : 10.1056/NEJMp2033734

N Engl J Med 2021; 384:489-491

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A Shared Evaluation Platform for Medical Training

John F. McConville, M.D., and James N. Woodruff, M.D.

doi : 10.1056/NEJMp2031317

N Engl J Med 2021; 384:491-493

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Learning How to Die — Lessons from the Irish Wake

Rose M. Olson, M.D.

doi : 10.1056/NEJMp2030773

N Engl J Med 2021; 384:494-495

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Repurposed Antiviral Drugs for Covid-19 — Interim WHO Solidarity Trial Results

WHO Solidarity Trial Consortium*

doi : 10.1056/NEJMoa2023184

N Engl J Med 2021; 384:497-511

World Health Organization expert groups recommended mortality trials of four repurposed antiviral drugs — remdesivir, hydroxychloroquine, lopinavir, and interferon beta-1a — in patients hospitalized with coronavirus disease 2019 (Covid-19).

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Phase 3 Trials of Tirbanibulin Ointment for Actinic Keratosis

Andrew Blauvelt, M.D., Steven Kempers, M.D., Edward Lain, M.D., Todd Schlesinger, M.D., Stephen Tyring, M.D., Ph.D., Seth Forman, M.D., Glynis Ablon, M.D., George Martin, M.D., Hui Wang, Ph.D., David L. Cutler, M.D., Jane Fang, M.B., B.S., and Min-Fun R. Kwan, M.B., B.S. for the Phase 3 Tirbanibulin for Actinic Keratosis Group*

doi : 10.1056/NEJMoa2024040

N Engl J Med 2021; 384:512-520

The tubulin polymerization and Src kinase signaling inhibitor tirbanibulin is being investigated as a topical treatment for actinic keratosis, a precursor of squamous-cell carcinoma.

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Posture, Gait, Quality of Life, and Hearing with a Vestibular Implant

Margaret R. Chow, B.S., Andrianna I. Ayiotis, B.S., Desi P. Schoo, M.D., Yoav Gimmon, P.T., Ph.D., Kelly E. Lane, R.V.T., Brian J. Morris, B.S., Mehdi A. Rahman, M.S., Nicolas S. Valentin, M.S., Peter J. Boutros, Ph.D., Stephen P. Bowditch, Au.D., Bryan K. Ward, M.D., Daniel Q. Sun, M.D., Carolina Trevi?o Guajardo, M.D., Michael C. Schubert, P.T., Ph.D., John P. Carey, M.D., and Charles C. Della Santina, M.D., Ph.D.

doi : 10.1056/NEJMoa2020457

N Engl J Med 2021; 384:521-532

Bilateral vestibular hypofunction is associated with chronic disequilibrium, postural instability, and unsteady gait owing to failure of vestibular reflexes that stabilize the eyes, head, and body. A vestibular implant may be effective in alleviating symptoms.

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Antibody Status and Incidence of SARS-CoV-2 Infection in Health Care Workers

Sheila F. Lumley, B.M., B.Ch., Denise O’Donnell, B.Sc., Nicole E. Stoesser, M.B., B.S., D.Phil., Philippa C. Matthews, F.R.C.P., D.Phil., Alison Howarth, Ph.D., Stephanie B. Hatch, Ph.D., Brian D. Marsden, D.Phil., Stuart Cox, Tim James, Ph.D., Fiona Warren, B.Sc., Liam J. Peck, D.Phil., Thomas G. Ritter, B.A., Zoe de Toledo, M.Sc., Laura Warren, David Axten, B.A., Richard J. Cornall, M.D., D.Phil., E. Yvonne Jones, D.Phil., David I. Stuart, Ph.D., Gavin Screaton, B.M., B.Ch., D.Phil., Daniel Ebner, B.Sc., Sarah Hoosdally, Ph.D., Meera Chand, M.B., B.S., Derrick W. Crook, F.R.C.Path., Anne-Marie O’Donnell, M.B., B.S., Christopher P. Conlon, M.D., Koen B. Pouwels, Ph.D., A. Sarah Walker, Ph.D., Tim E.A. Peto, F.R.C.P., Susan Hopkins, F.R.C.P., Timothy M. Walker, M.B., B.S., D.Phil., Katie Jeffery, F.R.C.Path., Ph.D., and David W. Eyre, B.M., B.Ch., D.Phil. for the Oxford University Hospitals Staff Testing Group*

doi : 10.1056/NEJMoa2034545

N Engl J Med 2021; 384:533-540

The relationship between the presence of antibodies to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the risk of subsequent reinfection remains unclear.

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Randomized Trial of a Vaccine Regimen to Prevent Chronic HCV Infection

Kimberly Page, Ph.D., M.P.H., Michael T. Melia, M.D., Rebecca T. Veenhuis, Ph.D., Matthew Winter, D.D.S., Kimberly E. Rousseau, B.S., Guido Massaccesi, B.S., William O. Osburn, Ph.D., Michael Forman, B.S., Elaine Thomas, M.D., Karla Thornton, M.D., M.P.H., Katherine Wagner, M.I.P.H., Ventzislav Vassilev, Ph.D., Lan Lin, M.D., Paula J. Lum, M.D., M.P.H., Linda C. Giudice, M.D., Ph.D., Ellen Stein, M.P.H., Alice Asher, R.N., Ph.D., Soju Chang, M.D., Richard Gorman, M.D., Marc G. Ghany, M.D., M.H.Sc., T. Jake Liang, M.D., Michael R. Wierzbicki, Ph.D., Elisa Scarselli, M.D., Alfredo Nicosia, Ph.D., Antonella Folgori, Ph.D., Stefania Capone, B.S., and Andrea L. Cox, M.D., Ph.D.

doi : 10.1056/NEJMoa2023345

N Engl J Med 2021; 384:541-549

A safe and effective vaccine to prevent chronic hepatitis C virus (HCV) infection is a critical component of efforts to eliminate the disease.

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Circadian Mechanisms in Medicine

Ravi Allada, M.D., and Joseph Bass, M.D., Ph.D.

doi : 10.1056/NEJMra1802337

N Engl J Med 2021; 384:550-561

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Heart-Shaped Lesion

Sami Karapolat, M.D., and Mustafa Sisman, M.D.

doi : 10.1056/NEJMicm2024088

N Engl J Med 2021; 384:562

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Mechanic’s Hands

Soumya Chatterjee, M.D.

doi : 10.1056/NEJMicm2026773

N Engl J Med 2021; 384:e16

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Case 4-2021: A 70-Year-Old Woman with Dyspnea on Exertion and Abnormal Findings on Chest Imaging

Richard M. Schwartzstein, M.D., Benjamin D. Medoff, M.D., Amita Sharma, M.D., Yolonda L. Colson, M.D., Justin Gainor, M.D., and Lida P. Hariri, M.D., Ph.D.

doi : 10.1056/NEJMcpc2027088

N Engl J Med 2021; 384:563-574

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A Large, Simple Trial Leading to Complex Questions

David P. Harrington, Ph.D., Lindsey R. Baden, M.D., and Joseph W. Hogan, Sc.D.

doi : 10.1056/NEJMe2034294

N Engl J Med 2021; 384:576-577

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Audio Interview: Does Vaccination Mean the End of Masking and Social Distancing?

Eric J. Rubin, M.D., Ph.D., Lindsey R. Baden, M.D., and Stephen Morrissey, Ph.D.

doi : 10.1056/NEJMe2102482

N Engl J Med 2021; 384:e32

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Regulatory T Cells in Multiple Sclerosis

Joan M. Goverman, Ph.D.

doi : 10.1056/NEJMcibr2033544

N Engl J Med 2021; 384:578-580

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Ustekinumab for Refractory Colitis Associated with Immune Checkpoint Inhibitors

doi : 10.1056/NEJMc2031717

N Engl J Med 2021; 384:581-583

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Atezolizumab for PD-L1–Selected Patients with NSCLC

doi : 10.1056/NEJMc2032432

N Engl J Med 2021; 384:583-585

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Endometrial Cancer

doi : 10.1056/NEJMc2035378

N Engl J Med 2021; 384:586

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Evinacumab for Homozygous Familial Hypercholesterolemia

doi : 10.1056/NEJMc2033612

N Engl J Med 2021; 384:e17

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One of Us

Raymond Givens, M.D., Ph.D.

doi : 10.1056/NEJMpv2100228

N Engl J Med 2021; 384:e18

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