Model of gastroesophageal reflux disease (GERD) pathogenesis in adults

EGJ: esophagogastric junction; LES-CD: lower esophageal sphincter-crural diphragm; TLESR: transient lower esophageal sphincter relaxation crural diagphram; SCJ: squamocolumnar junction.

Reproduced with permission from: Boeckxstaens G, El-Serag HB, Smout AJ, Kahrilas PJ. Symptomatic reflux disease: The present, the past and the future. Gut 2014; 63:1185. Copyright © 2014 BMJ Publishing Group Ltd & British Society of Gastroenterology.

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Model of gastroesophageal reflux disease (GERD) pathogenesis in adults