Differential diagnosis of RLS during pregnancy

Common mimics

Positional discomfort

Venous stasis

Leg edema

Leg cramps

Compression and stretch neuropathies

Sore leg muscles

Ligament sprain/tendon strain

Positional ischemia (numbness)

Dermatitis

Bruises

Less common mimics

Arthritis

Other orthopedic disorders

Peripheral neuropathy

Radiculopathy

Myopathy

Myelopathy

Fibromyalgia

Complex regional pain syndrome

Drug-induced akathisia

Sickle cell disease

RLS: restless legs syndrome.

Reproduced from: Picchietti DL, Hensley JG, Bainbridge JL, et al. Consensus clinical practice guidelines for the diagnosis and treatment of restless legs syndrome/Willis-Ekbom disease during pregnancy and lactation. Sleep Med Rev 2015; 22:64. Table used with the permission of Elsevier Inc. All rights reserved.

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Differential diagnosis of RLS during pregnancy