Rising PSA after definitive radiation therapy*

PSA: prostate-specific antigen; ADT: androgen deprivation therapy.
* A PSA rise of 2 ng/mL or more above the nadir PSA (Phoenix criteria).
¶ The staging evaluation may include computed tomography (CT) of the abdomen and pelvis, bone scan, and/or positron emission tomography (PET) scan using one of the more sensitive prostate cancer-specific radiotracers (eg, F-18 fluciclovine [Axumin] or gallium Ga-68 PSMA-11).
Δ Factors to consider include age, comorbidity, PSA kinetics, Gleason grade, and prognostic factors at original diagnosis.
◊ Options include radical prostatectomy, cryotherapy, brachytherapy.